{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:11:47Z","timestamp":1791821507731,"version":"4.3.4"},"reference-count":164,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,30]],"date-time":"2019-11-30T00:00:00Z","timestamp":1575072000000},"content-version":"vor","delay-in-days":333,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["2014-23211-0"],"award-info":[{"award-number":["2014-23211-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["32355-2017-0"],"award-info":[{"award-number":["32355-2017-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008353","name":"FAEPA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.mehy.2018.11.009","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T04:14:16Z","timestamp":1542860056000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["The role of endocrine disruptors in ocular surface diseases"],"prefix":"10.1016","volume":"122","author":[{"given":"Regina C.N.","family":"Pontelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00edlia C.O.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Z.","family":"Fantucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica","family":"de Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo M.","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0005","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","article-title":"TFOS DEWS II diagnostic methodology report","volume":"15","author":"Wolffsohn","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.mehy.2018.11.009_b0010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/archinte.159.12.1359","article-title":"Dry eye and dry mouth in the elderly","volume":"159","author":"Schein","year":"1999","journal-title":"Arch Intern Med"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0015","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/archopht.118.6.819","article-title":"Causes of blindness and visual impairment in a population of older Americans: the salisbury eye evaluation study","volume":"118","author":"Mu\u00f1oz","year":"2000","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0020","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul Surf"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0025","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/s41598-018-20273-9","article-title":"Prevalence and Risk Factors of self-reported dry eye in Brazil using a short symptom questionnaire","volume":"8","author":"de Castro","year":"2018","journal-title":"Sci Rep"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2018.11.009_b0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1046\/j.1365-3083.2001.00958.x","article-title":"IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sj\u00f6gren\u2019s syndrome","volume":"54","author":"Brayer","year":"2001","journal-title":"Scand J Immunol"},{"issue":"7","key":"10.1016\/j.mehy.2018.11.009_b0035","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1002\/art.39127","article-title":"Familial risk of Sj\u00f6gren\u2019s syndrome and co-aggregation of autoimmune diseases in affected families: a nationwide population study","volume":"67","author":"Kuo","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0040","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.ajo.2005.05.025","article-title":"Correlation between dry eye and rheumatoid arthritis activity","volume":"140","author":"Fujita","year":"2005","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0045","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/art.20093","article-title":"Sj\u00f6gren\u2019s syndrome associated with systemic lupus erythematosus: clinical and laboratory profiles and comparison with primary Sj\u00f6gren\u2019s syndrome","volume":"50","author":"Manoussakis","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.mehy.2018.11.009_b0050","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3109\/08916934.2015.1045583","article-title":"Increased incidence of Sjogren\u2019s syndrome in systemic sclerosis: A nationwide population study","volume":"48","author":"Tseng","year":"2015","journal-title":"Autoimmunity"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0055","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/09513590400027257","article-title":"Menopause and dry eye. A possible relationship","volume":"20","author":"Versura","year":"2005","journal-title":"Gynecol Endocrinol"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0060","first-page":"2632","article-title":"Comparative influence of steroid-hormones and immunosuppressive agents on autoimmune expression in lacrimal glands of a female mouse model of Sjogrens-syndrome","volume":"35","author":"Sato","year":"1994","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0065","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jcjo.2012.08.019","article-title":"Effects of phytoestrogen supplementation in postmenopausal women with dry eye syndrome: a randomized clinical trial","volume":"47","author":"Scuderi","year":"2012","journal-title":"Can J Ophthalmol"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0070","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/ICU.0b013e32836227bf","article-title":"Hormones and dry eye syndrome: an update on what we do and don\u2019t know","volume":"24","author":"Rocha","year":"2013","journal-title":"Curr Opin Ophthalmol"},{"issue":"12","key":"10.1016\/j.mehy.2018.11.009_b0075","first-page":"3732","article-title":"Androgen influence on the meibomian gland","volume":"41","author":"Sullivan","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0080","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1034\/j.1600-0420.2000.078002146.x","article-title":"Identification of androgen, estrogen and progesterone receptor mRNAs in the eye","volume":"78","author":"Wickham","year":"2000","journal-title":"Acta Ophthalmol Scand"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0085","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jtos.2017.04.001","article-title":"TFOS DEWS II sex, gender, and hormones report","volume":"15","author":"Sullivan","year":"2017","journal-title":"Ocul Surf"},{"key":"10.1016\/j.mehy.2018.11.009_b0090","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.exer.2016.08.009","article-title":"In