{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:15:04Z","timestamp":1786994104859,"version":"build-2736575974"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T00:00:00Z","timestamp":1481068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.mehy.2016.12.002","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T15:01:52Z","timestamp":1481122912000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients"],"prefix":"10.1016","volume":"99","author":[{"given":"Theo","family":"Wallimann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Riek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00f6ddel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0005","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1042\/bj2810021","article-title":"Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the \u201cphosphocreatine circuit\u201d for cellular energy homeostasis","volume":"281","author":"Wallimann","year":"1992","journal-title":"Biochem J"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0010","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1152\/physrev.2000.80.3.1107","article-title":"Creatine and creatinine metabolism","volume":"80","author":"Wyss","year":"2000","journal-title":"Physiol Rev"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0015","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0005-2728(92)90096-K","article-title":"Mitochondrial creatine kinase: a key enzyme of aerobic energy metabolism","volume":"1102","author":"Wyss","year":"1992","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0020","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1007\/s00726-011-0877-3","article-title":"The creatine kinase system and pleiotropic effects of creatine","volume":"40","author":"Wallimann","year":"2011","journal-title":"Amino Acids"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0025","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbadis.2005.09.004","article-title":"Mitochondrial creatine kinase in human health and disease","volume":"1762","author":"Schlattner","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mehy.2016.12.002_b0030","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S1566-3116(08)60040-7","article-title":"Functions of creatine kinase isoenzymes in spermatozoa","volume":"5","author":"Kaldis","year":"1997","journal-title":"Adv Dev Biol"},{"issue":"2Pt1","key":"10.1016\/j.mehy.2016.12.002_b0035","doi-asserted-by":"crossref","first-page":"C697","DOI":"10.1152\/ajpcell.1997.272.2.C697","article-title":"Metabolic support of Na+ pump in apically permeabilized A6 kidney cell epithelia: role of creatine kinase","volume":"272","author":"Guerrero","year":"1997","journal-title":"Am J Physiol"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0040","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1007\/s00726-016-2206-3","article-title":"Structural correlates of the creatine transporter function regulation: the undiscovered country","volume":"48","author":"Santacruz","year":"2016","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0045","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00726-016-2217-0","article-title":"Creatine kinase in cell cycle regulation and cancer","volume":"48","author":"Yan","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.mehy.2016.12.002_b0050","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(00)80186-5","article-title":"Altered calcium responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies","volume":"89","author":"Steeghs","year":"1997","journal-title":"Cell"},{"issue":"27","key":"10.1016\/j.mehy.2016.12.002_b0055","doi-asserted-by":"crossref","first-page":"24427","DOI":"10.1074\/jbc.M201777200","article-title":"Coupling of cell energetics with membrane metabolic sensing. Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out","volume":"277","author":"Abraham","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0060","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.physbeh.2009.02.003","article-title":"Mice lacking brain-type creatine kinase activity show defective thermoregulation","volume":"97","author":"Streijger","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2016.12.002_b0065","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1016\/B978-0-444-59565-2.00053-8","article-title":"Creatine deficiency syndromes","volume":"113","author":"Schulze","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.mehy.2016.12.002_b0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF01267955","article-title":"Creatine kinase in non-muscle tissues and cells","volume":"133\u2013134","author":"Wallimann","year":"1994","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0075","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s00726-016-2291-3","article-title":"Creatine transporter deficiency leads to increased whole body and cellular metabolism","volume":"48","author":"Perna","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.mehy.2016.12.002_b0080","doi-asserted-by":"crossref","DOI":"10.1093\/hmg\/ddw252","article-title":"A mouse model for creatine transporter deficiency reveals early onset cognitive impairment and neuropathology associated with brain aging","author":"Baroncelli","year":"2016","journal-title":"Hum Mol Gen"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0085","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s00726-016-2297-x","article-title":"Creatine: a miserable life without it","volume":"48","author":"Wallimann","year":"2016","journal-title":"Amino Acids"},{"issue":"42","key":"10.1016\/j.mehy.2016.12.002_b0090","first-page":"848","article-title":"Kreatin-supplementation und Nierenfunktion: Reines Kreatin ist nicht sch\u00e4dlich f\u00fcr die Nieren!","volume":"13","author":"Wallimann","year":"2013","journal-title":"Schweiz Med Forum"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0095","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/HJH.0000000000000370","article-title":"Distinct protein signature of hypertension-induced damage in the renal proteome of the two-kidney-one-clip rat model","volume":"33","author":"Vethe","year":"2015","journal-title":"J Hypertens"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1017\/S0007114513003012","article-title":"Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas","volume":"111","author":"Da Silva","year":"2014","journal-title":"Br