{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:40:38Z","timestamp":1789908038394,"version":"4.0.1"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","medical-hypotheses.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.mehy.2018.03.008","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T07:52:19Z","timestamp":1521618739000},"page":"29-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["The role of Alu-derived RNAs in Alzheimer\u2019s and other neurodegenerative conditions"],"prefix":"10.1016","volume":"115","author":[{"given":"Oksana","family":"Polesskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniya","family":"Kananykhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid M.","family":"Roy-Engel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Nazarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Kulemzina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancha","family":"Baranova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yegor","family":"Vassetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Myakishev-Rempel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2018.03.008_b0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/imm.12233","article-title":"Inflammation in neurodegenerative diseases\u2013an update","volume":"142","author":"Amor","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.mehy.2018.03.008_b0010","unstructured":"Latest Alzheimer\u2019s Facts & Figures. Latest Facts and Figures Report | Alzheimer\u2019s Association 2013. http:\/\/www.alz.org\/facts\/ [accessed October 2, 2016]."},{"key":"10.1016\/j.mehy.2018.03.008_b0015","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneurol.2011.2","article-title":"Epidemiology of Alzheimer disease","volume":"7","author":"Reitz","year":"2011","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.mehy.2018.03.008_b0020","unstructured":"Parkinson\u2019s Disease Incidence & Prevalence \u2013 Parkinson's Disease \u2013 HealthCommunities.com n.d. http:\/\/www.healthcommunities.com\/parkinsons-disease\/incidence-prevalence.shtml [accessed October 2, 2016]."},{"key":"10.1016\/j.mehy.2018.03.008_b0025","unstructured":"Multiple Sclerosis n.d. http:\/\/www.clevelandclinicmeded.com\/medicalpubs\/diseasemanagement\/neurology\/multiple_sclerosis\/ [accessed October 2, 2016]."},{"key":"10.1016\/j.mehy.2018.03.008_b0030","unstructured":"Harris-Kojetin L, Sengupta M, Park-Lee E, Valverde R, Caffrey C, Rome V, et al. Long-Term Care Providers and services users in the United States: data from the National Study of Long-Term Care Providers, 2013\u20132014. Vital Health Stat 3 2016:x \u2013 xii; 1\u2013105."},{"key":"10.1016\/j.mehy.2018.03.008_b0035","unstructured":"FastStats n.d. http:\/\/www.cdc.gov\/nchs\/fastats\/deaths.htm [accessed October 2, 2016])."},{"key":"10.1016\/j.mehy.2018.03.008_b0040","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/cdd.2015.16","article-title":"Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation","volume":"22","author":"Kaushal","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.mehy.2018.03.008_b0045","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1038\/tp.2012.45","article-title":"Genome-wide association study of Alzheimer\u2019s disease","volume":"2","author":"Kamboh","year":"2012","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.mehy.2018.03.008_b0050","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng.803","article-title":"Common variants at ABCA7, MS4A6A\/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer\u2019s disease","volume":"43","author":"Hollingworth","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2018.03.008_b0055","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2013.03.030","article-title":"Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer\u2019s disease","volume":"153","author":"Zhang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0060","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/ng.439","article-title":"Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer\u2019s disease","volume":"41","author":"Lambert","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2018.03.008_b0065","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer\u2019s disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2018.03.008_b0070","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/ng.801","article-title":"Common variants at MS4A4\/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer\u2019s disease","volume":"43","author":"Naj","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.mehy.2018.03.008_b0075","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2018.03.008_b0080","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2018.03.008_b0085","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.mehy.2018.03.008_b0090","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0095","doi-asserted-by":"crossref","first-page":"a006346","DOI":"10.1101\/cshperspect.a006346","article-title":"Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature","volume":"2","author":"Wyss-Coray","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.mehy.2018.03.008_b0100","unstructured":"Salmon DP, Butters N, DeTeresa R, Hill R. Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment. Annals of 1991."