{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T19:44:49Z","timestamp":1793130289722,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.mehy.2021.110548","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T12:30:46Z","timestamp":1614601846000},"page":"110548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Stromal cell-derived factor-1 may play pivotal role in distraction-stimulated neovascularization of diabetic foot ulcer"],"prefix":"10.1016","volume":"149","author":[{"given":"Jiezhuang","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zebin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2021.110548_b0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.mehy.2021.110548_b0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.numecd.2017.11.007","article-title":"Management of diabetes in older adults","volume":"28","author":"Sesti","year":"2018","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.mehy.2021.110548_b0015","doi-asserted-by":"crossref","first-page":"107843","DOI":"10.1016\/j.diabres.2019.107843","article-title":"Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9(th) edition","volume":"157","author":"Saeedi","year":"2019","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.mehy.2021.110548_b0020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jama.293.2.217","article-title":"Preventing foot ulcers in patients with diabetes","volume":"293","author":"Singh","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.mehy.2021.110548_b0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis","volume":"49","author":"Zhang","year":"2017","journal-title":"Ann Med"},{"key":"10.1016\/j.mehy.2021.110548_b0030","doi-asserted-by":"crossref","first-page":"17s","DOI":"10.1016\/j.jvs.2010.06.003","article-title":"The costs of diabetic foot: the economic case for the limb salvage team","volume":"52","author":"Driver","year":"2010","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.mehy.2021.110548_b0035","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic foot ulcers and their recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"New Engl J Med"},{"key":"10.1016\/j.mehy.2021.110548_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17060917","article-title":"Neuropathy and diabetic foot syndrome","volume":"17","author":"Volmer-Thole","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.mehy.2021.110548_b0045","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/jamasurg.2016.2018","article-title":"The current state of critical limb ischemia: a systematic review","volume":"151","author":"Farber","year":"2016","journal-title":"JAMA Surg"},{"key":"10.1016\/j.mehy.2021.110548_b0050","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.amjms.2015.11.011","article-title":"The effect of short-term hyperglycemia on the innate immune system","volume":"351","author":"Jafar","year":"2016","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.mehy.2021.110548_b0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1534734614564867","article-title":"Epidemiology of type 2 diabetic foot problems and predictive factors for amputation in China","volume":"14","author":"Jiang","year":"2015","journal-title":"Int J Lower Extremity Wounds"},{"key":"10.1016\/j.mehy.2021.110548_b0060","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1007\/s12020-020-02292-7","article-title":"Survival at 10 years following lower extremity amputations in patients with diabetic foot disease","volume":"69","author":"Soo","year":"2020","journal-title":"Endocrine"},{"key":"10.1016\/j.mehy.2021.110548_b0065","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jvs.2019.10.083","article-title":"Short-term contemporary outcomes for staged versus primary lower limb amputation in diabetic foot disease","volume":"72","author":"Cheun","year":"2020","journal-title":"J Vasc Surg"},{"issue":"Suppl 1","key":"10.1016\/j.mehy.2021.110548_b0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/dmrr.2702","article-title":"Footwear and offloading interventions to prevent and heal foot ulcers and reduce plantar pressure in patients with diabetes: a systematic review","volume":"32","author":"Bus","year":"2016","journal-title":"Diabetes\/Metab Res Rev"},{"key":"10.1016\/j.mehy.2021.110548_b0075","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.2337\/dc17-2584","article-title":"Decreasing an offloading device's size and offsetting its imposed limb-length discrepancy lead to improved comfort and gait","volume":"41","author":"Crews","year":"2018","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"10.1016\/j.mehy.2021.110548_b0080","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/dmrr.2705","article-title":"Effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review","volume":"32","author":"Hinchliffe","year":"2016","journal-title":"Diabetes\/Metab Res