{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T11:14:06Z","timestamp":1794222846485,"version":"4.8.0"},"reference-count":128,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.mehy.2020.109638","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T11:57:48Z","timestamp":1582113468000},"page":"109638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":131,"special_numbering":"C","title":["Ethanol metabolism: The good, the bad, and the ugly"],"prefix":"10.1016","volume":"140","author":[{"given":"David F.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz M.","family":"Matschinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mehy.2020.109638_b0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/abbi.1993.1552","article-title":"Thermodynamics of reactions of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate","volume":"307","author":"Alberty","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"10.1016\/j.mehy.2020.109638_b0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.2174\/187152710791292567","article-title":"Mechanisms of oxidative glutamate toxicity: the glutamate\/cystine antiporter system xc- as a neuroprotective drug target","volume":"9","author":"Albrecht","year":"2010","journal-title":"CNS Neurol Disord: Drug Targets"},{"key":"10.1016\/j.mehy.2020.109638_b0015","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/j.neuron.2019.05.050","article-title":"Natural and drug rewards engage distinct pathways that converge on coordinated hypothalamic and reward circuits","volume":"103","author":"Alhadeff","year":"2019","journal-title":"Neuron"},{"issue":"17","key":"10.1016\/j.mehy.2020.109638_b0020","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1001\/jama.295.17.2003","article-title":"Combined pharmacotherapies and behavioral interventions for alcohol dependence: the COMBINE study: a randomized controlled trial","volume":"295","author":"Anton","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.mehy.2020.109638_b0025","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/adb.12571","article-title":"Association of the alcohol dehydrogenase gene polymorphism rs1789891 with gray matter brain volume, alcohol consumption, alcohol craving and relapse risk","volume":"24","author":"Bach","year":"2017","journal-title":"Addict Biol"},{"key":"10.1016\/j.mehy.2020.109638_b0030","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.3891\/acta.chem.scand.12-1279","article-title":"The equilibrium constant of the system ethanol, aldehyde, DPN, DPNH and H+","volume":"12","author":"B\u00e4cklin","year":"1958","journal-title":"Acta Chem Scand"},{"issue":"7","key":"10.1016\/j.mehy.2020.109638_b0035","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/sj.npp.1301532","article-title":"Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine","volume":"33","author":"Baker","year":"2008","journal-title":"Neuropsychopharm"},{"key":"10.1016\/j.mehy.2020.109638_b0040","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1113\/jphysiol.1991.sp018901","article-title":"Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus","volume":"444","author":"Baskys","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.mehy.2020.109638_b0045","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e8langer","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.mehy.2020.109638_b0050","first-page":"253","article-title":"Racemic salsolinol and its enantiomers act as agonists of the m-opioid receptor by activating the Gi protein-adenylate cyclase pathway","volume":"10","author":"Berr\u00edos-C\u00e1rcamo","year":"2016","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"10.1016\/j.mehy.2020.109638_b0055","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1152\/jappl.1997.83.1.32","article-title":"Oxidation of lactate and acetate in rat skeletal muscle: analysis by 13C nuclear magnetic resonance spectroscopy","volume":"83","author":"Bertocci","year":"1997","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.mehy.2020.109638_b0060","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1055\/s-2007-1007344","article-title":"Genetic factors in alcohol metabolism and alcoholism","volume":"13","author":"Bosron","year":"1993","journal-title":"Semin Liver Dis"},{"issue":"Suppl 1","key":"10.1016\/j.mehy.2020.109638_b0065","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0091-3057(83)90147-8","article-title":"Immunohistochemical localization of alcohol dehydrogenase in human kidney, endocrine organs, and brain","volume":"18","author":"B\u0171hler","year":"1983","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.mehy.2020.109638_b0070","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cmet.2015.05.016","article-title":"AMPK activation of muscle autophagy prevents fasting induced hypoglycemia and myopathy during