},{"key":"10.1016\/j.mehy.2018.03.008_b0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/msj.20163","article-title":"Relationship between tau pathology and neuroinflammation in Alzheimer\u2019s disease","volume":"77","author":"Metcalfe","year":"2010","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.mehy.2018.03.008_b0110","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/978-94-007-5416-4_14","article-title":"Alzheimer\u2019s disease","volume":"65","author":"De-Paula","year":"2012","journal-title":"Subcell Biochem"},{"key":"10.1016\/j.mehy.2018.03.008_b0115","article-title":"A state of delirium: Deciphering the effect of inflammation on tau pathology in Alzheimer\u2019s disease","author":"Barron","year":"2016","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.mehy.2018.03.008_b0120","doi-asserted-by":"crossref","first-page":"7611","DOI":"10.1073\/pnas.86.19.7611","article-title":"Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease","volume":"86","author":"Griffin","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2018.03.008_b0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-2094-5-7","article-title":"The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective","volume":"5","author":"Shaftel","year":"2008","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.mehy.2018.03.008_b0130","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1172\/JCI31450","article-title":"Miller J-NH, Johnson RE, O\u2019Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology","volume":"117","author":"Shaftel","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2018.03.008_b0135","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1096\/fj.09-141754","article-title":"Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition","volume":"24","author":"Chakrabarty","year":"2010","journal-title":"FASEB J"},{"key":"10.1016\/j.mehy.2018.03.008_b0140","doi-asserted-by":"crossref","unstructured":"Isaac M, McCleery J, Tabet N. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer\u2019s disease. Cochrane Library 2012.","DOI":"10.1002\/14651858.CD006378.pub2"},{"key":"10.1016\/j.mehy.2018.03.008_b0145","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-141506","article-title":"Anti-inflammatory drugs and risk of Alzheimer\u2019s disease: an updated systematic review and meta-analysis","volume":"44","author":"Wang","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.mehy.2018.03.008_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2017.01.017","article-title":"The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease","author":"Larsen","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.mehy.2018.03.008_b0155","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"International human genome sequencing Consortium. Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2018.03.008_b0160","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/hdy.2011.43","article-title":"Origin and evolution of SINEs in eukaryotic genomes","volume":"107","author":"Kramerov","year":"2011","journal-title":"Heredity"},{"key":"10.1016\/j.mehy.2018.03.008_b0165","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1128\/MCB.11.8.3949","article-title":"Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution","volume":"11","author":"Strub","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0170","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.celrep.2014.03.011","volume":"7","author":"Su","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.mehy.2018.03.008_b0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/35041507","article-title":"Structure and assembly of the Alu domain of the mammalian signal recognition particle","volume":"408","author":"Weichenrieder","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2018.03.008_b0180","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1017\/S1355838201010160","article-title":"Hierarchical assembly of the Alu domain of the mammalian signal recognition particle","volume":"7","author":"Weichenrieder","year":"2001","journal-title":"RNA"},{"key":"10.1016\/j.mehy.2018.03.008_b0185","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1093\/nar\/gkv048","article-title":"Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9\/14 to 40S subunits","volume":"43","author":"Ivanova","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mehy.2018.03.008_b0190","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1101\/gad.197467.112","article-title":"Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H\/ACA RNPs","volume":"26","author":"J\u00e1dy","year":"2012","journal-title":"Genes Dev"},{"key":"10.1016\/j.mehy.2018.03.008_b0195","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.molcel.2007.12.013","article-title":"Human Alu RNA is a modular transacting repressor of mRNA transcription during heat shock","volume":"29","author":"Mariner","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0200","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1261\/rna.310307","article-title":"Characterization of the structure, function, and mechanism of B2 RNA, an ncRNA repressor of RNA polymerase II transcription","volume":"13","author":"Espinoza","year":"2007","journal-title":"RNA"},{"key":"10.1016\/j.mehy.2018.03.008_b0205","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1093\/nar\/gkl706","article-title":"Alu elements as regulators of gene expression","volume":"34","author":"H\u00e4sler","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mehy.2018.03.008_b0210","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1101\/gad.212639.112","article-title":"Control of myogenesis by rodent SINE-containing lncRNAs","volume":"27","author":"Wang","year":"2013","journal-title":"Genes Dev"},{"key":"10.1016\/j.mehy.2018.03.008_b0215","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/15476286.2015.1060395","article-title":"SINEUPs: A new class of natural and synthetic antisense long non-coding RNAs that activate translation","volume":"12","author":"Zucchelli","year":"2015","journal-title":"RNA Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0220","series-title":"Long Non-Coding RNAs","first-page":"119","article-title":"Multiple roles of alu-related noncoding RNAs","author":"Berger","year":"2011"},{"key":"10.1016\/j.mehy.2018.03.008_b0225","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.cell.2012.03.036","article-title":"DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88","volume":"149","author":"Tarallo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0230","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/odi.12462","article-title":"Mougeot J-LC. Alu retroelement-associated autoimmunity in Sj\u00f6gren\u2019s