{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:23:17Z","timestamp":1759710197492,"version":"build-2065373602"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.mehy.2020.110405","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T21:28:56Z","timestamp":1605907736000},"page":"110405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The potentially therapeutic role of tonsillectomy in the alleviation of several renal diseases apart from IgA nephropathy"],"prefix":"10.1016","volume":"146","author":[{"given":"Yuuki","family":"Nishino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Enya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Marutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mehy.2020.110405_b0005","doi-asserted-by":"crossref","first-page":"557","DOI":"10.2174\/1566524054863924","article-title":"Mucosa-associated lymphoid tissues in the aerodigestive tract: their shared and divergent traits and their importance to the orchestration of the mucosal immune system","volume":"5","author":"Kunisawa","year":"2005","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.mehy.2020.110405_b0010","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41590-018-0120-4","article-title":"Regulatory T cells in autoimmune disease","volume":"19","author":"Dominguez-Villar","year":"2018","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0015","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.humimm.2017.12.013","article-title":"Regulatory T cells for tolerance","volume":"79","author":"Kawai","year":"2018","journal-title":"Hum Immunol"},{"key":"10.1016\/j.mehy.2020.110405_b0020","first-page":"1","article-title":"Clinical manifestations and pathogenesis of tonsillar focal diseases: IgA nephropathy and palmoplantar pustulosis","volume":"72","author":"Harabuchi","year":"2011","journal-title":"Adv Otorhinolaryngol"},{"issue":"6","key":"10.1016\/j.mehy.2020.110405_b0025","first-page":"802","article-title":"Vasculitis and allergic diseases\u2014involve-ment of endogenous and exogenous adjuvants-IgA nephro-pathy as a tonsil-induced autoimmune\/inflammatory syndrome (TIAS)","volume":"25","author":"Suzuki","year":"2018","journal-title":"Allergy Immun"},{"issue":"7","key":"10.1016\/j.mehy.2020.110405_b0030","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/1346-8138.14348","article-title":"Treatment outcome and prognostic factors of tonsillectomy for palmoplantar pustulosis and pustulotic arthro-osteitis: a retrospective subjective and objective quantitative analysis of 138 patients","volume":"45","author":"Takahara","year":"2018","journal-title":"J Dermatol"},{"issue":"4","key":"10.1016\/j.mehy.2020.110405_b0035","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1523-1755.2004.00486.x","article-title":"Relationship between tonsils and IgA nephropathy as well as indications of tonsillectomy","volume":"65","author":"Xie","year":"2004","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0040","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10157-015-1138-7","article-title":"Significance of tonsillectomy combined with steroid pulse therapy for IgA nephropathy with mild proteinuria","volume":"20","author":"Komatsu","year":"2016","journal-title":"Clin Exp Nephrol"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0045","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s10157-009-0179-1","article-title":"Tonsillectomy and steroid pulse (TSP) therapy for patients with IgA nephropathy: a nationwide survey of TSP therapy in Japan and an analysis of the predictive factors for resistance to TSP therapy","volume":"13","author":"Miura","year":"2009","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.mehy.2020.110405_b0050","first-page":"175","article-title":"Clinical study of chronic tonsillitis with IgA nephropathy treated by tonsillectomy","volume":"523","author":"Tomioka","year":"1996","journal-title":"Acta Otolaryngol Suppl"},{"key":"10.1016\/j.mehy.2020.110405_b0055","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1053\/ajkd.2001.27690","article-title":"Tonsillectomy and steroid pulse therapy significantly impact on clinical remission in patients with IgA nephropathy","volume":"38","author":"Hotta","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.mehy.2020.110405_b0060","series-title":"New strategies for oral immunization. Current Topics in Microbiology and Immunology","first-page":"13","article-title":"Overview of the mucosal immune system","author":"Brandtzaeg","year":"1989"},{"issue":"10","key":"10.1016\/j.mehy.2020.110405_b0065","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/intimm\/dxx064","article-title":"NALT M cells are important for immune induction for the common mucosal immune system","volume":"29","author":"Date","year":"2017","journal-title":"Int Immunol"},{"issue":"10","key":"10.1016\/j.mehy.2020.110405_b0070","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJMra020109","article-title":"IgA