{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:43:33Z","timestamp":1787867013646,"version":"build-2784847793"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Medical Hypotheses"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.mehy.2021.110655","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T02:10:52Z","timestamp":1627611052000},"page":"110655","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine"],"prefix":"10.1016","volume":"155","author":[{"given":"Shyamshree S.S.","family":"Manna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mehy.2021.110655_b0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2011.00044","article-title":"Neurosteroids and GABA-A receptor function","volume":"2","author":"Wang","year":"2011","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1-2","key":"10.1016\/j.mehy.2021.110655_b0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0006-8993(92)90233-Y","article-title":"Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus","volume":"578","author":"Frye","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.mehy.2021.110655_b0015","article-title":"Non-genomic mechanisms of action of steroid hormones","volume":"191","author":"Baulieu","year":"1995","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.mehy.2021.110655_b0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.steroids.2017.11.005","article-title":"Communication between genomic and non-genomic signaling events coordinate steroid hormone actions","volume":"133","author":"Wilkenfeld","year":"2018","journal-title":"Steroids"},{"key":"10.1016\/j.mehy.2021.110655_b0025","article-title":"Endogenous role in the human brain and therapeutic potentials","volume":"186","author":"Neurosteroids","year":"2010","journal-title":"Elsevier B.V."},{"issue":"19","key":"10.1016\/j.mehy.2021.110655_b0030","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1111\/bph.13843","article-title":"Neurosteroid biosynthesis down-regulation and changes in GABAA receptor subunit composition: a biomarker axis in stress-induced cognitive and emotional impairment","volume":"174","author":"Locci","year":"2017","journal-title":"Br J Pharmacol"},{"issue":"1","key":"10.1016\/j.mehy.2021.110655_b0035","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.pneurobio.2003.09.001","article-title":"Neurosteroid modulation of GABAA receptors","volume":"71","author":"Lambert","year":"2003","journal-title":"Prog Neurobiol"},{"issue":"9","key":"10.1016\/j.mehy.2021.110655_b0040","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1523\/JNEUROSCI.22-09-03795.2002","article-title":"Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility","volume":"22","author":"Reddy","year":"2002","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.mehy.2021.110655_b0045","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1007\/s00213-005-0148-7","article-title":"Pharmacokinetic and behavioral effects of allopregnanolone in healthy women","volume":"186","author":"Timby","year":"2006","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.mehy.2021.110655_b0050","article-title":"Steroids in relation to epilepsy and anaesthesia","volume":"153","author":"B\u00e4ckstr\u00f6m","year":"1990","journal-title":"Ciba Found Symp"},{"key":"10.1016\/j.mehy.2021.110655_b0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s00737-002-0147-1","article-title":"GABA receptors, progesterone and premenstrual dysphoric disorder","volume":"6","author":"Sundstr\u00f6m Poromaa","year":"2003","journal-title":"Arch Womens Ment Health"},{"issue":"2","key":"10.1016\/j.mehy.2021.110655_b0060","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/1059-1311(92)90012-P","article-title":"Exacerbation of typical absence seizures by progesterone","volume":"1","author":"Gr\u00fcnewald","year":"1992","journal-title":"Seizure Eur J Epilepsy"},{"issue":"2","key":"10.1016\/j.mehy.2021.110655_b0065","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1046\/j.1471-4159.1994.62020815.x","article-title":"Quaternary structure of the native GABAA receptor determined by electron microscopic image analysis","volume":"62","author":"Nayeem","year":"1994","journal-title":"J Neurochem"},{"issue":"9-10","key":"10.1016\/j.mehy.2021.110655_b0070","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/S0028-3908(96)00068-8","article-title":"GABA(A) receptor subtypes differentiated by their \u03b3-subunit variants: Prevalence, pharmacology and subunit architecture","volume":"35","author":"Benke","year":"1996","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.mehy.2021.110655_b0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuropharm.2008.07.045","article-title":"GABAA receptors: subtypes provide diversity of function and pharmacology","volume":"56","author":"Olsen","year":"2009","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/j.mehy.2021.110655_b0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0163-7258(03)00037-8","article-title":"Formation and plasticity of GABAergic synapses: Physiological mechanisms and pathophysiological implications","volume":"98","author":"Fritschy","year":"2003","journal-title":"Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.mehy.2021.110655_b0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1017\/S0317167100053890","article-title":"A blood-brain barrier disruption model eliminating the hemodynamic effect of ketamine","volume":"31","author":"Fortin","year":"2004","journal-title":"Can J Neurol Sci"},{"issue":"3","key":"10.1016\/j.mehy.2021.110655_b0090","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1523\/JNEUROSCI.12-03-01040.1992","article-title":"The distribution of 13 GABA(A) receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon","volume":"12","author":"Wisden","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2021.110655_b0095","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.2435171100","article-title":"Ethanol