aging","volume":"21","author":"Bujak","year":"2015","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.mehy.2020.109638_b0075","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1530-0277.1999.tb04123.x","article-title":"Chronic ethanol upregulates NMDA and AMPA, but not kainate receptor subunit proteins in rat primary cortical cultures","volume":"23","author":"Chandler","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"issue":"3","key":"10.1016\/j.mehy.2020.109638_b0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3858\/emm.2010.42.3.021","article-title":"Chronic ethanol feeding impairs AMPK and MEF2 expression and is associated with GLUT4 decrease in rat myocardium","volume":"42","author":"Chen","year":"2010","journal-title":"Expt Mol Med"},{"issue":"7","key":"10.1016\/j.mehy.2020.109638_b0085","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.neuropharm.2012.02.017","article-title":"Chronic intermittent ethanol and withdrawal differentially modulate basolateral amygdala AMPA-type glutamate receptor function and trafficking","volume":"62","author":"Christian","year":"2012","journal-title":"Neuropharm"},{"key":"10.1016\/j.mehy.2020.109638_b0090","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0896-6273(00)80481-X","article-title":"Metabotropic glutamate receptor-mediated control of neurotransmitter release","volume":"20","author":"Cochilla","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2020.109638_b0095","first-page":"S56","article-title":"Alcohol and lipid metabolism","volume":"3","author":"Crabb","year":"2006","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.mehy.2020.109638_b0100","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1111\/j.1471-4159.2004.02935.x","article-title":"Activation of astrocytes in brain of conscious rats during acoustic stimulation: acetate utilization in working brain","volume":"92","author":"Cruz","year":"2005","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"10.1016\/j.mehy.2020.109638_b0105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1471-4159.2009.05895.x","article-title":"Acetate transport and utilization in the rat brain","volume":"109","author":"Deelchand","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2020.109638_b0110","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0022-5193(84)90036-5","article-title":"The ethanol withdrawal syndrome: a consequence of lack of substrate for a cerebral Krebs-cycle","volume":"106","author":"Derr","year":"1984","journal-title":"J Theor Biol"},{"key":"10.1016\/j.mehy.2020.109638_b0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0031-9384(86)90123-X","article-title":"Separation of the tremorous and muscular rigidity components of the ethanol withdrawal syndrome in the rat","volume":"38","author":"Derr","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2020.109638_b0120","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/0024-3205(81)90189-2","article-title":"Abatement by acetate of an ethanol withdrawal syndrome","volume":"29","author":"Derr","year":"1981","journal-title":"Life Sci"},{"key":"10.1016\/j.mehy.2020.109638_b0125","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.alcohol.2007.05.003","article-title":"Ethanol elimination rates in men and women in consideration of the calculated liver weight","volume":"41","author":"Dettling","year":"2007","journal-title":"Alcohol"},{"key":"10.1016\/j.mehy.2020.109638_b0130","doi-asserted-by":"crossref","first-page":"9069","DOI":"10.1016\/S0021-9258(17)44632-1","article-title":"Aspartate transport in synaptosomes from rat brain","volume":"258","author":"Ereci\u0144ska","year":"1983","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2020.109638_b0135","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1432-1033.1994.00549.x","article-title":"Alcohol dehydrogenase of class IV (ss-ADH) from human stomach. cDNA sequence and structure\/function relationships","volume":"224","author":"Farr\u00e8s","year":"1994","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.mehy.2020.109638_b0140","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1021\/cn900006n","article-title":"Intercellular glutamate signaling in the nervous system and beyond","volume":"1","author":"Featherstone","year":"2010","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.mehy.2020.109638_b0145","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1042\/bj0980244","article-title":"Influence of the metabolism of ethanol on the lactate\/pyruvate ratio of rat-liver slices","volume":"98","author":"Forsander","year":"1966","journal-title":"Biochem J"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0150","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1172\/JCI63967","article-title":"Malonyl-CoA: the regulator of fatty acid synthesis and