{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:00:49Z","timestamp":1771300849921,"version":"3.50.1"},"reference-count":139,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.mehy.2017.10.021","type":"journal-article","created":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T16:03:16Z","timestamp":1513958596000},"page":"15-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"special_numbering":"C","title":["Pathophysiological significance of protein hydrophobic interactions: An emerging hypothesis"],"prefix":"10.1016","volume":"110","author":[{"given":"Marek","family":"Kieliszek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boguslaw","family":"Lipinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0005","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1146\/annurev.bb.22.060193.002121","article-title":"Hydrogen bonding, hydrophobicity, packing, and protein folding","volume":"22","author":"Rose","year":"1993","journal-title":"Annu Rev Biophys"},{"issue":"43","key":"10.1016\/j.mehy.2017.10.021_b0010","doi-asserted-by":"crossref","first-page":"15422","DOI":"10.1021\/ja5088216","article-title":"Peptides displayed as high density brush polymers resist proteolysis and retain bioactivity","volume":"136","author":"Blum","year":"2014","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.mehy.2017.10.021_b0015","doi-asserted-by":"crossref","unstructured":"Israelachvili JN. Intermolecular and surface forces. 3rd ed. Academic 2011:494.","DOI":"10.1016\/B978-0-12-391927-4.10001-5"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0020","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/anie.199308191","article-title":"Molecular machines: how motion and other functions of living organisms can result from reversible chemical changes","volume":"32","author":"Urry","year":"1993","journal-title":"Angew Chem Int Ed Engl"},{"issue":"7059","key":"10.1016\/j.mehy.2017.10.021_b0025","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/nature04162","article-title":"Interfaces and the driving force of hydrophobic assembly","volume":"437","author":"Chandler","year":"2005","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0030","first-page":"169","article-title":"The role of hydrogen sulfide in pathologies of the vital organs and its clinical application","volume":"66","author":"Jin","year":"2015","journal-title":"J Physiol Pharmacol"},{"key":"10.1016\/j.mehy.2017.10.021_b0035","series-title":"Plasma homocysteine and cardiovascular disease. Atherosclerotic cardiovascular disease, hemostasis, and endothelial function","author":"Ueland","year":"1992"},{"issue":"14","key":"10.1016\/j.mehy.2017.10.021_b0040","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1111\/j.1742-4658.2011.08164.x","article-title":"Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies","volume":"278","author":"Hamodrakas","year":"2011","journal-title":"FEBS J"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0045","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1016\/S1359-0278(98)00002-9","article-title":"Protein aggregation: folding aggregates, inclusion bodies and amyloid","volume":"3","author":"Fink","year":"1998","journal-title":"Fold Des"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0050","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.tibtech.2006.02.007","article-title":"Protein quality in bacterial inclusion bodies","volume":"24","author":"Ventura","year":"2006","journal-title":"Trends Biotechnol"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0055","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/mbo3.81","article-title":"Expression of Fap amyloids in Pseudomonas aeruginosa, P. fluorescens, and P. putida results in aggregation and increased biofilm formation","volume":"2","author":"Dueholm","year":"2013","journal-title":"Microbiologyopen"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0060","doi-asserted-by":"crossref","first-page":"1741S","DOI":"10.1093\/jn\/136.6.1741S","article-title":"Pathophysiological consequences of homocysteine excess","volume":"136","author":"Jakubowski","year":"2006","journal-title":"J Nutr"},{"issue":"8","key":"10.1016\/j.mehy.2017.10.021_b0065","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1253\/circj.CJ-12-0039","article-title":"Lipoprotein (a) and homocysteine potentiate the risk of coronary artery disease in male subjects","volume":"76","author":"Ba\u00f1os-Gonz\u00e1lez","year":"2012","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0070","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.thromres.2014.01.024","article-title":"Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties","volume":"133","author":"Rowland","year":"2014","journal-title":"Throm Res"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.719","article-title":"Small-molecule conversion of toxic oligomers to nontoxic \u03b2-sheet\u2013rich amyloid fibrils","volume":"8","author":"Bieschke","year":"2012","journal-title":"Nat Chem Biol"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0080","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1073\/pnas.041617698","article-title":"An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated \u03b2-sheet structure for