{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:12:10Z","timestamp":1766268730792,"version":"3.40.5"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.mehy.2019.01.021","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T04:30:56Z","timestamp":1548390656000},"page":"13-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Frontal fibrosing alopecia: A new autoimmune entity?"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-152X","authenticated-orcid":false,"given":"Juan Esteban","family":"Garcia-Robledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian C.","family":"Arag\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Nieto-Aristiz\u00e1bal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"V\u00e1squez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel J.","family":"Tob\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2019.01.021_b0005","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1001\/archderm.1994.01690060100013","article-title":"Postmenopausal frontal fibrosing alopecia: scarring alopecia in a pattern distribution","volume":"130","author":"Kossard","year":"1994","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0010","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jaad.2017.05.045","article-title":"Frontal fibrosing alopecia among men: a clinicopathologic study of 7 cases","volume":"77","author":"Tolkachjov","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0015","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.ad.2016.07.004","article-title":"Frontal Fibrosing alopecia in men: presentations in 12 cases and a review of the literature","volume":"107","author":"Ormaechea-P\u00e9rez","year":"2016","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.mehy.2019.01.021_b0020","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/bjd.14535","article-title":"Frontal fibrosing alopecia: possible association with leave-on facial skin care products and sunscreens; a questionnaire study","volume":"175","author":"Aldoori","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0025","first-page":"992","article-title":"Frontal fibrosing alopecia - review of recent case reports and case series in PubMed","volume":"16","author":"Valesky","year":"2018","journal-title":"JDDG J der Dtsch Dermatologischen Gesellschaft"},{"key":"10.1016\/j.mehy.2019.01.021_b0030","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1365-2133.2012.11101.x","article-title":"Familial frontal fibrosing alopecia","volume":"168","author":"Dlova","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0035","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/bjd.14732","article-title":"Frontal fibrosing alopecia and sunscreens: cause or consequence?","volume":"175","author":"Donati","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0040","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ad.2016.11.012","article-title":"Update on frontal fibrosing alopecia","volume":"108","author":"Esteban-Luc\u00eda","year":"2017","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.mehy.2019.01.021_b0045","first-page":"443","article-title":"Alopecia frontal fibrosante: una enfermedad en auge","volume":"39","author":"de Quintana-Sancho","year":"2016","journal-title":"An Sist Sanit Navar"},{"key":"10.1016\/j.mehy.2019.01.021_b0050","doi-asserted-by":"crossref","first-page":"987.e1","DOI":"10.1016\/j.jaad.2015.08.020","article-title":"Facial lesions in frontal fibrosing alopecia (FFA): clinicopathological features in a series of 12 cases","volume":"73","author":"L\u00f3pez-Pesta\u00f1a","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0055","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.jaad.2011.12.038","article-title":"Frontal fibrosing alopecia: a review of 60 cases","volume":"67","author":"MacDonald","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0060","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0001-7310(07)70144-8","article-title":"Diagnostic and therapeutic assessment of frontal fibrosing alopecia","volume":"98","author":"Moreno-Ram\u00edrez","year":"2007","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.mehy.2019.01.021_b0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ad.2011.01.018","article-title":"Alopecia frontal fibrosante. Hallazgos dermatosc\u00f3picos","volume":"103","author":"Mireles-Rocha","year":"2012","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.mehy.2019.01.021_b0070","first-page":"7310","article-title":"Depression of the frontal veins in frontal fibrosing alopecia","author":"Gonz\u00e1lez-Guerra","year":"2018","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.mehy.2019.01.021_b0075","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1111\/j.1365-2133.2010.09664.x","article-title":"Frontal fibrosing alopecia in two sisters","volume":"162","author":"Junqueira Ribeiro Pereira","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1586\/17469872.3.6.677","article-title":"Hair and nail disorders of childhood","volume":"3","author":"Sotiriadis","year":"2008","journal-title":"Expert