vitro effects of sex hormones in human meibomian gland epithelial cells","volume":"151","author":"Schr\u00f6der","year":"2016","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.mehy.2018.11.009_b0095","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.2002.tb04217.x","article-title":"Androgen deficiency, Meibomian gland dysfunction, and evaporative dry eye","volume":"966","author":"Sullivan","year":"2002","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jsbmb.2005.04.037","article-title":"Androgen regulation of gene expression in the mouse lacrimal gland","volume":"96","author":"Richards","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0105","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1167\/iovs.12-10457","article-title":"The effects of estrogen and androgen on tear secretion and matrix metalloproteinase-2 expression in lacrimal glands of ovariectomized rats","volume":"55","author":"Song","year":"2013","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1542-0124(12)70147-7","article-title":"Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous-deficient dry eye","volume":"2","author":"Sullivan","year":"2004","journal-title":"Ocul Surf"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2018.11.009_b0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaut.2012.01.004","article-title":"Sex steroids in Sj\u00f6gren\u2019s syndrome","volume":"39","author":"Konttinen","year":"2012","journal-title":"J Autoimmun"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0120","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0014-4835(03)00120-9","article-title":"Estrogen prevention of lacrimal gland cell death and lymphocytic infiltration","volume":"77","author":"Azzarolo","year":"2003","journal-title":"Exp Eye Res"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-4835(79)90110-6","article-title":"Testosterone binding in the cytosol of bovine corneal epithelium","volume":"28","author":"Ploc","year":"1979","journal-title":"Exp Eye Res"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0130","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0022-4731(86)90259-1","article-title":"Sex steroids and 5-en-3\u03b2-hydroxysteroids in specific regions of the human brain and cranial nerves","volume":"25","author":"Lanthier","year":"1986","journal-title":"J Steroid Biochem"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0135","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1167\/iovs.05-1003","article-title":"Estrogen\u2019s and progesterone\u2019s impact on gene expression in the mouse lacrimal gland","volume":"47","author":"Suzuki","year":"2006","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"June","key":"10.1016\/j.mehy.2018.11.009_b0140","first-page":"1553","article-title":"Do sex steroids exert sex-specific and\/or opposite effects on gene expression in lacrimal and meibomian glands?","volume":"15","author":"Sullivan","year":"2009","journal-title":"Mol Vis"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0145","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1146\/annurev-physiol-012110-142200","article-title":"Endocrine disruptors: from endocrine to metabolic disruption","volume":"73","author":"Casals-Casas","year":"2011","journal-title":"Annu Rev Physiol"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0150","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1073\/pnas.1417731112","article-title":"Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish","volume":"112","author":"Kinch","year":"2015","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1016\/j.mehy.2018.11.009_b0155","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1007\/s00125-013-2944-7","article-title":"Hepatic DNA methylation modifications in early development of rats resulting from perinatal BPA exposure contribute to insulin resistance in adulthood","volume":"56","author":"Ma","year":"2013","journal-title":"Diabetologia"},{"issue":"February","key":"10.1016\/j.mehy.2018.11.009_b0160","first-page":"1","article-title":"BPA-induced deregulation of epigenetic patterns: effects on female Zebrafish reproduction","volume":"6","author":"Santangeli","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0165","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr Rev"},{"key":"10.1016\/j.mehy.2018.11.009_b0170","first-page":"1","article-title":"Chapter 1: Executive Summary","author":"World Health Organization","year":"2002","journal-title":"Int Progr Chem Safety Glob Assess Endocrine-disrupting Chem"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0175","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1590\/S0100-40422007000300027","article-title":"Desreguladores end\u00f3crinos no meio ambiente: efeitos e conseq\u00fc\u00eancias","volume":"30","author":"Bila","year":"2007","journal-title":"Quim Nova"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0180","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ecoenv.2003.12.011","article-title":"The blight of pollution keratoconjunctivitis among children in oil-producing industrial areas of Delta State, Nigeria","volume":"59","author":"Asonye","year":"2004","journal-title":"Ecotoxicol Environ Saf."},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0185","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.envres.2010.03.003","article-title":"The effects of chronic exposure to traffic derived air pollution on the ocular surface","volume":"110","author":"Novaes","year":"2010","journal-title":"Environ Res"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0190","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1590\/S0004-27492011000500016","article-title":"Efeitos adversos na superf\u00edcie ocular relacionados \u00e0 polui\u00e7\u00e3o ambiental","volume":"74","author":"Torricelli","year":"2011","journal-title":"Arq Bras Oftalmol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0195","doi-asserted-by":"crossref","first-page":"110","DOI":"10.5935\/0004-2749.20150028","article-title":"Impact of wildfire smoke in Buenos Aires, Argentina, on ocular surface","volume":"78","author":"Berra","year":"2015","journal-title":"Arq Bras