Rev"},{"key":"10.1016\/j.mehy.2021.110548_b0085","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1067\/mva.2002.121126","article-title":"Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization","volume":"35","author":"Arora","year":"2002","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.mehy.2021.110548_b0090","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1302\/0301-620X.79B2.0790273","article-title":"The Ilizarov method in nonunion, malunion and infection of fractures","volume":"79","author":"Marsh","year":"1997","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.mehy.2021.110548_b0095","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/CORR.0000000000001075","article-title":"Proximal tibial cortex transverse distraction facilitating healing and limb salvage in severe and recalcitrant diabetic foot ulcers","volume":"478","author":"Chen","year":"2020","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.mehy.2021.110548_b0100","article-title":"How to perform minimally invasive tibial cortex transverse transport surgery","author":"Li","year":"2020","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.mehy.2021.110548_b0105","first-page":"124","article-title":"Temporal and spatial increases in blood flow during distraction osteogenesis","author":"Aronson","year":"1994","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.mehy.2021.110548_b0110","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/01.blo.0000238795.82466.74","article-title":"Distraction osteogenesis promotes angiogenesis in the surrounding muscles","volume":"454","author":"Ohashi","year":"2007","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.mehy.2021.110548_b0115","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00223-017-0249-4","article-title":"Effect of SDF-1\/Cxcr4 signaling antagonist AMD3100 on bone mineralization in distraction osteogenesis","volume":"100","author":"Xu","year":"2017","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.mehy.2021.110548_b0120","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bone.2009.10.018","article-title":"Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man","volume":"46","author":"Lee","year":"2010","journal-title":"Bone"},{"key":"10.1016\/j.mehy.2021.110548_b0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bcmd.2003.09.025","article-title":"Tissue-specific muscle, neural and liver stem\/progenitor cells reside in the bone marrow, respond to an SDF-1 gradient and are mobilized into peripheral blood during stress and tissue injury","volume":"32","author":"Kucia","year":"2004","journal-title":"Blood Cells Mol Dis"},{"key":"10.1016\/j.mehy.2021.110548_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2004.10.014","article-title":"Mobilizing of haematopoietic stem cells to ischemic myocardium by plasmid mediated stromal-cell-derived factor-1alpha (SDF-1alpha) treatment","volume":"125","author":"Tang","year":"2005","journal-title":"Regul Pept"},{"key":"10.1016\/j.mehy.2021.110548_b0135","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1016\/S0002-9440(10)63248-8","article-title":"Expression of stromal cell-derived factor-1 and of its receptor CXCR4 in liver regeneration from oval cells in rat","volume":"165","author":"Mavier","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.mehy.2021.110548_b0140","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1517\/14712590903460286","article-title":"Role of the SDF-1-CXCR4 axis in stem cell-based therapies for ischemic cardiomyopathy","volume":"10","author":"Zaruba","year":"2010","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.mehy.2021.110548_b0145","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.mehy.2021.110548_b0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000342921","article-title":"Stromal cell-derived factor-1 enhances wound healing through recruiting bone marrow-derived mesenchymal stem cells to the wound area and promoting neovascularization","volume":"197","author":"Xu","year":"2013","journal-title":"Cells Tissues Org"},{"key":"10.1016\/j.mehy.2021.110548_b0155","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ejcts.2009.04.052","article-title":"Mesenchymal stem cells over-expressing SDF-1 promote angiogenesis and improve heart function in experimental myocardial infarction in rats","volume":"36","author":"Tang","year":"2009","journal-title":"Eur J Cardio-thoracic Surg"},{"key":"10.1016\/j.mehy.2021.110548_b0160","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1124\/mol.109.060400","volume":"77","author":"Carretero-Ortega","year":"2010","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.mehy.2021.110548_b0165","doi-asserted-by":"crossref","first-page":"44941","DOI":"10.18632\/oncotarget.10377","article-title":"EPCs enhance angiogenesis in renal regeneration","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.mehy.2021.110548_b0170","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1002\/term.2233","article-title":"Synergic effects of VEGF-A and SDF-1 on the angiogenic properties of endothelial progenitor cells","volume":"11","author":"Odent Grigorescu","year":"2017","journal-title":"J Tissue Eng Regener Med"},{"key":"10.1016\/j.mehy.2021.110548_b0175","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/sctm.18-0143","article-title":"Salidroside-pretreated