{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:40:51Z","timestamp":1768588851456,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.mehy.2018.09.011","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T06:43:24Z","timestamp":1536216204000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo\/leucoderma"],"prefix":"10.1016","volume":"121","author":[{"given":"U.V.","family":"Shivasaraun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raman","family":"Sureshkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenmala","family":"Karthika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nethravathi","family":"Puttappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.mehy.2018.09.011_b0005","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1365-4632.2011.05377.x","article-title":"A review of the worldwide prevalence of vitiligo in children\/adolescents and adults","volume":"51","author":"Kr\u00fcger","year":"2012","journal-title":"Int J Dermatol"},{"issue":"9","key":"10.1016\/j.mehy.2018.09.011_b0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163806","article-title":"The prevalence of vitiligo: a meta-analysis","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.mehy.2018.09.011_b0015","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1525-1470.2003.20304.x","article-title":"Epidemiology of childhood vitiligo: a study of 625 patients from north India","volume":"20","author":"Handa","year":"2003","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0020","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/gepi.1370020107","article-title":"Studies on vitiligo I. Epidemiological profile in Calcutta, India","volume":"2","author":"Das","year":"1985","journal-title":"Genet Epidemiol"},{"issue":"3","key":"10.1016\/j.mehy.2018.09.011_b0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2165\/00128071-200102030-00006","article-title":"Vitiligo","volume":"2","author":"Njoo","year":"2001","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"10.1016\/j.mehy.2018.09.011_b0030","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.jid.5700683","article-title":"Approaches to identify inhibitors of melanin biosynthesis via the quality control of tyrosinase","volume":"127","author":"Ando","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.mehy.2018.09.011_b0035","unstructured":"Dwivedi M, Laddha NC, Weetman AP, Begum R, Kemp H. Vitiligo\u2013A Complex Autoimmune Skin Depigmenting."},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev.me.11.020160.001155","article-title":"Hormonal control of pigmentation","volume":"11","author":"Lerner","year":"1960","journal-title":"Annu Rev Med"},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2340\/00015555-0794","article-title":"A practical classification of childhood hypopigmentation disorders","volume":"90","author":"Tey","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.mehy.2018.09.011_b0050","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/631927","article-title":"Oxidative stress and immune system in vitiligo and thyroid diseases","volume":"2015","author":"Colucci","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0055","first-page":"181","article-title":"Defective tetrahydrobiopterin and catecholamine biosynthesis in thedepigmentation disorder vitiligo","volume":"1226","author":"Schallereuter","year":"1994","journal-title":"BBA"},{"issue":"6","key":"10.1016\/j.mehy.2018.09.011_b0060","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0738-081X(97)00133-8","article-title":"Psoralen photochemotherapy for vitiligo","volume":"15","author":"Grimes","year":"1997","journal-title":"Clin Dermatol"},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0065","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1755-148X.2008.00528.x","article-title":"Update on skin repigmentation therapies in vitiligo","volume":"22","author":"Falabella","year":"2009","journal-title":"Pigment Cell Melanoma Res"},{"issue":"3","key":"10.1016\/j.mehy.2018.09.011_b0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-0749.1996.tb00098.x","article-title":"Vitiligo, psoralen, and melanogenesis: some observations and understanding","volume":"9","author":"Chakraborty","year":"1996","journal-title":"Pigment Cell Melanoma Res"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0075","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000249932","article-title":"An approach to the treatment of vitiligo by khellin","volume":"165","author":"Abdel-Fattah","year":"1982","journal-title":"Dermatology"},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0080","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1365-2133.2006.07584.x","article-title":"Effects of psoralen plus ultraviolet A irradiation on cultured epidermal cells in vitro and patients with vitiligo in vivo","volume":"156","author":"Wu","year":"2007","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0085","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/09546630252775207","article-title":"Treatment of vitiligo","volume":"13","author":"Taneja","year":"2002","journal-title":"J Dermatolog Treat"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0090","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1529-8019.2008.00178.x","article-title":"Vitiligo: new and emerging treatments","volume":"21","author":"Lotti","year":"2008","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.mehy.2018.09.011_b0095","first-page":"242","article-title":"Vitiligo and its management update: a review","volume":"20","author":"Tonsi","year":"2004","journal-title":"Pak J Med Sci"},{"issue":"3","key":"10.1016\/j.mehy.2018.09.011_b0100","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s10103-012-1185-1","article-title":"Effectiveness of a 308-nm excimer laser in treatment of vitiligo: a review","volume":"28","author":"Alhowaish","year":"2013","journal-title":"Lasers Med Sci"},{"issue":"5","key":"10.1016\/j.mehy.2018.09.011_b0105","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1067\/mjd.2000.103813","article-title":"Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser","volume":"42","author":"Njoo","year":"2000","journal-title":"J Am Acad Dermatol"},{"issue":"11","key":"10.1016\/j.mehy.2018.09.011_b0110","first-page":"969","article-title":"Depigmentation therapy with Q-switched