J Nutr"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0105","doi-asserted-by":"crossref","first-page":"F1799","DOI":"10.1152\/ajprenal.00356.2007","article-title":"Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo","volume":"293","author":"Edison","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.mehy.2016.12.002_b0110","first-page":"9","article-title":"Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse","volume":"1","author":"Ireland","year":"2009","journal-title":"BMC Dev Biol"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0115","doi-asserted-by":"crossref","first-page":"e32557","DOI":"10.1371\/journal.pone.0032557","article-title":"Amma-aminobutyric acid transporter 2 mediates the hepatic uptake of guanidinoacetate, the creatine biosynthetic precursor, in rats","volume":"7","author":"Tachikawa","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0120","doi-asserted-by":"crossref","first-page":"E256","DOI":"10.1152\/ajpendo.90547.2008","article-title":"Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo","volume":"296","author":"Da Silva","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"15","key":"10.1016\/j.mehy.2016.12.002_b0125","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/S0024-3205(01)01268-1","article-title":"Changes of tissue creatine concentrations upon oral supplementation of creatine-monohydrate in various animal species","volume":"69","author":"Ipsiroglu","year":"2001","journal-title":"Life Sci"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0130","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1007\/s00726-015-2150-7","article-title":"Dietary creatine supplementation during pregnancy: a study on the effects of creatine supplementation on creatine homeostasis and renal excretory function in spiny mice","volume":"48","author":"Ellery","year":"2016","journal-title":"Amino Acids"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0135","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1017\/S000711451300010X","article-title":"Creatine and guanidinoacetate content of human milk and infant formulas: implications for creatine deficiency syndromes and amino acid metabolism","volume":"110","author":"Edison","year":"2013","journal-title":"Br J Nutr"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0140","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s00726-016-2188-1","article-title":"The role of dietary creatine","volume":"48","author":"Brosnan","year":"2016","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0145","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s00726-016-2237-9","article-title":"The effects of creatine supplementation on thermoregulation and physical (cognitive) performance: a review and future prospects","volume":"48","author":"Twycross-Lewis","year":"2016","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/ajcn\/83.1.5","article-title":"Is it time to reevaluate methyl balance in humans?","volume":"83","author":"Stead","year":"2006","journal-title":"Am J Clin Nutr"},{"issue":"Pt1","key":"10.1016\/j.mehy.2016.12.002_b0155","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1113\/jphysiol.2002.026377","article-title":"Human, rat and chicken small intestinal Na+ Cl\u2212 creatine transporter: functional, molecular characterization and localization","volume":"545","author":"Peral","year":"2002","journal-title":"J Physiol"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0160","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1093\/clinchem\/35.8.1802","article-title":"Normal reference values for creatine, creatinine, and carnitine are lower in vegetarians","volume":"35","author":"Delanghe","year":"1989","journal-title":"Clin Chem"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0165","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1139\/h04-045","article-title":"Elevation of creatine in red blood cells in vegetarians and nonvegetarians after creatine supplementation","volume":"29","author":"MacCormick","year":"2004","journal-title":"Can J Appl Physiol"},{"key":"10.1016\/j.mehy.2016.12.002_b0170","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000185885","article-title":"Serum guanidino compound levels and clearance in uremic patients treated with continuous ambulatory peritoneal dialysis","volume":"54","author":"De Deyn","year":"1990","journal-title":"Nephron"},{"key":"10.1016\/j.mehy.2016.12.002_b0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1123\/ijsnem.14.5.517","article-title":"Muscle total creatine content and creatine transporter gene expression in vegetarians prior and following creatine supplementation","volume":"14","author":"Watt","year":"2004","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.002_b0180","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1249\/01.MSS.0000093614.17517.79","article-title":"Effect of creatine and weight training on muscle creatine and performance in vegetarians","volume":"35","author":"Burke","year":"2003","journal-title":"Med Sci Sports Exerc"},{"issue":"7","key":"10.1016\/j.mehy.2016.12.002_b0185","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1017\/S0007114510004733","article-title":"The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores","volume":"105","author":"Benton","year":"2011","journal-title":"Br J Nutr"},{"key":"10.1016\/j.mehy.2016.12.002_b0190","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s003940050005","article-title":"Dietary lean red meat and human evolution","volume":"39","author":"Mann","year":"2000","journal-title":"Eur J Nutr"},{"issue":"7308","key":"10.1016\/j.mehy.2016.12.002_b0195","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nature09248","article-title":"Evidence for stone-tool assisted consumption of animal tissues before 3.39 million years ago at Dikika, Ethiopia","volume":"466","author":"McPherron","year":"2010","journal-title":"Nature"},{"issue":"7595","key":"10.1016\/j.mehy.2016.12.002_b0200","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature16990","article-title":"Impact of meat and lower palaeolithic food processing techniques on chewing in humans","volume":"531","author":"Zink","year":"2016","journal-title":"Nature"},{"issue":"7592","key":"10.1016\/j.mehy.2016.12.002_b0205","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1038\/531S12a","article-title":"Brain food: clever