{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:28:37Z","timestamp":1780410517839,"version":"3.54.1"},"reference-count":8,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.mehy.2020.109835","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T11:34:27Z","timestamp":1589283267000},"page":"109835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Exercise as medicine for COVID-19: An ACE in the hole?"],"prefix":"10.1016","volume":"142","author":[{"given":"Kevin S.","family":"Heffernan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sae Young","family":"Jae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2020.109835_b0005","article-title":"A tale of two pandemics: how will COVID-19 and global trends in physical inactivity and sedentary behavior affect one another?","author":"Hall","year":"2020","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1016\/j.mehy.2020.109835_b0010","doi-asserted-by":"crossref","DOI":"10.1152\/ajplung.00097.2020","article-title":"Covid-19 infection and mortality - a physiologist's perspective enlightening clinical features and plausible interventional strategies","author":"Abassi","year":"2020","journal-title":"Am J Physiol Lung Cellular Molecular Physiol"},{"key":"10.1016\/j.mehy.2020.109835_b0015","unstructured":"Gurwitz D, Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics, Drug Develop Res; n\/a."},{"key":"10.1016\/j.mehy.2020.109835_b0020","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00109-012-0859-2","article-title":"Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury","volume":"90","author":"Rey-Parra","year":"2012","journal-title":"J Molecular Med (Berlin, Germany)"},{"key":"10.1016\/j.mehy.2020.109835_b0025","article-title":"Association of inpatient use of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19","author":"Zhang","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.mehy.2020.109835_b0030","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202000782","article-title":"Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: a double-edged sword?","author":"Yan","year":"2020","journal-title":"FASEB J: Off Pub Federation Am Soc Experiment Biol"},{"key":"10.1016\/j.mehy.2020.109835_b0035","doi-asserted-by":"crossref","first-page":"809","DOI":"10.2174\/0929866524666170728151401","article-title":"Physical exercise and ACE2-angiotensin-(1\u20137)-mas receptor axis of the renin angiotensin system","volume":"24","author":"Nunes-Silva","year":"2017","journal-title":"Protein Pept Lett"},{"key":"10.1016\/j.mehy.2020.109835_b0040","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/1535370216665174","article-title":"Original Research: ACE2 activator associated with physical exercise potentiates the reduction of pulmonary fibrosis","volume":"242","author":"Prata","year":"2017","journal-title":"Experimental Biol Med (Maywood, N.J.)"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720309658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720309658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:23:18Z","timestamp":1759692198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987720309658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":8,"alternative-id":["S0306987720309658"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109835","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise as medicine for COVID-19: An ACE in the hole?","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2020.109835","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"109835"}}