ruby laser after tanning in Vitiligo Universalis","volume":"27","author":"Kim","year":"2001","journal-title":"Dermatol Surg"},{"issue":"3","key":"10.1016\/j.mehy.2018.09.011_b0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1468-3083.2000.00038.x","article-title":"Depigmentation of the normally pigmented patches in universal vitiligo patients by cryotherapy","volume":"14","author":"Radmanesh","year":"2000","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0120","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1159\/000051626","article-title":"Surgical techniques for vitiligo: a review","volume":"202","author":"Van Geel","year":"2001","journal-title":"Dermatology"},{"issue":"4","key":"10.1016\/j.mehy.2018.09.011_b0125","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1524-4725.1995.tb00176.x","article-title":"Vitiligo: repigmentation with dermabrasion and thin split-thickness skin graft","volume":"21","author":"Agrawal","year":"1995","journal-title":"Dermatol Surg"},{"issue":"12","key":"10.1016\/j.mehy.2018.09.011_b0130","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1046\/j.1524-4725.1999.99069.x","article-title":"Suction blister epidermal grafting versus punch skin grafting in recalcitrant and stable vitiligo","volume":"25","author":"Gupta","year":"1999","journal-title":"Dermatol Surg"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0135","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1525-1470.2002.00035.x","article-title":"Epidermal grafting for vitiligo in adolescents","volume":"19","author":"Gupta","year":"2002","journal-title":"Pediatr Dermatol"},{"issue":"1","key":"10.1016\/j.mehy.2018.09.011_b0140","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1067\/mjd.2003.415","article-title":"Epidermal grafting in vitiligo: influence of age, site of lesion, and type of disease on outcome","volume":"49","author":"Gupta","year":"2003","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0145","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/0190-9622(92)70032-B","article-title":"Treatment of refractory and stable vitiligo by transplantation of in vitro cultured epidermal autografts bearing melanocytes","volume":"26","author":"Falabella","year":"1992","journal-title":"J Am Acad Dermatol"},{"issue":"10","key":"10.1016\/j.mehy.2018.09.011_b0150","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1111\/j.1524-4725.1989.tb03129.x","article-title":"Micropigmentation for the treatment of vitiligo","volume":"15","author":"Halder","year":"1989","journal-title":"J Dermatol Surg Oncol"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0155","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0923-1811(98)00064-4","article-title":"Psoralen photobiology and photochemotherapy: 50 years of science and medicine","volume":"19","author":"Bethea","year":"1999","journal-title":"J Dermatol Sci"},{"issue":"10","key":"10.1016\/j.mehy.2018.09.011_b0160","first-page":"1827","article-title":"Ethanomedicinal trends in Indian tradition for treatment of vitiligo","volume":"6","author":"Sharma","year":"2012","journal-title":"J Med Plant Res"},{"key":"10.1016\/j.mehy.2018.09.011_b0165","first-page":"761","article-title":"Plants used in the treatement of leucoderma by the tribals of Yerramalai forest of Kurnool District, Andhra Pradesh, India","volume":"121","author":"Bashaa","year":"2014","journal-title":"J Ethnobiol Trad Med"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0170","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ejpb.2008.05.008","article-title":"Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)","volume":"70","author":"Fang","year":"2008","journal-title":"Eur J Pharm Biopharm"},{"issue":"7","key":"10.1016\/j.mehy.2018.09.011_b0175","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/exd.12184","article-title":"A mouse model of vitiligo induced by monobenzone","volume":"22","author":"Zhu","year":"2013","journal-title":"Exp Dermatol"},{"issue":"4","key":"10.1016\/j.mehy.2018.09.011_b0180","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1755-148X.2011.00878.x","article-title":"Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity","volume":"24","author":"Van den Boorn","year":"2011","journal-title":"Pigment Cell Melanoma Res"},{"issue":"5","key":"10.1016\/j.mehy.2018.09.011_b0185","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1365-2133.2008.08464.x","article-title":"In vivo evaluation of piperine and synthetic analogues as potential treatments for vitiligo using a sparsely pigmented mouse model","volume":"158","author":"Faas","year":"2008","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.mehy.2018.09.011_b0190","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/1061186X.2015.1070855","article-title":"Nanosizedethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment","volume":"24","author":"Garg","year":"2016","journal-title":"J Drug Target"},{"key":"10.1016\/j.mehy.2018.09.011_b0195","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.colsurfb.2012.08.011","article-title":"Topical delivery of clobetasol propionate loaded microemulsion based gel for effective treatment of vitiligo: ex vivo permeation and skin irritation studies","volume":"102","author":"Patel","year":"2013","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"10.1016\/j.mehy.2018.09.011_b0200","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/ddr.10339","article-title":"Study and development of encapsulated forms of 4, 5\u2032, 8-trimethylpsoralen for topical drug delivery","volume":"61","author":"Lboutounne","year":"2004","journal-title":"Drug Dev Res"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718302706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718302706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T16:53:40Z","timestamp":1544201620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718302706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":40,"alternative-id":["S0306987718302706"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2018.09.011","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Flavonoids as adjuvant in psoralen based photochemotherapy in the management of vitiligo\/leucoderma","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2018.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}