{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:46:37Z","timestamp":1767339997244,"version":"build-2065373602"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,22]],"date-time":"2021-03-22T00:00:00Z","timestamp":1616371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.mehy.2021.110567","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T10:25:03Z","timestamp":1616495103000},"page":"110567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Hystero-epilepsy in the Tuesday Lessons and NMDA receptor function: A hypothesis for dissociative disorder"],"prefix":"10.1016","volume":"150","author":[{"given":"Tomoko","family":"Komagamine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Kokubun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2021.110567_b0005","doi-asserted-by":"crossref","unstructured":"Goetz CG. Charcot, hysteria, and simulated disorders. In: Hallett M, Stone J, Carson A (ed). Handb Clin Neurol, Elsevier, Amsterdam, 2016; 139: 11\u201323.","DOI":"10.1016\/B978-0-12-801772-2.00002-3"},{"key":"10.1016\/j.mehy.2021.110567_b0010","doi-asserted-by":"crossref","unstructured":"Aybek A, Vuilleumier P. Imaging studies of functional neurologic disorders. In: Hallett M, Stone J, Carson A (ed). Handb Clin Neurol, Elsevier, Amsterdam, 2016; 139:73\u201384.","DOI":"10.1016\/B978-0-12-801772-2.00007-2"},{"key":"10.1016\/j.mehy.2021.110567_b0015","series-title":"Hysteria","first-page":"104","author":"Scull","year":"2009"},{"key":"10.1016\/j.mehy.2021.110567_b0020","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/ana.21050","article-title":"Paraneoplastic anti\u2013N-methyl-D-aspartate (NMDA)-receptor encephalitis associated with ovarian teratoma","volume":"61","author":"Dalmau","year":"2007","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0025","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1474-4422(10)70253-2","article-title":"Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis","volume":"10","author":"Dalmau","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0030","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1136\/jnnp-2018-318584","article-title":"The Movement disorder associated with NMDAR antibody-encephalitis is complex and characteristic: an expert video-rating study","volume":"90","author":"Varley","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.mehy.2021.110567_b0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/0957154X19877145","article-title":"Battey\u2019s operation as a treatment for hysteria: a review of a series of cases in the nineteenth century","volume":"31","author":"Komagamine","year":"2020","journal-title":"Hist Psychiatry"},{"key":"10.1016\/j.mehy.2021.110567_b0040","unstructured":"Blin MM, Charcot JB, Colin H. original published 1887\u20131889. Policlinique Notes de cours de MM. Blin, Charcot, Henri Colin. Professeur Charcot, Le\u00e7ons du mardi \u00e0 la Salp\u00eatri\u00e8re. Tome I 1887\u20131888. Tome II 1888\u20131889. Reprint. Claude Tchou pour la Bibliotheque des Introuvables, Paris, 2002."},{"key":"10.1016\/j.mehy.2021.110567_b0045","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1212\/01.wnl.0000278388.90370.c3","article-title":"Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal","volume":"70","author":"Iizuka","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.mehy.2021.110567_b0050","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1001\/archneurol.2009.264","article-title":"Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications","volume":"66","author":"Kanbayashi","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0055","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-244X-12-37","article-title":"Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features","volume":"12","author":"Tsutsui","year":"2012","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.mehy.2021.110567_b0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1001\/archneur.1981.00510030085013","article-title":"Acquired reversible autistic syndrome in acute encephalopathic illness in children","volume":"38","author":"DeLong","year":"1982","journal-title":"Arch Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0065","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0022-3476(05)80326-9","article-title":"Coma associated with intense bursts of abnormal movements and long-lasting cognitive disturbances: an acute encephalopathy of obscure origin","volume":"121","author":"S\u00e9bire","year":"1992","journal-title":"J Pediatr"},{"key":"10.1016\/j.mehy.2021.110567_b0070","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/ana.21807","article-title":"N-methyl-D-aspartate (NMDA)-receptor antibodies in paediatric dyskinetic encephalitis lethargica","volume":"66","author":"Dale","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0075","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00005072-195007000-00001","article-title":"Post-infectious encephalomyelitis and multiple sclerosis; the significance of perivenous encephalomyelitis","volume":"9","author":"van