Oftalmol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0200","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jtos.2018.03.001","article-title":"Effects of environment pollution on the ocular surface","volume":"16","author":"Jung","year":"2018","journal-title":"Ocul Surf"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0205","first-page":"187","article-title":"Paraquat causes chronic ocular surface toxicity","volume":"21","author":"Vlahos","year":"1993","journal-title":"Aust N Z J Ophthalmol"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0210","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2131\/jts.21.57","article-title":"Environmental chemicals and experimental allergic conjunctivictis","volume":"21","author":"Miyata","year":"1996","journal-title":"J Toxicol Sci"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0215","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1136\/bjo.86.3.350","article-title":"The ocular surface toxicity of paraquat [1]","volume":"86","author":"McKeag","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.mehy.2018.11.009_b0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.placenta.2016.04.019","article-title":"Paraquat inhibits progesterone synthesis in human placental mitochondria","volume":"43","author":"Milczarek","year":"2016","journal-title":"Placenta"},{"issue":"1456","key":"10.1016\/j.mehy.2018.11.009_b0225","first-page":"83","article-title":"Ocular exposure to paraquat resulting in keratopathy, pseudomembranous conjunctivitis and symblepharon","volume":"130","author":"Avery","year":"2017","journal-title":"N Z Med J"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0230","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5935\/0004-2749.20140050","article-title":"Is dry eye an environmental disease?","volume":"77","author":"Alves","year":"2014","journal-title":"Arq Bras Oftalmol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0235","first-page":"S148","article-title":"Transient receptor potential (TRP) cation channels","volume":"158","author":"Are","year":"2009","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.mehy.2018.11.009_b0240","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/jcp.21141","article-title":"Transient receptor potential in corneal epithelium through inflammatory cytokine release vanilloid 1 activation induces MAPK signalingo","volume":"213","author":"Zhang","year":"2007","journal-title":"J Cell Physiol"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0245","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1590\/S0004-27492008000700016","article-title":"The corneal epithelium: clinical relevance of cytokine-mediated responses to maintenance of corneal health","volume":"71","author":"Reinach","year":"2008","journal-title":"Arq Bras Oftalmol"},{"key":"10.1016\/j.mehy.2018.11.009_b0250","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.exer.2015.02.013","article-title":"Reactive oxygen species 21 activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients","volume":"134","author":"Zheng","year":"2015","journal-title":"Exp Eye Res"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0255","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jtos.2017.05.004","article-title":"TFOS DEWS II iatrogenic report","volume":"15","author":"Gomes","year":"2017","journal-title":"Ocul Surf"},{"issue":"12","key":"10.1016\/j.mehy.2018.11.009_b0260","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1167\/iovs.04-0299","article-title":"Stimulation of Matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells","volume":"45","author":"Li","year":"2004","journal-title":"Investig Opthalmology Vis Sci"},{"issue":"9","key":"10.1016\/j.mehy.2018.11.009_b0265","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1167\/iovs.14-14642","article-title":"Hyperosmolar tears enhance cooling sensitivity of the corneal nerves in rats: Possible neural basis for cold-induced dry eye pain","volume":"55","author":"Hirata","year":"2014","journal-title":"Investig Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0270","doi-asserted-by":"crossref","first-page":"68","DOI":"10.5935\/0034-7280.20150016","article-title":"Lacrimal osmolaritu and ocular surface in experimental model of dry eye caused by toxicity","volume":"74","author":"Marques","year":"2015","journal-title":"Rev Bras Oftalmol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0275","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.yfrne.2013.11.001","article-title":"Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis","volume":"35","author":"Handa","year":"2014","journal-title":"Front Neuroendocrinol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0280","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.neuroscience.2008.12.058","article-title":"Estrogen impairs glucocorticoid dependent negative feedback on the hypothalamic-pituitary-adrenal axis via estrogen receptor alpha within the hypothalamus","volume":"159","author":"Weiser","year":"2009","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0285","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1210\/en.2017-00101","article-title":"Estradiol sensitizes the transient receptor potential vanilloid 1 receptor in pain responses","volume":"158","author":"Payrits","year":"2017","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0290","first-page":"1","article-title":"Estrogen modulates corneal nociception and maintains corneal homeostasis in rat eye","volume":"37","author":"Kumar","year":"2017","journal-title":"Cornea"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0295","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0178589","article-title":"Estradiol upregulates voltage-gated sodium channel 1.7 in trigeminal ganglion contributing to hyperalgesia of inflamed TMJ","volume":"12","author":"Bi","year":"2017","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0300","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1289\/ehp.93101378","article-title":"Developmental effects of endocrine-disrupting chemicals in wildlife and