{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:39:12Z","timestamp":1778737152158,"version":"3.51.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.mehy.2018.04.022","type":"journal-article","created":{"date-parts":[[2018,4,25]],"date-time":"2018-04-25T11:18:27Z","timestamp":1524655107000},"page":"49-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Exercise and chemotherapy-induced amenorrhea"],"prefix":"10.1016","volume":"116","author":[{"given":"Katlynn M.","family":"Mathis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Sturgeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renate M.","family":"Winkels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9602-7897","authenticated-orcid":false,"given":"Joachim","family":"Wiskemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy I.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2018.04.022_b0005","unstructured":"CDC, \u201cNo Title\u201d, Leading Causes of Death in Females, 2014, Online Available: https:\/\/www.cdc.gov\/women\/lcod\/2014\/race-ethnicity\/index.htm, 2016 (accessed: 01-Apr-2017)."},{"issue":"2","key":"10.1016\/j.mehy.2018.04.022_b0010","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/REP-12-0121","article-title":"What lies behind chemotherapy-induced ovarian toxicity?","volume":"144","author":"Ben-Aharon","year":"2012","journal-title":"Reproduction"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10549-014-2914-x","article-title":"What lies behind chemotherapy-induced amenorrhea for breast cancer patients: a meta-analysis","volume":"145","author":"Zhao","year":"2014","journal-title":"Breast Cancer ResTreat"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0020","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.critrevonc.2013.07.007","article-title":"Chemotherapy-induced ovarian toxicity in patients affected by endocrine-responsive early breast cancer","volume":"89","author":"Torino","year":"2014","journal-title":"Crit Rev Oncol Hematol"},{"issue":"2","key":"10.1016\/j.mehy.2018.04.022_b0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/ERC-11-0199","article-title":"Recognizing menopause in women with amenorrhea induced by cytotoxic chemotherapy for endocrine-responsive early breast cancer","volume":"19","author":"Torino","year":"2012","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0030","first-page":"147","article-title":"Incidence of chemotherapy-induced amenorrhea after adjuvant chemotherapy with taxane and anthracyclines in young patients with breast cancer","volume":"6","author":"Pourali","year":"2013","journal-title":"Iran J Cancer Prev"},{"key":"10.1016\/j.mehy.2018.04.022_b0035","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/1471-2407-10-281","article-title":"Incidence of chemotherapy-induced amenorrhea associated with epirubicin, docetaxel and navelbine in younger breast cancer patients","volume":"10","author":"Zhou","year":"2010","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mehy.2018.04.022_b0040","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00280-013-2227-5","article-title":"Chemotherapy-induced amenorrhea, menopause-specific quality of life, and endocrine profiles in premenopausal women with breast cancer who received adjuvant anthracycline-based chemotherapy : a prospective cohort study","volume":"72","author":"Yoo","year":"2013","journal-title":"Cancer Chemother Pharmacol"},{"issue":"56","key":"10.1016\/j.mehy.2018.04.022_b0050","article-title":"Incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel","volume":"8","author":"Berliere","year":"2008","journal-title":"BMC Cancer"},{"key":"10.1016\/j.mehy.2018.04.022_b0055","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s12282-011-0256-7","article-title":"Incidence of chemotherapy-induced amenorrhea in premenopausal patients with breast cancer following adjuvant anthracycline and taxane","volume":"18","author":"Okanami","year":"2011","journal-title":"Breast Cancer"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0060","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.fertnstert.2015.11.020","article-title":"Menses resumption after cancer treatment \u2013 induced amenorrhea occurs early or not at all","volume":"105","author":"Jacobson","year":"2016","journal-title":"Fertil Steril"},{"issue":"101","key":"10.1016\/j.mehy.2018.04.022_b0065","article-title":"Impact of chemotherapy-induced amenorrhea in breast cancer patients : the evaluation of ovarian function by menstrual history and hormonal levels","volume":"11","author":"Meng","year":"2013","journal-title":"World J Surg Oncol"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10549-009-0426-x","article-title":"Incidence of chemotherapy-induced amenorrhea in hormone-sensitive breast cancer patients: the impact of addition of taxanes to anthracycline-based regimens","volume":"120","author":"P\u00e9rez-Fidalgo","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.mehy.2018.04.022_b0075","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/annonc\/mdh266","article-title":"Incidence