{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:48:50Z","timestamp":1772808530339,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.mehy.2020.109747","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T02:19:09Z","timestamp":1587435549000},"page":"109747","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Improving brain power by applying a cool TRPM8 receptor agonist to the eyelid margin"],"prefix":"10.1016","volume":"142","author":[{"given":"Edward T.","family":"Wei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2020.109747_b0005","first-page":"1","article-title":"The aesthetics of heat. For a cultural history of climate in the age of global warming","volume":"2","author":"Horn","year":"2017","journal-title":"Metaphor J Lit Theory Media"},{"issue":"6","key":"10.1016\/j.mehy.2020.109747_b0010","first-page":"2008","article-title":"An empirical investigation of Montesquieu\u2019s theories on climate","volume":"10","author":"Piergallini","year":"2016","journal-title":"Intern J Social Behav Educ Econ Business Industrial Eng"},{"key":"10.1016\/j.mehy.2020.109747_b0015","doi-asserted-by":"crossref","unstructured":"Dell BM, Jones BF, Olken BA., 2012. Temperature shocks and economic growth: evidence from the last half century. Am Econ J Macroeconomics 2012, 4(3): 66\u201395. doi: 10.1257\/mac.4.3.66.","DOI":"10.1257\/mac.4.3.66"},{"key":"10.1016\/j.mehy.2020.109747_b0020","unstructured":"Goodman J. Heat and Learning. Working Paper 24639. National Bureau of Economic Research, 1050 Massachusetts Avenue Cambridge, MA 02138 May 2018, 2018. http:\/\/www.nber.org\/papers\/w24639."},{"key":"10.1016\/j.mehy.2020.109747_b0025","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.buildenv.2016.11.020","article-title":"Ten questions concerning thermal and indoor air quality effects on the performance of office work and schoolwork","volume":"112","author":"Wargocki","year":"2017","journal-title":"Build Environ"},{"key":"10.1016\/j.mehy.2020.109747_b0030","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-0668.2004.00280.x","article-title":"Effects of temperature and outdoor air supply rate on the performance of call center operators in the tropics","volume":"14","author":"Tham","year":"2004","journal-title":"Indoor Air, Suppl"},{"issue":"2","key":"10.1016\/j.mehy.2020.109747_b0035","first-page":"26","article-title":"Indoor air quality and productivity","volume":"44","author":"Tanabe","year":"2007","journal-title":"REHVA J"},{"key":"10.1016\/j.mehy.2020.109747_b0040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.apergo.2010.04.003","article-title":"The effects of air temperature on office workers\u2019 well-being, workload and productivity-evaluated with subjective ratings","volume":"42","author":"Lan","year":"2010","journal-title":"Appl Ergon"},{"key":"10.1016\/j.mehy.2020.109747_b0045","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0668.2011.00714.x","article-title":"Effects of thermal discomfort in an office on perceived air quality, SBS symptoms, physiological responses, and human performance","volume":"21","author":"Lan","year":"2011","journal-title":"Indoor Air"},{"key":"10.1016\/j.mehy.2020.109747_b0050","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/ina.12209","article-title":"The effect of slightly warm temperature on work performance and comfort in open-plan offices \u2013 a laboratory study","volume":"26","author":"Maula","year":"2016","journal-title":"Indoor Air"},{"issue":"4","key":"10.1016\/j.mehy.2020.109747_b0055","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1615\/InterfacPhenomHeatTransfer.v1.i4.40","article-title":"A model for tear film and ocular surface temperature for partial blinks","volume":"1","author":"Deng","year":"2013","journal-title":"Interfacial Phenom Heat Transf"},{"key":"10.1016\/j.mehy.2020.109747_b0060","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.envint.2018.10.053","article-title":"The mystery of dry indoor air \u2013 an overview","volume":"121","author":"Wolkoff","year":"2018","journal-title":"Environ Int"},{"key":"10.1016\/j.mehy.2020.109747_b0065","doi-asserted-by":"crossref","unstructured":"Yang JM, Li F, Liu Q, et al. A novel TRPM8 agonist relieves dry eye discomfort BMC Ophthalmology (2017) 17:101, 1\u201315, 2017. doi: 10.1186\/s12886-017-0495-2.","DOI":"10.1186\/s12886-017-0495-2"},{"key":"10.1016\/j.mehy.2020.109747_b0070","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1523\/JNEUROSCI.1943-12.2013","article-title":"A sensory-labeled line for cold: TRPM8-expressing sensory neurons define the cellular basis for cold, cold pain, and cooling-mediated analgesia","volume":"33","author":"Knowlton","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109747_b0075","doi-asserted-by":"crossref","unstructured":"Pertusa M, Gonza A, Ugarte G, Madrid XR. Critical role of the pore domain in the cold response of TRPM8 channels identified by ortholog functional comparison. J Biol Chem (2018) 293(32) 12454\u201312471. doi: 10.1074\/jbc.RA118.002256.","DOI":"10.1074\/jbc.RA118.002256"},{"key":"10.1016\/j.mehy.2020.109747_b0080","doi-asserted-by":"crossref","unstructured":"Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science. 