{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:06:04Z","timestamp":1790661964877,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.mehy.2020.109612","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T02:32:07Z","timestamp":1580869927000},"page":"109612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Astrocytes and their potential role in anti-NMDA receptor encephalitis"],"prefix":"10.1016","volume":"139","author":[{"given":"Fatme Seval","family":"Ismail","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro M.","family":"Faustmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2020.109612_b0005","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/cid\/cir1038","article-title":"The frequency of autoimmune N-methyl-d-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project","volume":"54","author":"Gable","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mehy.2020.109612_b0010","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1212\/WNL.0b013e3181fc2a06","article-title":"Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin","volume":"75","author":"Pr\u00fcss","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.mehy.2020.109612_b0015","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1708712","article-title":"Antibody-mediated encephalitis","volume":"378","author":"Dalmau","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.mehy.2020.109612_b0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ana.21050","article-title":"Paraneoplastic anti-Nmethyl-D-aspartate receptor encephalitis associated with ovarian teratoma","volume":"61","author":"Dalmau","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(12)70310-1","article-title":"Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study","volume":"12","author":"Titulaer","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0030","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1474-4422(10)70253-2","article-title":"Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis","volume":"10","author":"Dalmau","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0035","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(08)70224-2","article-title":"Anti-NMDA-receptor encephalitis: case series and analysis of the eff ects of antibodies","volume":"7","author":"Dalmau","year":"2008","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0040","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1212\/WNL.0000000000000126","article-title":"Clinical specifi cities of adult male patients with NMDA receptor antibodies encephalitis","volume":"82","author":"Viaccoz","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.mehy.2020.109612_b0045","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1474-4422(15)00401-9","article-title":"A clinical approach to diagnosis of autoimmune encephalitis","volume":"15","author":"Graus","year":"2016","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0050","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1523\/JNEUROSCI.0167-10.2010","article-title":"Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis","volume":"30","author":"Hughes","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109612_b0055","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1093\/brain\/aww208","article-title":"Human cerebrospinal fluid monoclonal N-methyl-d-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis","volume":"139","author":"Kreye","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.mehy.2020.109612_b0060","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/acn3.444","article-title":"NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody","volume":"4","author":"Malviya","year":"2017","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0065","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/brain\/awu310","article-title":"Human N-methyl d-aspartate receptor antibodies alter memory and behaviour in mice","volume":"138","author":"Planagum\u00e0","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.mehy.2020.109612_b0070","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/ana.24721","article-title":"Ephrin-B2 prevents N-methyl-Daspartate receptor antibody effects on memory and neuroplasticity","volume":"80","author":"Planagum\u00e0","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0075","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","article-title":"Tripartite synapses: glia, the unacknowledged partner","volume":"22","author":"Araque","year":"1999","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.mehy.2020.109612_b0080","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ceca.2005.06.015","article-title":"Glial calcium signaling and neuron-glia communication","volume":"38","author":"Perea","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.mehy.2020.109612_b0085","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.brainresrev.2009.10.005","article-title":"GLIA modulates synaptic transmission","volume":"63","author":"Perea","year":"2010","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.mehy.2020.109612_b0090","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2017.09.056","article-title":"Cell biology of astrocyte-synapse interactions","volume":"96","author":"Allen","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2020.109612_b0095","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/1073858406294270","article-title":"NMDA Receptors in glia","volume":"13","author":"Verkhratsky","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.mehy.2020.109612_b0100","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3390\/ijms20020309","article-title":"NMDA receptors in astrocytes. In search for roles in neurotransmission and astrocytic homeostasis","volume":"20","author":"Skowro\u0144ska","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.mehy.2020.109612_b0105","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1523\/JNEUROSCI.4689-05.2006","article-title":"NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes","volume":"26","author":"Lalo","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109612_b0110","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1038\/cdd.2015.49","article-title":"Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway","volume":"22","author":"Jimenez-Blasco","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.mehy.2020.109612_b0115","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/(SICI)1096-9861(19960610)369:4<483::AID-CNE1>3.0.CO;2-0","article-title":"Selective distribution of the NMDA-R1 glutamate receptor in astrocytes and presynaptic axon terminals in the nucleus locus coeruleus of the rat brain: an immunoelectron microscopic study","volume":"369","author":"Van Bockstaele","year":"1996","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cne.903620105","article-title":"Comparative ultrastructural localization of the NMDAR1 glutamate receptor in the rat basolateral amygdala and bed nucleus of the stria terminalis","volume":"362","author":"Gracy","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.mehy.2020.109612_b0125","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/glia.10141","article-title":"Microglia activation influences dye coupling and Cx43 expression of the astrocytic network","volume":"42","author":"Faustmann","year":"2003","journal-title":"Glia"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987719314045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987719314045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:18:25Z","timestamp":1759691905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987719314045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":25,"alternative-id":["S0306987719314045"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109612","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocytes and their potential role in anti-NMDA receptor encephalitis","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109612","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109612"}}