humans","volume":"101","author":"Colborn","year":"1993","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.mehy.2018.11.009_b0305","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.lfs.2015.10.022","article-title":"Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms","volume":"145","author":"Maqbool","year":"2016","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0310","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2015.06.009","article-title":"A review on endocrine disruptors and their possible impacts on human health","volume":"40","author":"Kabir","year":"2015","journal-title":"Environ Toxicol Pharmacol"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0315","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.fertnstert.2008.08.067","article-title":"Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing","volume":"90","author":"Crain","year":"2008","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2018.11.009_b0320","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.etap.2017.02.024","article-title":"Human exposure to endocrine disrupting chemicals: effects on the male and female reproductive systems","volume":"51","author":"Sifakis","year":"2017","journal-title":"Environ Toxicol Pharmacol"},{"key":"10.1016\/j.mehy.2018.11.009_b0325","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0960-0760(01)00174-1","article-title":"Oestrogenic activity of parabens in MCF7 human breast cancer cells","volume":"80","author":"Byford","year":"2002","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0330","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1289\/ehp.9924","article-title":"Flame retardants in placenta and breast milk and cryptorchildism in newborn boys","volume":"115","author":"Main","year":"2007","journal-title":"Environ Health Perspect"},{"issue":"2\u20135","key":"10.1016\/j.mehy.2018.11.009_b0335","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jsbmb.2004.12.008","article-title":"Assessment of human contamination of estrogenic endocrine-disrupting chemicals and their risk for human reproduction","volume":"93","author":"Tsutsumi","year":"2005","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0340","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0960-0760(93)90022-O","article-title":"Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens","volume":"44","author":"Adlercreutz","year":"1993","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0055905","article-title":"Bisphenol a exposure during adulthood alters expression of aromatase and 5\u03b1-reductase isozy mes in rat prostate","volume":"8","author":"Castro","year":"2013","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0350","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.toxlet.2013.10.022","article-title":"Endocrine disruption: fact or urban legend?","volume":"223","author":"Nohynek","year":"2013","journal-title":"Toxicol Lett"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0355","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0360","first-page":"1","article-title":"A influ\u00eancia da exposi\u00e7\u00e3o ambiental a disruptores end\u00f3crinos no crescimento e desenvolvimento de crian\u00e7as e adolescentes","volume":"10","author":"Correia","year":"2015","journal-title":"Rev Port Endocrinol Diabetes e Metab"},{"issue":"9\u201310","key":"10.1016\/j.mehy.2018.11.009_b0365","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.crvi.2017.07.004","article-title":"What is an endocrine disruptor?","volume":"340","author":"Monneret","year":"2017","journal-title":"Comptes Rendus \u2013 Biol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0370","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.scitotenv.2007.02.038","article-title":"Determining estrogenic steroids in Taipei waters and removal in drinking water treatment using high-flow solid-phase extraction and liquid chromatography\/tandem mass spectrometry","volume":"378","author":"Chen","year":"2007","journal-title":"Sci Total Environ"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2018.11.009_b0375","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0166-445X(99)00076-4","article-title":"Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay","volume":"49","author":"Folmar","year":"2000","journal-title":"Aquat Toxicol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0380","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1532-0456(00)00189-7","article-title":"Evaluation of estrogenic effects of municipal effluents to the freshwater mussel Elliptio complanata","volume":"128","author":"Gagn\u00e9","year":"2001","journal-title":"Comp Biochem Physiol Part C Toxicol Pharmacol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0385","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.scitotenv.2008.08.039","article-title":"Removal mechanisms for endocrine disrupting compounds (EDCs) in wastewater treatment \u2013 physical means, biodegradation, and chemical advanced oxidation: a review","volume":"407","author":"Liu","year":"2009","journal-title":"Sci Total Environ"},{"issue":"7","key":"10.1016\/j.mehy.2018.11.009_b0390","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1289\/ehp.1104052","article-title":"Endocrine disruptors and asthma-associated chemicals in consumer products","volume":"120","author":"Dodson","year":"2012","journal-title":"Environ Health Perspect"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0395","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1351\/pac200375050631","article-title":"Endocrine disruptors in the environment (IUPAC Technical Report)","volume":"75","author":"Lintelmann","year":"2003","journal-title":"Pure Appl Chem"},{"key":"10.1016\/j.mehy.2018.11.009_b0400","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.envint.2015.05.012","article-title":"Estrogenic endocrine disruptors: molecular mechanisms of action","volume":"83","author":"Kiyama","year":"2015","journal-title":"Environ Int"},{"issue":"8","key":"10.1016\/j.mehy.2018.11.009_b0405","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1289\/ehp.5494","article-title":"Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity","volume":"111","author":"Welshons","year":"2003","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.mehy.2018.11.009_b0410","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1155\/2012\/713696","article-title":"Endocrine-disrupting chemicals: associated disorders and mechanisms of action","volume":"2012","author":"De Coster","year":"2012","journal-title":"J Environ Public Health."