syndrome","volume":"22","author":"Brennan","year":"2016","journal-title":"Oral Dis"},{"key":"10.1016\/j.mehy.2018.03.008_b0235","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1126\/science.aac7442","article-title":"The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression","volume":"350","author":"Hung","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.mehy.2018.03.008_b0240","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0504","article-title":"The RNA-centred view of the synapse: non-coding RNAs and synaptic plasticity","volume":"369","author":"Smalheiser","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.mehy.2018.03.008_b0245","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.15252\/embj.201592655","article-title":"Long non-coding RNAs in corticogenesis: deciphering the non-coding code of the brain","volume":"34","author":"Aprea","year":"2015","journal-title":"EMBO J"},{"key":"10.1016\/j.mehy.2018.03.008_b0250","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.15252\/embj.201591458","article-title":"Alu element-containing RNAs maintain nucleolar structure and function","volume":"34","author":"Caudron-Herger","year":"2015","journal-title":"EMBO J"},{"key":"10.1016\/j.mehy.2018.03.008_b0255","doi-asserted-by":"crossref","first-page":"e1003588","DOI":"10.1371\/journal.pgen.1003588","article-title":"Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks","volume":"9","author":"Holdt","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.mehy.2018.03.008_b0260","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.celrep.2015.05.023","article-title":"Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome","volume":"11","author":"Gelfand","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.mehy.2018.03.008_b0265","doi-asserted-by":"crossref","first-page":"16082","DOI":"10.1073\/pnas.1403814111","article-title":"DICER1\/Alu RNA dysmetabolism induces Caspase-8\u2013mediated cell death in age-related macular degeneration","volume":"111","author":"Kim","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.mehy.2018.03.008_b0270","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature09830","article-title":"DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration","volume":"471","author":"Kaneko","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2018.03.008_b0275","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4161\/pri.4.2.11965","article-title":"Transcription of Alu DNA elements in blood cells of sporadic Creutzfeldt-Jakob disease (sCJD)","volume":"4","author":"Kiesel","year":"2010","journal-title":"Prion"},{"key":"10.1016\/j.mehy.2018.03.008_b0280","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/15287394.2011.529057","article-title":"Possible editing of Alu transcripts in blood cells of sporadic Creutzfeldt-Jakob disease (sCJD)","volume":"74","author":"Kiesel","year":"2011","journal-title":"J Toxicol Environ Health A"},{"key":"10.1016\/j.mehy.2018.03.008_b0285","article-title":"Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer\u2019s disease","author":"Gerakis","year":"2017","journal-title":"FEBS J"},{"key":"10.1016\/j.mehy.2018.03.008_b0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10495-016-1296-4","article-title":"The role of endoplasmic reticulum stress in neurodegenerative disease","volume":"22","author":"Xiang","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.mehy.2018.03.008_b0295","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1093\/nar\/23.10.1758","article-title":"Cell stress and translational inhibitors transiently increase the abundance of mammalian SINE transcripts","volume":"23","author":"Liu","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mehy.2018.03.008_b0300","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s12192-008-0010-z","article-title":"PCR-based detection of Pol III-transcribed transposons and its application to the rodent model of ultraviolet response","volume":"13","author":"Myakishev","year":"2008","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.mehy.2018.03.008_b0305","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0378-1119(99)00384-4","article-title":"Physiological stresses increase mouse short interspersed element (SINE) RNA expression in vivo","volume":"239","author":"Li","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.mehy.2018.03.008_b0310","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1379\/1466-1268(2001)006<0263:SIOBRI>2.0.CO;2","article-title":"Stress induction of Bm1 RNA in silkworm larvae: SINEs, an unusual class of stress genes","volume":"6","author":"Kimura","year":"2001","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.mehy.2018.03.008_b0315","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.molcel.2009.11.020","article-title":"Eukaryotic stress granules: the ins and outs of translation","volume":"36","author":"Buchan","year":"2009","journal-title":"Mol Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0320","doi-asserted-by":"crossref","first-page":"1809592","DOI":"10.1155\/2017\/1809592","article-title":"Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases","volume":"2017","author":"Chen","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.mehy.2018.03.008_b0325","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1083\/jcb.200512082","article-title":"RNA granules","volume":"172","author":"Anderson","year":"2006","journal-title":"J Cell Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0330","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tibs.2007.12.003","article-title":"Stress granules: the Tao of RNA triage","volume":"33","author":"Anderson","year":"2008","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.mehy.2018.03.008_b0335","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.tibs.2013.07.004","article-title":"Stress granules and cell signaling: more than just a passing phase?","volume":"38","author":"Kedersha","year":"2013","journal-title":"Trends Biochem