{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:23:56Z","timestamp":1791296636959,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100013202","name":"Touro University-California","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013202","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.mehy.2016.05.026","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T04:28:48Z","timestamp":1464150528000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance"],"prefix":"10.1016","volume":"93","author":[{"given":"Alejandro","family":"Gugliucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2016.05.026_b0005","article-title":"Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome","author":"Lustig","year":"2015","journal-title":"Obesity"},{"key":"10.1016\/j.mehy.2016.05.026_b0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/nyas.12030","article-title":"What is metabolic syndrome, and why are children getting it?","volume":"1281","author":"Weiss","year":"2013","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.mehy.2016.05.026_b0015","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrgastro.2010.41","article-title":"The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome","volume":"7","author":"Lim","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.mehy.2016.05.026_b0020","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1210\/jc.2014-3678","article-title":"Effect of a high-fructose weight-maintaining diet on lipogenesis and liver fat","volume":"100","author":"Schwarz","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2016.05.026_b0025","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/MOL.0b013e3283613bca","article-title":"Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies","volume":"24","author":"Stanhope","year":"2013","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.mehy.2016.05.026_b0030","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1172\/JCI37385","article-title":"Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight\/obese humans","volume":"119","author":"Stanhope","year":"2009","journal-title":"J Clin Investig"},{"key":"10.1016\/j.mehy.2016.05.026_b0035","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s11883-012-0276-6","article-title":"Fructose and risk of cardiometabolic disease","volume":"14","author":"Bray","year":"2012","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.mehy.2016.05.026_b0040","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.nut.2010.02.014","article-title":"Fructose and metabolic diseases: new findings, new questions","volume":"26","author":"Tappy","year":"2010","journal-title":"Nutrition"},{"key":"10.1016\/j.mehy.2016.05.026_b0045","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3945\/an.113.005249","article-title":"Clinical research strategies for fructose metabolism","volume":"5","author":"Laughlin","year":"2014","journal-title":"Adv Nutr"},{"key":"10.1016\/j.mehy.2016.05.026_b0050","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1053\/j.gastro.2013.11.049","article-title":"Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease","volume":"146","author":"Lambert","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mehy.2016.05.026_b0055","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/MOL.0000000000000080","article-title":"Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans","volume":"25","author":"Jacome-Sosa","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.mehy.2016.05.026_b0060","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/ijpo.238","article-title":"Oral fructose absorption in obese children with non-alcoholic fatty liver disease","volume":"10","author":"Sullivan","year":"2015","journal-title":"Pediatr Obes"},{"key":"10.1016\/j.mehy.2016.05.026_b0065","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.jash.2015.07.008","article-title":"A pilot study on the impact of a low fructose diet and allopurinol on clinic blood pressure among overweight and prehypertensive subjects: a randomized placebo controlled trial","volume":"9","author":"Madero","year":"2015","journal-title":"J Am Soc Hypertens"},{"key":"10.1016\/j.mehy.2016.05.026_b0070","first-page":"31","article-title":"Sugar-sweetened beverages, urate, gout and genetic interaction","volume":"20","author":"Merriman","year":"2014","journal-title":"Pac Health Dialog"},{"key":"10.1016\/j.mehy.2016.05.026_b0075","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.2337\/db12-1814","article-title":"Sugar, uric acid, and the etiology of diabetes and obesity","volume":"62","author":"Johnson","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.mehy.2016.05.026_b0080","doi-asserted-by":"crossref","first-page":"905","DOI":"10.7326\/0003-4819-156-12-201206190-00024","article-title":"Effects of excessive fructose intake on health","volume":"156","author":"Johnson","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.mehy.2016.05.026_b0085","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1152\/physrev.00019.2009","article-title":"Metabolic effects of fructose and the worldwide increase in obesity","volume":"90","author":"Tappy","year":"2010","journal-title":"Physiol Rev"},{"key":"10.1016\/j.mehy.2016.05.026_b0090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbrc.2015.01.140","article-title":"Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease","volume":"458","author":"Rabbani","year":"2015","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mehy.2016.05.026_b0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.semcdb.2011.02.015","article-title":"Glyoxalase in diabetes, obesity and related disorders","volume":"22","author":"Rabbani","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.mehy.2016.05.026_b0100","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/hep.26594","article-title":"High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase","volume":"58","author":"Ishimoto","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.mehy.2016.05.026_b0105","doi-asserted-by":"crossref","first-page":"ra21","DOI":"10.1126\/scisignal.aac5472","article-title":"Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis","volume":"9","author":"DeBosch","year":"2016","journal-title":"Sci