eating","volume":"531","author":"Gupta","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0210","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1042\/cs0830367","article-title":"Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation","volume":"83","author":"Harris","year":"1992","journal-title":"Clin Sci"},{"key":"10.1016\/j.mehy.2016.12.002_b0215","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/cs0840565","article-title":"Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man","volume":"84","author":"Greenhaff","year":"1993","journal-title":"Clin Sci"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0220","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00726-016-2252-x","article-title":"Creatine ingestion augments dietary carbohydrate mediated muscle glycogen supercompensation during the initial 24 h of recovery following prolonged exhaustive exercise in humans","volume":"48","author":"Roberts","year":"2016","journal-title":"Amino Acids"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0225","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1249\/00149619-200204000-00007","article-title":"Effects of creatine use on the athlete\u2019s kidney","volume":"1","author":"Farquhar","year":"2002","journal-title":"Curr Sports Med Rep"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0230","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s00726-011-0874-6","article-title":"Analysis of the efficacy, safety, and regulatory status of novel forms of creatine","volume":"40","author":"J\u00e4ger","year":"2011","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0235","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00726-015-2165-0","article-title":"Creatine for neuroprotection in neurodegenerative diseases: end of the story?","volume":"48","author":"Bender","year":"2016","journal-title":"Amino Acids"},{"key":"10.1016\/j.mehy.2016.12.002_b0240","doi-asserted-by":"crossref","first-page":"22404","DOI":"10.1016\/S0021-9258(18)54587-7","article-title":"Compartmentation of multiple forms of creatine kinase in the distal nephron of the rat kidney","volume":"266","author":"Friedman","year":"1991","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0245","doi-asserted-by":"crossref","first-page":"F167","DOI":"10.1152\/ajprenal.00162.2010","article-title":"Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells","volume":"299","author":"Li","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0250","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.V1291819","article-title":"Creatine transport in brush-border membrane vesicles isolated from rat kidney cortex","volume":"12","author":"Garc\u00eda-Delgado","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.002_b0255","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1016\/j.bbamem.2007.07.022","article-title":"Ontogeny up-regulates renal Na(+)\/Cl(\u2212)\/creatine transporter in rat","volume":"1768","author":"Garc\u00eda-Delgado","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0260","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00726-011-0853-y","article-title":"The metabolic burden of creatine synthesis","volume":"40","author":"Brosnan","year":"2011","journal-title":"Amino Acids"},{"key":"10.1016\/j.mehy.2016.12.002_b0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-5918-8-6","article-title":"The effects of age on skeletal muscle and the phosphocreatine energy system: can creatine supplementation help older adults","volume":"8","author":"Dalbo","year":"2009","journal-title":"Dyn Med"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2016.12.002_b0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1022465203458","article-title":"Effects of creatine supplementation on performance and training adaptations","volume":"244","author":"Kreider","year":"2003","journal-title":"Mol Cell Biochem"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0275","first-page":"CD004760","article-title":"Creatine for treating muscle disorders","author":"Kley","year":"2013","journal-title":"Chochrane Database Syst Rev"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0280","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s00726-011-0876-4","article-title":"Creatine as a therapeutic strategy for myophathies","volume":"40","author":"Tarnopolsky","year":"2011","journal-title":"Amino Acids"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0285","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/00365599709070349","article-title":"Altered muscle energy metabolism in post-absorptive patients with chronic renal failure","volume":"31","author":"Pastoris","year":"1997","journal-title":"Scand J Urol Nephrol"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2016.12.002_b0290","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1022470815270","article-title":"Alteration of energy production by the heart in CRF patients undergoing peritoneal dialysis","volume":"244","author":"Ogimoto","year":"2003","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0295","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1681\/ASN.2006030204","article-title":"Cross-talk between the kidney and the cardiovascular system","volume":"17","author":"Amann","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.mehy.2016.12.002_b0300","doi-asserted-by":"crossref","first-page":"222","DOI":"10.12688\/f1000research.5218.1","article-title":"A review of creatine supplementation in age-related diseases: more than a supplement for athletes","volume":"3","author":"Smith","year":"2014","journal-title":"F1000Res"},{"key":"10.1016\/j.mehy.2016.12.002_b0305","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jnutbio.2016.07.001","article-title":"Restriction of dietary methyl donors limits methionine availability and affects the partitioning of dietary methionine for creatine and phosphatidylcholine synthesis in the neonatal piglet","volume":"35","author":"Robinson","year":"2016","journal-title":"J Nutr Biochem"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0310","first-page":"45","article-title":"Effect of creatine on erythrocyte rheology in vitro","volume":"22","author":"Lipovac","year":"2000","journal-title":"Clin Hemorheol Microcirc"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0315","doi-asserted-by":"crossref","first-page":"e43178","DOI":"10.1371\/journal.pone.0043178","article-title":"Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane protective effects","volume":"7","author":"Tokarska-Schlattner","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0320","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00726-015-2161-4","article-title":"New insights into the trophic and cytoprotective effects of creatine in in vitro and in vivo models of cell maturation","volume":"48","author":"Sestili","year":"2016","journal-title":"Amino Acids"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0325","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ccell.2015.09.008","article-title":"Erythropoietin stimulates tumor growth via EphB43","volume":"28","author":"Pradeep","year":"2015","journal-title":"Cancer Cell"},{"issue":"33","key":"10.1016\/j.mehy.2016.12.002_b0330","doi-asserted-by":"crossref","first-page":"53654","DOI":"10.18632\/oncotarget.10687","article-title":"AMPK\u03b11 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2","volume":"7","author":"Zhou","year":"2016","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0335","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/ndt\/gfm793","article-title":"Guanidino compounds after creatine supplementation in renal failure patients and their relation to inflammatory status","volume":"23","author":"Taes","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0340","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00726-016-2173-8","article-title":"Potential of creatine or phosphocreatine supplementation in cerebrovascular disease and in ischemic heart disease","volume":"48","author":"Balestrino","year":"2016","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0345","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.aucc.2013.12.002","article-title":"Contrast media induced nephropathy: a literature review of the available evidence and recommendation for practice","volume":"27","author":"Deek","year":"2014","journal-title":"Aust Crit Care"},{"issue":"Suppl. 2","key":"10.1016\/j.mehy.2016.12.002_b0350","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/nutrit\/nuv046","article-title":"Effects of acute and chronic hypohydration on kidney health and function","volume":"73","author":"Feehally","year":"2015","journal-title":"Nutr Rev"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0355","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1053\/j.ajkd.2009.10.053","article-title":"Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney","volume":"55","author":"Gualano","year":"2010","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0360","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00005768-200102000-00002","article-title":"Creatine supplementation and health variables: a retrospective study","volume":"33","author":"Schilling","year":"2001","journal-title":"Med Sci Sports Exerc"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0365","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00421-007-0669-3","article-title":"Effects of creatine supplementation on renal function; a randomized, double-blind, placebo-controlled clinical trial","volume":"103","author":"Gualano","year":"2008","journal-title":"Eur J Appl Physiol"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.002_b0370","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/ndt\/17.11.1978","article-title":"Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis","volume":"17","author":"Chang","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.mehy.2016.12.002_b0375","first-page":"129","article-title":"Myocardial bioenergetics abnormalities in experimental uremia","volume":"9","author":"Chesser","year":"2016","journal-title":"Int J Nephrol Renovasc Dis"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0380","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1016\/S0021-9258(19)34115-8","article-title":"Muscle type MM creatine kinase is specifically bound to sarcoplasmic reticulum and can support Ca2+ uptake and regulate local ATP\/ADP ratios","volume":"265","author":"Rossi","year":"1990","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0385","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00004424-199803000-00007","article-title":"Evaluation of altered myocardial high energy phosphate metabolism in patients on maintenance dialysis using phosphorus-31 magnetic resonance spectroscopy","volume":"33","author":"Tagami","year":"1998","journal-title":"Invest Radiol"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0390","doi-asserted-by":"crossref","first-page":"e0163021","DOI":"10.1371\/journal.pone.0163021","article-title":"Nuclear magnetic resonance metabolomic profiling of mouse kidney, urine and serum following renal ischemia\/reperfusion injury","volume":"11","author":"Jouret","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mehy.2016.12.002_b0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13685538.2016.1225032","article-title":"Low glomerular filtration rate as an associated risk factor for sarcopenic muscle strenght: is creatinine or cystatin C-based estimation more relevant?","volume":"20","author":"Tufan","year":"2016","journal-title":"Aging Male"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0400","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/jcsm.12094","article-title":"Impact of creatine supplementation in combination with resistance training on lean mass in elderly","volume":"7","author":"Pinto","year":"2016","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0405","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/1874609806666131204153102","article-title":"Creatine supplementation: can it improve quality of life in the elderly without associated resistance training?","volume":"6","author":"Moon","year":"2013","journal-title":"Curr Aging Sci"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0410","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00726-016-2239-7","article-title":"Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain","volume":"48","author":"Gualano","year":"2016","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0415","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/nep.12202","article-title":"Decreased mobility after starting dialysis is an independent risk factor for short-term mortality after initiation of