amyloid","volume":"98","author":"Balbirnie","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"14","key":"10.1016\/j.mehy.2017.10.021_b0085","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1073\/pnas.142459399","article-title":"The protofilament structure of insulin amyloid fibrils","volume":"99","author":"Jim\u00e9nez","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0090","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1371\/journal.pbio.0050134","article-title":"A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils","volume":"5","author":"Vestergaard","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1016\/j.mehy.2017.10.021_b0095","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.msec.2016.09.049","article-title":"In vitro and in vivo insulin amyloid degradation mediated by Serratiopeptidase","volume":"70","author":"Metkar","year":"2017","journal-title":"Mater Sci Eng C"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0100","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jab.2017.01.003","article-title":"Lumbrokinase for degradation and reduction of amyloid fibrils associated with amyloidosis","volume":"15","author":"Metkar","year":"2017","journal-title":"J Appl Biomed"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.ATV.9.1.109","article-title":"Identification and distribution of fibrinogen, fibrin, and fibrin (ogen) degradation products in atherosclerosis. Use of monoclonal antibodies","volume":"9","author":"Bini","year":"1989","journal-title":"Arteriosclerosis"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0110","first-page":"1270","article-title":"The role of hemostatic factors in atherosclerosis in patients with chronic renal disease","volume":"7","author":"Zahran","year":"2015","journal-title":"Electron Physician"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0115","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.atherosclerosis.2007.05.028","article-title":"Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: effects of inflammation and oxidative stress","volume":"196","author":"Undas","year":"2008","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1160\/TH13-06-0497","article-title":"Fibrinogen depletion after plasma-dilution: impairment of proteolytic resistance and reversal via clotting factor concentrates","volume":"111","author":"He","year":"2014","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0125","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1161\/01.ATV.0000219688.43572.75","article-title":"Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects","volume":"26","author":"Undas","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.mehy.2017.10.021_b0130","unstructured":"von Rokitansky C. Abnormal conditions of the arteries. A manual of pathological anatomy. London: Sydenham Society; 1985 [Chapter 3] pp. 261\u2013275."},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0135","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/path.1700580207","article-title":"Thrombosis as a factor in the pathogenesis of coronary atherosclerosis","volume":"58","author":"Duguid","year":"1946","journal-title":"J Pathol"},{"key":"10.1016\/j.mehy.2017.10.021_b0140","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s11239-009-0367-6","article-title":"Modification of fibrin structure as a possible cause of thrombolytic resistance","volume":"29","author":"Lipinski","year":"2010","journal-title":"J Thromb Thrombolysis"},{"issue":"11","key":"10.1016\/j.mehy.2017.10.021_b0145","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1440-1681.2006.04483.x","article-title":"Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits","volume":"33","author":"Onogi","year":"2006","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"7","key":"10.1016\/j.mehy.2017.10.021_b0150","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.bbagen.2008.06.005","article-title":"Iron in arterial plaque: a modifiable risk factor for atherosclerosis","volume":"1790","author":"Sullivan","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2017.10.021_b0155","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-2999(95)00861-6","article-title":"The cardiovascular protective role of docosahexaenoic acid","volume":"300","author":"McLennan","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.mehy.2017.10.021_b0160","first-page":"8","article-title":"Fibrinogen splice variation and cross-linking: Effects on fibrin structure\/function and role of fibrinogen \u03b3\u2032 as thrombomodulin II","volume":"60\u201361","author":"Duval","year":"2016","journal-title":"Matrix Biol"},{"key":"10.1016\/j.mehy.2017.10.021_b0165","first-page":"9","article-title":"Hydroxyl radical and its scavengers in health and disease","author":"Lipinski","year":"2011","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.mehy.2017.10.021_b0170","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.matbio.2013.01.006","article-title":"An inhibitor of thrombin activated fibrinolysis inhibitor (TAFI) can reduce extracellular matrix accumulation in an in vitro model of glucose induced ECM expansion","volume":"32","author":"Atkinson","year":"2013","journal-title":"Matrix Biol"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0175","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/BF01403001","article-title":"Thromboembolic phenomena in neurosurgical patients operated upon for primary and metastatic brain