{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:40:54Z","timestamp":1759693254961,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.mehy.2019.109322","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T11:16:12Z","timestamp":1563794172000},"page":"109322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Can intravesical application of paracetamol benefit the chemotherapy treatment of bladder cancer?"],"prefix":"10.1016","volume":"131","author":[{"given":"Ersoy","family":"\u00d6ks\u00fcz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammet Serdar","family":"Bu\u011fday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2019.109322_b0005","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.2147\/DDDT.S164704","article-title":"Gemcitabine hydrochloride microspheres used for intravesical treatment of superficial bladder cancer: a comprehensive in vitro\/ex vivo\/in vivo evaluation","volume":"12","author":"Karavana","year":"2018","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"10.1016\/j.mehy.2019.109322_b0010","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1186\/s12885-017-3778-3","article-title":"An orthotopic xenograft model for high-risk non-muscle invasive bladder cancer in mice: influence of mouse strain, tumor cell count, dwell time and bladder pretreatment","volume":"17","author":"Huebner","year":"2017","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.mehy.2019.109322_b0015","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1158\/1078-0432.CCR-17-2066","article-title":"Dual inhibition of PIK3C3 and FGFR as a new therapeutic approach to treat bladder cancer","volume":"24","author":"Chen","year":"2018","journal-title":"Clin Cancer Res"},{"issue":"1","key":"10.1016\/j.mehy.2019.109322_b0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s002400000149","article-title":"Interferon-alpha inhibits cyclooxygenase-1 and stimulates cyclooxygenase-2 expression in bladder cancer cells in vitro","volume":"29","author":"Bostrom","year":"2001","journal-title":"Urol Res"},{"issue":"12","key":"10.1016\/j.mehy.2019.109322_b0025","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1096\/fasebj.12.12.1063","article-title":"Cyclooxygenase in biology and disease","volume":"12","author":"Dubois","year":"1998","journal-title":"FASEB J"},{"key":"10.1016\/j.mehy.2019.109322_b0030","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/215158","article-title":"The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies","volume":"2010","author":"Sobolewski","year":"2010","journal-title":"Int J Cell Biol"},{"issue":"2","key":"10.1016\/j.mehy.2019.109322_b0035","first-page":"362","article-title":"Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells","volume":"58","author":"Sheng","year":"1998","journal-title":"Cancer Res"},{"issue":"12","key":"10.1016\/j.mehy.2019.109322_b0040","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1111\/j.1440-1746.2006.04366.x","article-title":"Specific COX-2 inhibitor, meloxicam, suppresses proliferation and induces apoptosis in human HepG2 hepatocellular carcinoma cells","volume":"21","author":"Li","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.mehy.2019.109322_b0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.phrs.2016.02.020","article-title":"Acetaminophen from liver to brain: new insights into drug pharmacological action and toxicity","volume":"109","author":"Ghanem","year":"2016","journal-title":"Pharmacol Res"},{"issue":"11","key":"10.1016\/j.mehy.2019.109322_b0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050160","article-title":"Acetaminophen induces human neuroblastoma cell death through NFKB activation","volume":"7","author":"Posadas","year":"2012","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.mehy.2019.109322_b0055","first-page":"460","article-title":"Acetaminophen and DMSO modulate growth and gemcitabine cytotoxicity in FM3A breast cancer cells in vitro","volume":"51","author":"Bilir","year":"2004","journal-title":"Neoplasma"},{"issue":"12","key":"10.1016\/j.mehy.2019.109322_b0060","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/aje\/kwh153","article-title":"Case-control study of use of nonsteroidal antiinflammatory drugs and glioblastoma multiforme","volume":"159","author":"Sivak-Sears","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.mehy.2019.109322_b0065","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.eururo.2016.05.041","article-title":"EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016","volume":"71","author":"Babjuk","year":"2017","journal-title":"Euro Urol"},{"issue":"6","key":"10.1016\/j.mehy.2019.109322_b0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.biopha.2007.05.004","article-title":"Thirty years of BCG immunotherapy for non-muscle invasive bladder cancer: a success story with room for improvement","volume":"61","author":"Brandau","year":"2007","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.mehy.2019.109322_b0075","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2217\/1750743X.1.2.281","article-title":"Bacillus Calmette-Guerin immunotherapy for urothelial carcinoma of the bladder","volume":"1","author":"Kresowik","year":"2009","journal-title":"Immunotherapy"},{"key":"10.1016\/j.mehy.2019.109322_b0080","doi-asserted-by":"crossref","first-page":"9634902","DOI":"10.1155\/2018\/9634902","article-title":"Curcumin as treatment for bladder cancer: a preclinical study of cyclodextrin-curcumin complex and BCG as intravesical treatment in an orthotopic bladder cancer rat model","volume":"2018","author":"Falke","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.mehy.2019.109322_b0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.tice.2018.03.011","article-title":"Effects of intravesical therapy with platelet-rich plasma (PRP) and Bacillus Calmette-Guerin (BCG) in non-muscle invasive