dialysis","volume":"19","author":"Arai","year":"2014","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.mehy.2016.12.002_b0420","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/nm.1860","article-title":"Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption","volume":"14","author":"Chang","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.mehy.2016.12.002_b0425","doi-asserted-by":"crossref","first-page":"8","DOI":"10.22203\/eCM.v010a02","article-title":"Stimulatory effects of creatine on metabolic activity, differentiation and mineralization of primary osteoblast-like cells in monolayer and micromass cell cultures","volume":"10","author":"Gerber","year":"2005","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.mehy.2016.12.002_b0430","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1098\/rspb.2003.2492","article-title":"Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial","volume":"270","author":"Rae","year":"2003","journal-title":"Proc Biol Sci"},{"key":"10.1016\/j.mehy.2016.12.002_b0435","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/13825580600788100","article-title":"Creatine supplementation and cognitive performance in elderly individuals","volume":"14","author":"McMorris","year":"2007","journal-title":"Neuropsychol Dev Cogn B Aging Neuropsychol Cogn"},{"key":"10.1016\/j.mehy.2016.12.002_b0440","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.physbeh.2006.08.024","article-title":"Creatine supplementation, sleep deprivation, cortisol, melatonin and behavior","volume":"90","author":"McMorris","year":"2007","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2016.12.002_b0445","first-page":"1773","article-title":"Creatine supplementation enhances corticomotor excitability and cognitive performance during oxygen deprivation","volume":"35","author":"Turner","year":"2015","journal-title":"J Neurol"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0450","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1176\/appi.ajp.2012.12010009","article-title":"A randomized, double-blind placebo-controlled trial oral creatine monohydrate augmentation for enhanced response to a selective serotonin reuptake inhibitor in women with major depressive disorder","volume":"169","author":"Lyoo","year":"2012","journal-title":"Am J Psychiatry"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0455","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1007\/s00726-016-2194-3","article-title":"Creatine target engagement with brain bioenergetic: a dose-ranging phosphorus-31 magnetic resonance spectroscopy study of adolescent females with SSRI-resistant depression","volume":"48","author":"Kondo","year":"2016","journal-title":"Amino Acids"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0460","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.biopsych.2015.11.027","article-title":"Effects of creatine monohydrate augmentation on brain metabolic and network outcome measures in women with major depressive disorder","volume":"80","author":"Yoon","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.mehy.2016.12.002_b0465","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-016-0148-0","article-title":"Creatine prevents corticosterone-induced reduction in hippocampal proliferation and differentiation: possible implication for ist antidepressant effect","author":"Pazini","year":"2016","journal-title":"Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0470","doi-asserted-by":"crossref","first-page":"24","DOI":"10.20463\/jenb.2016.09.20.3.4","article-title":"Effects of creatine monohydrate supplementation and exercise on depression-like behaviors and raphe 5-HT neurons in mice","volume":"20","author":"Ahn","year":"2016","journal-title":"J Exerc Nutr Biochem"},{"issue":"15","key":"10.1016\/j.mehy.2016.12.002_b0475","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1042\/CS20160002","article-title":"Mitochondrial health, the epigenome and healthspan","volume":"130","author":"Aon","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.mehy.2016.12.002_b0480","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1007\/s00726-011-0875-5","article-title":"Creatine as antioxidant","volume":"40","author":"Sestili","year":"2011","journal-title":"Amino Acids"},{"issue":"49","key":"10.1016\/j.mehy.2016.12.002_b0485","doi-asserted-by":"crossref","first-page":"37361","DOI":"10.1074\/jbc.M604123200","article-title":"Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinase-dependent ADP recycling activity","volume":"281","author":"Meyer","year":"2006","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.mehy.2016.12.002_b0490","doi-asserted-by":"crossref","first-page":"6937","DOI":"10.1074\/jbc.275.10.6937","article-title":"Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ","volume":"275","author":"Kay","year":"2000","journal-title":"J Biol Chem"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0495","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s00726-016-2180-9","article-title":"Exploratory studies of the potential anti-cancer effects of creatine","volume":"48","author":"Campos-Ferraz","year":"2016","journal-title":"Amino Acids"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0500","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10495-015-1210-5","article-title":"Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation","volume":"21","author":"Sun","year":"2016","journal-title":"Apopoptosis"},{"issue":"Pt 2","key":"10.1016\/j.mehy.2016.12.002_b0505","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1042\/BJ20040386","article-title":"Octameric mitochondrial creatine kinase induces and stabilizes contact sites between the inner and outer membrane","volume":"385","author":"Speer","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.mehy.2016.12.002_b0510","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000046878","article-title":"Mitochondrial creatine kinase in contact sites: interaction with porin and adenine nucleotide translocase, role in permeability transition and sensitivity to oxidative damage","volume":"10","author":"Dolder","year":"2001","journal-title":"Neurosignals"},{"key":"10.1016\/j.mehy.2016.12.002_b0515","doi-asserted-by":"crossref","first-page":"17760","DOI":"10.1074\/jbc.M208705200","article-title":"Inhibition of the mitochondrial transition by creatine kinase substrates requirement for