mesenchymal stem cells enhance diabetic wound healing by promoting paracrine function and survival of mesenchymal stem cells under hyperglycemia","volume":"8","author":"Ariyanti","year":"2019","journal-title":"Stem cells Transl Med"},{"key":"10.1016\/j.mehy.2021.110548_b0180","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cyto.2017.09.012","article-title":"Influence of cytokine status on insulin resistance and circulating endothelial progenitor cells in type 2 diabetes mellitus","volume":"99","author":"Sosale","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.mehy.2021.110548_b0185","doi-asserted-by":"crossref","first-page":"10930","DOI":"10.1074\/jbc.M707451200","article-title":"Decreasing intracellular superoxide corrects defective ischemia-induced new vessel formation in diabetic mice","volume":"283","author":"Ceradini","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mehy.2021.110548_b0190","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1189\/jlb.1203609","article-title":"Evidence for the involvement of SDF-1 and CXCR4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by TNF-alpha and IFN-gamma","volume":"76","author":"Salvucci","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.mehy.2021.110548_b0195","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1089\/ars.2008.2121","article-title":"Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing","volume":"10","author":"Liu","year":"2008","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.mehy.2021.110548_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2019.103924","article-title":"miR-23c regulates wound healing by targeting stromal cell-derived factor-1\u03b1 (SDF-1\u03b1\/CXCL12) among patients with diabetic foot ulcer","volume":"127","author":"Amin","year":"2020","journal-title":"Microvasc Res"},{"key":"10.1016\/j.mehy.2021.110548_b0205","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1089\/cell.2012.0046","article-title":"Stromal cell-derived factor-1 receptor CXCR4-overexpressing bone marrow mesenchymal stem cells accelerate wound healing by migrating into skin injury areas","volume":"15","author":"Yang","year":"2013","journal-title":"Cell Reprogramm"},{"key":"10.1016\/j.mehy.2021.110548_b0210","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4161\/cc.9.1.10371","article-title":"HIF-1alpha dysfunction in diabetes","volume":"9","author":"Thangarajah","year":"2010","journal-title":"Cell cycle (Georgetown, Tex.)"},{"key":"10.1016\/j.mehy.2021.110548_b0215","first-page":"E1035","article-title":"Regulation of 11\u03b2-HSD1 expression during adipose tissue expansion by hypoxia through different activities of NF-\u03baB and HIF-1\u03b1, American journal of physiology","volume":"304","author":"Lee","year":"2013","journal-title":"Endocrinol Metab"},{"key":"10.1016\/j.mehy.2021.110548_b0220","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.7150\/ijms.5630","article-title":"The possible mechanisms underlying the impairment of HIF-1\u03b1 pathway signaling in hyperglycemia and the beneficial effects of certain therapies","volume":"10","author":"Xiao","year":"2013","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.mehy.2021.110548_b0225","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.joen.2010.05.011","article-title":"Regulation of the stromal cell-derived factor-1alpha-CXCR4 axis in human dental pulp cells","volume":"36","author":"Gong","year":"2010","journal-title":"J Endodontics"},{"key":"10.1016\/j.mehy.2021.110548_b0230","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1182\/blood-2006-05-025098","article-title":"Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells","volume":"108","author":"R\u00fcster","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.mehy.2021.110548_b0235","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing","volume":"25","author":"Chamberlain","year":"2007","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"10.1016\/j.mehy.2021.110548_b0240","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/sj.leu.2403184","article-title":"Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells 'hide out' in the bone marrow","volume":"18","author":"Ratajczak","year":"2004","journal-title":"Leukemia"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987721000669?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987721000669?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:24:34Z","timestamp":1759692274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987721000669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":48,"alternative-id":["S0306987721000669"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2021.110548","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stromal cell-derived factor-1 may play pivotal role in distraction-stimulated neovascularization of diabetic foot ulcer","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2021.110548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110548"}}