{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T22:55:43Z","timestamp":1780872943604,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.mehy.2016.12.013","type":"journal-article","created":{"date-parts":[[2016,12,29]],"date-time":"2016-12-29T07:51:37Z","timestamp":1482997897000},"page":"4-9","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["The prevention of benign prostatic hyperplasia (bph)"],"prefix":"10.1016","volume":"100","author":[{"given":"W.G.","family":"Roper","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2016.12.013_b0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0306-9877(98)90179-7","article-title":"The etiology of benign prostatic hypertrophy","volume":"50","author":"Roper","year":"1998","journal-title":"Med Hypotheses"},{"issue":"1\u20133","key":"10.1016\/j.mehy.2016.12.013_b0010","first-page":"270","article-title":"Lysophosphatidic acid as an autocrine and paracrine mediator","volume":"1582","author":"Xie","year":"2002","journal-title":"Biochem Biophys Acta"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.013_b0015","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.eururo.2006.07.016","article-title":"Seminal plasma cytokines and chemokines in prostate inflammation: Interleukin 8 as a predictive marker in BPH","volume":"51","author":"Penna","year":"2007","journal-title":"Euro Urol"},{"issue":"7","key":"10.1016\/j.mehy.2016.12.013_b0020","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.4049\/jimmunol.0801875","article-title":"Human BPH stromal cells as inducers and targets of chronic immuno-modulated inflammation","volume":"182","author":"Penna","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.mehy.2016.12.013_b0025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/pros.10077","article-title":"Lysophosphatidic acid stimulates proliferation of cultured smooth muscle cells from human BPH tissue","volume":"51","author":"Adolfsson Per","year":"2002","journal-title":"Prostate"},{"key":"10.1016\/j.mehy.2016.12.013_b0030","series-title":"The Prostate","author":"Blandy","year":"1986"},{"key":"10.1016\/j.mehy.2016.12.013_b0035","unstructured":"Hendry W, editor. Recent Adv Urol Androl, vol. 4, 1987, onlinelibrary.wiley.com, http:\/\/dx.doi.org\/10.1111\/j.1464-410X.1988.tb04284."},{"key":"10.1016\/j.mehy.2016.12.013_b0040","series-title":"Histology for pathologists","first-page":"757","author":"Sternberg","year":"1992"},{"key":"10.1016\/j.mehy.2016.12.013_b0045","series-title":"Gray's anatomy","first-page":"1133","author":"Gray","year":"2003"},{"key":"10.1016\/j.mehy.2016.12.013_b0050","series-title":"Campbells urology","author":"Walsh","year":"1987"},{"issue":"1","key":"10.1016\/j.mehy.2016.12.013_b0055","first-page":"14","article-title":"Zinc status of patients with BPH and prostate carcinoma. Indian","volume":"27","author":"Christudos","year":"2011","journal-title":"J Urol"},{"issue":"7","key":"10.1016\/j.mehy.2016.12.013_b0060","first-page":"2266","article-title":"Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen","volume":"83","author":"Khosia","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.mehy.2016.12.013_b0065","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/pros.2990060204","article-title":"The effect of prolactin on human BPH epithelial cell proliferation","volume":"6","author":"Syms","year":"1985","journal-title":"Prostate"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.013_b0070","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0022-5347(17)49168-3","article-title":"Evidence for the association between blood prolactin and androgen receptors in BPH","volume":"133","author":"Odoma","year":"1985","journal-title":"J Urol"},{"issue":"5","key":"10.1016\/j.mehy.2016.12.013_b0075","first-page":"557","article-title":"Webster","volume":"4","author":"Jerome","year":"1974","journal-title":"Role of Prolactin in BPH. Urology"},{"key":"10.1016\/j.mehy.2016.12.013_b0080","unstructured":"Borstwick D. Pathology of BPH. EDHealth.org."