nephropathy","volume":"347","author":"Donadio","year":"2002","journal-title":"New Engl J Med"},{"issue":"8888","key":"10.1016\/j.mehy.2020.110405_b0075","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0140-6736(94)90875-3","article-title":"Haemophilus parainfluenzae antigen and antibody in renal biopsy samples and serum of patients with IgA nephropathy","volume":"343","author":"Suzuki","year":"1994","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0080","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1523-1755.2004.00714.x","article-title":"Staphylococcus aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy","volume":"66","author":"Koyama","year":"2004","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0085","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/j.2040-4603.2013.tb00511.x","article-title":"Immune and inflammatory role in renal disease","volume":"3","author":"Imig","year":"2013","journal-title":"Compr Physiol"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0090","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/cei.13119","article-title":"The role of the immune system in kidney disease","volume":"192","author":"Tecklenborg","year":"2018","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"10.1016\/j.mehy.2020.110405_b0095","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1523-1755.2005.00146.x","article-title":"Role of macromolecular IgA in IgA nephropathy","volume":"67","author":"van der Boog","year":"2005","journal-title":"Kidney Int"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089707","article-title":"Changes in nephritogenic serum galactose-deficient IgA1 in IgA nephropathy following tonsillectomy and steroid therapy","volume":"9","author":"Nakata","year":"2014","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0105","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1007\/s10157-013-0921-6","article-title":"Serum levels of galactose-deficient immunoglobulin (Ig) A1 and related immune complex are associated with disease activity of IgA nephropathy","volume":"18","author":"Suzuki","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.mehy.2020.110405_b0110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3109\/00016489309130264","article-title":"Expanded primary T nodules in the palatine tonsils from patients with IgA nephropathy","volume":"508","author":"Kawaguchi","year":"1993","journal-title":"Acta Otolaryngol Suppl"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0115","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000189325","article-title":"IgA nephropathy with poorly developed lymphoepithelial symbiosis of the palatine tonsils","volume":"74","author":"Sato","year":"1996","journal-title":"Nephron"},{"issue":"4","key":"10.1016\/j.mehy.2020.110405_b0120","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1159\/000186474","article-title":"Confirmation of tonsillar anomalies in IgA nephropathy: a multicenter study","volume":"58","author":"B\u00e9n\u00e9","year":"1991","journal-title":"Nephron"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0125","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1172\/JCI110886","article-title":"Immunoglobulin A nephropathy. Quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance","volume":"71","author":"Bene","year":"1983","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.mehy.2020.110405_b0130","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-3083.1988.tb02362.x","article-title":"Tonsillar distribution of IgA and IgG immunocytes and production of IgA subclasses and J chain in tonsillitis vary with the presence or absence of IgA nephropathy","volume":"27","author":"Nagy","year":"1988","journal-title":"Scand J Immunol"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0135","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1006\/clin.1997.4389","article-title":"Enhanced expression of CD31 and CD54 on tonsillar high endothelial venules in IgA nephropathy","volume":"84","author":"Kennel-De March","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"issue":"12","key":"10.1016\/j.mehy.2020.110405_b0140","first-page":"2072","article-title":"Comprehensive microbiome analysis of tonsillar crypts in IgA nephropathy","volume":"32","author":"Watanabe","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.mehy.2020.110405_b0145","first-page":"68","article-title":"IgA nephropathy and aberrant glycosylation of tonsillar, serum and glomerular IgA1","volume":"72","author":"Hiki","year":"2011","journal-title":"Adv Otorhinolaryngol"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0150","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/iid3.248","article-title":"Recent advances in the immunological understanding of association between tonsil and immunoglobulin A nephropathy as a tonsil-induced autoimmune\/inflammatory syndrome","volume":"7","author":"Harabuchi","year":"2019","journal-title":"Immun Inflamm