{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T22:39:54Z","timestamp":1720564794342},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.mehy.2016.12.001","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T18:33:31Z","timestamp":1480962811000},"page":"19-22","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Improved cognitive and memory abilities in a patient with Alzheimer\u2019s disease treated with activated immune cells: Immune cell therapy may benefit more AD patients"],"prefix":"10.1016","volume":"99","author":[{"given":"B.","family":"Laumbacher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fellerhoff-Loesch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Wank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2016.12.001_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuron.2006.09.016","article-title":"A hundred years of Alzheimer\u2019s disease research","volume":"52","author":"Hardy","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2016.12.001_b0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0733-8619(05)70260-7","article-title":"The clinical epidemiology of Alzheimer\u2019s disease","volume":"14","author":"Keefover","year":"1996","journal-title":"Neurol Clin"},{"key":"10.1016\/j.mehy.2016.12.001_b0015","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nicl.2013.02.006","article-title":"Amyloid imaging in cognitive normal individuals, at-risk populations and preclinical Alzheimer\u2019s disease","author":"Chetelat","year":"2013","journal-title":"Neuroimage Clin"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0020","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ana.410380319","article-title":"Lack of an association between apolipoprotein E epsilon 4 and Alzheimer\u2019s disease in elderly Nigerians","volume":"38","author":"Osuntokun","year":"1995","journal-title":"Ann Neurol"},{"issue":"6980","key":"10.1016\/j.mehy.2016.12.001_b0025","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/bmj.310.6980.627","article-title":"Apolipoprotein E genotype and association between smoking and early onset Alzheimer\u2019s disease","volume":"310","author":"van Duijn","year":"1995","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0030","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0304-3940(96)12513-1","article-title":"Significantly increased frequency of the apolipoprotein E epsilon 4 allele in elderly non-demented leprosy patients","volume":"207","author":"Endoh","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.mehy.2016.12.001_b0035","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1212\/01.wnl.0000261919.22630.ea","article-title":"Imaging beta-amyloid burden in aging and dementia","volume":"68","author":"Rowe","year":"2007","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.001_b0040","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1212\/WNL.58.11.1629","article-title":"Cerebral angiopathy and cognitive function: the HAAS autopsy study","volume":"58","author":"Pfeifer","year":"2002","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0045","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol Aging"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.001_b0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.neuron.2009.08.039","article-title":"Immune activation in brain aging and neurodegeneration: too much or too little?","volume":"64","author":"Lucin","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2016.12.001_b0055","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2202-11-121","article-title":"Immunohistological detection of Chlamydia pneumoniae in the Alzheimer\u2019s disease brain","volume":"11","author":"Hammond","year":"2010","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.mehy.2016.12.001_b0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1742-2094-8-90","article-title":"Alzheimer\u2019s disease \u2013 a neurospirechetosis. Analysis of the evidence following Koch\u2019s and Hill\u2019s criteria","volume":"8","author":"Miklossy","year":"2011","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.mehy.2016.12.001_b0065","unstructured":"Plummer FA, Fowke K, Nagelkerke NJD et al. Evidence of Resistance to HIV among continuously exposed prostitutes in Nairobi, Kenya. In: 9th Int. Conf. AIDS Berlin (abs. WS-AO7-3); 1993, p. 23."},{"issue":"5","key":"10.1016\/j.mehy.2016.12.001_b0070","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jnr.10519","article-title":"Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells","volume":"71","author":"MacIntyre","year":"2003","journal-title":"J Neurosci Res"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.001_b0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s004300050071","article-title":"Identification and localization of Chlamydia pneumoniae in the Alzheimer\u2019s brain","volume":"187","author":"Balin","year":"1998","journal-title":"Med Microbiol Immunol"},{"key":"10.1016\/j.mehy.2016.12.001_b0080","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.schres.2011.04.015","article-title":"Increased prevalence of Chlamydophila DNA in post- mortem brain frontal cortex from patients with