Rev Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0085","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1038\/jid.2013.202","article-title":"PPAR\u03b4 inhibits UVB-induced secretion of MMP-1 through MKP-7-mediated suppression of JNK signaling","volume":"133","author":"Ham","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0090","first-page":"163","article-title":"DHEA and frontal fribrosing alopecia: molecular and physiopathological mechanism","volume":"5","author":"Neide Kalil","year":"2010","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsbmb.2013.02.006","article-title":"Steroidogenesis in the skin: implications for local immune functions","volume":"137","author":"Slominski","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.mehy.2019.01.021_b0100","first-page":"56","article-title":"Adverse effects and safety of 5-alpha reductase inhibitors (finasteride, dutasteride): a systematic review","volume":"9","author":"Hirshburg","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0105","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.15464","article-title":"Response to \u2018Frontal fibrosing alopecia in men: an association with facial moisturizers and sunscreens\u2019","volume":"177","author":"Strazzulla","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0110","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/bjd.15311","article-title":"Frontal fibrosing alopecia in men: an association with facial moisturizers and sunscreens","volume":"177","author":"Debroy Kidambi","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0115","article-title":"Introducing polyautoimmunity: secondary autoimmune diseases no longer exist","volume":"1","author":"Rojas-Villarraga","year":"2012","journal-title":"Autoimmune Dis"},{"key":"10.1016\/j.mehy.2019.01.021_b0120","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1590\/abd1806-4841.20186992","article-title":"Case report Coexistence of chronic cutaneous lupus erythematosus and frontal fibrosing alopecia","volume":"96","author":"Lima Do Nascimento","year":"2018","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0125","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1590\/abd1806-4841.20164526","article-title":"CAse report Frontal fibrosing alopecia in association with Sj\u00f6gren\u2019s syndrome: more than a simple coincidence","volume":"91","author":"Colossi Furlan","year":"2016","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/jdv.12642","article-title":"Coexistence of frontal fibrosing alopecia and discoid lupus erythematosus of the scalp in 7 patients: just a coincidence?","volume":"30","author":"del Rei","year":"2016","journal-title":"J Eur Acad Dermatology Venereol"},{"key":"10.1016\/j.mehy.2019.01.021_b0135","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1346-8138.2008.00555.x","article-title":"Postmenopausal frontal fibrosing alopecia in a Japanese woman with Sj\u00f6gren\u2019s syndrome","volume":"35","author":"Sato","year":"2008","journal-title":"J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000452449","article-title":"Frontal fibrosing alopecia and vitiligo: coexistence or true association?","volume":"2","author":"Katoulis","year":"2016","journal-title":"Ski Appendage Disord"},{"key":"10.1016\/j.mehy.2019.01.021_b0145","first-page":"229","article-title":"Lichen planopilaris: Epidemiologie und pr\u00e4valenz seiner subtypen - eine retrospektive analyse an 104 patienten","volume":"12","author":"Meinhard","year":"2014","journal-title":"JDDG - J Ger Soc Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaad.2004.05.014","article-title":"Frontal fibrosing alopecia in postmenopausal women","volume":"52","author":"Tosti","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaad.2003.04.001","article-title":"Primary cicatricial alopecias: clinicopathology of 112 cases","volume":"50","author":"Tan","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0160","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1067\/mjd.2003.68","article-title":"Summary of North American Hair Research Society (NAHRS) - sponsored workshop on cicatricial alopecia, Duke University Medical Center, February 10 and 11, 2001","volume":"48","author":"Olsen","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0190-9622(97)70326-8","article-title":"Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris","volume":"36","author":"Kossard","year":"1997","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0170","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1365-4632.2006.02507.x","article-title":"Frontal fibrosing alopecia versus lichen planopilaris: a clinicopathological study","volume":"45","author":"Poblet","year":"2006","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0175","first-page":"118","article-title":"Lichen planopilaris: Epidemiologie und pr\u00e4valenz seiner subtypen - eine retrospektive analyse an 104 patienten","volume":"12","author":"Meinhard","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0180","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/joim.12395","article-title":"Human autoimmune diseases: a comprehensive update","volume":"278","author":"Wang","year":"2015","journal-title":"J