{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:10:00Z","timestamp":1790651400163,"version":"4.1.0"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Romanian Research Ministry","award":["PN-II-RU-TE-2014-4-1783"],"award-info":[{"award-number":["PN-II-RU-TE-2014-4-1783"]}]},{"name":"Romanian Research Ministry","award":["CNFIS-FDI-2017-1350"],"award-info":[{"award-number":["CNFIS-FDI-2017-1350"]}]}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.mehy.2017.09.023","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T03:47:52Z","timestamp":1506570472000},"page":"42-45","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?"],"prefix":"10.1016","volume":"109","author":[{"given":"Sanda","family":"Boca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Berce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancuta","family":"Jurj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobe","family":"Petrushev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grigore-Aristide","family":"Gafencu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Selicean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vlad","family":"Moisoiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-4218","authenticated-orcid":false,"given":"Daiana","family":"Temian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-7092","authenticated-orcid":false,"given":"Wilhelm-Thomas","family":"Micu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simion","family":"Astilean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Braicu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-1519","authenticated-orcid":false,"given":"Ciprian","family":"Tomuleasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Berindan-Neagoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.mehy.2017.09.023_b0005","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/nm.3645","article-title":"Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition","volume":"20","author":"Xing","year":"2014","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.mehy.2017.09.023_b0010","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa1110557","article-title":"A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis","volume":"366","author":"Verstovsek","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.mehy.2017.09.023_b0015","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jamadermatol.2015.4445","article-title":"Topical Ruxolitinib for the treatment of alopecia Universalis","volume":"152","author":"Craiglow","year":"2016","journal-title":"JAMA Dermatol"},{"issue":"1","key":"10.1016\/j.mehy.2017.09.023_b0020","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/jbio.201100069","article-title":"Depth profiling of gold nanoparticles and characterization of point spread functions in reconstructed and human skin using multiphoton microscopy","volume":"5","author":"Labouta","year":"2012","journal-title":"J Biophotonics"},{"issue":"6","key":"10.1016\/j.mehy.2017.09.023_b0025","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/adhm.201200101","article-title":"Fate of intravenously administered gold nanoparticles in hair follicles: follicular delivery, pharmacokinetic interpretation, and excretion","volume":"1","author":"Kempson","year":"2012","journal-title":"Adv Healthc Mater"},{"issue":"4","key":"10.1016\/j.mehy.2017.09.023_b0030","doi-asserted-by":"crossref","first-page":"1530004","DOI":"10.1142\/S1793545815300049","article-title":"Hair follicles as a target structure for nanoparticles","volume":"8","author":"Lademann","year":"2015","journal-title":"J Innovative Opt Health Sci"},{"issue":"1","key":"10.1016\/j.mehy.2017.09.023_b0035","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1186\/s11671-015-1154-2","article-title":"Design of FLT3 inhibitor \u2013 gold nanoparticle conjugates as potential therapeutic agents for the treatment of acute myeloid leukemia","volume":"10","author":"Simon","year":"2015","journal-title":"Nanoscale Res Lett"},{"issue":"6","key":"10.1016\/j.mehy.2017.09.023_b0040","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/cbdd.12725","article-title":"Gelatin coated gold nanoparticles as carriers of FLT3 inhibitors for acute myeloid leukemia treatment","volume":"87","author":"Suarasan","year":"2016","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.mehy.2017.09.023_b0045","first-page":"3465","article-title":"Nanopharmacology in translational hematology and oncology","volume":"9","author":"Tomuleasa","year":"2014","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.mehy.2017.09.023_b0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejmech.2011.12.001","article-title":"Antiproliferative effect of novel platinum(II) and palladium(II) complexes on hepatic tumor stem cells in vitro","volume":"49","author":"Mikl\u00e1\u0161ov\u00e1","year":"2012","journal-title":"Eur J Med Chem"},{"issue":"4","key":"10.1016\/j.mehy.2017.09.023_b0055","doi-asserted-by":"crossref","first-page":"435","DOI":"10.15403\/jgld.2014.1121.244.375","article-title":"Exosome-carried microRNA-375 inhibits cell progression and dissemination via Bcl-2 blocking in colon cancer","volume":"24","author":"Zaharie","year":"2015","journal-title":"J Gastrointestin Liver Dis"},{"key":"10.1016\/j.mehy.2017.09.023_b0060","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2147\/IJN.S37481","article-title":"Reversing chemoresistance of malignant glioma stem cells using gold nanoparticles","volume":"8","author":"Orza","year":"2013","journal-title":"Int J Nanomed"},{"issue":"2","key":"10.1016\/j.mehy.2017.09.023_b0065","first-page":"187","article-title":"Gold nanoparticles conjugated with cisplatin\/doxorubicin\/capecitabine lower the chemoresistance of hepatocellular carcinoma-derived cancer cells","volume":"21","author":"Tomuleasa","year":"2012","journal-title":"J Gastrointestin Liver Dis"},{"issue":"25","key":"10.1016\/j.mehy.2017.09.023_b0070","doi-asserted-by":"crossref","first-page":"21155","DOI":"10.1021\/acsami.7b05145","article-title":"Antibody conjugated, raman tagged hollow gold-silver nanospheres for specific targeting and multimodal dark-field\/SERS\/two photon-FLIM imaging of CD19(+) B lymphoblasts","volume":"9","author":"Nagy-Simon","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.mehy.2017.09.023_b0075","first-page":"641","article-title":"Gold nanoparticles enhance the effect of tyrosine kinase inhibitors in acute myeloid leukemia therapy","volume":"11","author":"Petrushev","year":"2016","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.mehy.2017.09.023_b0080","article-title":"Fibroblast dynamics as an in vitro screening platform for anti-fibrotic drugs in primary myelofibrosis","author":"Tomuleasa","year":"2017","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.mehy.2017.09.023_b0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.15403\/jgld.2014.1121.261.juj","article-title":"Antiproliferative and apoptotic effects of lidocaine on human hepatocarcinoma cells. A preliminary study","volume":"26","author":"Jurj","year":"2017","journal-title":"J Gastrointestin Liver Dis"},{"issue":"1","key":"10.1016\/j.mehy.2017.09.023_b0090","first-page":"1","article-title":"Glioblastoma stem cells: a new target for metformin and arsenic trioxide","volume":"28","author":"Carmignani","year":"2014","journal-title":"J Biol Regul Homeost Agents"},{"key":"10.1016\/j.mehy.2017.09.023_b0095","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jconrel.2016.07.035","article-title":"Nanomedicine approaches in acute lymphoblastic leukemia","volume":"238","author":"Tatar","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.mehy.2017.09.023_b0100","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.2147\/IJN.S108711","article-title":"In vivo assessment of bone marrow toxicity by gold nanoparticle-based bioconjugates in Crl:CD1(ICR) mice","volume":"11","author":"Berce","year":"2016","journal-title":"Int J Nanomed"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987717307478?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987717307478?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T10:35:54Z","timestamp":1603017354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987717307478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":20,"alternative-id":["S0306987717307478"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2017.09.023","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ruxolitinib-conjugated gold nanoparticles for topical administration: An alternative for treating alopecia?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2017.09.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}