{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:58:40Z","timestamp":1773921520358,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.mehy.2019.109260","type":"journal-article","created":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T11:15:42Z","timestamp":1560510942000},"page":"109260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit"],"prefix":"10.1016","volume":"130","author":[{"given":"Victoria J. Berdikova","family":"Bohne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8yvind","family":"Bohne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2019.109260_b0005","series-title":"Beyoung Myalgic Enchephalomyelitis\/chronic Fatigue Syndrome: Redefining an illness","author":"Committee on Diagnostic Criteria for Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","year":"2015"},{"key":"10.1016\/j.mehy.2019.109260_b0010","article-title":"Metabolic features and regulation of the healing cycle \u2013 a new model for chronic disease pathogenesis and treatment","author":"Naviaux","year":"2018","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mehy.2019.109260_b0015","first-page":"1","article-title":"Metabolic features of chronic fatigue syndrome","volume":"114","author":"Naviaux","year":"2016","journal-title":"PNAS PLUS"},{"key":"10.1016\/j.mehy.2019.109260_b0020","first-page":"1","article-title":"Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles","volume":"6","author":"Yamano","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.mehy.2019.109260_b0025","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1007\/s11306-015-0816-5","article-title":"Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients","volume":"11","author":"Armstrong","year":"2015","journal-title":"Metabolomics"},{"key":"10.1016\/j.mehy.2019.109260_b0030","article-title":"Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy\/chronic fatigue syndrome","volume":"1","author":"Fluge","year":"2016","journal-title":"ICI Insight"},{"key":"10.1016\/j.mehy.2019.109260_b0035","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.2772","article-title":"Increased ventricular lactate in chronic fatigue syndrome. III. Relationship to cortical glutathione and clinical symptoms implicate oxidative stress in disorder pathology","author":"Shungu","year":"2012","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mehy.2019.109260_b0040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/nbm.1512","article-title":"Increased ventricular lactate in chronic fatigue syndrome measured by 1H MRS imaging at 3.0 T. II: comparison with major depressive disorder","volume":"23","author":"Murrough","year":"2010","journal-title":"NMR Biomed"},{"key":"10.1016\/j.mehy.2019.109260_b0045","first-page":"15","article-title":"Elevations of ventricular lactate levels occur in both chronic fatigue syndrome and fybromyalgia","volume":"5","author":"Natelson","year":"2017","journal-title":"Fatigue"},{"key":"10.1016\/j.mehy.2019.109260_b0050","first-page":"104","article-title":"Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains","volume":"16","author":"Yu","year":"2008","journal-title":"Cell Press"},{"key":"10.1016\/j.mehy.2019.109260_b0055","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jtbi.2006.07.019","article-title":"A simplified model for mitochondrial ATP production","volume":"243","author":"Bertram","year":"2006","journal-title":"J Theor Biol"},{"key":"10.1016\/j.mehy.2019.109260_b0060","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J Physiol"},{"key":"10.1016\/j.mehy.2019.109260_b0065","doi-asserted-by":"crossref","first-page":"25309","DOI":"10.1074\/jbc.M113.476648","article-title":"Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria","volume":"288","author":"Elustondo","year":"2013","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2019.109260_b0070","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1172\/JCI110682","article-title":"Treatment of lactic acidosis with dichloroacetate in dogs","volume":"70","author":"Park","year":"1982","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2019.109260_b0075","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijscr.2014.09.026","article-title":"Temporary hyperlactataemia during partial hepatectomy: report of two cases","volume":"6","author":"Zou","year":"2015","journal-title":"Intern J Surg Case Rep"},{"key":"10.1016\/j.mehy.2019.109260_b0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1300\/J092v11n01_02","article-title":"Myalgic encephalomyelitis\/chronic fatigue syndrome: clinical working case definition, diagnostic and treatment protocols","volume":"11","author":"Carruthers","year":"2003","journal-title":"J Chronic Fatigue Syndr"},{"key":"10.1016\/j.mehy.2019.109260_b0085","first-page":"11064","article-title":"A prospective, proof-of-concept investigation of KPAX002 in chronic fatigue syndrome","volume":"8","author":"Kaiser","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.mehy.2019.109260_b0090","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ijcard.2008.04.051","article-title":"Increased oxidative stress suggested by low serum vitamin E concentrations in patients with chronic fatigue syndrome","volume":"136","author":"Miwa","year":"2009","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.mehy.2019.109260_b0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0306-3623(96)00474-0","article-title":"The pharmacology of the antioxidant lipoic acid","volume":"29","author":"Biewenga","year":"1997","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.mehy.2019.109260_b0100","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0021-9258(18)98146-9","article-title":"Lactatic dehydrogenase: V. Inhibition by oxamate and by oxalate","volume":"234","author":"Novoa","year":"1959","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2019.109260_b0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mehy.2018.03.002","article-title":"Treating patients suffering from myalgic encephalopathy\/chronic fatigue syndrome (ME\/CFS) with sodium dichloroacetate: an open-label, proff-off-principle pilot trial","volume":"114","author":"Comhaire","year":"2018","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2019.109260_b0110","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2497348","article-title":"Understanding muscle dysfunction in chronic fatigue syndrome","author":"Rutherford","year":"2016","journal-title":"J Aging Res"},{"key":"10.1016\/j.mehy.2019.109260_b0115","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1365-2796.2009.02160.x","article-title":"Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome","volume":"267","author":"Jones","year":"2010","journal-title":"J Internal Med"},{"key":"10.1016\/j.mehy.2019.109260_b0120","article-title":"The issue of HPLC determination of endogenous lipoic acid in human plasma","author":"Sechovcova","year":"2017","journal-title":"Biomed Chrom"},{"key":"10.1016\/j.mehy.2019.109260_b0125","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s10545-010-9169-4","article-title":"Dihydrolipoamide dehydrogenase (DLD) deficiency in a Spanish patient with myopathic presentation due to a new mutation in the interface domain","volume":"33","author":"Quintana","year":"2010","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.mehy.2019.109260_b0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/(SICI)1096-8628(19990115)82:2<177::AID-AJMG15>3.0.CO;2-9","article-title":"Molecular basis of lipoamide dehydrogenase deficiency in Ashkenazi Jews","volume":"82","author":"Shaag","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.mehy.2019.109260_b0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mito.2014.09.006","article-title":"Riboflavin responsive mitochondrial myopathy is a new phenotype of dihydrolipoamide dehydrogenase deficiency. The chaperon-like effect of vitamin B2","volume":"18","author":"Carrozzo","year":"2014","journal-title":"Mitochondrion"},{"key":"10.1016\/j.mehy.2019.109260_b0140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2110-5820-3-12","article-title":"Clinical use of lactate monitoring in critically ill patients","volume":"3","author":"Bakker","year":"2013","journal-title":"Ann Intensive Care"},{"key":"10.1016\/j.mehy.2019.109260_b0145","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.mayocp.2013.06.012","article-title":"Etiology and therapeutic approach to elevated lactate","volume":"88","author":"Andersen","year":"2013","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.mehy.2019.109260_b0150","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/brain\/awl383","article-title":"Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations","volume":"130","author":"Ostergaard","year":"2017","journal-title":"Brain"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718312994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987718312994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:17:09Z","timestamp":1759691829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987718312994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":30,"alternative-id":["S0306987718312994"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2019.109260","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suggested pathology of systemic exertion intolerance disease: Impairment of the E3 subunit or crossover of swinging arms of the E2 subunit of the pyruvate dehydrogenase complex decreases regeneration of cofactor dihydrolipoic acid of the E2 subunit","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2019.109260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109260"}}