{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:26:56Z","timestamp":1788852416111,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.mehy.2016.09.018","type":"journal-article","created":{"date-parts":[[2016,9,24]],"date-time":"2016-09-24T21:26:55Z","timestamp":1474752415000},"page":"48-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Is lithium essential for epididymal sperm maturation?"],"prefix":"10.1016","volume":"96","author":[{"given":"Tanmoy","family":"Halder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam","family":"Datta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasenjit","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2016.09.018_b0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/jmor.1051910206","article-title":"Epididymis of the Indian wall lizard (Hemidactylus flaviviridis) during the sexual cycle and in response to mammalian pituitary gonadotrophins and testosterone","volume":"19","author":"Haider","year":"1987","journal-title":"J Morphol"},{"key":"10.1016\/j.mehy.2016.09.018_b0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3109\/01485019508987858","article-title":"Relationship between intracellular calcium, energy metabolism and motility of ram spermatozoa","volume":"351","author":"Breitbat","year":"1995","journal-title":"Arch Androl"},{"key":"10.1016\/j.mehy.2016.09.018_b0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/humrep\/13.suppl_4.20","article-title":"Role of ionic environment and internal Ph on sperm activity","volume":"4","author":"Hamameh","year":"1998","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2016.09.018_b0020","series-title":"Regulatory mechanisms of male reproductive physiology","first-page":"115","article-title":"Specific proteins of the male reproductive tract","author":"Schellpfeffer","year":"1976"},{"key":"10.1016\/j.mehy.2016.09.018_b0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/019262301301418856","article-title":"Overview of male reproductive pathology","volume":"29","author":"Foley","year":"2001","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.mehy.2016.09.018_b0030","first-page":"288","article-title":"Inductive coupled plasma emission spectroscopic and flame photometric analysis of goat epididymal fluid","volume":"2","author":"Gaur","year":"2000","journal-title":"Asian J Androl"},{"key":"10.1016\/j.mehy.2016.09.018_b0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/j.1939-4640.2003.tb02653.x","article-title":"Epididymosomes and prostasomes: their role in post testicular maturation of the sperm cells","volume":"24","author":"Saez","year":"2003","journal-title":"J Androl"},{"key":"10.1016\/j.mehy.2016.09.018_b0040","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1265\/jjh.60.418","article-title":"Trace elements and sperm parameters in semen of male partners of infertile couples","volume":"60","author":"Shinohara","year":"2005","journal-title":"Nippon Eiseigaku Zasshi"},{"issue":"10","key":"10.1016\/j.mehy.2016.09.018_b0045","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1080\/10934529.2013.777243","article-title":"The impact of lead and cadmium on selected motility, pro-oxidant and antioxidant parameters of bovine seminal plasma and spermatozoa","volume":"48","author":"Tvrda","year":"2013","journal-title":"J Environ Sci Health Part A"},{"issue":"2","key":"10.1016\/j.mehy.2016.09.018_b0050","first-page":"536","article-title":"Relationships between iron and copper content, motility characteristics and antioxidant status in bovine seminal plasma","volume":"2","author":"Tvrda","year":"2012","journal-title":"J Microbiol Biotechnol Food Sci"},{"issue":"I","key":"10.1016\/j.mehy.2016.09.018_b0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1080\/07315724.2002.10719188","article-title":"Lithium: occurrence, dietary intakes, nutritional essentiality","volume":"21","author":"Schrauzer","year":"2002","journal-title":"J Am Coll Nutr"},{"key":"10.1016\/j.mehy.2016.09.018_b0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/(SICI)1520-670X(1998)11:2\/3<251::AID-JTRA15>3.0.CO;2-Q","article-title":"Ultratrace elements in nutrition: current knowledge and speculation","volume":"11","author":"Nielson","year":"1998","journal-title":"J Trace Elem Expt Med"},{"key":"10.1016\/j.mehy.2016.09.018_b0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF02783685","article-title":"Evidence for dietary essentiality of lithium in rat","volume":"34","author":"Pickett","year":"1992","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.mehy.2016.09.018_b0070","series-title":"Lithium in biology and medicine","first-page":"148","article-title":"The biological importance of lithium","author":"Anke","year":"1990"},{"key":"10.1016\/j.mehy.2016.09.018_b0075","series-title":"Trace elements from soil to human","author":"Kabata-Pendias","year":"2007"},{"key":"10.1016\/j.mehy.2016.09.018_b0080","first-page":"39","article-title":"Manic depressive psychosis in India and the possible role of lithium as a natural prophylactic: II\u2013Lithium content of diet and some biological fluids in Indian subjects","volume":"26","author":"Jathar","year":"1980","journal-title":"J Postgrad Med"},{"key":"10.1016\/j.mehy.2016.09.018_b0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0015-0282(16)45801-2","article-title":"Effects of psychotropic drugs on human sperm motility","volume":"55","author":"Levin","year":"1981","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2016.09.018_b0090","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/acta.0.1250313","article-title":"Studies on the effect of prolactin treatment on testicular steroidogenesis and gametogenesis in lithium treated rats","volume":"125","author":"Ghosh","year":"1991","journal-title":"Acta Endocrinol"},{"issue":"2","key":"10.1016\/j.mehy.2016.09.018_b0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0024-3205(90)90045-S","article-title":"Effects of lithium chloride on testicular steroidogenic and gametogenic functions in mature male albino rats","volume":"16","author":"Ghosh","year":"1990","journal-title":"Life Sci"},{"issue":"8","key":"10.1016\/j.mehy.2016.09.018_b0100","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10815-010-9426-3","article-title":"Lithium protects