{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:50:06Z","timestamp":1761562206548},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.mehy.2017.02.006","type":"journal-article","created":{"date-parts":[[2017,2,15]],"date-time":"2017-02-15T16:00:23Z","timestamp":1487174423000},"page":"44-47","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Dying for love: Perimenopausal degeneration of vaginal microbiome drives the chronic inflammation-malignant transformation of benign prostatic hyperplasia to prostatic adenocarcinoma"],"prefix":"10.1016","volume":"101","author":[{"given":"Albert Stuart","family":"Reece","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2017.02.006_b0005","series-title":"Bailey and Love\u2019s Short Practice of Surgery","author":"Williams","year":"2013"},{"key":"10.1016\/j.mehy.2017.02.006_b0010","series-title":"United States Cancer Statistics: 1999\u20132013 Incidence and Mortality Web-based Report","year":"2016"},{"key":"10.1016\/j.mehy.2017.02.006_b0015","unstructured":"National Cancer Institute SEER Fact Sheets: Surveillance Epidemiology and End Results Program: Prostate Cancer. Cancer Statistics: Statistical Summaries - Prostate Cancer, <https:\/\/seer.cancer.gov\/statfacts\/html\/prost.html>; 2016."},{"key":"10.1016\/j.mehy.2017.02.006_b0020","series-title":"Harrison\u2019s Principles of Internal Medicine","year":"2008"},{"key":"10.1016\/j.mehy.2017.02.006_b0025","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1158\/1055-9965.EPI-13-1126","article-title":"Chronic inflammation in benign prostate tissue is associated with high-grade prostate cancer in the placebo arm of the prostate cancer prevention trial","volume":"23","author":"Gurel","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.mehy.2017.02.006_b0030","unstructured":"Marjolin JN, Ulcere Dictionnaire de Medicine, Paris, 1828."},{"key":"10.1016\/j.mehy.2017.02.006_b0035","doi-asserted-by":"crossref","first-page":"42660","DOI":"10.1074\/jbc.M304984200","article-title":"Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase","volume":"278","author":"Onuma","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2017.02.006_b0040","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.ccell.2016.03.005","article-title":"Tumoral immune cell exploitation in colorectal cancer metastases can be targeted effectively by anti-CCR5 therapy in cancer patients","volume":"29","author":"Halama","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.mehy.2017.02.006_b0045","doi-asserted-by":"crossref","first-page":"10230","DOI":"10.1038\/ncomms10230","article-title":"Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity","volume":"7","author":"Laurent","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.mehy.2017.02.006_b0050","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1007\/s13277-016-5028-8","article-title":"Transforming growth factor-beta1 in carcinogenesis, progression, and therapy in cervical cancer","volume":"37","author":"Zhu","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.mehy.2017.02.006_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/jcm5010007","article-title":"Reversible human TGF-beta signal shifting between tumor suppression and fibro-carcinogenesis: implications of Smad phospho-isoforms for hepatic epithelial-mesenchymal transitions","volume":"5","author":"Yoshida","year":"2016","journal-title":"J Clin Med"},{"key":"10.1016\/j.mehy.2017.02.006_b0060","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.canlet.2015.11.007","article-title":"Crosstalk between transforming growth factor-beta signaling pathway and long non-coding RNAs in cancer","volume":"370","author":"Wang","year":"2016","journal-title":"Cancer Lett"},{"key":"10.1016\/j.mehy.2017.02.006_b0065","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrc3500","article-title":"Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer","volume":"13","author":"Wakefield","year":"2013","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.mehy.2017.02.006_b0070","unstructured":"National Cancer Institute. Breast Cancer Risk in American Women, <https:\/\/www.cancer.gov\/types\/breast\/risk-fact-sheet>; 2016, [accessed 3.12.2016]."},{"key":"10.1016\/j.mehy.2017.02.006_b0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.mehy.2009.08.042","article-title":"Duct obstruction: the possible etiopathogenesis of benign prostatic hyperplasia","volume":"74","author":"Lan","year":"2010","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2017.02.006_b0080","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.mehy.2007.07.012","article-title":"The overlooked cause of benign prostatic hyperplasia: prostatic urethral angulation","volume":"70","author":"Cho","year":"2008","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2017.02.006_b0085","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mehy.2008.08.022","article-title":"Is prostate cancer an HPV-associated lesion?","volume":"72","author":"Kong","year":"2009","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2017.02.006_b0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mehy.2011.10.034","article-title":"Ciprofloxacin as a prophylactic agent against prostate cancer: a \u201ctwo hit\u201d hypothesis","volume":"78","author":"Kloskowski","year":"2012","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2017.02.006_b0095","first-page":"161","article-title":"The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome","volume":"72","author":"Jayaram","year":"2014","journal-title":"Pathog