tumours","volume":"109","author":"Constantini","year":"1991","journal-title":"Acta Neurochir"},{"key":"10.1016\/j.mehy.2017.10.021_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.07.004","article-title":"The inflammatory micro environment in tumor progression: the role of tumor\u2013associated macrophages","volume":"66","author":"Allavena","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.mehy.2017.10.021_b0185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2174\/187221309787158371","article-title":"Chronic inflammation and oxidative stress as a major cause of age\u2013related diseases and cancer","volume":"3","author":"Khansari","year":"2009","journal-title":"Recent Pat Inflamm Allergy Drug Discov"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0190","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1042\/BJ20071341","article-title":"Genetyczne aspekty zapalenia i raka","volume":"410","author":"Hold","year":"2008","journal-title":"Biochem J"},{"key":"10.1016\/j.mehy.2017.10.021_b0195","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00204-010-0577-x","article-title":"Towards a unifying, systems biology understanding of large\u2013scale cellular death and destruction caused by poorly liganded iron: Parkinson\u2019s. Huntingston's, Alzheimer's, prion, bactericides, chemical toxicology and others as examples","volume":"84","author":"Kell","year":"2010","journal-title":"Arch Toxicol"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12094-011-0621-1","article-title":"The role of iron in tumour cell proliferation","volume":"13","author":"Steegmann-Olmedillas","year":"2001","journal-title":"Clin Transl Oncol"},{"key":"10.1016\/j.mehy.2017.10.021_b0205","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.ahj.2011.08.013","article-title":"Effect of controlled reduction of body iron stores on clinical outcomes in peripheral arterial diseases","volume":"162","author":"Zacharski","year":"2011","journal-title":"Am Heart J"},{"key":"10.1016\/j.mehy.2017.10.021_b0210","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0306-9877(91)90006-K","article-title":"Significance of fibrin formation and dissolution in the pathogenesis and treatment of cancer","volume":"36","author":"Egyud","year":"1991","journal-title":"Med Hypotheses"},{"issue":"7","key":"10.1016\/j.mehy.2017.10.021_b0215","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3109\/02841869109091823","article-title":"Cytosol albumin content in operable breast cancer correlations to steroid hormone receptors, other prognostic factors and prognosis","volume":"30","author":"S\u00f8reide","year":"1991","journal-title":"Acta Oncol"},{"key":"10.1016\/j.mehy.2017.10.021_b0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00004630-199001000-00002","article-title":"Fibrinolysis inhibition in human burn blister fluid","volume":"11","author":"Rockwell","year":"1990","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.mehy.2017.10.021_b0225","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0960-894X(00)80588-0","article-title":"Thiol\u2013induced crosslinking of human blood proteins. Implications for tumor immunity","volume":"2","author":"Lipinski","year":"1992","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.mehy.2017.10.021_b0230","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0163-7258(94)90023-X","article-title":"Coley's toxins, tumor necrosis factor and cancer research: a historical perspective","volume":"64","author":"Wieman","year":"1994","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.mehy.2017.10.021_b0235","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/S0140-6736(71)92788-7","article-title":"Viruses in the treatment of cancer","volume":"2","author":"Csatary","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2017.10.021_b0240","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00184874","article-title":"Adjuvant treatment orally advanced renal cancer with autologous virus\u2013modified tumor vaccines","volume":"13","author":"Kirchner","year":"1995","journal-title":"World J Urol"},{"key":"10.1016\/j.mehy.2017.10.021_b0245","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/BF01521342","article-title":"Immunotherapy of human colon cancer by antibody\u2013targeted superantigens","volume":"41","author":"Dohlsten","year":"1995","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.mehy.2017.10.021_b0250","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1054\/mehy.1999.0876","article-title":"Resistance of cancer cells to immune recognition and killing","volume":"54","author":"Lipinski","year":"2000","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2017.10.021_b0255","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0891-5849(94)90007-8","article-title":"On the nature of selenium toxicity and cancerostatic activity","volume":"17","author":"Spallholtz","year":"1994","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.mehy.2017.10.021_b0260","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1079\/BJN20031015","article-title":"Selenium and its relationship to cancer: an update","volume":"91","author":"Whanger","year":"2004","journal-title":"Br J Nutr"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0265","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3390\/molecules21050609","article-title":"Current