{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T16:19:09Z","timestamp":1778257149252,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.mehy.2019.01.019","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T04:31:11Z","timestamp":1548390671000},"page":"31-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Is polycystic ovary syndrome a 20th Century phenomenon?"],"prefix":"10.1016","volume":"124","author":[{"given":"Raymond J.","family":"Rodgers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6271-7803","authenticated-orcid":false,"given":"Larisa","family":"Suturina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daria","family":"Lizneva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Hummitzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen F.","family":"Irving-Rodgers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2019.01.019_b0005","unstructured":"NIH, Evidence-based Methodology Workshop on Polycystic Ovary Syndrome executive summary https:\/\/prevention.nih.gov\/docs\/programs\/pcos\/FinalReport.pdf; 2012."},{"key":"10.1016\/j.mehy.2019.01.019_b0010","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00006254-198202000-00001","article-title":"Morphology and morphogenesis of the Stein-Leventhal ovary and of so-called \u201chyperthecosis\u201d","volume":"37","author":"Hughesdon","year":"1982","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.mehy.2019.01.019_b0015","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.tem.2018.08.005","article-title":"New perspectives on the pathogenesis of PCOS: neuroendocrine origins","volume":"29","author":"Walters","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.mehy.2019.01.019_b0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2019.01.019_b0025","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/cen.12068","article-title":"Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study","volume":"78","author":"Mani","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.mehy.2019.01.019_b0030","doi-asserted-by":"crossref","DOI":"10.1002\/dmrr.3054","article-title":"Polycystic ovary syndrome and the risk of cardiometabolic complications in longitudinal studies","volume":"34","author":"Jacewicz-Swiecka","year":"2018","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.mehy.2019.01.019_b0035","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2019.01.019_b0040","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.fertnstert.2008.06.035","article-title":"The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report","volume":"91","author":"Azziz","year":"2009","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2019.01.019_b0045","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.5694\/mja11.10915","article-title":"Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline","volume":"195","author":"Teede","year":"2011","journal-title":"Med J Aust"},{"key":"10.1016\/j.mehy.2019.01.019_b0050","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2019.01.019_b0055","unstructured":"CC.\u041a. \u041bec\u043do\u0439 and S.K. [Lesnoy, \u0427ac\u0442\u0438\u0447\u043da\u044f pe\u0437e\u043a\u0446\u0438\u044f \u044f\u0438\u0447\u043d\u0438\u043ao\u0432 \u043fp\u0438 o\u043b\u0438\u0433o\u043ce\u043doppee \u0438 a\u043ce\u043doppee. [Partial ovary resection upon oligomenorrhea and amenorrhea.] \u0413\u0438\u043de\u043ao\u043bo\u0433\u0438\u044f \u0438 A\u043ay\u0448epc\u0442\u0432o, [Gynaecology and Obstetrics] 2 (1928), pp. 184\u2013191."},{"key":"10.1016\/j.mehy.2019.01.019_b0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0002-9378(15)30642-6","article-title":"Amenorrhea associated with bilateral polycystic ovaries","volume":"29","author":"Stein","year":"1935","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.mehy.2019.01.019_b0065","article-title":"Laparoscopic drilling by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome","volume":"6","author":"Farquhar","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.mehy.2019.01.019_b0070","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2019.01.019_b0075","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1093\/humrep\/des232","article-title":"Prevalence, phenotype and cardiometabolic risk of polycystic ovary syndrome under different diagnostic criteria","volume":"27","author":"Yildiz","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2019.01.019_b0080","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1479-828X.1994.tb01041.x","article-title":"The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women","volume":"34","author":"Farquhar","year":"1994","journal-title":"Aust New Zealand J Obst Gynaecol"},{"key":"10.1016\/j.mehy.2019.01.019_b0085","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(88)91612-1","article-title":"Polycystic ovaries\u2013a common finding in normal women","volume":"1","author":"Polson","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2019.01.019_b0090","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1055\/s-0032-1304608","article-title":"Age associated differences in prevalence of individual rotterdam criteria and metabolic risk factors during reproductive age in 446 caucasian women with polycystic ovary syndrome","volume":"44","author":"Glintborg","year":"2012","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.mehy.2019.01.019_b0095","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1016\/j.fertnstert.2010.09.032","article-title":"Polycystic ovary syndrome: an ancient disorder?","volume":"95","author":"Azziz","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2019.01.019_b0100","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fertnstert.2016.05.016","article-title":"Evolutionary determinants of polycystic ovary syndrome: part 2","volume":"106","author":"Fessler","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2019.01.019_b0105","first-page":"514","article-title":"A history of the autopsy. A review","volume":"73","author":"King","year":"1973","journal-title":"Am J Pathol"},{"key":"10.1016\/j.mehy.2019.01.019_b0110","series-title":"A manual of pathological anatomy","author":"Rokitansky","year":"1855"},{"key":"10.1016\/j.mehy.2019.01.019_b0115","first-page":"1","article-title":"Regnier de Graaf on the human reproductive organs. An annotated translation of Tractatus de Virorum Organis Generationi Inservientibus (1668) and De Mulierub Organis Generationi Inservientibus Tractatus Novus (1962)","volume":"17","author":"Jocelyn","year":"1972","journal-title":"J Reprod Fertil