Dis"},{"issue":"4","key":"10.1016\/j.mehy.2020.110405_b0155","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10157-015-1223-y","article-title":"Evidence-based clinical practice guidelines for IgA nephropathy 2014","volume":"20","author":"Yuzawa","year":"2016","journal-title":"Clin Exp Nephrol"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40620-015-0247-4","article-title":"The role of tonsillectomy in IgA nephropathy","volume":"29","author":"Feriozzi","year":"2016","journal-title":"J Nephrol"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0165","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000441852","article-title":"Tonsillectomy in a European cohort of 1,147 patients with IgA nephropathy","volume":"132","author":"Feehally","year":"2016","journal-title":"Nephron"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0170","doi-asserted-by":"crossref","first-page":"298","DOI":"10.5414\/CNP67298","article-title":"Tonsillectomy in the treatment of pediatric Henoch-Sch\u00f6nlein nephritis","volume":"67","author":"Inoue","year":"2007","journal-title":"Clin Nephrol"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0175","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10157-011-0463-8","article-title":"Successful therapy with tonsillectomy for severe ISKDC grade VI Henoch-Sch\u00f6nlein purpura nephritis and persistent nephrotic syndrome","volume":"15","author":"Ohara","year":"2011","journal-title":"Clin Exp Nephrol"},{"issue":"4","key":"10.1016\/j.mehy.2020.110405_b0180","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s10157-017-1515-5","article-title":"Comparison of long-term follow-up outcomes between multiple-drugs combination therapy and tonsillectomy pulse therapy for pediatric IgA nephropathy","volume":"22","author":"Kawasaki","year":"2018","journal-title":"Clin Exp Nephrol"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0185","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s10157-018-1553-7","article-title":"Initial treatment with pulse methylprednisolone followed by short-term prednisolone and tonsillectomy for childhood IgA nephropathy","volume":"22","author":"Yamada","year":"2018","journal-title":"Clin Exp Nephrol"},{"issue":"7","key":"10.1016\/j.mehy.2020.110405_b0190","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1440-1797.2012.01620.x","article-title":"Effect and therapeutic mechanisms of tonsillectomy for childhood IgA nephropathy","volume":"17","author":"Nishi","year":"2012","journal-title":"Nephrology (Carlton)"},{"issue":"9","key":"10.1016\/j.mehy.2020.110405_b0195","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1111\/ped.14264","article-title":"Early tonsillectomy for severe IgA nephropathy significantly reduces proteinuria","volume":"62","author":"Enya","year":"2020","journal-title":"Pediatr Int"},{"key":"10.1016\/j.mehy.2020.110405_b0200","article-title":"Short- and long-term impacts of adenoidectomy with\/without tonsillectomy on immune function of young children <3 years of age: A cohort study","volume":"98","author":"Yan","year":"2019","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.mehy.2020.110405_b0205","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jaci.2016.06.003","article-title":"Regulatory T cells in allergic diseases","volume":"138","author":"Rivas","year":"2016","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"10.1016\/j.mehy.2020.110405_b0210","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/intimm\/dxn044","article-title":"Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)","volume":"20","author":"Bonelli","year":"2008","journal-title":"Int Immunol"},{"issue":"11","key":"10.1016\/j.mehy.2020.110405_b0215","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1093\/rheumatology\/keq237","article-title":"Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients","volume":"49","author":"van Roon","year":"2010","journal-title":"Rheumatology (Oxford)"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0220","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0092-8674(00)80856-9","article-title":"Regulatory T cells: key controllers of immunologic self-tolerance","volume":"101","author":"Sakaguchi","year":"2000","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0225","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/nep.12574","article-title":"Regulatory T cells in immune-mediated renal disease","volume":"21","author":"Ghali","year":"2016","journal-title":"Nephrology (Carlton)"},{"issue":"10","key":"10.1016\/j.mehy.2020.110405_b0230","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1681\/ASN.2005080842","article-title":"CD4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease","volume":"17","author":"Mahajan","year":"2006","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"10.1016\/j.mehy.2020.110405_b0235","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1007\/s11255-014-0851-6","article-title":"CD4 (+) CD 25 (+) Treg cells