knowledge on the importance of selenium in food for living organisms: a review","volume":"21","author":"Kieliszek","year":"2016","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0270","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.nut.2012.11.012","article-title":"Selenium: significance, and outlook for supplementation","volume":"29","author":"Kieliszek","year":"2013","journal-title":"Nutrition"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0275","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2174\/1871520616666160607011024","article-title":"Sodium selenite as an anticancer agent","volume":"17","author":"Lipinski","year":"2017","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/j.mehy.2017.10.021_b0280","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.mehy.2004.10.012","article-title":"Rationale for the treatment of cancer with sodium selenite","volume":"64","author":"Lipinski","year":"2005","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2017.10.021_b0285","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02789164","article-title":"Supplementation with selenium augments the function of natural killer cells","volume":"52","author":"Kiremidjian-Schumacher","year":"1996","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.mehy.2017.10.021_b0290","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.3390\/nu7064978","article-title":"Pharmacokinetics and toxicity of sodium selenite in the treatment of patients with carcinoma in a phase I trial: the SECAR Study","volume":"7","author":"Brodin","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/j.mehy.2017.10.021_b0295","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0145-2126(92)90136-U","article-title":"The anti\u2013leukemic effect and mechanism of sodium selenite","volume":"16","author":"Jiang","year":"1992","journal-title":"Leuk Res"},{"key":"10.1016\/j.mehy.2017.10.021_b0300","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.canlet.2009.03.010","article-title":"Selenite is a potent cytotoxic agent for human primary AML cells","volume":"282","author":"Olm","year":"2009","journal-title":"Cancer Lett"},{"key":"10.1016\/j.mehy.2017.10.021_b0305","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3835(96)04373-X","article-title":"Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways","volume":"107","author":"Sinha","year":"1996","journal-title":"Cancer Lett"},{"issue":"10","key":"10.1016\/j.mehy.2017.10.021_b0310","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s10552-007-9058-9","article-title":"Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis","volume":"18","author":"Kabat","year":"2007","journal-title":"Cancer Cause Control"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0315","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/sj.bjc.6605118","article-title":"Intake of meat, meat mutagens, and iron and the risk of breast cancer in the prostate, lung, colorectal, and ovarian cancer screening trial","volume":"101","author":"Ferrucci","year":"2009","journal-title":"Br J Cancer"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0320","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/mnfr.200500156","article-title":"Green tea catechins as brain-permeable, natural iron chelators-antioxidants for the treatment of neurodegenerative disorders","volume":"50","author":"Mandel","year":"2006","journal-title":"Mol Nutr Food Res"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0325","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/01635580802582777","article-title":"Antineoplastic effects of n\u20133 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies","volume":"61","author":"Calviello","year":"2009","journal-title":"Nutr Cancer"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0330","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1207\/s15327914nc5402_8","article-title":"Chemopreventive effects of dietary flaxseed on colon tumor development","volume":"54","author":"Bommareddy","year":"2006","journal-title":"Nutr Cancer"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0335","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1517\/17460441.2.6.809","article-title":"Allylic structures in cancer drugs and body metabolites that control cell life and death","volume":"2","author":"Radin","year":"2007","journal-title":"Expert Opin Drug Discovery"},{"key":"10.1016\/j.mehy.2017.10.021_b0340","article-title":"Newly recognized anticarcinogenic fatty acids","volume":"52","author":"Pariza","year":"1990"},{"issue":"22","key":"10.1016\/j.mehy.2017.10.021_b0345","doi-asserted-by":"crossref","first-page":"5588","DOI":"10.1182\/blood-2008-08-170837","article-title":"Enolase\u20131 promotes plasminogen\u2013mediated recruitment of monocytes to the acutely inflamed lung","volume":"113","author":"Wygrecka","year":"2009","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0350","doi-asserted-by":"crossref","first-page":"S213","DOI":"10.1097\/01.CCM.0000057846.21303.AB","article-title":"Coagulation, fibrinolysis, and fibrin deposition in acute lung injury","volume":"31","author":"Idell","year":"2003","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0355","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/0049-3848(95)00025-9","article-title":"Increased procoagulant and