Intern Med"},{"key":"10.1016\/j.mehy.2019.01.021_b0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5530\/jyp.2017.9.4","article-title":"Autoimmune disorders-immunopathogenesis and potential therapies","volume":"9","author":"Ganapathy","year":"2017","journal-title":"J Young Pharm"},{"key":"10.1016\/j.mehy.2019.01.021_b0190","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Epidemiology and estimated population burden of selected autoimmune diseases in the United States","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.mehy.2019.01.021_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2007.05.002","article-title":"Epidemiology of autoimmune diseases in Denmark","volume":"29","author":"Eaton","year":"2007","journal-title":"J Autoimmun"},{"key":"10.1016\/j.mehy.2019.01.021_b0200","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1172\/JCI200114235","article-title":"Mechanisms for the induction of autoimmunity by infectious agents","volume":"108","author":"Wucherpfennig","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2019.01.021_b0205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/icb.1997.16","article-title":"Molecular mimicry: can epitope mimicry induce autoimmune disease?","volume":"75","author":"Davies","year":"1997","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.mehy.2019.01.021_b0210","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1001\/jama.1957.02980130015004","article-title":"Chronic thyroiditis and autoimmunization","volume":"164","author":"Witebsky","year":"1957","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.mehy.2019.01.021_b0215","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/0167-5699(93)90244-F","article-title":"Defining criteria for autoimmune diseases (Witebsky\u2019s postulates revisited)","volume":"14","author":"Rose","year":"1993","journal-title":"Immunol Today"},{"key":"10.1016\/j.mehy.2019.01.021_b0220","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.autrev.2012.02.001","article-title":"Updated assessment of the prevalence, spectrum and case definition of autoimmune disease","volume":"11","author":"Hayter","year":"2012","journal-title":"Autoimmun Rev"},{"issue":"3","key":"10.1016\/j.mehy.2019.01.021_b0225","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jbspin.2016.11.012","article-title":"The autoimmune tautology. A summary of evidence","volume":"84","author":"Anaya","year":"2017","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.mehy.2019.01.021_b0230","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.jaad.2017.01.001","article-title":"Hypopigmentation in frontal fibrosing alopecia","volume":"76","author":"Lin","year":"2017","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0235","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1111\/ijd.14021","article-title":"Frontal fibrosing alopecia: is the melanocyte of the upper hair follicle the antigenic target?","volume":"57","author":"Katoulis","year":"2018","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0240","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jaad.2009.01.017","article-title":"Melanocytes: a possible autoimmune target in alopecia areata","volume":"61","author":"Trautman","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.23528.x","article-title":"Hair follicle pigmentation","volume":"124","author":"Slominski","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0250","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1007\/s10067-016-3330-x","article-title":"Hypogonadism and the risk of rheumatic autoimmune disease","volume":"35","author":"Baillargeon","year":"2016","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.mehy.2019.01.021_b0255","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1590\/S0104-42302010000500021","article-title":"Female androgen deficiency","volume":"56","author":"Fonseca","year":"2010","journal-title":"Rev Assoc Med Bras"},{"key":"10.1016\/j.mehy.2019.01.021_b0260","doi-asserted-by":"crossref","DOI":"10.4161\/21624011.2014.954968","article-title":"New insights into androgenic immune regulation","volume":"3","author":"Arredouani","year":"2014","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.mehy.2019.01.021_b0265","doi-asserted-by":"crossref","first-page":"314","DOI":"10.5582\/irdr.2016.01065","article-title":"Frontal fibrosing alopecia treatment options","volume":"5","author":"Fertig","year":"2016","journal-title":"Intractable Rare Dis Res"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718312039?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718312039?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T22:27:44Z","timestamp":1550788064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718312039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":53,"alternative-id":["S0306987718312039"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2019.01.021","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frontal fibrosing alopecia: A new autoimmune entity?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2019.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}