of chemotherapy-induced amenorrhea depending on the timing of treatment by menstrual cycle phase in women with early breast cancer","volume":"15","author":"Di Cosimo","year":"2004","journal-title":"Ann Oncol"},{"issue":"8","key":"10.1016\/j.mehy.2018.04.022_b0080","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1093\/annonc\/mdi241","article-title":"Chemotherapy-induced amenorrhea: influence on disease-free survival and overall survival in receptor-positive premenopausal early breast cancer patients","volume":"16","author":"Vanhuyse","year":"2005","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0085","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s10549-010-0899-7","article-title":"Bone mineral density loss during adjuvant chemotherapy in pre-menopausal women with early breast cancer: is it dependent on oestrogen deficiency?","volume":"123","author":"Cameron","year":"2010","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0090","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/07357900701829777","article-title":"A pilot study of predictive markers of chemotherapy-related amenorrhea among premenopausal women with early stage breast cancer","volume":"26","author":"Anders","year":"2008","journal-title":"Cancer Invest"},{"key":"10.1016\/j.mehy.2018.04.022_b0095","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(10)60355-8","article-title":"Primary ovarian insufficiency","volume":"376","author":"De Vos","year":"2010","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.mehy.2018.04.022_b0100","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1200\/JCO.2013.52.8877","article-title":"Prospective study of fertility concerns and preservation strategies in young women with breast cancer","volume":"32","author":"Ruddy","year":"2014","journal-title":"J Clin Oncol"},{"issue":"20","key":"10.1016\/j.mehy.2018.04.022_b0105","doi-asserted-by":"crossref","first-page":"4174","DOI":"10.1200\/JCO.2004.01.159","article-title":"Web-based survey of fertility issues in young women with breast cancer","volume":"22","author":"Partridge","year":"2004","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0110","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10549-010-0996-7","article-title":"Pharmacological interventions for fertility preservation during chemotherapy: a systematic review and meta-analysis","volume":"122","author":"Ben-Aharon","year":"2010","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"10.1016\/j.mehy.2018.04.022_b0115","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1200\/JCO.2011.34.6890","article-title":"Randomized trial using gonadotropin-releasing hormone agonist triptorelin for the preservation of ovarian function during (neo)adjuvant chemotherapy for breast cancer","volume":"30","author":"Munster","year":"2012","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.mehy.2018.04.022_b0120","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ctrv.2013.12.001","article-title":"Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: systematic review and meta-analysis of randomized trials","volume":"40","author":"Del Mastro","year":"2014","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.mehy.2018.04.022_b0125","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1152\/japplphysiol.00033.2011","article-title":"Effects of exercise on endothelium and endothelium\/smooth muscle cross talk : role of exercise-induced hemodynamics","volume":"111","author":"Newcomer","year":"2011","journal-title":"J Appl Physiol"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0125388","article-title":"Aerobic exercise training prevents the onset of endothelial dysfunction via increased nitric oxide bioavailability and reduced reactive oxygen species in an experimental model of menopause","volume":"10","author":"Braga","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1055\/s-2000-13308","article-title":"Influence of an acute exercise on neutrophil and platelet adhesion, nitric oxide plasma metabolites in inactive and active subjects","volume":"21","author":"Cuzzolin","year":"2000","journal-title":"Int J Sports Med"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2018.04.022_b0140","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1023\/A:1026032404105","article-title":"Oxidant, antioxidant and physical exercise","volume":"253","author":"Banerjee","year":"2003","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.mehy.2018.04.022_b0145","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.freeradbiomed.2007.02.001","article-title":"Moderate exercise is an antioxidant: upregulation of antioxidant genes by training","volume":"44","author":"Gomez-Cabrera","year":"2008","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0150","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/10715762.2013.844341","article-title":"Antioxidant and anti-inflammatory effects of exercise: role of redox signaling","volume":"48","author":"Ji","year":"2014","journal-title":"Free Radic