oxidation","volume":"122","author":"Foster","year":"2012","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.mehy.2020.109638_b0155","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"Frost","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.mehy.2020.109638_b0160","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.510290420","article-title":"High-level expression of rat class I alcohol dehydrogenase is sufficient for ethanol-induced fat accumulation in transduced HeLa cells","volume":"29","author":"Galli","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.mehy.2020.109638_b0165","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0741-8329(99)00091-9","article-title":"Mechanism of the antialcohol effect of gamma-hydroxybutyric acid","volume":"20","author":"Gessa","year":"2000","journal-title":"Alcohol"},{"issue":"24","key":"10.1016\/j.mehy.2020.109638_b0170","doi-asserted-by":"crossref","first-page":"10663","DOI":"10.1523\/JNEUROSCI.18-24-10663.1998","article-title":"Suppression of ethanol-reinforced behavior by naltrexone is associated with attenuation of the ethanol-induced increase in dialysate dopamine levels in the nucleus accumbens","volume":"18","author":"Gonzales","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109638_b0175","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0014-2999(90)90022-X","article-title":"Ethanol withdrawal seizures and the NMDA receptor complex","volume":"176","author":"Grant","year":"1990","journal-title":"Eur J Phamacol"},{"key":"10.1016\/j.mehy.2020.109638_b0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-8993(91)90125-F","article-title":"Brain regional specificity and time course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal","volume":"547","author":"Gulya","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2020.109638_b0185","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1023\/A:1011115809810","article-title":"Glucose transporters and glucose utilization in rat brain after acute ethanol administration","volume":"15","author":"Handa","year":"2000","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.mehy.2020.109638_b0190","doi-asserted-by":"crossref","first-page":"20170774","DOI":"10.1098\/rsif.2017.0774","article-title":"Keeping the home fires burning: AMP-activated protein kinase","volume":"15","author":"Hardie","year":"2018","journal-title":"J R Soc Interface"},{"key":"10.1016\/j.mehy.2020.109638_b0195","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tcb.2015.10.013","article-title":"AMPK: an energy-sensing pathway with multiple inputs and outputs","volume":"26","author":"Hardie","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.mehy.2020.109638_b0200","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0006-8993(74)90319-9","article-title":"Metabolic effects of acetaldehyde in the intact rat brain cortex and its subcellular fractions","volume":"70","author":"Hassinen","year":"1974","journal-title":"Brain Res"},{"issue":"17","key":"10.1016\/j.mehy.2020.109638_b0205","first-page":"1","article-title":"Glutamine-glutamate cycle flux is similar in cultured astrocytes and brain and both glutamate production and oxidation are mainly catalyzed by aspartate aminotransferase","volume":"6","author":"Hertz","year":"2017","journal-title":"Biology"},{"issue":"2","key":"10.1016\/j.mehy.2020.109638_b0210","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.mehy.2020.109638_b0215","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI65153","article-title":"Increased brain uptake and oxidation of acetate in heavy drinkers","volume":"123","author":"Jiang","year":"2013","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.mehy.2020.109638_b0220","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/00365517709091505","article-title":"Ethanol effects of substrate utilization by the human brain","volume":"37","author":"Juhlin-Dannfelt","year":"1977","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.mehy.2020.109638_b0225","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.mehy.2020.109638_b0230","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/adb.12130","article-title":"Long-term inhibition of ethanol intake by the administration of an aldehyde dehydrogenase-2 (ALDH2)-coding lentiviral vector into the ventral tegmental area of rats","volume":"20","author":"Karahanian","year":"2015","journal-title":"Addict Biol"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0235","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1530-0277.1989.tb00412.x","article-title":"Immunocytochemistry of alcohol dehydrogenase in the rat central nervous system","volume":"13","author":"Kerr","year":"1989","journal-title":"Alcoholisn: Clin Exptl Res"},{"issue":"2","key":"10.1016\/j.mehy.2020.109638_b0240","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1530-0277.1983.tb05433.x","article-title":"Role of acetaldehyde and acetate in the development of ethanol-induced cardiac lipidosis, studied in isolated perfused rat