{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T17:04:59Z","timestamp":1768583099184,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016S1A5B8925203"],"award-info":[{"award-number":["NRF-2016S1A5B8925203"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.mehy.2017.05.017","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T12:32:10Z","timestamp":1495629130000},"page":"36-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Potential therapeutic effect of alkaline reduced water in polycystic ovarian syndrome"],"prefix":"10.1016","volume":"104","author":[{"given":"Jesmin","family":"Ara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selikem Abla","family":"Nuwormegbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. Easter Joy","family":"Sajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-Yong","family":"Shim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2017.05.017_b0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-8-41","article-title":"Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med"},{"issue":"12","key":"10.1016\/j.mehy.2017.05.017_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CLEP.S37559","article-title":"Epidemiology, diagnosis, and management of polycystic ovary syndrome","volume":"6","author":"Sirmans","year":"2013","journal-title":"Clin Epidemiol"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.017_b0015","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/jwh.2014.5000","article-title":"Prevalence of infertility and use of fertility treatment in women with polycystic ovary syndrome: data from a large community-based cohort study","volume":"24","author":"Joham","year":"2015","journal-title":"J Women's Health"},{"issue":"25","key":"10.1016\/j.mehy.2017.05.017_b0020","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.mehy.2017.05.017_b0025","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bpobgyn.2004.05.002","article-title":"The genetics of polycystic ovary syndrome","volume":"18","author":"Amato","year":"2004","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.mehy.2017.05.017_b0030","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0015-0282(02)03275-2","article-title":"Molecular progress in infertility: polycystic ovary syndrome","volume":"78","author":"Legro","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2017.05.017_b0035","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/bmj.332.7539.434","article-title":"Should obese women with polycystic ovary syndrome receive treatment for infertility?","volume":"332","author":"Balen","year":"2006","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.mehy.2017.05.017_b0040","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"11","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.mehy.2017.05.017_b0045","first-page":"1","article-title":"Ghrelin is independently associated with anti-mullerian hormone levels in obese but not non-obese women with polycystic ovary syndrome","volume":"21","author":"Garin","year":"2016","journal-title":"Endocrine"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.017_b0050","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0015-0282(16)56632-1","article-title":"Endocrine consequences of weight loss in obese, hyperandrogenic, anovulatory women","volume":"61","author":"Guzick","year":"1994","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2017.05.017_b0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/158102","article-title":"Ghrelin in female and male reproduction","author":"Dupont","year":"2010","journal-title":"Int J Pept"},{"key":"10.1016\/j.mehy.2017.05.017_b0060","first-page":"1","article-title":"Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth","author":"Rojas","year":"2014","journal-title":"Int J Reprod Biomed"},{"key":"10.1016\/j.mehy.2017.05.017_b0065","first-page":"1470","article-title":"Restoration of reproductive potential by lifestyle modification in obese polycystic ovary syndrome: role of insulin sensitivity and luteinizing hormone","volume":"84","author":"Huber-Buchholz","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.017_b0070","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.fertnstert.2007.04.043","article-title":"Obesity, weight loss, and the polycystic ovary syndrome: effect of treatment with diet and orlistat for 24 weeks on insulin resistance and androgen levels","volume":"89","author":"Panidis","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2017.05.017_b0075","first-page":"Cd007506","article-title":"Lifestyle changes in women with polycystic ovary syndrome","volume":"7","author":"Moran","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"10","key":"10.1016\/j.mehy.2017.05.017_b0080","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1053\/meta.2000.9523","article-title":"Change of cytokine balance in diet-induced obese mice","volume":"49","author":"Mito","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.mehy.2017.05.017_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/987285","article-title":"MicroRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome","volume":"2014","author":"Ge","year":"2014","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.mehy.2017.05.017_b0090","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/bbrc.1997.6622","article-title":"Electrolyzed\u2013reduced water scavenges active oxygen species and protects DNA from oxidative damage","volume":"234","author":"Shirahata","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.mehy.2017.05.017_b0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.tifs.2011.10.009","article-title":"Advanced research on the health benefit of reduced water","volume":"23","author":"Shirahata","year":"2012","journal-title":"Trends Food Sci