microcompartmentation","volume":"278","author":"Dolder","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0520","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.12.046","volume":"581","author":"Golshani-Hebroni","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.mehy.2016.12.002_b0525","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1159\/000323992","article-title":"Supplementation of creatine and ribose prevents apoptosis in ischemic cardiomyocytes","volume":"26","author":"Caretti","year":"2010","journal-title":"Cell Physiol Biochem"},{"issue":"39","key":"10.1016\/j.mehy.2016.12.002_b0530","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.2174\/138161281939131127114218","article-title":"Supplementation of creatine and ribose prevents apoptosis and right ventricla hypertrophy in hypoxic hearts","volume":"19","author":"Caretti","year":"2013","journal-title":"Curr Pharm Des"},{"issue":"12","key":"10.1016\/j.mehy.2016.12.002_b0535","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s10495-015-1175-4","article-title":"Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein induced apoptosis by modulating the PI3K\/Akt\/eNOS pathway","volume":"20","author":"Ahsan","year":"2015","journal-title":"Apoptosis"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0540","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000069043","article-title":"Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia","volume":"24","author":"Adcock","year":"2002","journal-title":"Dev Neurosci"},{"issue":"7","key":"10.1016\/j.mehy.2016.12.002_b0545","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1172\/JCI83942","article-title":"Paracellular epithelial sodium transport maximizes energy efficiency in the kidney","volume":"126","author":"Pei","year":"2016","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0550","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1161\/01.RES.0000137170.41939.d9","article-title":"Is the failing heart energy starved? On using chemical energy to support cardiac function","volume":"95","author":"Ingwall","year":"2004","journal-title":"Circ Res"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0555","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/sj.jcbfm.9600351","article-title":"Improved reperfusion and neuroprotection by creatine in a mouse model of stroke","volume":"27","author":"Prass","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0560","first-page":"297","article-title":"Creatine phosphate administration preserves myocardial function in a model of off-pump coronary revascularization","volume":"46","author":"Woo","year":"2005","journal-title":"J Cardiovasc Surg (Torino)"},{"issue":"10041","key":"10.1016\/j.mehy.2016.12.002_b0565","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0140-6736(16)30508-6","article-title":"The heart and vascular system in dialysis","volume":"388","author":"Wanner","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0570","doi-asserted-by":"crossref","first-page":"e28578","DOI":"10.5812\/asjsm.28578","article-title":"Effects of complementary creatine monohydrate and physical training on inflammatory and endothelial dysfunction markers among heart failure patients","volume":"7","author":"Hemati","year":"2016","journal-title":"Asian J Sports Med"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0575","doi-asserted-by":"crossref","first-page":"C320","DOI":"10.1152\/ajpcell.2001.281.1.C320","article-title":"Functional aspects of creatine kinase isoenzymes in endothelial cells","volume":"281","author":"Decking","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0580","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/pr.2012.174","article-title":"Creatine pretreatment prevents birth asphyxia-induced injury of the newborn spiny mouse kidney","volume":"73","author":"Ellery","year":"2013","journal-title":"Pediatr Res"},{"key":"10.1016\/j.mehy.2016.12.002_b0585","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neuint.2015.11.002","article-title":"Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy \u2013 creatine prophylaxis and the need for multi-organ protection","volume":"95","author":"Ellery","year":"2016","journal-title":"Neurochem Int"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0590","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/pr.2016.153","article-title":"Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse","volume":"80","author":"LaRosa","year":"2016","journal-title":"Pediatr Res"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0595","doi-asserted-by":"crossref","first-page":"e0149840","DOI":"10.1371\/journal.pone.0149840","article-title":"Maternal creatine supplementation during pregnancy prevents long-term changes in diaphragm muscle structure and function after birth asphyxia","volume":"11","author":"LaRosa","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mehy.2016.12.002_b0600","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/1471-2393-14-150","article-title":"Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy","volume":"14","author":"Dickinson","year":"2014","journal-title":"BMC Pregnancy Childbirth"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0605","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1475-2891-13-115","article-title":"Effects of dietary creatine supplementation on systemic microvasculature density and reactivity in healthy young adults","volume":"13","author":"Moraes","year":"2014","journal-title":"Nutr J"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.002_b0610","doi-asserted-by":"crossref","first-page":"e0141975","DOI":"10.1371\/journal.pone.0141975","article-title":"Diminution of Oxidative Damage to Human Erythrocytes and Lymphocytes by Creatine: Possible Role of Creatine in Blood","volume":"10","author":"Qasim","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0615","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1182\/blood.V53.5.966.966","article-title":"Comparison of red cell creatine level and reticulocyte count in appraising the severity of hemolytic process","volume":"53","author":"Fehr","year":"1979","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0620","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1046\/j.1525-1594.2003.07214.x","article-title":"The effect of vitamin E-bonded dialyzer membrane on red blood cell survival in hemodialyzed patients","volume":"27","author":"Nakatan","year":"2003","journal-title":"Arif