hearts","volume":"1","author":"Kiviluoma","year":"1982","journal-title":"Alcoholism: Clin Exptl Res"},{"key":"10.1016\/j.mehy.2020.109638_b0245","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1096\/fj.201700442R","article-title":"AMPK in skeletal muscle function and metabolism","volume":"32","author":"Kj\u00f8bsted","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/j.mehy.2020.109638_b0250","article-title":"The citric acid cycle","author":"Krebs","year":"1953","journal-title":"Nobel Lecture"},{"key":"10.1016\/j.mehy.2020.109638_b0255","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1098\/rspb.1964.0019","article-title":"The Croonian lecture. Gluconeogenesis","volume":"159","author":"Krebs","year":"1964","journal-title":"Proc R Soc Lond B"},{"key":"10.1016\/j.mehy.2020.109638_b0260","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1042\/bj1120117","article-title":"Inhibition of hepatic gluconeogenesis by ethanol","volume":"112","author":"Krebs","year":"1969","journal-title":"Biochem J"},{"key":"10.1016\/j.mehy.2020.109638_b0265","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1172\/JCI106470","article-title":"Ethanol-induced hyperlacticacidemia: inhibition of lactate utilization","volume":"50","author":"Kreisberg","year":"1971","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.mehy.2020.109638_b0270","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1176\/ajp.2007.164.3.519","article-title":"Effect of Memantine on cue-induced alcohol craving in recovering alcohol-dependent patients","volume":"164","author":"Krupitsky","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.mehy.2020.109638_b0275","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1530-0277.2007.00344.x","article-title":"Antiglutamatergic strategies for ethanol detoxification: comparison with placebo and diazepam","volume":"31","author":"Krupitsky","year":"2007","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.mehy.2020.109638_b0280","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s12640-017-9818-6","article-title":"Salsolinol: an unintelligible and double-faced molecule\u2014lessons learned from in vivo and in vitro experiments","volume":"33","author":"Kurnik-\u0141ucka","year":"2018","journal-title":"Neurotox Res"},{"key":"10.1016\/j.mehy.2020.109638_b0285","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1530-0277.2009.01087.x","article-title":"A critical evaluation of influence of ethanol and diet on salsolinol enantiomers in humans and rats","volume":"34","author":"Lee","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.mehy.2020.109638_b0290","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/ars.2011.4391","article-title":"The cystine\/glutamate antiporter system Xc- in health and disease: from molecular mechanisms to novel therapeutic opportunities","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antiox Redox Signal"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0295","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/oxfordjournals.alcalc.a045057","article-title":"Acamprosate appears to decrease alcohol intake in weaned alcoholics","volume":"25","author":"Lhuintre","year":"1990","journal-title":"Alcohol Alcohol"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0300","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.biopsych.2011.02.024","article-title":"Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases","volume":"70","author":"Li","year":"2011","journal-title":"Biol Psychiatry"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0305","doi-asserted-by":"crossref","first-page":"G1173","DOI":"10.1152\/ajpgi.90349.2008","article-title":"Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylation","volume":"295","author":"Liangpunsakul","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"3","key":"10.1016\/j.mehy.2020.109638_b0310","first-page":"220","article-title":"Relationships between nutrition, alcohol use, and liver disease","volume":"27","author":"Lieber","year":"2003","journal-title":"Alcohol Res Health"},{"key":"10.1016\/j.mehy.2020.109638_b0315","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1159\/000459999","article-title":"An experimental model of alcohol feeding and liver injury in the baboon","volume":"3","author":"Lieber","year":"1974","journal-title":"J Med Primatol"},{"key":"10.1016\/j.mehy.2020.109638_b0320","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1172\/JCI105200","article-title":"Effects of prolonged ethanol intake: production of fatty liver despite adequate diets","volume":"44","author":"Lieber","year":"1965","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.mehy.2020.109638_b0325","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/acer.14137","article-title":"Chronic ethanol exposure disrupts lactate and glucose homeostasis and induces dysfunction of the astrocyte-neuron lactate shuttle in the