},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0415","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/JOE-14-0111","article-title":"Phthalate exposure in utero causes epigenetic changes and impairs insulin signalling","volume":"223","author":"Rajesh","year":"2014","journal-title":"J Endocrinol"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0420","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/bdrc.20197","article-title":"Endocrine disrupting chemicals and the developmental programming of adipogenesis and obesity","volume":"93","author":"Janesick","year":"2011","journal-title":"Birth Defects Res Part C \u2013 Embryo Today Rev"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0425","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2174\/156652412798376161","article-title":"The emerging role of endocrine disruptors in pathogenesis of insulin resistance: a concept implicating nonalcoholic fatty liver disease","volume":"12","author":"Polyzos","year":"2012","journal-title":"Curr Mol Med"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0430","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.reprotox.2007.07.005","article-title":"Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure","volume":"24","author":"vom Saal","year":"2007","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.mehy.2018.11.009_b0435","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","article-title":"Bisphenol A and human health: A review of the literature","volume":"42","author":"Rochester","year":"2013","journal-title":"Reprod Toxicol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0440","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul Surf."},{"key":"10.1016\/j.mehy.2018.11.009_b0445","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jenvman.2012.03.021","article-title":"Bisphenol A exposure, effects, and policy: a wildlife perspective","volume":"104","author":"Flint","year":"2012","journal-title":"J Environ Manage"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0450","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1210\/er.2008-0021","article-title":"Bisphenol-a and the great divide: a review of controversies in the field of endocrine disruption","volume":"30","author":"Vandenberg","year":"2009","journal-title":"Endocr Rev"},{"issue":"1\u20132","key":"10.1016\/j.mehy.2018.11.009_b0455","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2011.05.002","article-title":"Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects","volume":"127","author":"Rubin","year":"2011","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2\u20133","key":"10.1016\/j.mehy.2018.11.009_b0460","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.tox.2007.12.028","article-title":"Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor","volume":"246","author":"Kr\u00fcger","year":"2008","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0465","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/toxsci\/kfi074","article-title":"Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds","volume":"84","author":"Kitamura","year":"2005","journal-title":"Toxicol Sci"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0470","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/toxsci\/kfu030","article-title":"Are structural analogues to bisphenol a safe alternatives?","volume":"139","author":"Rosenmai","year":"2014","journal-title":"Toxicol Sci"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0475","first-page":"147","article-title":"Occurrence, efficacy, metabolism, and toxicity of triclosan","volume":"28","author":"Fang","year":"2010","journal-title":"J Environ Sci Heal - Part C Environ Carcinog Ecotoxicol Rev"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0480","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jat.1660","article-title":"Triclosan: Environmental exposure, toxicity and mechanisms of action","volume":"31","author":"Dann","year":"2011","journal-title":"J Appl Toxicol"},{"issue":"9","key":"10.1016\/j.mehy.2018.11.009_b0485","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1248\/bpb.28.1748","article-title":"Effects of nonylphenol and triclosan on production of plasma vitellogenin and testosterone in male South African Clawed Frogs (Xenopus laevis)","volume":"28","author":"Matsumura","year":"2005","journal-title":"Biol Pharm Bull"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0490","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/toxsci\/kfn225","article-title":"The effects of triclosan on puberty and thyroid hormones in male wistar rats","volume":"107","author":"Zorrilla","year":"2009","journal-title":"Toxicol Sci"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0495","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.aquatox.2003.12.005","article-title":"Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin","volume":"67","author":"Ishibashi","year":"2004","journal-title":"Aquat Toxicol"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0500","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/toxsci\/kfq180","article-title":"Triclosan exposure modulates estrogen-dependent responses in the female wistar rat","volume":"117","author":"Stoker","year":"2010","journal-title":"Toxicol Sci"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0505","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1158\/1940-6207.CAPR-16-0257","article-title":"Activation of TRPA1 channel by antibacterial agent triclosan induces vegf secretion in human prostate cancer stromal cells","volume":"10","author":"Derouiche","year":"2017","journal-title":"Cancer Prev Res"},{"issue":"11","key":"10.1016\/j.mehy.2018.11.009_b0510","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1016\/j.pain.2013.07.012","article-title":"Changes in sensory activity of ocular surface sensory nerves during allergic keratoconjunctivitis","volume":"154","author":"Acosta","year":"2013","journal-title":"Pain"},{"issue":"11","key":"10.1016\/j.mehy.2018.11.009_b0515","doi-asserted-by":"crossref","first-page":"S136","DOI":"10.1097\/ICO.0000000000000602","article-title":"Transient receptor potential channels and corneal stromal inflammation","volume":"34","author":"Okada","year":"2015","journal-title":"Cornea"},{"issue":"7","key":"10.1016\/j.mehy.2018.11.009_b0520","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.fct.2005.01.020","article-title":"Safety assessment of esters of p-hydroxybenzoic acid (parabens)","volume":"43","author":"Soni","year":"2005","journal-title":"Food Chem Toxicol"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0525","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/10937404.2013.809252","article-title":"Parabens: potential impact of low-affinity estrogen receptor binding chemicals on human health","volume":"16","author":"Karpuzoglu","year":"2013","journal-title":"J Toxicol Environ Heal \u2013 Part B Crit Rev."