Signal"},{"key":"10.1016\/j.mehy.2016.05.026_b0110","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1074\/jbc.M113.527002","article-title":"Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis","volume":"289","author":"Debosch","year":"2014","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2016.05.026_b0115","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1210\/me.2013-1137","article-title":"Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice","volume":"27","author":"DeBosch","year":"2013","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.mehy.2016.05.026_b0120","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tcb.2015.10.013","article-title":"AMPK: an energy-sensing pathway with multiple inputs and outputs","volume":"26","author":"Hardie","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.mehy.2016.05.026_b0125","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cmet.2013.08.019","article-title":"AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation","volume":"18","author":"Gowans","year":"2013","journal-title":"Cell Metab"},{"key":"10.1016\/j.mehy.2016.05.026_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ceb.2014.09.004","article-title":"AMPK: positive and negative regulation, and its role in whole-body energy homeostasis","volume":"33","author":"Hardie","year":"2015","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.mehy.2016.05.026_b0135","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.cmet.2014.09.013","article-title":"AMPK\u2013sensing energy while talking to other signaling pathways","volume":"20","author":"Hardie","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.mehy.2016.05.026_b0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/BST20130244","article-title":"AMPK: a cellular energy sensor primarily regulated by AMP","volume":"42","author":"Gowans","year":"2014","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.mehy.2016.05.026_b0145","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3945\/an.114.008177","article-title":"Fructose-containing sugars and cardiovascular disease","volume":"6","author":"Rippe","year":"2015","journal-title":"Adv Nutr"},{"key":"10.1016\/j.mehy.2016.05.026_b0150","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.mayocp.2014.12.019","article-title":"Added fructose: a principal driver of type 2 diabetes mellitus and its consequences","volume":"90","author":"DiNicolantonio","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.mehy.2016.05.026_b0155","first-page":"109","article-title":"Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction","volume":"4","author":"Basaranoglu","year":"2015","journal-title":"Hepatobiliary Surgery Nutr"},{"key":"10.1016\/j.mehy.2016.05.026_b0160","doi-asserted-by":"crossref","first-page":"50","DOI":"10.2337\/db13-1606","article-title":"The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy","volume":"63","author":"Rabbani","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.mehy.2016.05.026_b0165","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1172\/JCI82204","article-title":"Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver","volume":"125","author":"Satapati","year":"2015","journal-title":"J Clin Investig"},{"key":"10.1016\/j.mehy.2016.05.026_b0170","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1161\/CIRCRESAHA.110.223545","article-title":"Oxidative stress and diabetic complications","volume":"107","author":"Giacco","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.mehy.2016.05.026_b0175","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1046\/j.1523-1755.2000.07705.x","article-title":"The missing link: a single unifying mechanism for diabetic complications","volume":"77","author":"Nishikawa","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.mehy.2016.05.026_b0180","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.mehy.2009.06.044","article-title":"\u201cBlinding\u201d of AMP-dependent kinase by methylglyoxal: a mechanism that allows perpetuation of hepatic insulin resistance?","volume":"73","author":"Gugliucci","year":"2009","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2016.05.026_b0185","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.3390\/nu6083187","article-title":"Dietary fructose reduction improves markers of cardiovascular disease risk in Hispanic-American adolescents with NAFLD","volume":"6","author":"Jin","year":"2014","journal-title":"Nutrients"},{"key":"10.1016\/j.mehy.2016.05.026_b0190","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2337\/dc13-2085","article-title":"Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar","volume":"37","author":"Bray","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.mehy.2016.05.026_b0195","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1681\/ASN.2013080901","article-title":"Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy","volume":"25","author":"Lanaspa","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.mehy.2016.05.026_b0200","doi-asserted-by":"crossref","first-page":"40732","DOI":"10.1074\/jbc.M112.399899","article-title":"Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver","volume":"287","author":"Lanaspa","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2016.05.026_b0205","doi-asserted-by":"crossref","first-page":"R97","DOI":"10.1530\/JOE-15-0447","article-title":"Current understanding of metformin effect on the control of hyperglycemia in diabetes","volume":"228","author":"An","year":"2016","journal-title":"J Endocrinol"},{"key":"10.1016\/j.mehy.2016.05.026_b0210","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.1158\/1078-0432.CCR-14-3300","article-title":"Molecular pathways: is AMPK a friend or a foe in cancer?","volume":"21","author":"Hardie","year":"2015","journal-title":"Clin Cancer Res"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716301621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716301621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T21:51:33Z","timestamp":1589665893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716301621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":42,"alternative-id":["S0306987716301621"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.05.026","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase and lead to increased lipogenesis and hepatic insulin resistance","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}