Sci"},{"issue":"590\u2013604","key":"10.1016\/j.mehy.2018.03.008_b0340","first-page":"e13","article-title":"Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules","volume":"172","author":"Markmiller","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0345","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.molmed.2016.05.005","article-title":"Hypo- and Hyper-Assembly Diseases of RNA-Protein Complexes","volume":"22","author":"Shukla","year":"2016","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.mehy.2018.03.008_b0350","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fncel.2015.00423","article-title":"Alterations in stress granule dynamics driven by TDP-43 and FUS: a link to pathological inclusions in ALS?","volume":"9","author":"Aulas","year":"2015","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.mehy.2018.03.008_b0355","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4161\/15476286.2014.972208","article-title":"mRNP granules. Assembly, function, and connections with disease","volume":"11","author":"Buchan","year":"2014","journal-title":"RNA Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0360","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/imr.12051","article-title":"Post-transcriptional regulatory networks in immunity","volume":"253","author":"Ivanov","year":"2013","journal-title":"Immunol Rev"},{"key":"10.1016\/j.mehy.2018.03.008_b0365","doi-asserted-by":"crossref","first-page":"11203","DOI":"10.1093\/nar\/gku822","article-title":"Direct binding of the Alu binding protein dimer SRP9\/14 to 40S ribosomal subunits promotes stress granule formation and is regulated by Alu RNA","volume":"42","author":"Berger","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mehy.2018.03.008_b0370","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.immuni.2006.08.007","article-title":"Type I interferons in host defense","volume":"25","author":"Stetson","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.mehy.2018.03.008_b0375","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.biochi.2007.03.001","article-title":"The dsRNA protein kinase PKR: virus and cell control","volume":"89","author":"Garc\u00eda","year":"2007","journal-title":"Biochimie"},{"key":"10.1016\/j.mehy.2018.03.008_b0380","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nsmb.2827","article-title":"Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA","volume":"21","author":"White","year":"2014","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0385","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.cell.2006.03.043","article-title":"Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex","volume":"125","author":"Han","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0390","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cell.2013.04.003","article-title":"The long and short of microRNA","volume":"153","author":"Yates","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0395","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0400","first-page":"77","article-title":"Role of Dicer in posttranscriptional RNA silencing","volume":"320","author":"Jaskiewicz","year":"2008","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1016\/j.mehy.2018.03.008_b0405","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrm3994","article-title":"Swiss army knives: non-canonical functions of nuclear Drosha and Dicer","volume":"16","author":"Burger","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0410","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.yexcr.2015.07.019","article-title":"Regulatory roles of Alu transcript on gene expression","volume":"338","author":"Zhang","year":"2015","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.mehy.2018.03.008_b0415","doi-asserted-by":"crossref","first-page":"13781","DOI":"10.1073\/pnas.1206494109","article-title":"ERK1\/2 activation is a therapeutic target in age-related macular degeneration","volume":"109","author":"Dridi","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2018.03.008_b0420","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mce.2016.02.008","article-title":"Alu RNA accumulation in hyperglycemia augments oxidative stress and impairs eNOS and SOD2 expression in endothelial cells","volume":"426","author":"Wang","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.mehy.2018.03.008_b0425","article-title":"The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy","volume":"2010","author":"Sim\u00f3","year":"2010","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.mehy.2018.03.008_b0430","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/1471-2164-7-133","article-title":"Alu elements contain many binding sites for transcription factors and may play a role in regulation of developmental processes","volume":"7","author":"Polak","year":"2006","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mehy.2018.03.008_b0435","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2164-8-23","article-title":"Widespread Alu repeat-driven expansion of consensus DR2 retinoic acid response elements during primate evolution","volume":"8","author":"Laperriere","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mehy.2018.03.008_b0440","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/bioinformatics\/bti307","article-title":"A comparative analysis of relative occurrence of transcription factor binding sites in vertebrate genomes and gene promoter areas","volume":"21","author":"Stepanova","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mehy.2018.03.008_b0445","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0092-8674(00)00064-7","article-title":"Combinatorial roles of the nuclear receptor corepressor in transcription and development","volume":"102","author":"Jepsen","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.mehy.2018.03.008_b0450","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1101\/gad.14.2.121","article-title":"The coregulator exchange in transcriptional functions of nuclear