{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:23:05Z","timestamp":1759710185087,"version":"build-2065373602"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971319","81571366"],"award-info":[{"award-number":["81971319","81571366"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.mehy.2019.109427","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T13:32:52Z","timestamp":1570714372000},"page":"109427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Moderate osteoporosis itself is beneficial for bones"],"prefix":"10.1016","volume":"134","author":[{"given":"Zhonghua","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.mehy.2019.109427_b0005","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1177\/0022034515572021","article-title":"Infection and medication-related osteonecrosis of the jaw","volume":"94","author":"Katsarelis","year":"2015","journal-title":"J Dent Res"},{"issue":"9","key":"10.1016\/j.mehy.2019.109427_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092213","article-title":"Medical treatment for osteoporosis: from molecular to clinical opinions","volume":"20","author":"Chen","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2019","key":"10.1016\/j.mehy.2019.109427_b0015","first-page":"9271595","article-title":"Study on the dynamic biological characteristics of human bone marrow mesenchymal stem cell senescence","volume":"4","author":"Chen","year":"2019","journal-title":"Stem Cells Int"},{"issue":"3","key":"10.1016\/j.mehy.2019.109427_b0020","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00223-019-00572-7","article-title":"Increased cellular presence after sciatic neurectomy improves the bone mechano-adaptive response in aged mice","volume":"105","author":"Piet","year":"2019","journal-title":"Calcif Tissue Int"},{"issue":"4","key":"10.1016\/j.mehy.2019.109427_b0025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.5125\/jkaoms.2018.44.4.174","article-title":"Prognostic factors for outcome of surgical treatment in medication-related osteonecrosis of the jaw","volume":"44","author":"Shin","year":"2018","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"issue":"3","key":"10.1016\/j.mehy.2019.109427_b0030","first-page":"e282","article-title":"Changes in dimension of neurovascular canals in the mandible and maxilla: A radiographic finding in patients diagnosed with MRONJ","volume":"23","author":"Goller-Bulut","year":"2018","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"8","key":"10.1016\/j.mehy.2019.109427_b0035","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.14219\/jada.archive.2006.0355","article-title":"Dental management of patients receiving oralbisphosphonate therapy: expert panel recommendations","volume":"137","author":"American Dental Association Council on Scientific Affairs","year":"2006","journal-title":"J Am Dent Assoc"},{"issue":"1","key":"10.1016\/j.mehy.2019.109427_b0040","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3892\/ol.2015.3156","article-title":"Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws","volume":"10","author":"G\u00fcnaldi","year":"2015","journal-title":"Oncol Lett"},{"issue":"2","key":"10.1016\/j.mehy.2019.109427_b0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.5114\/aoms.2015.50964","article-title":"Incidence and risk predictors for osteonecrosis of the jaw in cancer patients treated with intravenous bisphosphonates","volume":"11","author":"Kos","year":"2015","journal-title":"Arch Med Sci"},{"issue":"1","key":"10.1016\/j.mehy.2019.109427_b0050","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/jop.12646","article-title":"Denosumab-related osteonecrosis of the jaw: A retrospective study","volume":"47","author":"Egloff-Juras","year":"2018","journal-title":"J Oral Pathol Med"},{"issue":"33","key":"10.1016\/j.mehy.2019.109427_b0055","doi-asserted-by":"crossref","first-page":"8722","DOI":"10.1073\/pnas.1704460114","article-title":"Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance","volume":"114","author":"Lloyd","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.mehy.2019.109427_b0060","article-title":"The effects of long-term use of nitrogen-containing bisphosphonates on fracture healing","volume":"11","author":"Begkas","year":"2019","journal-title":"Cureus"},{"issue":"2","key":"10.1016\/j.mehy.2019.109427_b0065","first-page":"224","article-title":"Bisphosphonate-related osteonecrosis of the jaw complicated with wrist scaphoid osteomyelitis: a case report","volume":"37","author":"Sun","year":"2019","journal-title":"Hua Xi Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.mehy.2019.109427_b0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.mehy.2017.07.013","article-title":"Implications of bisphosphonate calcium ion depletion interfering with desmosome epithelial seal in osseointegrated implants and pressure ulcers","volume":"107","author":"Touyz","year":"2017","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2019.109427_b0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.mehy.2019.02.003","article-title":"Osteoporosis therapies might lead to intervertebral disc degeneration via affecting cartilage endplate","volume":"125","author":"Sun","year":"2019","journal-title":"Med Hypotheses"},{"issue":"4","key":"10.1016\/j.mehy.2019.109427_b0080","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.joca.2018.01.005","article-title":"Bisphosphonates intake and its association with changes of periarticular bone area and three-dimensional shape: data from the Osteoarthritis Initiative (OAI)","volume":"26","author":"Haj-Mirzaian","year":"2018","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987719309326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987719309326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:16:58Z","timestamp":1759691818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987719309326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":16,"alternative-id":["S0306987719309326"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2019.109427","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moderate osteoporosis itself is beneficial for bones","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2019.109427","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109427"}}