},{"key":"10.1016\/j.mehy.2018.11.009_b0530","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.envint.2014.02.007","article-title":"Parabens. From environmental studies to human health","volume":"67","author":"B\u0142edzka","year":"2014","journal-title":"Environ Int"},{"key":"10.1016\/j.mehy.2018.11.009_b0535","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/jat.1358","article-title":"Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks","author":"Darbre","year":"2008","journal-title":"J Appl Toxicol"},{"key":"10.1016\/j.mehy.2018.11.009_b0540","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.fct.2013.03.036","article-title":"Comparative study on transcriptional activity of 17 parabens mediated by estrogen receptor \u03b1 and \u03b2 and androgen receptor","volume":"57","author":"Watanabe","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0545","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1021\/es304659r","article-title":"Characteristic profiles of urinary p -hydroxybenzoic acid and its esters (Parabens) in children and adults from the United States and China","volume":"47","author":"Wang","year":"2013","journal-title":"Environ Sci Technol"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0550","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1248\/jhs.51.557","article-title":"Androgenic and antiandrogenic effects of alkylphenols and parabens assessed using the reporter gene assay with stably transfected CHO-K1 Cells (AR-EcoScreen System)","volume":"51","author":"Satoh","year":"2005","journal-title":"J Heal Sci."},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0555","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1289\/ehp.01109239","article-title":"In vitro and in vivo estrogenicity of UV screens","volume":"109","author":"Schlumpf","year":"2001","journal-title":"Environ Health Perspect"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0560","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.tiv.2005.01.004","article-title":"Estrogenic activity of 37 components of commercial sunscreen lotions evaluated by in vitro assays","volume":"19","author":"Morohoshi","year":"2005","journal-title":"Toxicol Vitr"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0565","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1210\/en.2006-1280","article-title":"The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase","volume":"148","author":"Schmutzler","year":"2007","journal-title":"Endocrinology"},{"issue":"5","key":"10.1016\/j.mehy.2018.11.009_b0570","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2533\/chimia.2008.368","article-title":"UV Filters in the Aquatic Environment Induce Hormonal Effects and Affect Fertility and Reproduction in Fish","volume":"62","author":"Fent","year":"2008","journal-title":"Chim Int J Chem"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0575","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.taap.2005.02.006","article-title":"Additive estrogenic effects of mixtures of frequently used UV filters on pS2-gene transcription in MCF-7 cells","volume":"208","author":"Heneweer","year":"2005","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0580","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfj082","article-title":"Comparison of in vitro and in vivo estrogenic activity of UV filters in fish","volume":"90","author":"Kunz","year":"2006","journal-title":"Toxicol Sci"},{"issue":"5\u20136","key":"10.1016\/j.mehy.2018.11.009_b0585","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00204-002-0348-4","article-title":"Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay","volume":"76","author":"Schreurs","year":"2002","journal-title":"Arch Toxicol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0590","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.taap.2008.07.017","article-title":"Profiling of benzophenone derivatives using fish and human estrogen receptor-specific in vitro bioassays","volume":"232","author":"Molina-Molina","year":"2008","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0595","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1093\/toxsci\/kfi035","article-title":"Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays","volume":"83","author":"Schreurs","year":"2005","journal-title":"Toxicol Sci"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0600","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0300-483X(02)00382-7","article-title":"Role of antioxidants in paraquat toxicity","volume":"180","author":"Suntres","year":"2002","journal-title":"Toxicology"},{"key":"10.1016\/j.mehy.2018.11.009_b0605","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1289\/ehp.845537","article-title":"Paraquat: Model for oxidant-initiated toxicity","volume":"55","author":"Bus","year":"1984","journal-title":"Environ Health Perspect"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0610","first-page":"141","article-title":"Pesticides and oxidative stress: a review","volume":"10","author":"Abdollahi","year":"2004","journal-title":"Med Sci Monit"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0615","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/bjo.53.10.688","article-title":"Ocular damage caused by Paraquat","volume":"53","author":"Joyce","year":"1969","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0620","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2131\/jts.21.57","article-title":"Environmental