Bogaert","year":"1950","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0080","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/BF00343107","article-title":"Beitrag zur akuten diffusen lymphocyt\u00e4ren Meningoencephalitis und Encephalopathie","volume":"206","author":"Iizuka","year":"1965","journal-title":"Arch Psychiatr Nervenkr"},{"key":"10.1016\/j.mehy.2021.110567_b0085","first-page":"45","article-title":"Acute reversible limbic encephalitis developing with psychosis and prone to affect young woman without notable changes in MRI: report of 4 cases and discussion","volume":"59","author":"Yuasa","year":"2003","journal-title":"Neurol Med"},{"key":"10.1016\/j.mehy.2021.110567_b0090","unstructured":"Fukutake T, Yamanaka I, Hattori T, Shibayama H. Non-herpetic encephalitis presenting with psychiatric symptoms at onset, status epilepticus, coma and respiratory suppression in peak, and unique involuntary movement ('acute diffuse lymphocytic meningoencephalitis'?): clinical features and long-term outcome of six patients. Neurol Med 2003;59:188\u201394 [Article in Japanese]."},{"key":"10.1016\/j.mehy.2021.110567_b0095","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ana.21928","article-title":"In search of lost time from \u201cdemonic possession\u201d to anti- NMDAR encephalitis","volume":"67","author":"S\u00e9bire","year":"2010","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0100","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1097\/MOP.0b013e3283402d2f","article-title":"Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents","volume":"22","author":"Florance-Ryan","year":"2010","journal-title":"Curr Opin Pediat"},{"key":"10.1016\/j.mehy.2021.110567_b0105","unstructured":"Charcot JM. Richer Les d\u00e9moniaques dans l\u2019art. Original published in, Facsimile reprint 1887 Amsterdam. B.M Isra\u00ebl 1972."},{"key":"10.1016\/j.mehy.2021.110567_b0110","unstructured":"Richer P. \u00c9tudes cliniques sur l\u2019hyst\u00e9ro-\u00e9pilepsie ou grande hyst\u00e9rie 1e ed. Adrien Delahaye et \u00c9mile Lecrosnier, 1881, Paris. Source gallica.bnf.fr\/National Library of France."},{"key":"10.1016\/j.mehy.2021.110567_b0115","unstructured":"Charcot JM. Lectures on the diseases of the nervous system. Delivered at la Salp\u00eatri\u00e8re. Vol I. Translated by Sigerson G. Facsimile reprint ed of the London, New Sydenham Society, 1877. The classics of Neurology & Neurosurgery Library. Birmingham, Alabama: Gryphon Edition Ltd; 1985."},{"key":"10.1016\/j.mehy.2021.110567_b0120","article-title":"Opisthotonus (arc de cercle) in anti-NMDA receptor encephalitis","author":"Garcia","year":"2018","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1016\/j.mehy.2021.110567_b0125","series-title":"Epilepsy and the functional anatomy of the human brain","first-page":"382","author":"Penfield","year":"1954"},{"key":"10.1016\/j.mehy.2021.110567_b0130","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/jnnp.61.2.194","article-title":"A case report of paroxysmal dystonic choreoathetosis due to hypoglycaemia induced by an insulinoma","volume":"61","author":"Shaw","year":"1996","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.mehy.2021.110567_b0135","first-page":"799","article-title":"Hashimoto\u2019s encephalopathy. Epidemiology, pathogenesis and management. CND","volume":"21","author":"Mocellin","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.mehy.2021.110567_b0140","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/ana.410180413","article-title":"Complex partial seizures of frontal lobe origin","volume":"18","author":"Williamson","year":"1985","journal-title":"Ann Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0145","first-page":"297","volume":"139","year":"2016","journal-title":"Nonepileptic seizures \u2013 objective phenomena"},{"key":"10.1016\/j.mehy.2021.110567_b0150","first-page":"2356","article-title":"Consideration of psychotic symptomatology in anti-NMDAR encephalitis: Similarity to cycloid psychosis","volume":"7","author":"Serv\u00e9n","year":"2019","journal-title":"Clin Case Rep"},{"key":"10.1016\/j.mehy.2021.110567_b0155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1474-4422(12)70310-1","article-title":"Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study","volume":"12","author":"Titulaer","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0160","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.psym.2011.08.004","article-title":"Pseudopseudoseizures: conditions that may mimic psychogenic non-epileptic seizures","volume":"52","author":"Caplan","year":"2011","journal-title":"Psychosomatics"},{"key":"10.1016\/j.mehy.2021.110567_b0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40981-016-0048-3","article-title":"Anti-NMDA receptor encephalitis presenting as an acute psychotic episode misdiagnosed as dissociative disorder: a case report","volume":"2","author":"Shimoyama","year":"2016","journal-title":"JA Clin Rep"},{"key":"10.1016\/j.mehy.2021.110567_b0170","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1002\/mds.25072","article-title":"The distinct movement disorder in anti-NMDA receptor encephalitis may be related to Status Dissociatus: a