2019 March 01; 363(6430). doi: 10.1126\/science.aav9334.","DOI":"10.1126\/science.aav9334"},{"key":"10.1016\/j.mehy.2020.109747_b0085","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1523\/JNEUROSCI.3189-10.2010","article-title":"Gating of transient receptor potential melastatin 8 (TRPM8) channels activated by cold and chemical agonists in planar lipid bilayers","volume":"30","author":"Zakharian","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109747_b0090","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1152\/jn.1997.77.6.3252","article-title":"Quantitative analysis of orofacial thermoreceptive neurons in the superficial medullary dorsal horn of the rat","volume":"77","author":"Hutchison","year":"1997","journal-title":"J Neurophysiol"},{"issue":"2","key":"10.1016\/j.mehy.2020.109747_b0095","first-page":"5","article-title":"Sensory\/cooling agents for skin discomfort 14","volume":"14","author":"Wei","year":"2012","journal-title":"J Skin Barrier Res"},{"key":"10.1016\/j.mehy.2020.109747_b0100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1523\/JNEUROSCI.3976-07.2008","article-title":"Visualizing cold spots: TRPM8-expressing sensory neurons and their projections","volume":"28","author":"Dhaka","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2020.109747_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnana.2015.00071","article-title":"Transient receptor potential cation channel subfamily v member 1 expressing corneal sensory neurons can be subdivided into at least three subpopulations","volume":"9","author":"Alamri","year":"2015","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.mehy.2020.109747_b0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10571-012-9888-1","article-title":"The distribution of transient receptor potential melastatin-8 in the rat soft palate, epiglottis, and pharynx","volume":"33","author":"Sato","year":"2013","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.mehy.2020.109747_b0115","first-page":"174","article-title":"Comparison of various histamines antagonists","volume":"3","author":"Reuse","year":"1948","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/j.mehy.2020.109747_b0120","first-page":"387","article-title":"Recent advances in ophthalmic drug delivery system","volume":"4","author":"Manish","year":"2012","journal-title":"Int J Pharm Pharm Sci"},{"key":"10.1016\/j.mehy.2020.109747_b0125","doi-asserted-by":"crossref","unstructured":"Knop E, Korb DR, Blackie Ca, Knop N. The lid margin is an underestimated structure for preservation of ocular surface health and development of dry eye disease. Dev. Ophthalmol. 45, 108\u201322, 2010. doi: 10.1159\/000315024.","DOI":"10.1159\/000315024"},{"key":"10.1016\/j.mehy.2020.109747_b0130","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.158.3804.1064","article-title":"Multiple temperature-sensitive spots innervated by single nerve fibers","volume":"158","author":"Kenshalo","year":"1967","journal-title":"Science (80-.)"},{"key":"10.1016\/j.mehy.2020.109747_b0135","doi-asserted-by":"crossref","unstructured":"Korb DR, Blackie Ca. \u201cDry eye\u201d is the wrong diagnosis for millions. Optom Vis Sci 92, e350\u2013e354, 2015. doi: 10.1097\/OPX.0000000000000676.","DOI":"10.1097\/OPX.0000000000000676"},{"key":"10.1016\/j.mehy.2020.109747_b0140","article-title":"Human skin wetness perception: psychophysical and neurophysiological bases","volume":"8940","author":"Filingeri","year":"2015","journal-title":"Temperature"},{"key":"10.1016\/j.mehy.2020.109747_b0145","doi-asserted-by":"crossref","unstructured":"Typolt O, Filingeri D. Evidence for the involvement of peripheral cold-sensitive TRPM8 channels in human cutaneous hygrosensation. Am J Physiol Regul Integr Comp Physiol, 2020, Jan 22. doi: 10.1152\/ajpregu.00332.2019. [Epub ahead of print].","DOI":"10.1152\/ajpregu.00332.2019"},{"key":"10.1016\/j.mehy.2020.109747_b0150","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2307\/1412750","article-title":"The synthetic experiment","volume":"11","author":"Bentley","year":"1900","journal-title":"Am J Psychol"},{"issue":"3","key":"10.1016\/j.mehy.2020.109747_b0155","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/lary.24265","article-title":"Regional peak mucosal cooling predicts the perception of nasal patency","volume":"124","author":"Zhao","year":"2014","journal-title":"Laryngoscope"},{"key":"10.1016\/j.mehy.2020.109747_b0160","unstructured":"Wei ET. Topical agents for the treatment of sensory discomfort in the nasal cavity. US Patent 9,642,868, 2017."},{"key":"10.1016\/j.mehy.2020.109747_b0165","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009675","article-title":"Prevalence of dry eye disease in visual display terminal workers: a systematic review and meta-analysis","volume":"6","author":"Courtin","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.mehy.2020.109747_b0170","article-title":"Drugs, games, and devices for enhancing cognition: implications for work and society","volume":"195\u2013217","author":"Bruhl","year":"2016","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.mehy.2020.109747_b0175","unstructured":"Wei ET. Di-isopropyl-phosphinoyl-alkanes as topical agents for the treatment of sensory discomfort. US Patent 9,895,382, 2017."}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720301213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720301213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:20:39Z","timestamp":1759692039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987720301213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":35,"alternative-id":["S0306987720301213"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109747","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Improving brain power by applying a cool TRPM8 receptor agonist to the eyelid margin","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109747","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109747"}}