{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:27:15Z","timestamp":1768343235502,"version":"3.49.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.mehy.2016.04.027","type":"journal-article","created":{"date-parts":[[2016,4,16]],"date-time":"2016-04-16T16:16:29Z","timestamp":1460823389000},"page":"103-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton\u2019s base reservoir with net base-producing diets"],"prefix":"10.1016","volume":"91","author":[{"given":"Anthony","family":"Sebastian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda A.","family":"Frassetto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2016.04.027_b0005","series-title":"Basic and applied bone biology","author":"Burr","year":"2013"},{"key":"10.1016\/j.mehy.2016.04.027_b0010","series-title":"Osteoporosis","author":"Marcus","year":"2013"},{"key":"10.1016\/j.mehy.2016.04.027_b0015","series-title":"International osteoporosis foundation","article-title":"Bone care for the postmenopausal woman","author":"Dawson-Hughes","year":"2013"},{"key":"10.1016\/j.mehy.2016.04.027_b0020","series-title":"Calcium","author":"Higdon","year":"2010"},{"key":"10.1016\/j.mehy.2016.04.027_b0025","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/ki.1995.171","article-title":"Trade-offs in the adaptation to acidosis","volume":"47","author":"Alpern","year":"1995","journal-title":"Kidney Int"},{"key":"10.1016\/j.mehy.2016.04.027_b0030","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0272-6386(97)90045-7","article-title":"The clinical spectrum of chronic metabolic acidosis: homeostatic mechanisms produce significant morbidity","volume":"29","author":"Alpern","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.mehy.2016.04.027_b0035","first-page":"912","article-title":"Long-latency deficiency disease: insights from calcium and vitamin D","volume":"78","author":"Heaney","year":"2003"},{"key":"10.1016\/j.mehy.2016.04.027_b0040","first-page":"40","article-title":"Acidosis and bone","volume":"20","author":"Bushinsky","year":"1994"},{"key":"10.1016\/j.mehy.2016.04.027_b0045","first-page":"238","article-title":"Acid\u2013base imbalance and the skeleton","volume":"40","author":"Bushinsky","year":"2001"},{"key":"10.1016\/j.mehy.2016.04.027_b0050","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00041552-200007000-00008","article-title":"The effects of acid on bone","volume":"9","author":"Bushinsky","year":"2000","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.mehy.2016.04.027_b0055","first-page":"F811","article-title":"Bone buffering of acid and base in humans","volume":"285","author":"Lemann","year":"2003"},{"key":"10.1016\/j.mehy.2016.04.027_b0060","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1172\/JCI105467","article-title":"The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis","volume":"45","author":"Lemann","year":"1966","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2016.04.027_b0065","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1159\/000420160","article-title":"The role of bone in the regulation of systemic acid\u2013base balance","volume":"91","author":"Green","year":"1991","journal-title":"Contrib Nephrol"},{"issue":"4","key":"10.1016\/j.mehy.2016.04.027_b0070","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1210\/jc.2014-4166","article-title":"Arterialized venous bicarbonate is associated with lower bone mineral density and an increased rate of bone loss in older men and women","volume":"100","author":"Tabatabai","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2016.04.027_b0075","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/ajcn\/73.1.118","article-title":"A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women","volume":"73","author":"Sellmeyer","year":"2001","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0080","first-page":"1114","article-title":"Effect of age on blood acid\u2013base composition in adult humans: role of age-related renal functional decline","volume":"271","author":"Frassetto","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.mehy.2016.04.027_b0085","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ki.1983.210","article-title":"Effect of diet on plasma acid\u2013base composition in normal humans","volume":"24","author":"Kurtz","year":"1983","journal-title":"Kidney Int"},{"key":"10.1016\/j.mehy.2016.04.027_b0090","first-page":"159","article-title":"Acid production","author":"Kleinman","year":"1987"},{"key":"10.1016\/j.mehy.2016.04.027_b0095","first-page":"1621","article-title":"The acid\u2013base effects of the contemporary Western diet: an evolutionary perspective","author":"Sebastian","year":"2007"},{"key":"10.1016\/j.mehy.2016.04.027_b0100","doi-asserted-by":"crossref","first-page":"415S","DOI":"10.1093\/jn\/138.2.415S","article-title":"Extracellular pH regulates bone cell function","volume":"138","author":"Arnett","year":"2008","journal-title":"J Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0105","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1088\/0143-0815\/10\/3\/001","article-title":"Reference values for resting blood flow to organs of man","volume":"10","author":"Williams","year":"1989","journal-title":"Clin Phys Physiol Meas"},{"key":"10.1016\/j.mehy.2016.04.027_b0110","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/07315724.2006.10719536","article-title":"Dietary acid\u2013base balance, bone resorption, and calcium excretion","volume":"25","author":"Jajoo","year":"2006","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0115","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1210\/jc.2008-1662","article-title":"Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women","volume":"94","author":"Dawson-Hughes","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2016.04.027_b0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1210\/jc.2012-3099","article-title":"Effect of potassium citrate on bone density, microarchitecture, and fracture risk in healthy older adults without osteoporosis: a randomized controlled trial","volume":"98","author":"Jehle","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"28","key":"10.1016\/j.mehy.2016.04.027_b0125","first-page":"497","article-title":"Potassium citrate supplementation results in sustained improvement in calcium balance in older men and women","volume":"2013","author":"Moseley","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2016.04.027_b0130","doi-asserted-by":"crossref","DOI":"10.1201\/b14402-9","article-title":"An evolutionary perspective on the acid\u2013base effects of diet","author":"Sebastian","year":"2005"},{"key":"10.1016\/j.mehy.2016.04.027_b0135","first-page":"F216","article-title":"Metabolic alkalosis decreases bone calcium efflux by suppressing osteoclasts and stimulating osteoblasts","volume":"271","author":"Bushinsky","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.mehy.2016.04.027_b0140","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0169-6009(08)80131-6","article-title":"Medium pH modulates