hypothesis","volume":"27","author":"Stamelou","year":"2012","journal-title":"Mov Disord"},{"key":"10.1016\/j.mehy.2021.110567_b0175","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0163-7258(03)00054-8","article-title":"N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability","volume":"99","author":"Krystal","year":"2003","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.mehy.2021.110567_b0180","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1124\/jpet.115.227629","article-title":"Phosphorylation of the N-methyl-D-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal","volume":"355","author":"Anderson","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.mehy.2021.110567_b0185","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1093\/schbul\/sbs076","article-title":"NMDA receptor and schizophrenia: a brief history","volume":"38","author":"Coyle","year":"2012","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.mehy.2021.110567_b0190","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/schbul\/sbw063","article-title":"Unique overlapping symptoms in schizophrenia spectrum and dissociative disorders in relation to models of psychopathology: a systematic review","volume":"43","author":"Renard","year":"2017","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.mehy.2021.110567_b0195","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12888-016-0948-9","article-title":"Prevalence of elevated serum anti- N-methyl-D-aspartate receptor antibody titers in patients presenting exclusively with psychiatric symptoms: a comparative follow-up study","volume":"16","author":"Ando","year":"2016","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.mehy.2021.110567_b0200","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2147\/NDT.S125800","article-title":"N-methyl-D-aspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection","volume":"13","author":"Tsutsui","year":"2017","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.mehy.2021.110567_b0205","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1001\/jama.1971.03180200050011","article-title":"Dissociative anesthesia","volume":"215","author":"Pender","year":"1971","journal-title":"JAMA"},{"key":"10.1016\/j.mehy.2021.110567_b0210","doi-asserted-by":"crossref","first-page":"R1031","DOI":"10.1016\/j.cub.2014.08.051","article-title":"Thanatosis","volume":"24","author":"Rogers","year":"2014","journal-title":"Curr Biol"},{"key":"10.1016\/j.mehy.2021.110567_b0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s00265-017-2436-8","article-title":"A review of thanatosis","volume":"72","author":"Humphreys","year":"2018","journal-title":"Bahav Ecol Soci"},{"key":"10.1016\/j.mehy.2021.110567_b0220","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.physbeh.2008.02.013","article-title":"Modulation of tonic immobility in guinea pig PAG by homocystic acid, a glutamate agonist","volume":"94","author":"Coutinho","year":"2008","journal-title":"Physiol Behav"},{"key":"10.1016\/j.mehy.2021.110567_b0225","doi-asserted-by":"crossref","first-page":"736","DOI":"10.3389\/fneur.2020.00736","article-title":"The neurology of death and the dying brain: a pictorial essay","volume":"11","author":"Kondziella","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.mehy.2021.110567_b0230","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11910-019-0983-2","article-title":"Seminology and mechanisms of near-death-experiences","volume":"19","author":"Peinkhofer","year":"2019","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.mehy.2021.110567_b0235","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.concog.2019.01.011","article-title":"Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports","volume":"69","author":"Martial","year":"2019","journal-title":"Conscious Cogn"},{"key":"10.1016\/j.mehy.2021.110567_b0240","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0140-6736(00)82013-9","article-title":"Dissociation in people who have near-death experiences: out of their bodies or out of their minds?","volume":"355","author":"Greyson","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.mehy.2021.110567_b0245","article-title":"On chorea and other allied movement disorders of early life. Chap IV Chorea as a fatal disease","author":"Sturges","year":"1881","journal-title":"London: Smith Elder & Co."}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987721000852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987721000852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:24:33Z","timestamp":1759692273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987721000852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":49,"alternative-id":["S0306987721000852"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2021.110567","relation":{},"ISSN":["0306-9877"],"issn-type":[{"type":"print","value":"0306-9877"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hystero-epilepsy in the Tuesday Lessons and NMDA receptor function: A hypothesis for dissociative disorder","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2021.110567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"110567"}}