Dis"},{"key":"10.1016\/j.mehy.2017.02.006_b0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023051","article-title":"The perinatal microbiome and pregnancy: moving beyond the vaginal microbiome","volume":"5","author":"Prince","year":"2015","journal-title":"Cold Spring Harbor Perspect Med"},{"key":"10.1016\/j.mehy.2017.02.006_b0105","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1210\/en.2015-1177","article-title":"Alterations in the vaginal microbiome by maternal stress are associated with metabolic reprogramming of the offspring gut and brain","volume":"156","author":"Jasarevic","year":"2015","journal-title":"Endocrinology"},{"key":"10.1016\/j.mehy.2017.02.006_b0110","doi-asserted-by":"crossref","first-page":"16865","DOI":"10.1038\/srep16865","article-title":"Cervical intraepithelial neoplasia disease progression is associated with increased vaginal microbiome diversity","volume":"5","author":"Mitra","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.mehy.2017.02.006_b0115","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.contraception.2014.04.006","article-title":"Vaginal microbiome changes with levonorgestrel intrauterine system placement","volume":"90","author":"Jacobson","year":"2014","journal-title":"Contraception"},{"key":"10.1016\/j.mehy.2017.02.006_b0120","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1055\/s-0036-1581057","article-title":"The gestational vaginal microbiome and spontaneous preterm birth among nulliparous African American women","volume":"33","author":"Nelson","year":"2016","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.mehy.2017.02.006_b0125","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/1471-0528.13229","article-title":"Re: the vaginal microbiome, vaginal anti-microbial defence mechanisms and the clinical challenge of reducing infection-related preterm birth","volume":"122","author":"Griffin","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.mehy.2017.02.006_b0130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/1471-0528.13115","article-title":"The vaginal microbiome, vaginal anti-microbial defence mechanisms and the clinical challenge of reducing infection-related preterm birth","volume":"122","author":"Witkin","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.mehy.2017.02.006_b0135","doi-asserted-by":"crossref","first-page":"e26602","DOI":"10.1371\/journal.pone.0026602","article-title":"Vaginal microbiome and epithelial gene array in post-menopausal women with moderate to severe dryness","volume":"6","author":"Hummelen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.mehy.2017.02.006_b0140","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3343\/alm.2016.36.5.441","article-title":"Analysis of the vaginal microbiome by next-generation sequencing and evaluation of its performance as a clinical diagnostic tool in vaginitis","volume":"36","author":"Hong","year":"2016","journal-title":"Ann Lab Med"},{"key":"10.1016\/j.mehy.2017.02.006_b0145","doi-asserted-by":"crossref","first-page":"3411","DOI":"10.1128\/AAC.02469-14","article-title":"Rifaximin modulates the vaginal microbiome and metabolome in women affected by bacterial vaginosis","volume":"58","author":"Laghi","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mehy.2017.02.006_b0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1471-2180-12-83","article-title":"Quantification of bacterial species of the vaginal microbiome in different groups of women, using nucleic acid amplification tests","volume":"12","author":"Jespers","year":"2012","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.mehy.2017.02.006_b0155","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1007\/s10096-015-2490-y","article-title":"Vaginal microbiome and metabolome highlight specific signatures of bacterial vaginosis","volume":"34","author":"Vitali","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.mehy.2017.02.006_b0160","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-micro-092611-150157","article-title":"Vaginal microbiome: rethinking health and disease","volume":"66","author":"Ma","year":"2012","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.mehy.2017.02.006_b0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.maturitas.2016.05.015","article-title":"Menopause and the vaginal microbiome","volume":"91","author":"Muhleisen","year":"2016","journal-title":"Maturitas"},{"key":"10.1016\/j.mehy.2017.02.006_b0170","doi-asserted-by":"crossref","first-page":"e104511","DOI":"10.1371\/journal.pone.0104511","article-title":"A systems biology approach investigating the effect of probiotics on the vaginal microbiome and host responses in a double blind, placebo-controlled clinical trial of post-menopausal women","volume":"9","author":"Bisanz","year":"2014","journal-title":"PLoS One"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716309227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987716309227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T08:58:58Z","timestamp":1536051538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987716309227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":34,"alternative-id":["S0306987716309227"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2017.02.006","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dying for love: Perimenopausal degeneration of vaginal microbiome drives the chronic inflammation-malignant transformation of benign prostatic hyperplasia to prostatic adenocarcinoma","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2017.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}