Suppl"},{"key":"10.1016\/j.mehy.2019.01.019_b0120","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1210\/jc.2005-1494","article-title":"Heritability of polycystic ovary syndrome in a Dutch twin-family study","volume":"91","author":"Vink","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2019.01.019_b0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mce.2012.10.009","article-title":"Genetics of the polycystic ovary syndrome","volume":"373","author":"Kosova","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.mehy.2019.01.019_b0130","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.fertnstert.2016.04.040","article-title":"Genetic determinants of polycystic ovary syndrome: progress and future directions","volume":"106","author":"Jones","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2019.01.019_b0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mce.2013.01.001","article-title":"The Polycystic Ovary Syndrome and recent human evolution","volume":"373","author":"Corbett","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.mehy.2019.01.019_b0140","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1002\/ajhb.20937","article-title":"Type 2 diabetes, cardiovascular disease, and the evolutionary paradox of the polycystic ovary syndrome: a fertility first hypothesis","volume":"21","author":"Corbett","year":"2009","journal-title":"Am J Human Biol"},{"key":"10.1016\/j.mehy.2019.01.019_b0145","doi-asserted-by":"crossref","first-page":"E2412","DOI":"10.1210\/jc.2014-2703","article-title":"The polycystic ovary syndrome evolutionary paradox: a genome-wide association studies-based, in silico, evolutionary explanation","volume":"99","author":"Casarini","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2019.01.019_b0150","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.rbmo.2016.01.011","article-title":"Is polycystic ovary syndrome a sexual conflict? A review","volume":"32","author":"Casarini","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"10.1016\/j.mehy.2019.01.019_b0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fertnstert.2016.05.010","article-title":"Evolutionary determinants of polycystic ovary syndrome: part 1","volume":"106","author":"Unluturk","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2019.01.019_b0160","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrg1426","article-title":"Uncovering cryptic genetic variation","volume":"5","author":"Gibson","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.mehy.2019.01.019_b0165","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/humrep\/des027","article-title":"Birthweight and thinness at birth independently predict symptoms of polycystic ovary syndrome in adulthood","volume":"27","author":"Davies","year":"2012","journal-title":"Hum Reprod"},{"key":"10.1016\/j.mehy.2019.01.019_b0170","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1210\/jc.2005-2757","article-title":"Review: fetal programming of polycystic ovary syndrome by androgen excess: evidence from experimental, clinical, and genetic association studies","volume":"91","author":"Xita","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.mehy.2019.01.019_b0175","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s11154-007-9046-0","article-title":"Polycystic ovary syndrome and its developmental origins","volume":"8","author":"Dumesic","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"key":"10.1016\/j.mehy.2019.01.019_b0180","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1933719113485294","article-title":"The role of TGF-beta in polycystic ovary syndrome","volume":"21","author":"Raja-Khan","year":"2014","journal-title":"Reprod Sci"},{"key":"10.1016\/j.mehy.2019.01.019_b0185","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.fertnstert.2016.08.031","article-title":"Polycystic ovary syndrome and environmental toxins","volume":"106","author":"Rutkowska","year":"2016","journal-title":"Fertil Steril"},{"key":"10.1016\/j.mehy.2019.01.019_b0190","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/ACI.0000000000000209","article-title":"In-utero exposures and the evolving epidemiology of paediatric allergy","volume":"15","author":"Khan","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.mehy.2019.01.019_b0195","first-page":"42","article-title":"Developmental origins of non-communicable disease: implications for research and public health","volume":"11","author":"Barouki","year":"2012","journal-title":"Environ Health Global Access Sci Source"},{"key":"10.1016\/j.mehy.2019.01.019_b0200","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S2040174409990171","article-title":"A conceptual framework for the developmental origins of health and disease","volume":"1","author":"Gluckman","year":"2010","journal-title":"J Develop Origins Health Dis"},{"key":"10.1016\/j.mehy.2019.01.019_b0205","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1210\/me.2016-1086","article-title":"Minireview: epigenomic plasticity and vulnerability to EDC exposures","volume":"30","author":"Walker","year":"2016","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.mehy.2019.01.019_b0210","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaci.2017.05.015","article-title":"An exposome perspective: early-life events and immune development in a changing world","volume":"140","author":"Renz","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.mehy.2019.01.019_b0215","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1467-789X.2012.01053.x","article-title":"The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis","volume":"14","author":"Lim","year":"2013","journal-title":"Obes Rev"},{"key":"10.1016\/j.mehy.2019.01.019_b0220","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/tobaccocontrol-2011-050338","article-title":"The history of the discovery of the cigarette-lung cancer link: evidentiary traditions, corporate denial, global toll","volume":"21","author":"Proctor","year":"2012","journal-title":"Tobacco Control"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718312374?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718312374?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T22:24:18Z","timestamp":1550787858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718312374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":44,"alternative-id":["S0306987718312374"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2019.01.019","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is polycystic ovary syndrome a 20th Century phenomenon?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2019.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}