brain","volume":"43","author":"Lindberg","year":"2019","journal-title":"Alcoholism: Clin Exp Res"},{"issue":"11","key":"10.1016\/j.mehy.2020.109638_b0330","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1111\/j.1530-0277.1999.tb04073.x","article-title":"Ethanol consumption, amino acid and glutathione blood levels in patients with and without chronic liver disease","volume":"23","author":"Loguercio","year":"1999","journal-title":"Alcohol Clin Exp Res"},{"issue":"5","key":"10.1016\/j.mehy.2020.109638_b0335","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1172\/JCI104574","article-title":"Ethanol metabolism and production of free acetate in the human liver","volume":"41","author":"Lundquist","year":"1962","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2020.109638_b0340","doi-asserted-by":"crossref","first-page":"13968","DOI":"10.1523\/JNEUROSCI.2808-07.2007","article-title":"Repeated N-acetylcysteine administration alters plasticity-dependent effects of cocaine","volume":"27","author":"Madayag","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109638_b0345","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1055\/s-2004-832936","article-title":"Epidemiology of alcoholic liver disease","volume":"24","author":"Mandayam","year":"2004","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.mehy.2020.109638_b0350","first-page":"5045","article-title":"Distribution of alcohol dehydrogenase mRNA in the rat central nervous system: Consequences for brain ethanol and retinoid metabolism","volume":"268","author":"Mart\u00ednez","year":"2001","journal-title":"Eur J Biochem"},{"issue":"5","key":"10.1016\/j.mehy.2020.109638_b0355","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/alcalc\/agq039","article-title":"Acetyl-L-carnitine for alcohol craving and relapse prevention in anhedonic alcoholics: a randomized, double-blind, placebo-controlled pilot trial","volume":"45","author":"Martinotti","year":"2010","journal-title":"Alcohol Alcohol"},{"issue":"148","key":"10.1016\/j.mehy.2020.109638_b0360","first-page":"2019","article-title":"The central role of glucokinase in glucose homeostasis: a perspective 50 years after demonstrating the presence of the enzyme in islets of Langerhans","volume":"10","author":"Matschinsky","year":"2019","journal-title":"Frontiers Physiol"},{"issue":"12","key":"10.1016\/j.mehy.2020.109638_b0365","doi-asserted-by":"crossref","first-page":"4128","DOI":"10.1016\/S0021-9258(17)34693-8","article-title":"Carnitine palmitoyltransferase 1: The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA","volume":"253","author":"McGarry","year":"1978","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2020.109638_b0370","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/s41586-019-1700-7","article-title":"Alcohol metabolism contributes to brain histone acetylation","volume":"574","author":"Mews","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2020.109638_b0375","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00213-010-2076-4","article-title":"Inhibitory effects of alcohol on glucose transport across the blood\u2013brain barrier leads to neurodegeneration: preventive role of acetyl-L-carnitine","volume":"214","author":"Muneer","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.mehy.2020.109638_b0380","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.neuron.2017.09.020","article-title":"Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress","volume":"96","author":"Nasca","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.mehy.2020.109638_b0385","doi-asserted-by":"crossref","first-page":"14960","DOI":"10.1073\/pnas.1516016112","article-title":"Stress dynamically regulates behavior and glutamatergic gene expression in hippocampus by opening a window of epigenetic plasticity","volume":"112","author":"Nasca","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.mehy.2020.109638_b0390","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0741-8329(85)90090-4","article-title":"Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics","volume":"2","author":"Nuutinen","year":"1985","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.mehy.2020.109638_b0395","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.pbb.2011.04.015","article-title":"Glutamatergic medications for the treatment of drug and behavioral addictions","volume":"100","author":"Olive","year":"2012","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"10.1016\/j.mehy.2020.109638_b0400","first-page":"239","article-title":"Double-blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol","volume":"30","author":"Paille","year":"1995","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.mehy.2020.109638_b0405","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/jcbfm.2010.2","article-title":"Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1 H-[13C]-NMR","volume":"30","author":"Patel","year":"2010","journal-title":"J