Res"},{"key":"10.1016\/j.mehy.2018.04.022_b0155","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3837623","article-title":"Regular and moderate exercise counteracts the decline of antioxidant protection but not methylglyoxal-dependent glycative burden in the ovary of reproductively aging mice","volume":"2016","author":"Falone","year":"2016","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0160","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2463\/mrms.2014-0025","article-title":"MR imaging-based evaluation of morphological changes in the uterus and ovaries of patients following neoadjuvant chemotherapy for cervical cancer","volume":"14","author":"Himoto","year":"2015","journal-title":"Magn Reson Med Sci"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0165","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1095\/biolreprod50.3.653","article-title":"Age-related changes of the population of human ovarian follicles: increase in the disappearance of non-growing and early-growing follicles in agin women","volume":"50","author":"Gougeon","year":"1994","journal-title":"Biol Reprod"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0170","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0015-0282(16)57788-7","article-title":"Ovarian senescence and its significance on uterine and ovarian perfusion","volume":"64","author":"Kurjak","year":"1995","journal-title":"Fertil Steril"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0175","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/GRF.0b013e3181f96b54","article-title":"Toxicity of chemotherapy and radiation on female reproduction","volume":"53","author":"Meirow","year":"2010","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.mehy.2018.04.022_b0180","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1634\/theoncologist.2015-0044","article-title":"Long-term follow-up of chemotherapy-induced ovarian failure in young breast cancer patients : the role of vascular toxicity","volume":"20","author":"Ben-Aharon","year":"2015","journal-title":"Oncologist"},{"key":"10.1016\/j.mehy.2018.04.022_b0185","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1634\/theoncologist.2012-0172","article-title":"Chemotherapy-induced ovarian failure as a prototype for acute vascular toxicity","volume":"17","author":"Ben-Aharon","year":"2012","journal-title":"Oncologist"},{"key":"10.1016\/j.mehy.2018.04.022_b0190","volume":"vol. 94","author":"Luderer","year":"2014"},{"issue":"2","key":"10.1016\/j.mehy.2018.04.022_b0195","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1095\/biolreprod.111.095224","article-title":"Roles of reactive oxygen species and antioxidants in ovarian toxicity","volume":"86","author":"Devine","year":"2012","journal-title":"Biol Reprod"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0200","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/OGX.0b013e318224e97b","article-title":"The effects of chemotherapy and radiotherapy on fertility in premenopausal women","volume":"66","author":"Fleischer","year":"2011","journal-title":"Obstet Gynecol Surv"},{"issue":"11","key":"10.1016\/j.mehy.2018.04.022_b0205","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.freeradbiomed.2004.02.067","article-title":"Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis","volume":"36","author":"Lopez","year":"2004","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0210","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/toxsci\/kfm087","article-title":"Cyclophosphamide-induced apoptosis in COV434 human granulosa cells involves oxidative stress and glutathione depletion","volume":"98","author":"Tsai-Turton","year":"2007","journal-title":"Toxicol Sci"},{"issue":"50","key":"10.1016\/j.mehy.2018.04.022_b0215","doi-asserted-by":"crossref","first-page":"47107","DOI":"10.1074\/jbc.M104516200","article-title":"Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells: the role of intracellular oxidation","volume":"276","author":"Troyano","year":"2001","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0220","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.reprotox.2010.07.003","article-title":"Doxorubicin-induced apoptosis in germinal vesicle (GV) oocytes","volume":"30","author":"Bar-Joseph","year":"2010","journal-title":"Reprod Toxicol"},{"issue":"8\u20139","key":"10.1016\/j.mehy.2018.04.022_b0225","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/0959-8049(92)90541-9","article-title":"Modulation by D, L-buthionine-S, R-sulphoximine of etoposide cytotoxicity on human non-small cell lung, ovarian and breast carcinoma cell lines","volume":"28A","author":"Mans","year":"1992","journal-title":"Eur J Cancer"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0230","first-page":"519","article-title":"Interaction of buthionine sulfoximine and the stabilization of DNA-topoisomerase II complexes by doxorubicin","volume":"22","author":"Bonner","year":"1992","journal-title":"Radiat