receptors","volume":"14","author":"Glass","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.mehy.2018.03.008_b0455","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/nsmb.2400","article-title":"DICER- and AGO3-dependent generation of retinoic acid\u2013induced DR2 Alu RNAs regulates human stem cell proliferation","volume":"19","author":"Hu","year":"2012","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0460","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.neuint.2011.04.004","article-title":"Carotenoids and Alzheimer\u2019s disease: an insight into therapeutic role of retinoids in animal models","volume":"59","author":"Obulesu","year":"2011","journal-title":"Neurochem Int"},{"key":"10.1016\/j.mehy.2018.03.008_b0465","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/ejn.12142","article-title":"Amyloid \u03b2 inhibits retinoic acid synthesis exacerbating Alzheimer disease pathology which can be attenuated by an retinoic acid receptor \u03b1 agonist","volume":"37","author":"Goncalves","year":"2013","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.mehy.2018.03.008_b0470","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2018.03.008_b0475","doi-asserted-by":"crossref","first-page":"e62143","DOI":"10.1371\/journal.pone.0062143","article-title":"Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis","volume":"8","author":"Freeman","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mehy.2018.03.008_b0480","doi-asserted-by":"crossref","first-page":"e55375","DOI":"10.1371\/journal.pone.0055375","article-title":"Triggering of Inflammasome by Aggregated \u03b1\u2013Synuclein, an Inflammatory Response in Synucleinopathies","volume":"8","author":"Codolo","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mehy.2018.03.008_b0485","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fphar.2014.00038","article-title":"The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders","volume":"5","author":"Urrutia","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.mehy.2018.03.008_b0490","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jsb.2005.11.001","article-title":"Study of the localization of iron, ferritin, and hemosiderin in Alzheimer\u2019s disease hippocampus by analytical microscopy at the subcellular level","volume":"153","author":"Quintana","year":"2006","journal-title":"J Struct Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0495","doi-asserted-by":"crossref","unstructured":"Sayre LM, Perry G, Harris P, Liu Y. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer\u2019s disease. Journal of 2000.","DOI":"10.1046\/j.1471-4159.2000.0740270.x"},{"key":"10.1016\/j.mehy.2018.03.008_b0500","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0140-6736(87)91361-4","article-title":"Increased nigral iron content in postmortem parkinsonian brain","volume":"2","author":"Dexter","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2018.03.008_b0505","doi-asserted-by":"crossref","first-page":"581256","DOI":"10.1155\/2014\/581256","article-title":"Nigral iron elevation is an invariable feature of Parkinson\u2019s disease and is a sufficient cause of neurodegeneration","volume":"2014","author":"Ayton","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.mehy.2018.03.008_b0510","doi-asserted-by":"crossref","first-page":"10679","DOI":"10.1073\/pnas.0701532104","article-title":"Dendritic BC200 RNA in aging and in Alzheimer\u2019s disease","volume":"104","author":"Mus","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2018.03.008_b0515","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.bbamcr.2012.05.001","article-title":"NDM29, a RNA polymerase III-dependent non coding RNA, promotes amyloidogenic processing of APP and amyloid \u03b2 secretion","volume":"1823","author":"Massone","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mehy.2018.03.008_b0520","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/nar\/gkl1082","article-title":"Two primate-specific small non-protein-coding RNAs in transgenic mice: neuronal expression, subcellular localization and binding partners","volume":"35","author":"Khanam","year":"2007","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.mehy.2018.03.008_b0525","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1523\/JNEUROSCI.13-06-02382.1993","article-title":"Primary structure, neural-specific expression, and dendritic location of human BC200 RNA","volume":"13","author":"Tiedge","year":"1993","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2018.03.008_b0530","doi-asserted-by":"crossref","first-page":"E89","DOI":"10.1073\/pnas.1216922110","article-title":"P53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs","volume":"110","author":"Leonova","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2018.03.008_b0535","doi-asserted-by":"crossref","first-page":"e1000843","DOI":"10.1371\/journal.pcbi.1000843","article-title":"Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq","volume":"6","author":"Xu","year":"2010","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.mehy.2018.03.008_b0540","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/nar\/gku1361","article-title":"Identification of RNA polymerase III-transcribed Alu loci by computational screening of RNA-Seq data","volume":"43","author":"Conti","year":"2015","journal-title":"Nucleic Acids Res"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718300987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718300987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T22:14:41Z","timestamp":1751494481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718300987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":108,"alternative-id":["S0306987718300987"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2018.03.008","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of Alu-derived RNAs in Alzheimer\u2019s and other neurodegenerative conditions","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2018.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}