Cerebral Blood Flow Metab"},{"key":"10.1016\/j.mehy.2020.109638_b0410","first-page":"E1007","article-title":"Skeletal muscle pyruvate dehydrogenase activity during acetate infusion in humans","volume":"268","author":"Putman","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.mehy.2020.109638_b0415","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1369-1600.2006.00030.x","article-title":"The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake","volume":"11","author":"Quintanilla","year":"2006","journal-title":"Addict Biol"},{"key":"10.1016\/j.mehy.2020.109638_b0420","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1111\/j.1471-4159.1970.tb11392.x","article-title":"Alcohol dehydrogenase activity in rat brain and liver","volume":"17","author":"Raskin","year":"1970","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2020.109638_b0425","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0022-3565(25)30667-1","article-title":"Body temperature in mice: a quantitative measure of alcohol tolerance and physical dependence","volume":"199","author":"Ritzmann","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mehy.2020.109638_b0430","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuropharm.2018.12.001","article-title":"Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism?","volume":"146","author":"Rivera-Meza","year":"2019","journal-title":"Neuropharm"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0435","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/jnc.13916","article-title":"Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation","volume":"140","author":"Rowlands","year":"2017","journal-title":"J Neurochem"},{"issue":"8","key":"10.1016\/j.mehy.2020.109638_b0440","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1001\/archpsyc.1996.01830080023006","article-title":"Relapse prevention by acamprosate. Results from a placebo-controlled study on alcohol dependence","volume":"53","author":"Sass","year":"1996","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.mehy.2020.109638_b0445","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-3565(24)29296-X","article-title":"Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system","volume":"299","author":"Schoepp","year":"2001","journal-title":"J Pharm Exptl Ther"},{"key":"10.1016\/j.mehy.2020.109638_b0450","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-319-08894-5_2","article-title":"Glutamate metabolism in the brain focusing on astrocytes","volume":"11","author":"Schousboe","year":"2014","journal-title":"Adv Neurobiol"},{"key":"10.1016\/j.mehy.2020.109638_b0455","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/sj.npp.1300453","article-title":"Acute alcohol effects on neuronal and attentional processing: striatal reward system and inhibitory sensory interactions under acute ethanol challenge","volume":"29","author":"Schreckenberger","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.mehy.2020.109638_b0460","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(18)97605-2","article-title":"Pyruvate carboxylase III. Some physical and chemical properties of the highly purified enzyme","volume":"240","author":"Scrutton","year":"1965","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2020.109638_b0465","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuroscience.2016.06.001","article-title":"AMP Kinase regulates ligand-gated K-ATP channels in substantia nigra dopamine neurons","volume":"330","author":"Shen","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2020.109638_b0470","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuroscience.2014.05.031","article-title":"AMP kinase regulates K-ATP currents evoked by NMDA receptor stimulation in rat subthalamic nucleus neurons","volume":"274","author":"Shen","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2020.109638_b0475","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1093\/jn\/137.7.1750","article-title":"Sodium acetate induces a metabolic alkalosis but not the increase in fatty acid oxidation observed following bicarbonate ingestion in humans","volume":"137","author":"Smith","year":"2007","journal-title":"J Nutr"},{"key":"10.1016\/j.mehy.2020.109638_b0480","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-8993(93)90246-J","article-title":"Radioligand binding to the N-methyl-D-aspartate receptor\/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion","volume":"602","author":"Snell","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2020.109638_b0485","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0168-8278(96)80193-0","article-title":"Effects of acute and chronic ethanol administration on hepatic hemodynamics and hepatic oxygen consumption in awake rats","volume":"24","author":"Souda","year":"1996","journal-title":"J