schizophrenia","volume":"129","author":"Fellerhoff","year":"2011","journal-title":"Schizophr Res"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0085","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/sj.mp.4001925","article-title":"Associations between Chlamydophila infections, schizophrenia and risk of HLA-A10","volume":"12","author":"Fellerhoff","year":"2007","journal-title":"Mol Psychiatry"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.001_b0090","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0306-9877(02)00163-9","article-title":"Schizophrenia and other mental disorders require long-term adoptive immunotherapy","volume":"59","author":"Wank","year":"2002","journal-title":"Med Hypotheses"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.001_b0095","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.mehy.2005.03.013","article-title":"High risk of schizophrenia and other mental disorders associated with chlamydial infections: hypothesis to combine drug treatment and adoptive immunotherapy","volume":"65","author":"Fellerhoff","year":"2005","journal-title":"Med Hypotheses"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0100","doi-asserted-by":"crossref","first-page":"269","DOI":"10.2217\/imt.14.6","article-title":"Benefits of a continuous therapy for cancer patients with a novel adoptive cell therapy by cascade priming (CAPRI)","volume":"6","author":"Wank","year":"2014","journal-title":"Immunotherapy"},{"key":"10.1016\/j.mehy.2016.12.001_b0105","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-203107","article-title":"Life-threatening edema of the tongue: the detection of the RNA of B henselae in the saliva of a male patient and his dog as well as of the DNA of three Bartonella species in the blood of the patient","volume":"2014","author":"L\u00f6sch","year":"2014","journal-title":"BMJ Case Rep"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0110","doi-asserted-by":"crossref","first-page":"293","DOI":"10.7326\/0003-4819-107-2-293","article-title":"The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells","volume":"107","author":"Denicoff","year":"1987","journal-title":"Ann Intern Med"},{"issue":"7","key":"10.1016\/j.mehy.2016.12.001_b0115","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nrn1428","article-title":"Immune signalling in neural development, synaptic plasticity and disease","volume":"5","author":"Boulanger","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mehy.2016.12.001_b0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1471-2202-11-121","article-title":"Immunohistological detection of Chlamydia pneumoniae in the Alzheimer\u2019s disease brain","volume":"11","author":"Hammond","year":"2010","journal-title":"BMC Neurosci"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.001_b0125","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1080\/135502801753248169","article-title":"Association of HSV1 and apolipoprotein E-varepsilon4 in Alzheimer\u2019s disease","volume":"7","author":"Itzhaki","year":"2001","journal-title":"J Neurovirol"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.001_b0130","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/archpedi.1991.02160010104026","article-title":"Cat-scratch disease: acute encephalopathy and other neurologic manifestations","volume":"145","author":"Carithers","year":"1991","journal-title":"Am J Dis Child"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.001_b0135","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1532-5415.2004.52109.x","article-title":"A randomized, controlled trial of doxycycline and rifampin for patients with Alzheimer\u2019s disease","volume":"52","author":"Loeb","year":"2004","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.mehy.2016.12.001_b0140","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1752-1947-6-6","article-title":"Responsiveness of a patient in a persistent vegetative state after a come to weekly injections of autologous activated immune cells","volume":"6","author":"Fellerhoff","year":"2012","journal-title":"J Med Case Rep"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.001_b0145","doi-asserted-by":"crossref","first-page":"6303","DOI":"10.4049\/jimmunol.162.11.6303","article-title":"Cutting edge: clonally restricted production of the neurotrophins brain-derived neurotrophic factor and neurotrophin-3 mRNA by human immune cells and Th1\/Th2-polarized expression of their receptors","volume":"162","author":"Besser","year":"1999","journal-title":"J Immunol"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716304182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716304182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T05:36:06Z","timestamp":1692596166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716304182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":29,"alternative-id":["S0306987716304182"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.12.001","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improved cognitive and memory abilities in a patient with Alzheimer\u2019s disease treated with activated immune cells: Immune cell therapy may benefit more AD patients","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}