{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T21:38:09Z","timestamp":1774388289340,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.mehy.2019.02.041","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T07:23:22Z","timestamp":1550561002000},"page":"90-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Migraine associated with gastrointestinal disorders: A pathophysiological explanation"],"prefix":"10.1016","volume":"125","author":[{"given":"Majid","family":"Talafi Noghani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Namdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.mehy.2019.02.041_b0005","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1468-2982.2007.01288.x","article-title":"The global burden of headache: a documentation of headache prevalence and disability worldwide","volume":"27","author":"Stovner","year":"2007","journal-title":"Cephalalgia"},{"issue":"10100","key":"10.1016\/j.mehy.2019.02.041_b0010","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"Vos","year":"2016","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.mehy.2019.02.041_b0015","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1526-4610.2011.01945.x","article-title":"Cost of health care among patients with chronic and episodic migraine in canada and the USA: results from the international burden of migraine study (IBMS). Headache","volume":"51","author":"Stokes","year":"2011","journal-title":"J Head Face Pain"},{"issue":"5","key":"10.1016\/j.mehy.2019.02.041_b0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10194-012-0460-7","article-title":"Cost of healthcare for patients with migraine in five European countries: results from the International Burden of Migraine Study (IBMS)","volume":"13","author":"Bloudek","year":"2012","journal-title":"J Headache Pain"},{"key":"10.1016\/j.mehy.2019.02.041_b0025","article-title":"In commemorating one thousandth anniversary of the Avicenna's Canon of Medicine: gastric headache, a forgotten clinical entity from the medieval Persia","volume":"5","author":"Fazljou","year":"2013","journal-title":"Acta Med Iran"},{"key":"10.1016\/j.mehy.2019.02.041_b0030","doi-asserted-by":"crossref","unstructured":"The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629-808.","DOI":"10.1177\/0333102413485658"},{"issue":"4","key":"10.1016\/j.mehy.2019.02.041_b0035","first-page":"171","article-title":"Gastrointestinal headache; a narrative review","volume":"4","author":"Noghani","year":"2016","journal-title":"Emergency"},{"issue":"7","key":"10.1016\/j.mehy.2019.02.041_b0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11916-015-0501-4","article-title":"What the gut can teach us about migraine","volume":"19","author":"Hindiyeh","year":"2015","journal-title":"Curr. Pain Headache Rep."},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S2468-1253(16)30038-3","article-title":"Association between functional gastrointestinal disorders and migraine in children and adolescents: a case-control study","volume":"1","author":"Le Gal","year":"2016","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.mehy.2019.02.041_b0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10072-017-3141-0","article-title":"Comorbidity of gastrointestinal disorders, migraine, and tension-type headache: a cross-sectional study in Iran","volume":"39","author":"Martami","year":"2017","journal-title":"Neurol Sci"},{"key":"10.1016\/j.mehy.2019.02.041_b0055","series-title":"The Headaches","first-page":"1","article-title":"History of the headache","author":"Isler","year":"2006"},{"issue":"5","key":"10.1016\/j.mehy.2019.02.041_b0060","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1097\/00000441-191505000-00002","article-title":"Gastric headaches (1827-1924)","volume":"149","author":"Cheney","year":"1915","journal-title":"Am J Med Sci"},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0065","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1152\/physrev.00034.2015","article-title":"Pathophysiology of migraine: a disorder of sensory processing","volume":"97","author":"Goadsby","year":"2017","journal-title":"Physiol Rev"},{"issue":"9","key":"10.1016\/j.mehy.2019.02.041_b0070","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0024-3205(90)90129-F","article-title":"Mast cells: the immune gate to the brain","volume":"46","author":"Theoharides","year":"1990","journal-title":"Life Sci"},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0006-8993(03)02975-5","article-title":"Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice","volume":"980","author":"Kandere-Grzybowska","year":"2003","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.mehy.2019.02.041_b0080","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0006-8993(00)03026-2","article-title":"Acute stress increases permeability of the blood\u2013brain-barrier through activation of brain mast cells","volume":"888","author":"Esposito","year":"2001","journal-title":"Brain Res"},{"issue":"11","key":"10.1016\/j.mehy.2019.02.041_b0085","first-page":"1475","article-title":"Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine","volume":"6","author":"Lassen","year":"1995","journal-title":"Neuro Rep"},{"issue":"5","key":"10.1016\/j.mehy.2019.02.041_b0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1468-2982.2001.00196.x","article-title":"Migraine and function of the immune system: a meta-analysis of clinical literature published between 1966 and 1999","volume":"21","author":"Kemper","year":"2001","journal-title":"Cephalalgia"},{"issue":"12","key":"10.1016\/j.mehy.2019.02.041_b0095","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1365-2222.1993.tb00287.x","article-title":"Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronical headaches","volume":"23","author":"Wantke","year":"1993","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"10.1016\/j.mehy.2019.02.041_b0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/gutjnl-2015-309151","article-title":"The role of mast cells in functional GI disorders","volume":"65","author":"Wouters","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.mehy.2019.02.041_b0105","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.trsl.2016.04.009","article-title":"Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets","volume":"176","author":"Yadav","year":"2016","journal-title":"Transl Res"},{"issue":"1","key":"10.1016\/j.mehy.2019.02.041_b0110","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","article-title":"Integration of genetic and immunological insights into a model of celiac disease pathogenesis","volume":"29","author":"Abadie","year":"2011","journal-title":"Annu Rev Immunol"},{"issue":"8","key":"10.1016\/j.mehy.2019.02.041_b0115","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nrn3071","article-title":"Gut