Hepatology"},{"issue":"560","key":"10.1016\/j.mehy.2020.109638_b0490","first-page":"1","article-title":"Linking Dysregulated AMPK signaling and ER stress in ethanol-induced liver injury in hepatic alcohol dehydrogenase deficient deer mice","volume":"9","author":"Srinivasan","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.mehy.2020.109638_b0495","first-page":"H799","article-title":"Substrate dependence of metabolic state and coronary flow in perfused rat heart","volume":"249","author":"Starnes","year":"1985","journal-title":"Am J Physiol"},{"key":"10.1016\/j.mehy.2020.109638_b0500","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1111\/j.1530-0277.2008.00801.x","article-title":"Alcohol withdrawal-induced hippocampal neurotoxicity in vitro and seizures in vivo are both reduced by memantine","volume":"32","author":"Stepanyan","year":"2008","journal-title":"Alcoholism: Clin Exptl Res"},{"key":"10.1016\/j.mehy.2020.109638_b0505","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0022-3565(25)31052-9","article-title":"The effects of 6-hydroxydopamine on tolerance to and dependence on ethanol","volume":"203","author":"Tabakoff","year":"1977","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mehy.2020.109638_b0510","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0140-6736(95)91685-7","article-title":"Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver","volume":"346","author":"Teli","year":"1995","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.mehy.2020.109638_b0515","first-page":"420","article-title":"Hepatic microsomal ethanol oxidation. Hydrogen peroxide formation and the role of catalase. Euro","volume":"25","author":"Thurman","year":"1972","journal-title":"J Biochem"},{"issue":"3","key":"10.1016\/j.mehy.2020.109638_b0520","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/(SICI)1098-2396(199711)27:3<242::AID-SYN9>3.0.CO;2-D","article-title":"Brain microdialysis of GABA and glutamate: what does it signify?","volume":"27","author":"Timmerman","year":"1997","journal-title":"Synapse"},{"issue":"12","key":"10.1016\/j.mehy.2020.109638_b0525","first-page":"240S","article-title":"AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats","volume":"29","author":"Tomita","year":"2005","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.mehy.2020.109638_b0530","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1176\/ajp.155.6.726","article-title":"Increased glutamatergic neurotransmission and oxidative stress after alcohol withdrawal","volume":"155","author":"Tsai","year":"1998","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.mehy.2020.109638_b0535","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroimage.2012.08.057","article-title":"Acute alcohol intoxication decreases glucose metabolism but increases acetate uptake in the human brain","volume":"64","author":"Volkow","year":"2013","journal-title":"NeuroImage"},{"key":"10.1016\/j.mehy.2020.109638_b0540","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.neuroimage.2005.07.004","article-title":"Low doses of alcohol substantially decrease glucose metabolism in the human brain","volume":"29","author":"Volkow","year":"2006","journal-title":"NeuroImage"},{"key":"10.1016\/j.mehy.2020.109638_b0545","first-page":"178","article-title":"Recovery of brain glucose metabolism in detoxified alcoholics","volume":"151","author":"Volkow","year":"1994","journal-title":"J Psychiatry"},{"issue":"7","key":"10.1016\/j.mehy.2020.109638_b0550","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.4877-14.2015","article-title":"Alcohol decreases baseline brain glucose metabolism more in heavy drinkers than controls but has no effect on stimulation-induced metabolic increases","volume":"35","author":"Volkow","year":"2015","journal-title":"J Neurosci"},{"issue":"35","key":"10.1016\/j.mehy.2020.109638_b0555","doi-asserted-by":"crossref","first-page":"14444","DOI":"10.1073\/pnas.1306011110","article-title":"Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure","volume":"110","author":"Wang","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.mehy.2020.109638_b0560","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1530-0277.2000.tb02061.x","article-title":"Regional brain metabolism during alcohol intoxication","volume":"24","author":"Wang","year":"2000","journal-title":"Alcohol Clin Exp Res"},{"issue":"43","key":"10.1016\/j.mehy.2020.109638_b0565","doi-asserted-by":"crossref","first-page":"15124","DOI":"10.1523\/JNEUROSCI.2783-12.2012","article-title":"Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: Implications for alcohol drinking behavior","volume":"32","author":"Wang","year":"2012","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109638_b0570","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1523\/JNEUROSCI.18-14-05225.1998","article-title":"Preferential utilization of acetate by astrocytes is attributable to