chemicals and experimental allergic conjunctivitis","volume":"21","author":"Miyata","year":"1996","journal-title":"J Toxicol Sci"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0625","first-page":"12","article-title":"Mitogen activated protein kinase-dependent activation of c-Jun and c-Fos is required for neuronal differentiation but not for growth and stress response in PC12 cells","volume":"207","author":"Eriksson","year":"2006","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.mehy.2018.11.009_b0630","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2013.05.057","article-title":"Glyphosate induces human breast cancer cells growth via estrogen receptors","volume":"59","author":"Thongprakaisang","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0635","first-page":"1","article-title":"Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement","volume":"15","author":"Myers","year":"2016","journal-title":"Environ Heal A Glob Access Sci Source"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0640","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12302-014-0014-5","article-title":"Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize","volume":"26","author":"S\u00e9ralini","year":"2014","journal-title":"Environ Sci Eur"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0645","first-page":"1","article-title":"Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure","volume":"14","author":"Mesnage","year":"2015","journal-title":"Environ Heal A Glob Access Sci Source"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0650","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1289\/ehp.7728","article-title":"Differential effects of glyphosate and roundup on human placental cells and aromatase","volume":"113","author":"Richard","year":"2005","journal-title":"Environ Health Perspect"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0655","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00204-011-0788-9","article-title":"Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression","volume":"86","author":"Romano","year":"2012","journal-title":"Arch Toxicol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0660","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.mehy.2018.11.009_b0665","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.freeradbiomed.2013.06.043","article-title":"Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells","volume":"65","author":"De Liz Oliveira Cavalli","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.mehy.2018.11.009_b0670","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.toxrep.2015.07.021","article-title":"Analysis of endocrine disruption effect of Roundup\u00ae in adrenal gland of male rats","volume":"2","author":"Pandey","year":"2015","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.mehy.2018.11.009_b0675","article-title":"Glaucome cortisonique: \u00e9tude \u00e9pid\u00e9miologique, clinique et th\u00e9rapeutique","volume":"49\u201352","author":"El Afrit","year":"2007","journal-title":"J Fr Ophtalmol"},{"issue":"11","key":"10.1016\/j.mehy.2018.11.009_b0680","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1001\/jamaophthalmol.2013.4575","article-title":"Association of statin use with cataracts a propensity score-matched analysis","volume":"131","author":"Leuschen","year":"2013","journal-title":"JAMA Ophthalmol"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0685","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5005\/jp-journals-10028-1226","article-title":"Steroid-induced glaucoma: an avoidable irreversible blindness","volume":"11","author":"Phulke","year":"2017","journal-title":"J Curr glaucoma Pract."},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0690","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0733-8635(18)30318-8","article-title":"Ocular effects of topical and systemic steroids","volume":"10","author":"Renfro","year":"1992","journal-title":"Dermatol Clin"},{"issue":"192 S","key":"10.1016\/j.mehy.2018.11.009_b0695","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1755-3768.1989.tb07097.x","article-title":"Repair of the corneal epithelial adhesion structures following keratectomy wounds in diabetic rabbits","volume":"67","author":"Azar","year":"1989","journal-title":"Acta Ophthalmol"},{"issue":"9","key":"10.1016\/j.mehy.2018.11.009_b0700","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2337\/dc08-0342","article-title":"Ocular associations of diabetes other than diabetic retinopathy","volume":"31","author":"Jeganathan","year":"2008","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0705","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12020-009-9208-9","article-title":"Influence of insulin treatment on the lacrimal gland and ocular surface of diabetic rats","volume":"36","author":"M\u00f3dulo","year":"2009","journal-title":"Endocrine"},{"issue":"7","key":"10.1016\/j.mehy.2018.11.009_b0710","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1111\/j.1755-3768.2010.01993.x","article-title":"Comorbidities of dry eye disease: a nationwide population-based study","volume":"90","author":"Wang","year":"2012","journal-title":"Acta Ophthalmol"},{"issue":"6","key":"10.1016\/j.mehy.2018.11.009_b0715","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1073\/pnas.75.6.2918","article-title":"Diabetic cataract formation: potential role of glycosylation of lens crystallins","volume":"75","author":"Stevens","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0720","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1136\/bjo.2004.055640","article-title":"Evidence about evidence","volume":"89","author":"Reeves","year":"2005","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0725","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/bjo.84.10.1210","article-title":"Tear secretion and tear function in insulin dependent diabetics","volume":"84","author":"Murat","year":"2000","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"10.1016\/j.mehy.2018.11.009_b0730","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/OPX.0b013e318181a947","article-title":"Long-term