Technol"},{"issue":"2","key":"10.1016\/j.mehy.2017.05.017_b0100","doi-asserted-by":"crossref","first-page":"e0171192","DOI":"10.1371\/journal.pone.0171192","article-title":"Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water","volume":"12","author":"Hamasaki","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.017_b0105","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.mehy.2015.01.018","article-title":"Potential ghrelin-mediated benefits and risks of hydrogen water","volume":"84","author":"McCarty","year":"2015","journal-title":"Med Hypotheses"},{"issue":"7","key":"10.1016\/j.mehy.2017.05.017_b0110","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/oby.2011.6","article-title":"Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db\/db mice","volume":"19","author":"Kamimura","year":"2011","journal-title":"Obesity"},{"key":"10.1016\/j.mehy.2017.05.017_b0115","series-title":"Redox regulation by reduced water as active hydrogen donors and intracellular ROS scavengers for prevention of type 2 diabetes. Cell technology for cell products","first-page":"99","author":"Shirahata","year":"2007"},{"issue":"7","key":"10.1016\/j.mehy.2017.05.017_b0120","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1248\/bpb.b12-00781","article-title":"Anti-obesity effect of alkaline reduced water in high fat-fed obese mice","volume":"36","author":"Ignacio","year":"2013","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10.1016\/j.mehy.2017.05.017_b0125","first-page":"1","article-title":"Effect of mineral-induced alkaline reduced water on sprague-dawley rats fed on high-fat diet","volume":"12","author":"Jin","year":"2006","journal-title":"J Exp Biomed Sci"},{"key":"10.1016\/j.mehy.2017.05.017_b0130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1100\/tsw.2010.94","article-title":"The role of oxidative stress in the aging process","volume":"10","author":"Oliveira","year":"2010","journal-title":"Sci World J"},{"issue":"4","key":"10.1016\/j.mehy.2017.05.017_b0135","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.3390\/w5042094","article-title":"Physico-chemical, biological and therapeutic characteristics of electrolyzed reduced alkaline water (ERAW)","volume":"5","author":"Henry","year":"2013","journal-title":"Water"},{"issue":"2","key":"10.1016\/j.mehy.2017.05.017_b0140","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1055\/s-2002-32501","article-title":"Leptin and ovarian folliculogenesis: implications for ovulation induction and ART outcomes","volume":"20","author":"Brannian","year":"2002","journal-title":"Semin Repord Med"},{"issue":"5","key":"10.1016\/j.mehy.2017.05.017_b0145","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1056\/NEJM199602013340503","article-title":"Serum immunoreactive-leptin concentrations in normal-weight and obese humans","volume":"334","author":"Considine","year":"1996","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.mehy.2017.05.017_b0150","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/2230-8210.180005","article-title":"Leptin and body mass index in polycystic ovary syndrome","volume":"20","author":"Jalilian","year":"2016","journal-title":"Indian J Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.mehy.2017.05.017_b0155","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1600-0897.1995.tb00934.x","article-title":"Circulating tumor necrosis factor (TNF)-\u03b1 in normally cycling women and patients with premature ovarian failure and polycystic ovaries","volume":"34","author":"Naz","year":"1995","journal-title":"Am J Reprod Immunol"},{"issue":"6","key":"10.1016\/j.mehy.2017.05.017_b0160","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1172\/JCI57132","article-title":"Inflammatory links between obesity and metabolic disease","volume":"121","author":"Lumeng","year":"2011","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.mehy.2017.05.017_b0170","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1271\/bbb.70.31","article-title":"Anti-diabetic effect of alkaline-reduced water on OLETF rats","volume":"70","author":"Jin","year":"2006","journal-title":"Biosci Biotechnol Biochem"},{"issue":"19","key":"10.1016\/j.mehy.2017.05.017_b0175","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4103\/0366-6999.190668","article-title":"Hydrogen-rich water exerting a protective effect on ovarian reserve function in a mouse model of immune premature ovarian failure induced by zona pellucida 3","volume":"129","author":"He","year":"2016","journal-title":"Chin Med J"},{"issue":"3","key":"10.1016\/j.mehy.2017.05.017_b0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.nutres.2008.01.008","article-title":"Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance","volume":"28","author":"Kajiyama","year":"2008","journal-title":"Nutr Res"},{"key":"10.1016\/j.mehy.2017.05.017_b0185","first-page":"1","article-title":"Modulation of steroidogenesis by vitamin D3 in granulosa cells of the mouse model of polycystic ovarian syndrome","author":"Bakhshalizadeh","year":"2017","journal-title":"Syst Biol Reprod Med"},{"issue":"12","key":"10.1016\/j.mehy.2017.05.017_b0190","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1210\/jc.2010-0770","article-title":"Statins inhibit growth of human theca-interstitial cells in PCOS and non-PCOS tissues independently of cholesterol availability","volume":"95","author":"Sokalska","year":"2010","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771730124X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030698771730124X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T10:21:45Z","timestamp":1656411705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030698771730124X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":37,"alternative-id":["S030698771730124X"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2017.05.017","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential therapeutic effect of alkaline reduced water in polycystic ovarian syndrome","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2017.05.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}