Organs"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0625","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/clinchem\/42.2.313","article-title":"Enzymatic measurement of creatine in erythrocytes","volume":"42","author":"Beyer","year":"1996","journal-title":"Clin Chem"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0630","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1123\/ijsnem.17.6.624","article-title":"Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementation","volume":"17","author":"Brault","year":"2007","journal-title":"Int J Sport Nutr Exerc Metab"},{"issue":"3Pt1","key":"10.1016\/j.mehy.2016.12.002_b0635","doi-asserted-by":"crossref","first-page":"C660","DOI":"10.1152\/ajpcell.1995.268.3.C660","article-title":"Creatine kinase required for swelling-activated K-Cl cotransport in dog red blood cells","volume":"268","author":"Colclasure","year":"1995","journal-title":"Am J Physiol"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0640","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbamem.2004.05.004","article-title":"Regulation of Na+\/Mg2+ antiport in rat erythrocytes","volume":"1664","author":"Ebel","year":"2004","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0645","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.freeradbiomed.2005.10.035","article-title":"Creatine supplementation affords cytoprotection in oxidatively injured cultured mammalian cells via direct antioxidant activity","volume":"40","author":"Sestili","year":"2006","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0650","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1179\/1351000215Y.0000000020","article-title":"Creatine supplementation decreases plasma lipid peroxidation markers and enhances anaerobic performance in rats","volume":"21","author":"Deminice","year":"2016","journal-title":"Redox Rep Commun Free Rad Res"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0655","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1172\/JCI31807","article-title":"Foxo3 is required for the regulation of oxidative stress in erythropoiesis","volume":"117","author":"Marinkovic","year":"2007","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0660","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.nut.2013.03.003","article-title":"Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans","volume":"29","author":"Deminice","year":"2013","journal-title":"Nutrition"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0665","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1017\/S0007114508162985","article-title":"Effects of creatine supplementation on homocysteine levels and lipid peroxidation in rats","volume":"102","author":"Deminice","year":"2009","journal-title":"Br J Nutr"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0670","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00726-016-2172-9","article-title":"Creatine supplementation prevents hyperhomocysteinemia, oxidative stress and cancer induced cachexia progression in Walker-256 tumor-bearing mice","volume":"48","author":"Deminice","year":"2016","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0675","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1046\/j.1523-1755.2003.00206.x","article-title":"Creatine supplementation decreases homocysteine in an animal model of uremia","volume":"64","author":"Taes","year":"2003","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0680","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1111\/j.1523-1755.2004.66019.x","article-title":"Creatine supplementation does not decrease total plasma homocystein in chronic hemodialysis patients","volume":"66","author":"Taes","year":"2004","journal-title":"Kidney Int"},{"issue":"10","key":"10.1016\/j.mehy.2016.12.002_b0685","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.3945\/jn.115.216739","article-title":"Low-dose creatine supplementation lowers plasma guanidinoacetate, but not plasma homocysteine, in a double-blind, randomized, Placebo-Controlled Trial","volume":"145","author":"Peters","year":"2015","journal-title":"J Nutr"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0690","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1203\/PDR.0b013e318176180e","article-title":"The arginine-creatine pathway is disturbed in children and adolescents with renal transplants","volume":"64","author":"Andrade","year":"2008","journal-title":"Pediatr Res"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0695","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1159\/000187931","article-title":"Creatine reduces collagen accumulation in the kidneys of diabetic db\/db mice","volume":"67","author":"Lubec","year":"1994","journal-title":"Nephron"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0700","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-2007-949591","article-title":"Effect of creatine on the pancreatic beta-cell","volume":"115","author":"Rocic","year":"2007","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0705","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1021\/jf505998z","article-title":"Creatine is a scavenger for methylglyoxal under physiological conditions via formation of N-(4-methyl-5-oxo-1-imidazoline-2-yI)sarcosine (MG-HCr)","volume":"63","author":"L\u00f6bner","year":"2015","journal-title":"J Agric Food Chem"},{"issue":"6","key":"10.1016\/j.mehy.2016.12.002_b0710","doi-asserted-by":"crossref","first-page":"E322","DOI":"10.25011\/cim.v32i6.10669","article-title":"Comparison of antihyperglycemic effects of creatine and metformin in type II diabetic patients","volume":"32","author":"Rocic","year":"2009","journal-title":"Clin Invest Med"},{"issue":"21\u201322","key":"10.1016\/j.mehy.2016.12.002_b0715","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10354-011-0905-7","article-title":"Comparison of antihyperglycemic effects of creatine and glibenclamide in type II diabetic patients","volume":"161","author":"Rocic","year":"2011","journal-title":"Wien Med Wochenschr"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0720","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s00726-016-2277-1","article-title":"Creatine supplementation and glycemic control: a systematic review","volume":"48","author":"Pinto","year":"2016","journal-title":"Amino