},{"issue":"3","key":"10.1016\/j.mehy.2016.12.013_b0085","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1128\/JB.124.3.1148-1152.1975","article-title":"Proulx P phospholipase D activity of gram negative bacteria","volume":"124","author":"Cole","year":"1975","journal-title":"J. Bacteriol"},{"key":"10.1016\/j.mehy.2016.12.013_b0090","series-title":"Medical microbiology","first-page":"142","author":"Baron","year":"1991"},{"issue":"4","key":"10.1016\/j.mehy.2016.12.013_b0095","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1464-410X.1994.tb07612.x","article-title":"Ejaculation in men: a dynamic endorectal ultrasonographical study","volume":"73","author":"Gilvernet","year":"1994","journal-title":"Br J Urol"},{"key":"10.1016\/j.mehy.2016.12.013_b0100","article-title":"Antibacterial activity of human urine Dept Medicine, New York Hospital, Cornell medical center","volume":"47","author":"Kaye","year":"1968","journal-title":"N Y J Clin Invest"},{"issue":"3","key":"10.1016\/j.mehy.2016.12.013_b0105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0094-0143(21)00960-5","article-title":"Walsh P Clinical and experimental studies of BPH","volume":"17","author":"Coffey","year":"1990","journal-title":"Urol Clin Am"},{"key":"10.1016\/j.mehy.2016.12.013_b0110","unstructured":"Auglin J, et al. Induction of prostate apostosis by alpha 1-adrenoreceptor antagonists. Divisions of urology, molecular biology and biochemistry. Uni of Maryland, Medical center, Baltimore, USA; 2000."},{"key":"10.1016\/j.mehy.2016.12.013_b0115","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/j.1476-5381.1996.tb15742.x","article-title":"Quantification and distribution of alpha-1 AR subtype mRNA in the human prostate Comparison of benign hypertrophied and non-hypertrophied tissue","volume":"119","author":"Nasu","year":"1996","journal-title":"Br J of Pharmacol"},{"key":"10.1016\/j.mehy.2016.12.013_b0120","unstructured":"Korsmeyer S. BCL-2 gene family and the regulation of programmed cell death Cancer Research Presentation. In: 20th annual scientific conference Developmental Biology and Cancer, Bethesda, 1998."},{"key":"10.1016\/j.mehy.2016.12.013_b0125","unstructured":"Graph, reprinted from Griffin and Wilson, Harrison\u2019s Principles of Internal Medicine, 12th Ed., vol. 2, 1985, p. 1769."},{"key":"10.1016\/j.mehy.2016.12.013_b0130","unstructured":"Kirby R, Fitzpatrick J, McConnell J. Textbook of BPH, books google.com.au, 2008, p. 97."},{"key":"10.1016\/j.mehy.2016.12.013_b0135","unstructured":"Stamm W, Turk M. Urinary tract infection and pyelonephritis. Harrison\u2019s Textbook of Medicine. 12th ed., vol 1 New York: McGraw-Hill, 1991 Genetic Factors, 1991, p. 540."},{"issue":"12","key":"10.1016\/j.mehy.2016.12.013_b0140","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1056\/NEJM198903233201205","article-title":"Association of the Lewis blood-group phenotype with recurrent UTI in women","volume":"320","author":"Sheinfeld","year":"1989","journal-title":"N. Engl J Med"},{"key":"10.1016\/j.mehy.2016.12.013_b0145","unstructured":"Franks L. Research methods: tissue culture in the investigation of prostate cancer. Department of Cellular Pathology, Imperial Cancer Research Fund, London, UK."},{"key":"10.1016\/j.mehy.2016.12.013_b0150","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ncb3047","article-title":"Single luminal epithelial progenitors can generate prostatic organoids in culture","volume":"16","author":"Chua","year":"2014","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.mehy.2016.12.013_b0155","unstructured":"Pizza M, www.reuters.com\/article\/us-novartis-ecoli-idUSTRE6424FW20100503, May 3, 2010."},{"key":"10.1016\/j.mehy.2016.12.013_b0160","article-title":"Primary prostate stromal cells modulate the morphology and migration of primary prostate epithelial cells in type 1 collagen gels","author":"Hall","year":"2002","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.mehy.2016.12.013_b0165","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1086\/386328","article-title":"Cranberry Juice and Urinary Tract Infection","volume":"38","author":"Raz","year":"2004","journal-title":"Oxford Journals. Medicine and Health. Clin Infect Dis"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716307113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716307113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T05:00:30Z","timestamp":1658293230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716307113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":33,"alternative-id":["S0306987716307113"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2016.12.013","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The prevention of benign prostatic hyperplasia (bph)","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2016.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}