matrix, mineral, and energy metabolism in cultured chick bones and osteoblast-like cells","volume":"24","author":"Ramp","year":"1994","journal-title":"Bone Miner"},{"key":"10.1016\/j.mehy.2016.04.027_b0145","doi-asserted-by":"crossref","first-page":"C111","DOI":"10.1152\/ajpcell.1992.262.1.C111","article-title":"Role of calcium and cAMP messenger systems in intracellular pH regulation of osteoblastic cells","volume":"262","author":"Green","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1016\/j.mehy.2016.04.027_b0150","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1056\/NEJM199406233302502","article-title":"Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate","volume":"330","author":"Sebastian","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2016.04.027_b0155","series-title":"Clinician\u2019s guide to prevention and treatment of osteoporosis","author":"National Osteoporosis Foundation","year":"2014"},{"key":"10.1016\/j.mehy.2016.04.027_b0160","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/ajcn\/82.5.921","article-title":"Dietary protein content and the diet\u2019s net acid load: opposing effects on bone health","volume":"82","author":"Sebastian","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0165","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s00223-003-0091-8","article-title":"Effects of potassium citrate supplementation on bone metabolism","volume":"74","author":"Marangella","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.mehy.2016.04.027_b0170","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/ajcn\/82.5.1107","article-title":"Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children","volume":"82","author":"Alexy","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0175","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/ki.1997.26","article-title":"Effect of chronic metabolic acidosis on the growth hormone\/IGF-1 endocrine axis: new cause of growth hormone insensitivity in humans","volume":"51","author":"Brungger","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.mehy.2016.04.027_b0180","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1093\/ajcn\/76.6.1308","article-title":"Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors","volume":"76","author":"Sebastian","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0185","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/jbmr.2554","article-title":"Potassium bicarbonate supplementation lowers bone turnover and calcium excretion in older men and women: a randomized dose-finding trial","volume":"30","author":"Dawson-Hughes","year":"2015","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.mehy.2016.04.027_b0190","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(68)90908-2","article-title":"Diet and osteoporosis","volume":"1","author":"Wachman","year":"1968","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2016.04.027_b0195","first-page":"16","article-title":"Cytosolic pH regulation in osteoblasts","volume":"20","author":"Green","year":"1994","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.mehy.2016.04.027_b0200","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/10409230091169249","article-title":"Nucleotide pyrophosphatases\/phosphodiesterases on the move","volume":"35","author":"Bollen","year":"2000","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.mehy.2016.04.027_b0205","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s00223-013-9745-3","article-title":"Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles\u2019 biomimetics","volume":"93","author":"Simao","year":"2013","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.mehy.2016.04.027_b0210","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00223-004-0285-8","article-title":"Acidosis inhibits bone formation by osteoblasts in vitro by preventing mineralization","volume":"77","author":"Brandao-Burch","year":"2005","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.mehy.2016.04.027_b0215","doi-asserted-by":"crossref","first-page":"8662","DOI":"10.1039\/c2jm16141a","article-title":"Bone regeneration: importance of local pH-strontium-doped borosilicate scaffold","volume":"22","author":"Shen","year":"2012","journal-title":"J Mater Chem"},{"key":"10.1016\/j.mehy.2016.04.027_b0220","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/10408368209107027","article-title":"Biochemistry of alkaline phosphatase isoenzymes","volume":"16","author":"Crofton","year":"1982","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/j.mehy.2016.04.027_b0225","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ajcn.81.2.341","article-title":"Origins and evolution of the Western diet: health implications for the 21st century","volume":"81","author":"Cordain","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.mehy.2016.04.027_b0230","doi-asserted-by":"crossref","first-page":"R546","DOI":"10.1152\/ajpregu.00491.2005","article-title":"Role of potassium in regulating blood flow and blood pressure","volume":"290","author":"Haddy","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.mehy.2016.04.027_b0235","doi-asserted-by":"crossref","first-page":"2829","DOI":"10.1073\/pnas.0813069106","article-title":"Potassium softens vascular endothelium and increases nitric oxide release","volume":"106","author":"Oberleithner","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2016.04.027_b0240","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S8756-3282(97)00202-0","article-title":"Effects of nitric oxide synthase inhibitors on bone formation in rats","volume":"21","author":"Turner","year":"1997","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2016.04.027_b0245","first-page":"E955","article-title":"Nitric oxide is an early mediator of the increase in bone formation by mechanical stimulation","volume":"270","author":"Fox","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.mehy.2016.04.027_b0250","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2567.2001.01261.x","article-title":"Nitric oxide and bone","volume":"103","author":"van\u2019t Hof","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.mehy.2016.04.027_b0255","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1056\/NEJMoa1305224","article-title":"Romosozumab in postmenopausal women with osteopenia","volume":"370","author":"McClung","year":"2014","journal-title":"N Engl J Med"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716300445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716300445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T15:47:08Z","timestamp":1567784828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716300445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":51,"alternative-id":["S0306987716300445"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.04.027","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton\u2019s base reservoir with net base-producing diets","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.04.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}