feelings: the emerging biology of gut\u2013brain communication","volume":"12","author":"Mayer","year":"2011","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"10.1016\/j.mehy.2019.02.041_b0120","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1053\/j.gastro.2006.10.026","article-title":"Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders","volume":"131","author":"Mayer","year":"2006","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.mehy.2019.02.041_b0125","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0301-0511(95)05145-7","article-title":"Neurobiology of visceral afferent neurons: neuroanatomy, functions, organ regulations and sensations","volume":"42","author":"J\u00e4nig","year":"1996","journal-title":"Biol Psychol"},{"issue":"1","key":"10.1016\/j.mehy.2019.02.041_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2003.10.041","article-title":"Critical role of mast cells in inflammatory diseases and the effect of acute stress","volume":"146","author":"Theoharides","year":"2004","journal-title":"J Neuroimmunol"},{"issue":"5","key":"10.1016\/j.mehy.2019.02.041_b0135","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1053\/S1542-3565(03)00184-8","article-title":"Gastric mucosal mast cells are increased in Helicobacter pylori-negative functional dyspepsia","volume":"1","author":"Hall","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nri2018","article-title":"Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data","volume":"7","author":"Bischoff","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.mehy.2019.02.041_b0145","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1007\/s10620-008-0207-0","article-title":"Antral inflammatory cells, gastric emptying, and electrogastrography in pediatric functional dyspepsia","volume":"53","author":"Friesen","year":"2008","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.mehy.2019.02.041_b0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/MPG.0b013e3181d1363c","article-title":"Symptoms and subtypes in pediatric functional dyspepsia: relation to mucosal inflammation and psychological functioning","volume":"51","author":"Schurman","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"5","key":"10.1016\/j.mehy.2019.02.041_b0155","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/0333102412472070","article-title":"Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia","volume":"33","author":"Yeom","year":"2013","journal-title":"Cephalalgia"},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0160","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/gutjnl-2012-303857","article-title":"Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia","volume":"63","author":"Vanheel","year":"2014","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0165","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.anndiagpath.2015.02.001","article-title":"Quantitative evaluation of duodenal eosinophils and mast cells in adult patients with functional dyspepsia","volume":"19","author":"Wang","year":"2015","journal-title":"Ann Diagn Pathol"},{"issue":"3","key":"10.1016\/j.mehy.2019.02.041_b0170","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0016-5085(89)90627-6","article-title":"Mast cells are closely apposed to nerves in the human gastrointestinal mucosa","volume":"97","author":"Stead","year":"1989","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.mehy.2019.02.041_b0175","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cne.901840303","article-title":"An autoradiographic examination of the central distribution of the trigeminal, facial, glossopharyngeal, and vagal nerves in the monkey","volume":"184","author":"Beckstead","year":"1979","journal-title":"J Comp Neurol"},{"issue":"3","key":"10.1016\/j.mehy.2019.02.041_b0180","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/cne.902550310","article-title":"Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation","volume":"255","author":"Menetrey","year":"1987","journal-title":"J Compar Neurol"},{"issue":"3","key":"10.1016\/j.mehy.2019.02.041_b0185","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/cne.903030313","article-title":"Trigeminal primary afferent projections to \u201cnon-trigeminal\u201d areas of the rat central nervous system","volume":"303","author":"Marfurt","year":"1991","journal-title":"J Compar Neurol"},{"issue":"17","key":"10.1016\/j.mehy.2019.02.041_b0190","doi-asserted-by":"crossref","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","article-title":"Migraine: multiple processes, complex pathophysiology","volume":"35","author":"Burstein","year":"2015","journal-title":"J Neurosci"},{"issue":"4","key":"10.1016\/j.mehy.2019.02.041_b0195","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.mehy.2009.05.047","article-title":"Headache associated with visceral disorders is \u201cparasympathetic referred pain\u201d","volume":"73","author":"Han","year":"2009","journal-title":"Med Hypotheses"},{"issue":"12","key":"10.1016\/j.mehy.2019.02.041_b0200","doi-asserted-by":"crossref","first-page":"5745","DOI":"10.1210\/endo.136.12.7588332","article-title":"Stress-induced intracranial mast cell degranulation: a corticotropin-releasing hormone-mediated effect","volume":"136","author":"Theoharides","year":"1995","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.mehy.2019.02.041_b0205","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00004714-200204000-00001","article-title":"Mast cells and stress\u2014A psychoneuroimmunological perspective","volume":"22","author":"Theoharides","year":"2002","journal-title":"J Clin Psychopharmacol"},{"key":"10.1016\/j.mehy.2019.02.041_b0210","article-title":"Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism","author":"Vanuytsel","year":"2013","journal-title":"Gut"},{"issue":"15","key":"10.1016\/j.mehy.2019.02.041_b0215","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1177\/0333102411421683","article-title":"Primary headache syndromes in systemic mastocytosis","volume":"31","author":"Smith","year":"2011","journal-title":"Cephalalgia"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718311265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718311265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T02:31:23Z","timestamp":1662949883000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718311265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":43,"alternative-id":["S0306987718311265"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2019.02.041","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Migraine associated with gastrointestinal disorders: A pathophysiological explanation","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2019.02.041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}