incidence of dry eye in an older population","volume":"85","author":"Moss","year":"2008","journal-title":"Optom Vis Sci"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0735","first-page":"1","article-title":"The ocular surface tfos dews ii report executive summary","volume":"15","author":"Craig","year":"2017","journal-title":"TFOS DEWS II Rep Exec Summ"},{"issue":"8","key":"10.1016\/j.mehy.2018.11.009_b0740","first-page":"2537","article-title":"Impact of androgen therapy in Sjogren\u2019s syndrome: hormonal influence on lymphocyte populations and la expression in lacrimal glands of MRL\/Mp-lpr\/lpr Mice","volume":"33","author":"Sato","year":"1992","journal-title":"Invest Ophthalmol"},{"key":"10.1016\/j.mehy.2018.11.009_b0745","doi-asserted-by":"crossref","unstructured":"Rocha FJ, Sato EH, Sullivan BD, Sullivan DA. Comparative efficacy of androgen analogues in suppressing lacrimal gland inflammation in a mouse model (MRLilpr) of sjogren\u2019s syndrome.In: Sullivan DA (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes. Advances in Experimental Medicine and Biology.vol 350. Springer, Boston, MA; 1994:697\u2013700.","DOI":"10.1007\/978-1-4615-2417-5_117"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0750","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.4049\/jimmunol.146.10.3405","article-title":"Endocrine, neural, and immune control of secretory component output by lacrimal gland acinar cells","volume":"146","author":"Kelleher","year":"1991","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0755","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.iy.13.040195.001515","article-title":"Neuroendocrine-immune system interactions and autoimmunity","volume":"13","author":"Wilder","year":"1995","journal-title":"Annu Rev Immunol"},{"issue":"3","key":"10.1016\/j.mehy.2018.11.009_b0760","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.exer.2003.09.003","article-title":"The role of the lacrimal functional unit in the pathophysiology of dry eye","volume":"78","author":"Stern","year":"2004","journal-title":"Exp Eye Res"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0765","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1080\/02713680500514644","article-title":"Sex-related effect on gene expression in the mouse meibomian gland","volume":"31","author":"Richards","year":"2006","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.mehy.2018.11.009_b0770","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5380\/dma.v28i0.31007","article-title":"Meio s\u00e9culo de Primavera silenciosa: um livro que mudou o mundo","volume":"28","author":"Bonzi","year":"2013","journal-title":"Desenvolv e Meio Ambient"},{"issue":"4","key":"10.1016\/j.mehy.2018.11.009_b0775","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1542-0124(12)70177-5","article-title":"The aging lacrimal gland: changes in structure and function","volume":"6","author":"Rocha","year":"2008","journal-title":"Ocul Surf"},{"issue":"8","key":"10.1016\/j.mehy.2018.11.009_b0780","first-page":"893","article-title":"The role of oxidative stress in corneal diseases and injuries","volume":"30","author":"Cejkova","year":"2015","journal-title":"Histol Histopathol"},{"issue":"8","key":"10.1016\/j.mehy.2018.11.009_b0785","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.freeradbiomed.2008.07.021","article-title":"Oxidative stress in diseases of the human cornea","volume":"45","author":"Shoham","year":"2008","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.mehy.2018.11.009_b0790","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0013-9351(03)00062-8","article-title":"Effects of bisphenol A on the metabolisms of active oxygen species in mouse tissues","volume":"93","author":"Kabuto","year":"2003","journal-title":"Environ Res"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0795","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1002\/etc.634","article-title":"Oxidative stress in zebrafish embryos induced by short-term exposure to bisphenol A, nonylphenol, and their mixture","volume":"30","author":"Wu","year":"2011","journal-title":"Environ Toxicol Chem"},{"issue":"10","key":"10.1016\/j.mehy.2018.11.009_b0800","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1167\/iovs.05-0426","article-title":"Androgen control of gene expression in the mouse meibomian gland","volume":"46","author":"Schirra","year":"2005","journal-title":"Investig Opthalmology Vis Sci"},{"issue":"2","key":"10.1016\/j.mehy.2018.11.009_b0805","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.exer.2005.11.026","article-title":"Androgen regulation of lipogenic pathways in the mouse meibomian gland","volume":"83","author":"Schirra","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.mehy.2018.11.009_b0810","first-page":"248","article-title":"Long-term exposure to bisphenol S damages the visual system and reduces the tracking capability of male zebrafish (Danio rerio)","author":"Liu","year":"2017","journal-title":"J Appl Toxicol"},{"issue":"SUPPL. 3","key":"10.1016\/j.mehy.2018.11.009_b0815","first-page":"451","article-title":"Identifying critical windows of exposure for children\u2019s health","volume":"108","author":"Selevan","year":"2000","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.mehy.2018.11.009_b0820","first-page":"573","article-title":"Critical windows of exposure for children\u2019s health: cancer in human epidemiological studies and neoplasms in experimental animal models lucy","volume":"108","author":"Anderson","year":"2000","journal-title":"Environ Heal"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718308818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718308818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:14:56Z","timestamp":1759691696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718308818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":164,"alternative-id":["S0306987718308818"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2018.11.009","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of endocrine disruptors in ocular surface diseases","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2018.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}