transport","volume":"18","author":"Waniewski","year":"1998","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109638_b0575","doi-asserted-by":"crossref","first-page":"7023","DOI":"10.1113\/JP273839","article-title":"Oxidative phosphorylation: regulation and role in cellular and tissue metabolism","volume":"595","author":"Wilson","year":"2017","journal-title":"J Physiol"},{"issue":"12","key":"10.1016\/j.mehy.2020.109638_b0580","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13327","article-title":"The thermodynamic basis of glucose-stimulated insulin release: a model of the core mechanism","volume":"5","author":"Wilson","year":"2017","journal-title":"Physiol Rep"},{"issue":"2","key":"10.1016\/j.mehy.2020.109638_b0585","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/japplphysiol.01077.2017","article-title":"Glutamate dehydrogenase: Role in regulating metabolism and insulin release in pancreatic \u03b2-cells","volume":"125","author":"Wilson","year":"2018","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.mehy.2020.109638_b0590","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1152\/japplphysiol.00352.2018","article-title":"Metabolic homeostasis: Oxidative phosphorylation and the metabolic requirements of higher plants and animals","volume":"125","author":"Wilson","year":"2019","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.mehy.2020.109638_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2019.109375","article-title":"Hyperbaric oxygen toxicity in brain: a case of hyperoxia induced hypoglycemic brain syndrome","volume":"132","author":"Wilson","year":"2019","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.mehy.2020.109638_b0600","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/j.1471-4159.1986.tb00725.x","article-title":"Transport of cysteate by synaptosomes isolated from rat brain: Evidence that it utilizes the same transporter as aspartate, glutamate and cysteine sulfinate","volume":"47","author":"Wilson","year":"1986","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2020.109638_b0605","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1124\/jpet.102.039735","article-title":"Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine","volume":"303","author":"Xi","year":"2002","journal-title":"J Pharm Exptl Ther"},{"key":"10.1016\/j.mehy.2020.109638_b0610","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/j.1525-1594.1987.tb02661.x","article-title":"Effect of acetate administration on rats with chronic uremia","volume":"11","author":"Yamamoto","year":"1987","journal-title":"Artif Organs"},{"key":"10.1016\/j.mehy.2020.109638_b0615","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107705","article-title":"AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in substantia nigra neurons","volume":"158","author":"Yang","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mehy.2020.109638_b0620","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1053\/j.gastro.2004.09.049","article-title":"The role of AMP-activated protein kinase in the action of ethanol in the liver","volume":"127","author":"You","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mehy.2020.109638_b0625","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1471-4159.1983.tb00849.x","article-title":"Pyruvate carboxylase activity in primary cultures of astrocytes and neurons","volume":"41","author":"Yu","year":"1983","journal-title":"J Neurochem"},{"key":"10.1016\/j.mehy.2020.109638_b0630","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/13556219772444","article-title":"Ethanol metabolism in the brain","volume":"2","author":"Zimatkin","year":"1997","journal-title":"Addiction Biol"},{"key":"10.1016\/j.mehy.2020.109638_b0635","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1530-0277.2006.00181.x","article-title":"Enzymatic mechanisms of ethanol oxidation in the brain","volume":"30","author":"Zimatkin","year":"2006","journal-title":"Alcoholism: Clin Exptl Res"},{"issue":"6","key":"10.1016\/j.mehy.2020.109638_b0640","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1111\/j.1530-0277.1992.tb00713.x","article-title":"Regional distribution of low-Km mitochondrial aldehyde dehydrogenase in the rat central nervous system","volume":"16","author":"Zimatkin","year":"1992","journal-title":"Alcohol Clin Exp Res"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720300797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720300797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:19:27Z","timestamp":1759691967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987720300797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":128,"alternative-id":["S0306987720300797"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109638","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethanol metabolism: The good, the bad, and the ugly","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109638"}}