{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:28:16Z","timestamp":1761744496251},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.mehy.2017.05.011","type":"journal-article","created":{"date-parts":[[2017,5,10]],"date-time":"2017-05-10T01:15:42Z","timestamp":1494378942000},"page":"166-169","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Granulocytes as an effector mechanism of BCG therapy for bladder cancer"],"prefix":"10.1016","volume":"104","author":[{"suffix":"III","given":"Ronald L.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Le","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2017.05.011_b0005","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.juro.2007.08.122","article-title":"History of bacillus Calmette-Guerin and bladder cancer: an immunotherapy success story","volume":"179","author":"Herr","year":"2008","journal-title":"J Urol"},{"issue":"2","key":"10.1016\/j.mehy.2017.05.011_b0010","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0022-5347(17)58737-6","article-title":"Intracavitary Bacillus Calmette-Guerin in the treatment of superficial bladder tumors","volume":"116","author":"Morales","year":"1976","journal-title":"J Urol"},{"issue":"9165","key":"10.1016\/j.mehy.2017.05.011_b0015","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/S0140-6736(98)07422-4","article-title":"BCG immunotherapy of bladder cancer: 20years on","volume":"353","author":"Alexandroff","year":"1999","journal-title":"The Lancet"},{"issue":"3","key":"10.1016\/j.mehy.2017.05.011_b0020","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrurol.2014.15","article-title":"The mechanism of action of BCG therapy for bladder cancer [mdash] a current perspective","volume":"11","author":"Redelman-Sidi","year":"2014","journal-title":"Nat Rev Urol"},{"key":"10.1016\/j.mehy.2017.05.011_b0025","unstructured":"Busch W. Aus der Sitzung der medicinischen Section vom 13 November 1867. Berl Klin Wochenschr 1868; 5: 137."},{"issue":"3","key":"10.1016\/j.mehy.2017.05.011_b0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00000658-189112000-00015","article-title":"Contribution to the knowledge of sarcoma","volume":"14","author":"Coley","year":"1891","journal-title":"Ann Surg"},{"key":"10.1016\/j.mehy.2017.05.011_b0035","first-page":"689","article-title":"Nouvelle contribution \u00e0 l\u2019\u00e9tude de la vaccination des bovid\u00e9s contre la tuberculose","volume":"22","author":"Calmette","year":"1908","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.mehy.2017.05.011_b0040","first-page":"162","article-title":"Nouvelles recherches exp\u00e9rimentales sur la vaccination des bovid\u00e9s contre la tuberculose et sur le sort des bouilles tuberculeux dans l\u2019organisme des vaccines","volume":"27","author":"Calmette","year":"1913","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.mehy.2017.05.011_b0045","first-page":"553","article-title":"Nouvelles recherches exp\u00e9rimentales sur la vaccination des bovid\u00e9s contre la tuberculose","volume":"34","author":"Calmette","year":"1920","journal-title":"Ann Inst Pasteur"},{"key":"10.1016\/j.mehy.2017.05.011_b0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/184291a0","article-title":"Effect of Bacillus Calmette-Guerin infection on transplanted tumours in the mouse","volume":"184","author":"Old","year":"1959","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.mehy.2017.05.011_b0055","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/S0022-5347(17)37668-1","article-title":"Intravesical Evans strain BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall","volume":"147","author":"Prescott","year":"1992","journal-title":"J Urol"},{"issue":"3","key":"10.1016\/j.mehy.2017.05.011_b0060","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1097\/01.ju.0000073852.24341.4a","article-title":"Immune mechanisms in bacillus Calmette-Guerin immunotherapy for superficial bladder cancer","volume":"170","author":"B\u00f6hle","year":"2003","journal-title":"J Urol"},{"issue":"8","key":"10.1016\/j.mehy.2017.05.011_b0065","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00262-003-0384-9","article-title":"Urinary interleukin-2 may predict clinical outcome of intravesical bacillus Calmette-Guerin immunotherapy for carcinoma in situ of the bladder","volume":"52","author":"Watanabe","year":"2003","journal-title":"Cancer Immunol Immunother"},{"issue":"8","key":"10.1016\/j.mehy.2017.05.011_b0070","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1007\/s00262-008-0643-x","article-title":"A possible mechanism of intravesical BCG therapy for human bladder carcinoma: involvement of innate effector cells for the inhibition of tumor growth","volume":"58","author":"Higuchi","year":"2009","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.mehy.2017.05.011_b0075","first-page":"306","article-title":"Induction of urinary IL1, IL2, IL6, and TNF during intravesical immunotherapy with BCG in superficial bladder cancer","volume":"33","author":"De Boer","year":"1991","journal-title":"Cancer Immunol Immunother"},{"issue":"1","key":"10.1016\/j.mehy.2017.05.011_b0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1043-4666(02)00490-8","article-title":"Role of Th1 and Th2 cytokines in BCG-induced IFN-\u03b3 production: cytokine promotion and simulation of BCG effect","volume":"21","author":"Luo","year":"2003","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.mehy.2017.05.011_b0085","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1038\/sj.jid.5701223","article-title":"Dynamics of neutrophil infiltration during cutaneous wound healing and infection using fluorescence imaging","volume":"128","author":"Kim","year":"2008","journal-title":"J Invest Dermatol"},{"issue":"8","key":"10.1016\/j.mehy.2017.05.011_b0090","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s002620100216","article-title":"Fever and cancer in perspective","volume":"50","author":"Hobohm","year":"2001","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.mehy.2017.05.011_b0095","doi-asserted-by":"crossref","unstructured":"Nauts HC, McLaren JR. Coley toxins-the first century[M]\/\/Consensus on Hyperthermia for the 1990s. Springer US, 1990; 483\u2013500.","DOI":"10.1007\/978-1-4684-5766-7_52"},{"key":"10.1016\/j.mehy.2017.05.011_b0100","first-page":"23","article-title":"Analysis of neutrophil chemotaxis","author":"Nuzzi","year":"2007","journal-title":"Adhesion