Acids"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0725","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00726-007-0508-1","article-title":"Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training","volume":"34","author":"Gualano","year":"2008","journal-title":"Amino Acids"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0730","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1249\/MSS.0b013e3181fcee7d","article-title":"Creatine in type 2 diabetes: a randomized, double-blind, placebo-controlled trial","volume":"43","author":"Gualano","year":"2011","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0735","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00726-012-1246-6","article-title":"Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-alpha","volume":"43","author":"Alves","year":"2012","journal-title":"Amino Acids"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.002_b0740","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00421-010-1676-3","article-title":"Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial","volume":"111","author":"Gualano","year":"2011","journal-title":"Eur J Appl Physiol"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.002_b0745","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1139\/h11-014","article-title":"Effect of creatine suppleentation on measured glomerular filtration rate in postmenopausal women","volume":"36","author":"Neves","year":"2011","journal-title":"Appl Physiol Nutr Metab"},{"issue":"8","key":"10.1016\/j.mehy.2016.12.002_b0750","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s00726-016-2183-6","article-title":"Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings","volume":"48","author":"Deminice","year":"2016","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.002_b0755","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/cs0910113","article-title":"High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women","volume":"91","author":"Earnest","year":"1996","journal-title":"Clin Sci (Lond)"},{"issue":"10","key":"10.1016\/j.mehy.2016.12.002_b0760","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.3945\/jn.111.144857","article-title":"Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet","volume":"141","author":"Deminice","year":"2011","journal-title":"J Nutr"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0765","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jnutbio.2014.11.014","article-title":"Creatine supplementation prevents fatty liver in rats fed choline-deficient diet: a burden of one-carbon and fatty acid metabolism","volume":"26","author":"Deminice","year":"2015","journal-title":"J Nutr Biochem"},{"issue":"11","key":"10.1016\/j.mehy.2016.12.002_b0770","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.bbalip.2014.09.001","article-title":"Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation","volume":"1841","author":"Da Silva","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mehy.2016.12.002_b0775","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1002\/mnfr.200500081","article-title":"Hypercholesterolemia and inflammation in atherogenesis: two sides of the same coin","volume":"49","author":"Steinberg","year":"2005","journal-title":"Mol Nutr Food Res"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0780","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0306-4522(02)00088-X","article-title":"Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease?","volume":"112","author":"Wyss","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2016.12.002_b0785","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.intimp.2015.12.034","article-title":"Beyond muscles: the untapped potential of creatine","volume":"37","author":"Riesberg","year":"2016","journal-title":"Int Immunopharmacol"},{"issue":"49","key":"10.1016\/j.mehy.2016.12.002_b0790","doi-asserted-by":"crossref","first-page":"19820","DOI":"10.1073\/pnas.1302840110","article-title":"Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in coitis","volume":"110","author":"Glover","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.mehy.2016.12.002_b0795","first-page":"297","article-title":"Creatine phosphate administration preserves myocardial function in a model of off-pump coronary revascularization","volume":"46","author":"WooYJ","year":"2005","journal-title":"J Cardiovas Surg"},{"key":"10.1016\/j.mehy.2016.12.002_b0800","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0002-8703(88)90611-4","article-title":"Reduction of ventricular arrhythmias by creatine phosphate in patients with acute myocardial infarction","volume":"116","author":"Ruda","year":"1988","journal-title":"Am Heart J"},{"issue":"9","key":"10.1016\/j.mehy.2016.12.002_b0805","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/s11064-010-0198-z","article-title":"Muralidhara. Attenuation of rotenone-induced mitochondrial oxidative damage and neurotoxicity in Drosophila melanogaster supplemented with creatine","volume":"35","author":"Hosamani","year":"2010","journal-title":"Neurochem Res"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.002_b0810","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00726-011-1132-7","article-title":"In sickness and in health: the widespread application of creatine supplementation","volume":"43","author":"Gualano","year":"2012","journal-title":"Amino Acids"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.002_b0815","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/sdi.12378","article-title":"Pharmacologic treatment of common symptoms in dialysis patients: a narrative review","volume":"28","author":"Moledina","year":"2015","journal-title":"Semin Dial"},{"key":"10.1016\/j.mehy.2016.12.002_b0820","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-1-4020-6486-9_16","article-title":"Creatine and creatine kinase in health and disease \u2013 a bright future ahead?","volume":"46","author":"Wyss","year":"2007","journal-title":"Subcell Biochem"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716307204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716307204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T11:02:27Z","timestamp":1657969347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716307204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":164,"alternative-id":["S0306987716307204"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.12.002","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}