Oncol"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0235","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3325\/cmj.2014.55.206","article-title":"Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study","volume":"55","author":"Panchuk","year":"2014","journal-title":"Croat Med J"},{"issue":"2","key":"10.1016\/j.mehy.2018.04.022_b0240","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1534735414564425","article-title":"Efficacy of antioxidants as a complementary and alternative medicine (CAM) in combination with the chemotherapeutic agent doxorubicin","volume":"14","author":"Sheu","year":"2015","journal-title":"Integr Cancer Ther"},{"issue":"19","key":"10.1016\/j.mehy.2018.04.022_b0245","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1016\/j.bmcl.2013.07.070","article-title":"Doxorubicin-antioxidant co-drugs","volume":"23","author":"Chegaev","year":"2013","journal-title":"Bioorg Med Chem Lett"},{"issue":"9","key":"10.1016\/j.mehy.2018.04.022_b0250","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1371\/journal.pone.0023492","article-title":"In vivo bioimaging as a novel strategy to detect Doxorubicin-Induced damage to gonadal blood vessels","volume":"6","author":"Bar-Joseph","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.mehy.2018.04.022_b0255","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.7863\/jum.2009.28.8.1043","article-title":"Three-dimensional power Doppler angiography of cyclic ovarian blood flow","volume":"28","author":"Hope","year":"2009","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.mehy.2018.04.022_b0270","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0028-2243(92)90241-P","article-title":"Oxygen tension in follicular fluid falls with follicle maturation","volume":"43","author":"Fischer","year":"1992","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"10.1016\/j.mehy.2018.04.022_b0275","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ctrv.2011.09.002","article-title":"Endothelial vascular toxicity from chemotherapeutic agents: preclinical evidence and clinical implications","volume":"38","author":"Soultati","year":"2012","journal-title":"Cancer Treat Rev"},{"issue":"9","key":"10.1016\/j.mehy.2018.04.022_b0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0075157","article-title":"Doxorubicin-induced vascular toxicity \u2013 targeting potential pathways may reduce procoagulant activity","volume":"8","author":"Ben Aharon","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.mehy.2018.04.022_b0285","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1093\/humrep\/dem027","article-title":"Cortical fibrosis and blood-vessels damage in human ovaries exposed to chemotherapy. potential mechanisms of ovarian injury","volume":"22","author":"Meirow","year":"2007","journal-title":"Hum Reprod"},{"issue":"50","key":"10.1016\/j.mehy.2018.04.022_b0290","doi-asserted-by":"crossref","first-page":"47266","DOI":"10.1074\/jbc.M106829200","article-title":"Doxorubicin-induced apoptosis is associated with increased transcription of endothelial nitric-oxide synthase: Effect of antiapoptotic antioxidants and calcium","volume":"276","author":"Kalivendi","year":"2001","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.mehy.2018.04.022_b0295","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1349-7006.2008.00696.x","article-title":"Cisplatin up-regulates ICAM-1 expression in endothelial cell via a NF-\u03baB dependent pathway","volume":"99","author":"Yu","year":"2008","journal-title":"Cancer Sci"},{"issue":"5","key":"10.1016\/j.mehy.2018.04.022_b0300","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.ejca.2003.12.012","article-title":"Microalbuminuria, decreased fibrinolysis, and inflammation as early signs of atherosclerosis in long-term survivors of disseminated testicular cancer","volume":"40","author":"Nuver","year":"2004","journal-title":"Eur J Cancer"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0305","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1538-7836.2009.03300.x","article-title":"Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes","volume":"7","author":"Swystun","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"12","key":"10.1016\/j.mehy.2018.04.022_b0310","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1158\/1535-7163.MCT-06-0154","article-title":"Effects of the chemotherapeutic agent doxorubicin on the protein C anticoagulant pathway","volume":"5","author":"Woodley-Cook","year":"2006","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.mehy.2018.04.022_b0320","first-page":"247","article-title":"Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro","volume":"23","author":"Nuver","year":"2010","journal-title":"Oncol Rep"},{"key":"10.1016\/j.mehy.2018.04.022_b0325","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/sj.bjp.0703959","article-title":"Chronic vascular toxicity of doxorubicin in an organ-cultured artery","volume":"132","author":"Murata","year":"2001","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.mehy.2018.04.022_b0330","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/13697137.2010.522278","article-title":"Impact