Protein Protocols"},{"issue":"5","key":"10.1016\/j.mehy.2017.05.011_b0105","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1084\/jem.98.5.493","article-title":"Studies on the pathogenesis of fever: II. Characterization of fever-producing substances from polymorphonuclear leukocytes and from the fluid of sterile exudates","volume":"98","author":"Bennett","year":"1953","journal-title":"J Exp Med"},{"key":"10.1016\/j.mehy.2017.05.011_b0110","series-title":"Fever: its biology, evolution, and function","author":"Kluger","year":"2015"},{"issue":"137","key":"10.1016\/j.mehy.2017.05.011_b0115","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003586","article-title":"Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer","volume":"4","author":"Biot","year":"2012","journal-title":"Sci Transl Med"},{"issue":"5","key":"10.1016\/j.mehy.2017.05.011_b0120","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0022-5347(17)45922-2","article-title":"Histological parameters and pitfalls in the interpretation of bladder biopsies in bacillus Calmette-Guerin treatment of superficial bladder cancer","volume":"135","author":"Lage","year":"1986","journal-title":"J Urol"},{"issue":"6","key":"10.1016\/j.mehy.2017.05.011_b0125","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF01741603","article-title":"Presence of activated lymphocytes in the urine of patients with superficial bladder cancer after intravesical immunotherapy with bacillus Calmette-Guerin","volume":"33","author":"De Boer","year":"1991","journal-title":"Cancer Immunol Immunother"},{"issue":"16","key":"10.1016\/j.mehy.2017.05.011_b0130","doi-asserted-by":"crossref","first-page":"8250","DOI":"10.1158\/0008-5472.CAN-06-1416","article-title":"Neutrophil granulocytes are required for effective Bacillus Calmette-Guerin immunotherapy of bladder cancer and orchestrate local immune responses","volume":"66","author":"Suttmann","year":"2006","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.011_b0135","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.urolonc.2007.11.031","article-title":"Role of neutrophils in BCG immunotherapy for bladder cancer","volume":"26","author":"Simons","year":"2008","journal-title":"Urol Oncol: Semin Original Invest"},{"issue":"11","key":"10.1016\/j.mehy.2017.05.011_b0140","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1073\/pnas.1031601100","article-title":"Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice","volume":"100","author":"Cui","year":"2003","journal-title":"Proc Natl Acad Sci"},{"issue":"20","key":"10.1016\/j.mehy.2017.05.011_b0145","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1073\/pnas.0602382103","article-title":"Transferable anticancer innate immunity in spontaneous regression\/complete resistance mice","volume":"103","author":"Hicks","year":"2006","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.mehy.2017.05.011_b0150","doi-asserted-by":"crossref","unstructured":"Cui Z. Near term prospects for broad spectrum amelioration of cancer. The Future of Aging. Springer Netherlands 2010; 307\u201329.","DOI":"10.1007\/978-90-481-3999-6_9"},{"issue":"1","key":"10.1016\/j.mehy.2017.05.011_b0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2867-11-26","article-title":"Novel innate cancer killing activity in humans","volume":"11","author":"Blanks","year":"2011","journal-title":"Cancer Cell Int"},{"issue":"5","key":"10.1016\/j.mehy.2017.05.011_b0160","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3724\/SP.J.1008.2012.00474","article-title":"Screening of granulocytes with cancer killing activity and their in vitro anti-tumor effects","volume":"32","author":"Guo","year":"2012","journal-title":"Acad J Second Military Med Univ"},{"issue":"7","key":"10.1016\/j.mehy.2017.05.011_b0165","doi-asserted-by":"crossref","first-page":"e950163","DOI":"10.4161\/15384101.2014.950163","article-title":"Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells","volume":"3","author":"Yan","year":"2014","journal-title":"Oncoimmunology"},{"issue":"6","key":"10.1016\/j.mehy.2017.05.011_b0170","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1172\/JCI113527","article-title":"Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations","volume":"81","author":"Lehrer","year":"1988","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.mehy.2017.05.011_b0175","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.iy.11.040193.000541","article-title":"Defensins: antimicrobial and cytotoxic peptides of mammalian cells","volume":"11","author":"Lehrer","year":"1993","journal-title":"Annu Rev Immunol"},{"issue":"9","key":"10.1016\/j.mehy.2017.05.011_b0180","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrmicro976","article-title":"Primate defensins","volume":"2","author":"Lehrer","year":"2004","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.011_b0185","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1128\/AEM.55.4.832-836.1989","article-title":"Cell surface charge characteristics and their relationship to bacterial attachment to meat surfaces","volume":"55","author":"Dickson","year":"1989","journal-title":"Appl Environ Microbiol"},{"issue":"11","key":"10.1016\/j.mehy.2017.05.011_b0190","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.7150\/thno.16358","article-title":"Targeting negative surface charges of cancer cells by multifunctional nanoprobes","volume":"6","author":"Chen","year":"2016","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.mehy.2017.05.011_b0195","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jprot.2009.01.002","article-title":"Human defensins as cancer biomarkers and antitumour molecules","volume":"72","author":"Droin","year":"2009","journal-title":"J Proteomics"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771730316X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771730316X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T01:52:43Z","timestamp":1602035563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030698771730316X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":39,"alternative-id":["S030698771730316X"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2017.05.011","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Granulocytes as an effector mechanism of BCG therapy for bladder cancer","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2017.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}