and IgA nephropathy patients with tonsillectomy: a clinical and pathological study","volume":"46","author":"Huang","year":"2014","journal-title":"Int Urol Nephrol"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0240","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1159\/000350533","article-title":"Tonsillar CD4+CD25+ regulatory T cells from IgA nephropathy patients have decreased immunosuppressive activity in experimental IgA nephropathy rats","volume":"37","author":"Huang","year":"2013","journal-title":"Am J Nephrol"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0245","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-3476(87)80285-8","article-title":"Syndrome of periodic fever, pharyngitis, and aphthous stomatitis","volume":"110","author":"Marshall","year":"1987","journal-title":"J Pediatr"},{"key":"10.1016\/j.mehy.2020.110405_b0250","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/1471-2431-10-65","article-title":"Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome","volume":"10","author":"Brown","year":"2010","journal-title":"BMC Pediatr"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0255","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jpeds.2010.12.014","article-title":"Tonsillectomy in children with periodic fever with aphthous stomatitis, pharyngitis, and adenitis syndrome","volume":"159","author":"Garavello","year":"2011","journal-title":"J Pediatr"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0260","first-page":"202","article-title":"Decreased CD4+CD25+ cells and increased dimeric IgA-producing cells in tonsils in IgA nephropathy","volume":"23","author":"Huang","year":"2010","journal-title":"J Nephrol"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0265","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00467-012-2295-5","article-title":"Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome and IgA nephropathy","volume":"28","author":"Sugimoto","year":"2013","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"10.1016\/j.mehy.2020.110405_b0270","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3165\/jjpn.cr.2018.0145","article-title":"A case of membranoproliferative glomerulonephritis in whom clinical remission could be achieved by tonsillectomy","volume":"32","author":"Miyazaki","year":"2019","journal-title":"Japanese J Pediatr Nephrol"},{"issue":"4","key":"10.1016\/j.mehy.2020.110405_b0275","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00467-012-2387-2","article-title":"Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome","volume":"28","author":"Kimata","year":"2013","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.mehy.2020.110405_b0280","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1824-7288-39-42","article-title":"CD19 + CD23+ B cells, CD4 + CD25+ T cells, E-selectin and interleukin-12 levels in children with steroid sensitive nephrotic syndrome","volume":"39","author":"Yildiz","year":"2013","journal-title":"Ital J Pediatr"},{"issue":"9","key":"10.1016\/j.mehy.2020.110405_b0285","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s00467-009-1214-x","article-title":"T regulatory cell function in idiopathic minimal lesion nephrotic syndrome","volume":"24","author":"Araya","year":"2009","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"10.1016\/j.mehy.2020.110405_b0290","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/ped.13255","article-title":"Regulatory T cells and CTLA-4 in idiopathic nephrotic syndrome","volume":"59","author":"Tsuji","year":"2017","journal-title":"Pediatr Int"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0295","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1681\/ASN.2007111244","article-title":"Induction of T regulatory cells attenuates idiopathic nephrotic syndrome","volume":"20","author":"Le Berre","year":"2009","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.mehy.2020.110405_b0300","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1186\/s12882-019-1580-y","article-title":"Pathologic tonsillar findings similar to IgA nephropathy and the role of tonsillectomy in a patient with nephrotic syndrome","volume":"20","author":"Enya","year":"2019","journal-title":"BMC Nephrol"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720332965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987720332965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:25:19Z","timestamp":1759692319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987720332965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":60,"alternative-id":["S0306987720332965"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2020.110405","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The potentially therapeutic role of tonsillectomy in the alleviation of several renal diseases apart from IgA nephropathy","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2020.110405","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110405"}}