against toxic effects of cadmium in the rat testes","volume":"27","author":"Al-Azemi","year":"2010","journal-title":"J Assist Reprod Genet"},{"key":"10.1016\/j.mehy.2016.09.018_b0105","first-page":"639","article-title":"Lithium chloride protects Pc12 pheochromocytome cell line from morphine-induced apoptosis","volume":"11","author":"Sahebgharani","year":"2008","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.mehy.2016.09.018_b0110","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1365-2125.1989.tb03565.x","article-title":"Lithium inhibits human sperm motility in-vitro","volume":"28","author":"Raoof","year":"1989","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.mehy.2016.09.018_b0115","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJM197308022890508","article-title":"The mechanism of lithium action","volume":"289","author":"Signer","year":"1973","journal-title":"New Eng J Med"},{"issue":"5","key":"10.1016\/j.mehy.2016.09.018_b0120","first-page":"747","article-title":"The influence of different doses of lithium administered in drinking water on lipid peroxidation and the activity of antioxidant enzymes in rats","volume":"15","author":"Kielczykowska","year":"2006","journal-title":"Polish J Environ Stud"},{"key":"10.1016\/j.mehy.2016.09.018_b0125","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1016\/S0140-6736(69)90868-X","article-title":"Does lithium depletion cause atherosclerotic heart disease?","volume":"294","author":"Voors","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2016.09.018_b0130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mehy.2016.02.002","article-title":"Is violence in part a lithium deficiency state?","volume":"89","author":"Goldstein","year":"2016","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2016.09.018_b0135","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3727\/096368909X471251","article-title":"Review of lithium effects on brain and blood cell","volume":"18","author":"Young","year":"2009","journal-title":"Cell Transplant"},{"key":"10.1016\/j.mehy.2016.09.018_b0140","first-page":"1303","article-title":"Erythro-9-[3(2-hydroxynonyl)] adenine is an inhibitor of sperm motility that blocks dyneine ATPase and protein carboxy-methylase activities","volume":"89","author":"Bouchard","year":"1981","journal-title":"Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2016.09.018_b0145","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1095\/biolreprod.108.070367","article-title":"Increase activity of the human sperm tyrosine kinase by the CAMP-dependent pathway in the presence of calcium","volume":"79","author":"Lawson","year":"2008","journal-title":"Biol Reprod"},{"key":"10.1016\/j.mehy.2016.09.018_b0150","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/humrep\/16.9.1931","article-title":"Phospatidylinosito13-kinase: inhabitation enhances human sperm motility","volume":"16","author":"Lucont","year":"1981","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2016.09.018_b0155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ydbio.2007.09.017","article-title":"External Ca2+ acts upstream of adenylyl cyclase in the bicarbonate signaled of sperm motility","volume":"312","author":"Carlson","year":"2007","journal-title":"Dev Biol"},{"key":"10.1016\/j.mehy.2016.09.018_b0160","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1095\/biolreprod.104.033548","article-title":"Effects of a dual 5-alpha-reductase inhibitor on rat epididymal sperm maturation and fertility","volume":"72","author":"Henderson","year":"2005","journal-title":"Biol Reprod"},{"issue":"5","key":"10.1016\/j.mehy.2016.09.018_b0165","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1139\/o96-072","article-title":"Cyclic-AMP phosphodiesterase: a regulator of forward motility initiation during epididymal sperm maturation","volume":"74","author":"Jaiswal","year":"1996","journal-title":"Biochem Cell Biol"},{"key":"10.1016\/j.mehy.2016.09.018_b0170","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1095\/biolreprod.109.080127","article-title":"Human sperm termotaxis is medicated by phospholipase C and inositol triphosphate receptor Ca2+ channel","volume":"82","author":"Bahat","year":"2010","journal-title":"Biol Reprod"},{"key":"10.1016\/j.mehy.2016.09.018_b0175","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4103\/2277-9175.115793","article-title":"Lithium carbonate inducing disorders in three parameters of rat sperm","volume":"2","author":"Toghyani","year":"2013","journal-title":"Adv Biomed Res"},{"key":"10.1016\/j.mehy.2016.09.018_b0180","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signaling in intact cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr Biol"},{"key":"10.1016\/j.mehy.2016.09.018_b0185","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1095\/biolreprod62.6.1647","article-title":"A role of phosphorylation of glycogen synthase kinase-3 alpha in bovine sperm motility","volume":"62","author":"Vijayaraghavan","year":"2000","journal-title":"Biol Reprod"},{"key":"10.1016\/j.mehy.2016.09.018_b0190","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1006\/bbrc.1993.2595","article-title":"Lithium and tacrne increase the expression of nitric oxide synthase mRNA in the hippocampus of Rat","volume":"197","author":"Bagetta","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mehy.2016.09.018_b0195","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/REP-10-0151","article-title":"Nitric oxide stimulates human sperm motility via activation of the cyclic GMP\/protein kinase G signalling pathway","volume":"141","author":"Miraglia","year":"2011","journal-title":"Reproduction"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716301876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716301876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T00:16:46Z","timestamp":1568420206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716301876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":39,"alternative-id":["S0306987716301876"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.09.018","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is lithium essential for epididymal sperm maturation?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}