antifibrinolytic activities in the lungs with idiopathic pulmonary fibrosis","volume":"77","author":"Kotani","year":"1995","journal-title":"Thromb Res"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0360","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1378\/chest.128.3.1475","article-title":"Anticoagulant therapy for idiopathic pulmonary fibrosis","volume":"128","author":"Kubo","year":"2005","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.mehy.2017.10.021_b0365","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.healun.2006.03.004","article-title":"Effect of the free radical scavenger MCI-186 on pulmonary ischemia\u2013reperfusion injury in dogs","volume":"25","author":"Akao","year":"2006","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0370","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/157339806776843094","article-title":"The role of coagulation and fibrinolysis in the pathogenesis of acute lung injury","volume":"2","author":"Bastarache","year":"2006","journal-title":"Curr Respir Med Rev"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0375","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2165\/00129784-200404020-00001","article-title":"Should thrombolytic therapy be used in patients with pulmonary embolism?","volume":"4","author":"Konstantinides","year":"2004","journal-title":"Am J Cardiovasc Drugs"},{"key":"10.1016\/j.mehy.2017.10.021_b0380","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/thx.2009.114439","article-title":"Coagulation factors in the airways in moderate and severe asthma and the effect of inhaled steroids","volume":"64","author":"Brims","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.mehy.2017.10.021_b0385","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1136\/thx.2010.155234","article-title":"Relationship of vitamin D status to adult lung function and COPD","volume":"66","author":"Shaheen","year":"2011","journal-title":"Thorax"},{"key":"10.1016\/j.mehy.2017.10.021_b0390","first-page":"30","article-title":"Selenium supplementation in intrinsic asthma","volume":"48","author":"Hasselmark","year":"1993","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0395","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1440-1797.2009.01128.x","article-title":"Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: overview of coagulation, thrombophilias and history of anticoagulants","volume":"14","author":"Adams","year":"2009","journal-title":"Nephrology"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0400","first-page":"225","article-title":"Impaired fibrinolytic response to increased thrombin activation in type 1 diabetes mellitus: effects of the glycosaminoglycan sulodexide","volume":"19","author":"Ceriello","year":"1993","journal-title":"Diabetes Metab"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0405","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3324\/haematol.10828","article-title":"Venous thromboembolism\u2013a manifestation of the metabolic syndrome","volume":"92","author":"Ay","year":"2007","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0410","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1475-2840-8-24","article-title":"Relevance of hemostatic risk factors on coronary morphology in patients with diabetes mellitus type 2","volume":"8","author":"Jax","year":"2009","journal-title":"Cardiovasc Diabetol"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0415","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/01.ASN.0000115400.52705.83","article-title":"Role of the coagulation\/fibrinolysis system in fibrin-associated glomerular injury","volume":"15","author":"Hertig","year":"2004","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0420","doi-asserted-by":"crossref","first-page":"523","DOI":"10.2143\/AC.64.4.2041618","article-title":"Fibrinogen is associated with silent myocardial ischaemia in type 2 diabetes mellitus","volume":"64","author":"Guardado-Mendoza","year":"2009","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.mehy.2017.10.021_b0425","unstructured":"Khodabandehlou T, Le Devehat C. Hemorheological disturbances as a marker of diabetic foot syndrome deterioration. Clin Hemorheol Microcirc 2004; 30(3,4): 219\u2013223."},{"issue":"8","key":"10.1016\/j.mehy.2017.10.021_b0430","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/PAS.0b013e3181abdfa7","article-title":"Prevalence and origin of amyloid in kidney biopsies","volume":"33","author":"von Hutten","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0435","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1084\/jem.96.6.605","article-title":"Studies on the generalized Shwartzman reaction","volume":"96","author":"Thomas","year":"1952","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0440","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.129.3.585","article-title":"The role of the platelet in the generalized Shwartzman reaction","volume":"129","author":"Margaretten","year":"1969","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0445","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/infdis\/120.2.160","article-title":"A hypothesis for the pathogenesis of the generalized Shwartzman reaction","volume":"120","author":"Lipinski","year":"1969","journal-title":"J Infect