of platinum-based chemotherapy on the progression of atherosclerosis","volume":"14","author":"Sekijima","year":"2011","journal-title":"Climacteric"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0335","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/en.2005-1281","article-title":"Opposing effects of glutathione depletion and follicle-stimulating hormone on reactive oxygen species and apoptosis in cultured preovulatory rat follicles","volume":"147","author":"Tsai-Turton","year":"2006","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.mehy.2018.04.022_b0340","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1161\/01.CIR.0000154560.88933.7E","article-title":"Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease","volume":"111","author":"Adams","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.mehy.2018.04.022_b0345","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijcard.2016.12.145","article-title":"Effect of exercise training on endothelial function in heart failure patients: a systematic review meta-analysis","volume":"231","author":"Pearson","year":"2017","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.mehy.2018.04.022_b0350","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1042\/CS20090433","article-title":"Exercise and possible molecular mechanisms of protection from vascular disease and diabetes: the central role of ROS and nitric oxide","volume":"118","author":"Newsholme","year":"2010","journal-title":"Clin Sci"},{"issue":"7","key":"10.1016\/j.mehy.2018.04.022_b0355","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.cjca.2015.12.023","article-title":"Vascular complications of cancer chemotherapy","volume":"32","author":"Cameron","year":"2016","journal-title":"Can J Cardiol"},{"issue":"12","key":"10.1016\/j.mehy.2018.04.022_b0360","first-page":"4501","article-title":"Evidence for acute vascular toxicity of cisplatin-based chemotherapy in patients with germ cell tumour","volume":"31","author":"Dieckmann","year":"2011","journal-title":"Anticancer Res"},{"key":"10.1016\/j.mehy.2018.04.022_b0365","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/CS20110469","article-title":"Impact of exercise training on arterial wall thickness in humans","volume":"122","author":"Thijssen","year":"2012","journal-title":"Clin Sci"},{"issue":"7","key":"10.1016\/j.mehy.2018.04.022_b0370","doi-asserted-by":"crossref","first-page":"R510","DOI":"10.1152\/ajpregu.00539.2013","article-title":"Biomarkers of vascular function in premenopausal and recent postmenopausal women of similar age: effect of exercise training","volume":"306","author":"Nyberg","year":"2014","journal-title":"AJP Regul Integr Comp Physiol"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0375","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1177\/0003319710385338","article-title":"Supervised exercise training reduces plasma levels of the endothelial inflammatory markers E-selectin and ICAM-1 in patients with peripheral arterial disease","volume":"62","author":"Saetre","year":"2011","journal-title":"Angiology"},{"issue":"10","key":"10.1016\/j.mehy.2018.04.022_b0380","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1177\/2047487313491662","article-title":"Chronic exercise leads to antiaggregant, antioxidant and anti-inflammatory effects in heart failure patients","volume":"21","author":"de Meirelles","year":"2014","journal-title":"Eur J Prev Cardiol"},{"issue":"4","key":"10.1016\/j.mehy.2018.04.022_b0385","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/FJC.0b013e31829c9993","article-title":"Doxorubicin-induced vascular dysfunction and its attenuation by exercise preconditioning","volume":"62","author":"Gibson","year":"2013","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"10.1016\/j.mehy.2018.04.022_b0390","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1249\/01.MSS.0000117130.91142.38","article-title":"Training enhances vascular relaxation after chemotherapy-induced vasoconstriction","volume":"36","author":"Hayward","year":"2004","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"10.1016\/j.mehy.2018.04.022_b0395","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1161\/01.CIR.0000080893.55729.28","article-title":"Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress","volume":"108","author":"Goto","year":"2003","journal-title":"Circulation"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718301816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718301816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T12:00:24Z","timestamp":1535112024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718301816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":75,"alternative-id":["S0306987718301816"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2018.04.022","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise and chemotherapy-induced amenorrhea","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2018.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}