bladder cancer","volume":"52","author":"Dias","year":"2018","journal-title":"Tissue and Cell"},{"issue":"8","key":"10.1016\/j.mehy.2019.109322_b0090","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.7314\/APJCP.2013.14.8.4539","article-title":"Cyclooxygenase-2 expression in urinary bladder transitional cell carcinoma and its association with clinicopathological characteristics","volume":"14","author":"Tabriz","year":"2013","journal-title":"Asian Pac J Cancer Prev"},{"issue":"6","key":"10.1016\/j.mehy.2019.109322_b0095","first-page":"952","article-title":"Prostaglandin receptors EP1-4 as a potential marker for clinical outcome in urothelial bladder cancer","volume":"4","author":"von der Emde","year":"2014","journal-title":"Am J Cancer Res"},{"issue":"6","key":"10.1016\/j.mehy.2019.109322_b0100","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/1756287215599695","article-title":"Celecoxib for the prevention of nonmuscle invasive bladder cancer: results from a matched control study","volume":"7","author":"Pagliarulo","year":"2015","journal-title":"Ther Adv Urol"},{"issue":"10","key":"10.1016\/j.mehy.2019.109322_b0105","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1158\/1940-6207.CAPR-11-0409","article-title":"Boxing bladder cancer with COX-2-specific inhibition","volume":"4","author":"Kelly","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"issue":"1","key":"10.1016\/j.mehy.2019.109322_b0110","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/ijc.27590","article-title":"Nonsteroidal anti-inflammatory drugs and other analgesic use and bladder cancer in northern New England","volume":"132","author":"Baris","year":"2013","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.mehy.2019.109322_b0115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1158\/1940-6207.CAPR-13-0288","article-title":"Naproxen induces cell-cycle arrest and apoptosis in human urinary bladder cancer cell lines and chemically induced cancers by targeting PI3K","volume":"7","author":"Kim","year":"2014","journal-title":"Cancer Prev Res (Phila)"},{"issue":"12","key":"10.1016\/j.mehy.2019.109322_b0120","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1096\/fj.01-0390rev","article-title":"Cyclooxygenase-independent actions of cyclooxygenase inhibitors","volume":"15","author":"Tegeder","year":"2001","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.mehy.2019.109322_b0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4161\/cbt.3.1.571","article-title":"Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines","volume":"3","author":"Kardosh","year":"2004","journal-title":"Cancer Biol Ther"},{"issue":"23","key":"10.1016\/j.mehy.2019.109322_b0130","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1016\/j.bmcl.2005.08.063","article-title":"Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: new lead compounds for the development of anticancer agents","volume":"15","author":"Gobec","year":"2005","journal-title":"Bioorg Med Chem Lett"},{"issue":"3","key":"10.1016\/j.mehy.2019.109322_b0135","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0026-895X(25)14551-3","article-title":"Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine","volume":"18","author":"Corcoran","year":"1980","journal-title":"Mol Pharmacol"},{"issue":"8","key":"10.1016\/j.mehy.2019.109322_b0140","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1016\/S0021-9258(19)67754-9","article-title":"Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes","volume":"266","author":"Burcham","year":"1991","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.mehy.2019.109322_b0145","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ejphar.2006.01.008","article-title":"Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines","volume":"532","author":"Bernardi","year":"2006","journal-title":"Euro J Pharmacol"},{"issue":"2","key":"10.1016\/j.mehy.2019.109322_b0150","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3892\/ijmm.2015.2254","article-title":"Acetaminophen induces JNK\/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells","volume":"36","author":"Yiang","year":"2015","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.mehy.2019.109322_b0155","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1742-7843.2004.pto_940105.x","article-title":"Mechanism of acetaminophen-induced apoptosis in cultured cells: roles of caspase-3, DNA fragmentation factor, and the Ca2+ and Mg2+ endonuclease DNAS1L3","volume":"94","author":"Boulares","year":"2004","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"10.1016\/j.mehy.2019.109322_b0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5505\/ejm.2019.16362","article-title":"Effect of acetaminophen on viability of HeLa cells","volume":"24","author":"G\u00f6rgi\u015fen","year":"2019","journal-title":"East J Med"},{"issue":"2","key":"10.1016\/j.mehy.2019.109322_b0165","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11060-015-1976-x","article-title":"Therapeutic potential of cyclooxygenase-3 inhibitors in the management of glioblastoma","volume":"126","author":"Oksuz","year":"2016","journal-title":"J Neuro-oncol"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987719304359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987719304359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:18:02Z","timestamp":1759691882000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987719304359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":33,"alternative-id":["S0306987719304359"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2019.109322","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Can intravesical application of paracetamol benefit the chemotherapy treatment of bladder cancer?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2019.109322","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109322"}}