Dis"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0450","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1525-1373.1999.d01-137.x","article-title":"Antioxidants, NF\u03baB activation, and diabetogenesis","volume":"222","author":"Ho","year":"1999","journal-title":"Proc Soc Exp Biol Med"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0455","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s11883-000-0069-1","article-title":"Antioxidants and vitamins to reduce cardiovascular disease","volume":"2","author":"Devaraj","year":"2000","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.mehy.2017.10.021_b0460","doi-asserted-by":"crossref","unstructured":"Doi K, Suzuki Y, Nakao A, Fujita T, Noiri E. Radical scavenger edaravone developed for clinical use ameliorates ischemia\/reperfusion injury in rat kidney. Kidney Int 2004; 65(5): 1714\u20131723.","DOI":"10.1111\/j.1523-1755.2004.00567.x"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0465","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejphar.2008.01.033","article-title":"The radical scavenger edaravone counteracts diabetes in multiple low-dose streptozotocin-treated mice","volume":"583","author":"Fukudome","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.mehy.2017.10.021_b0470","doi-asserted-by":"crossref","unstructured":"Borcea V, Nourooz-Zadeh J, Wolff, SP, Klevesath M, Hofmann M, Urich H, Wahl P, Ziegler R, Tritschler H, Halliwell B, Nawroth PP. \u03b1-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic Biol Med 1999; 26(11): 1495\u20131500.","DOI":"10.1016\/S0891-5849(99)00011-8"},{"issue":"15","key":"10.1016\/j.mehy.2017.10.021_b0475","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1021\/bi00518a019","article-title":"Self-association of insulin and the role of hydrophobic bonding: a thermodynamic model of insulin dimerization","volume":"20","author":"Pocker","year":"1981","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0480","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00274577","article-title":"Insulin Wakayama: familial mutant insulin syndrome in Japan","volume":"30","author":"Nanjo","year":"1987","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.mehy.2017.10.021_b0485","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1172\/JCI30134","article-title":"Fibrin (ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin \u03b1M\u03b22 binding motif","volume":"117","author":"Flick","year":"2007","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.mehy.2017.10.021_b0490","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1136\/ard.2003.011767","article-title":"A fibrin based model for rheumatoid synovitis","volume":"62","author":"Sanchez-Pernaute","year":"2003","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"10.1016\/j.mehy.2017.10.021_b0495","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1111\/j.1538-7836.2003.00462.x","article-title":"Arthritis is linked to local and systemic activation of coagulation and fibrinolysis pathways","volume":"1","author":"So","year":"2003","journal-title":"J Thromb Haemost"},{"issue":"8","key":"10.1016\/j.mehy.2017.10.021_b0500","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/art.1780340809","article-title":"Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis","volume":"34","author":"Weinberg","year":"1991","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.mehy.2017.10.021_b0505","first-page":"71","article-title":"Hemostatic factors and cardiovascular disease in active rheumatoid arthritis: an 8 year followup study","volume":"27","author":"W\u00e5llberg-Jonsson","year":"2000","journal-title":"J Rheumatol"},{"key":"10.1016\/j.mehy.2017.10.021_b0510","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1053\/joms.2003.50047","article-title":"Crosslinking of fibrinogen and fibronectin by free radicals: a possible initial step in adhesion formation in osteoarthritis of the temporomandibular joint","volume":"61","author":"Dijkgraaf","year":"2003","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.mehy.2017.10.021_b0515","first-page":"24","article-title":"The role of fibrinolysis in adhesion formation","volume":"577","author":"Holmdahl","year":"1997","journal-title":"Eur J Surg Suppl"},{"key":"10.1016\/j.mehy.2017.10.021_b0520","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1742-1241.2004.00143.x","article-title":"Coagulation and inflammatory markers in Alzheimer's and vascular dementi","volume":"59","author":"Gupta","year":"2005","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.mehy.2017.10.021_b0525","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/978-1-4419-9214-7_15","article-title":"Role of annexin II tetramer in the regulation of plasmin activity","volume":"39","author":"Choi","year":"2003","journal-title":"Annexins"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0530","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00001721-199609000-00011","article-title":"Modulation of fibrin assembly and polymerization by the [beta]-amyloid of Alzheimer's disease","volume":"7","author":"Merkle","year":"1996","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"5","key":"10.1016\/j.mehy.2017.10.021_b0535","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2362.2002.00994.x","article-title":"Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer\u2019s disease brain and damage the blood\u2013brain barrier","volume":"32","author":"Fiala","year":"2002","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0540","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0165-5728(97)00072-6","article-title":"Fibrin deposition in the central nervous system correlates with the degree of Theiler's murine encephalomyelitis virus-induced demyelinating disease","volume":"77","author":"Inoue","year":"1997","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.mehy.2017.10.021_b0545","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/01.wad.0000213844.21001.a2","article-title":"New insight into Alzheimer's disease: demonstration of fibrin(ogen)-serum albumin insoluble deposits in brain tissue","volume":"20","author":"Lipinski","year":"2006","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"8","key":"10.1016\/j.mehy.2017.10.021_b0550","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1084\/jem.20070304","article-title":"Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease","volume":"204","author":"Paul","year":"2007","journal-title":"J Exp Med"},{"issue":"10","key":"10.1016\/j.mehy.2017.10.021_b0555","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/brain\/124.10.1978","article-title":"Plasminogen activators in multiple sclerosis lesions: implications for the inflammatory response and axonal damage","volume":"124","author":"Gveric","year":"2001","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0560","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/00004647-200006000-00012","article-title":"Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model","volume":"20","author":"Ninomia","year":"2002","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0565","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0896-6273(02)00617-7","article-title":"Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation","volume":"33","author":"Akassoglou","year":"2002","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.mehy.2017.10.021_b0570","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/01.STR.0000189721.31432.26","article-title":"Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia","volume":"36","author":"van Oijen","year":"2005","journal-title":"Stroke"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0575","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0014-5793(90)80760-G","article-title":"Antibodies to the \u03b2-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood","volume":"264","author":"Stem","year":"1990","journal-title":"FEBS Lett"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0580","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1023\/A:1010995121153","article-title":"Diversity of amyloid \u03b2 protein fragment [1\u201340]-formed channels","volume":"21","author":"Kourie","year":"2001","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0585","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.bjp.0704047","article-title":"Protection against \u03b2-amyloid peptide toxicity in vivo with long-term administration of ferulic acid","volume":"133","author":"Yan","year":"2001","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0590","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0006-8993(97)00490-3","article-title":"Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in a transient cerebral ischemia","volume":"762","author":"Yamamoto","year":"1997","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0595","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1248\/cpb.52.186","article-title":"The reaction rate of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one (MCI-186)) with hydroxyl radical","volume":"52","author":"Abe","year":"2004","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.mehy.2017.10.021_b0600","unstructured":"Zhang ZY, Huang XM, He YZ, DING LM. Influence and significance of edaravone on serum reactive protein level in acute cerebral infarction patients. Chin J Mod Appl Pharm 2006; 23(4): 336\u2013337."},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0605","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1527-3458.2006.00009.x","article-title":"Neuroprotective effects of edaravone: a novel free radical scavenger in cerebrovascular injury","volume":"12","author":"Yoshida","year":"2006","journal-title":"CNS Drug Rev"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0610","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jns.2004.03.002","article-title":"Free radical scavenger, edaravone, in stroke with internal carotid artery occlusion","volume":"221","author":"Toyoda","year":"2004","journal-title":"J Neurol Sci Discip"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0615","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1124\/jpet.104.069088","article-title":"Edaravone protects against hypoxia\/ischemia-induced endoplasmic reticulum dysfunction","volume":"311","author":"Qi","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mehy.2017.10.021_b0620","doi-asserted-by":"crossref","unstructured":"Nakajima Y, Masaoka N, Hayakawa Y, Watanabe M, Nagaishi M, Sakata H, Yamamoto T. The production of hydroxyl radicals in the fetal lamb brain resulting from occlusion of the umbilical circulation and the transplacental effect of MCI-186 to inhibit hydroxyl radical production. Pediatr Res 2006; 59(2): 216\u2013220.","DOI":"10.1203\/01.pdr.0000196373.52086.c2"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0625","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1194\/jlr.M300526-JLR200","article-title":"Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1\u03b2 administration","volume":"45","author":"Song","year":"2004","journal-title":"J Lipid Res"},{"issue":"23","key":"10.1016\/j.mehy.2017.10.021_b0630","doi-asserted-by":"crossref","first-page":"20804","DOI":"10.1074\/jbc.M202387200","article-title":"Neuroprotective effect of eicosapentaenoic acid in hippocampus of rats exposed to \u03b3-irradiation","volume":"277","author":"Lonergan","year":"2002","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.mehy.2017.10.021_b0635","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1749-6632.1991.tb00228.x","article-title":"Essential fatty acids in Alzheimer's disease","volume":"640","author":"Corrigan","year":"1991","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"10.1016\/j.mehy.2017.10.021_b0640","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/med.20100","article-title":"Recent advances in the treatment of thromboembolic diseases: venous thromboembolism","volume":"27","author":"Agrawal","year":"2007","journal-title":"Med Res Rev"},{"issue":"2","key":"10.1016\/j.mehy.2017.10.021_b0645","first-page":"113","article-title":"The role of fibrinogen, fibrin and fibrin (ogen) degradation products (FDPs) in tumor progression","volume":"17","author":"Ko\u0142odziejczyk","year":"2013","journal-title":"Contemp Oncol"},{"issue":"9","key":"10.1016\/j.mehy.2017.10.021_b0650","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1002\/jemt.22047","article-title":"Iron enhances generation of fibrin fibers in human blood: implications for pathogenesis of stroke","volume":"75","author":"Lipinski","year":"2012","journal-title":"Microsc Res Tech"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0655","doi-asserted-by":"crossref","first-page":"e28539","DOI":"10.4161\/onci.28539","article-title":"Iron-induced parafibrin formation in tumors fosters immune evasion","volume":"3","author":"Lipinski","year":"2014","journal-title":"Oncoimmunology"},{"issue":"3\u20134","key":"10.1016\/j.mehy.2017.10.021_b0660","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/10641960600549371","article-title":"Thrombolysis beyond the three-hour time window","volume":"28","author":"Leys","year":"2006","journal-title":"Clin Exp Hypertens"},{"issue":"10","key":"10.1016\/j.mehy.2017.10.021_b0665","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1503\/cmaj.1041561","article-title":"Canadian alteplase for stroke effectiveness study (CASES) investigators. thrombolysis for acute ischemic stroke: results of the canadian alteplase for Stroke effectiveness study","volume":"172","author":"Hill","year":"2005","journal-title":"Can Med Assoc J"},{"issue":"10","key":"10.1016\/j.mehy.2017.10.021_b0670","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.healun.2008.06.009","article-title":"Patient with hypofibrinolysis-mediated thromboembolism converted to a hypercoagulable\/hyperfibrinolytic state via ventricular assist device placement","volume":"27","author":"Nielsen","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0675","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0049-3848(91)90189-4","article-title":"Nonradical excited oxygen species induce selective thrombolysis in vivo","volume":"62","author":"Stief","year":"1991","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.mehy.2017.10.021_b0680","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ultras.2007.11.008","article-title":"Ultrasound enhanced thrombolysis in acute arterial ischemia","volume":"48","author":"Tsivgoulis","year":"2008","journal-title":"Ultrasonics"},{"issue":"Suppl. 2","key":"10.1016\/j.mehy.2017.10.021_b0685","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000203127","article-title":"Microbubbles for thrombolysis of acute ischemic stroke","volume":"27","author":"Meairs","year":"2009","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.mehy.2017.10.021_b0690","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/ana.21723","article-title":"Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial","volume":"66","author":"Molina","year":"2009","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.mehy.2017.10.021_b0695","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.nutres.2009.01.009","article-title":"Nattokinase decreases plasma levels of fibrinogen, factor VII, and factor VIII in human subjects","volume":"29","author":"Hsia","year":"2009","journal-title":"Nutr Res Pract"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987717309052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987717309052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T02:44:54Z","timestamp":1660185894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987717309052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":139,"alternative-id":["S0306987717309052"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2017.10.021","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiological significance of protein hydrophobic interactions: An emerging hypothesis","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2017.10.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}