enhances \u03b14\u03b23\u03b4 and \u03b16\u03b23\u03b4 \u03b3-aminobutyric acid type A receptors at low concentrations known to affect humans","volume":"100","author":"Wallner","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.mehy.2021.110655_b0100","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.bcp.2004.07.025","article-title":"Specific GABAA circuits in brain development and therapy","volume":"68","author":"M\u00f6hler","year":"2004","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.mehy.2021.110655_b0105","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.300.1.2","article-title":"A new benzodiazepine pharmacology","volume":"300","author":"M\u00f6hler","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.mehy.2021.110655_b0110","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0166-2236(96)80023-3","article-title":"Which GABAA-receptor subtypes really occur in the brain?","volume":"19","author":"McKernan","year":"1996","journal-title":"Trends Neurosci"},{"issue":"6","key":"10.1016\/j.mehy.2021.110655_b0115","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1523\/JNEUROSCI.4751-07.2008","article-title":"Which GABAA receptor subunits are necessary for tonic inhibition in the hippocampus?","volume":"28","author":"Glykys","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2021.110655_b0120","doi-asserted-by":"crossref","first-page":"795","DOI":"10.2174\/1568026023393507","article-title":"Subunit composition, distribution and function of GABA-A receptor subtypes","volume":"2","author":"Sieghart","year":"2005","journal-title":"Curr Top Med Chem"},{"issue":"9","key":"10.1016\/j.mehy.2021.110655_b0125","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrn1496","article-title":"Molecular and neuronal substrates for general anaesthetics","volume":"5","author":"Rudolph","year":"2004","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"10.1016\/j.mehy.2021.110655_b0130","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrd3502","article-title":"Beyond classical benzodiazepines: Novel therapeutic potential of GABA A receptor subtypes","volume":"10","author":"Rudolph","year":"2011","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.mehy.2021.110655_b0135","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1358\/dof.2006.031.08.1008656","article-title":"GABAA receptors as targets for different classes of drugs","volume":"31","author":"Sieghart","year":"2006","journal-title":"Drugs Future"},{"issue":"6755","key":"10.1016\/j.mehy.2021.110655_b0140","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/44579","article-title":"Benzodiazepine actions mediated by specific \u03b3-aminobutyric acid(A) receptor subtypes","volume":"401","author":"Rudolph","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.mehy.2021.110655_b0145","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0014-5793(91)81076-K","article-title":"Cloning, pharmacological characteristics and expression pattern of the rat GABAA receptor \u03b14 subunit","volume":"289","author":"Wisden","year":"1991","journal-title":"FEBS Lett"},{"key":"10.1016\/j.mehy.2021.110655_b0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0165-6147(91)90495-E","article-title":"Function and pharmacology of multiple GABAA receptor subunits","volume":"12","author":"L\u00fcddens","year":"1991","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.mehy.2021.110655_b0155","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1073\/pnas.92.17.7749","article-title":"Benzodiazepine-insensitive mice generated by targeted disruption of the \u03b32 subunit gene of \u03b3-aminobutyric acid type A receptors","volume":"92","author":"Gunther","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2021.110655_b0160","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0026-895X(25)13351-8","article-title":"Role of the \u03b2 subunit in determining the pharmacology of human \u03b3- aminobutyric acid type A receptors","volume":"44","author":"Hadingham","year":"1993","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.mehy.2021.110655_b0165","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1126\/science.290.5489.131","article-title":"Molecular and neuronal substrate for the selective attenuation of anxiety","volume":"290","author":"Low","year":"2000","journal-title":"Science (80-)"},{"key":"10.1016\/j.mehy.2021.110655_b0170","doi-asserted-by":"crossref","unstructured":"Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdell\u00e8s B, Heavens RP, et al. Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann N Y Acad Sci 1999;868:645\u201353. 10.1111\/j.1749-6632.1999.tb11341.x.","DOI":"10.1111\/j.1749-6632.1999.tb11341.x"},{"issue":"13","key":"10.1016\/j.mehy.2021.110655_b0175","doi-asserted-by":"crossref","first-page":"5572","DOI":"10.1523\/JNEUROSCI.22-13-05572.2002","article-title":"Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the \u03b15 subunit of the GABAA receptor","volume":"22","author":"Collinson","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2021.110655_b0180","doi-asserted-by":"crossref","first-page":"8980","DOI":"10.1073\/pnas.142288699","article-title":"Trace fear conditioning involves hippocampal \u03b15 GABAA receptors","volume":"99","author":"Crestani","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.mehy.2021.110655_b0185","doi-asserted-by":"crossref","first-page":"6785","DOI":"10.1523\/JNEUROSCI.1067-04.2004","article-title":"Requirement of \u03b15-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice","volume":"24","author":"Van Rijnsoever","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2021.110655_b0190","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1111\/j.1460-9568.2004.03642.x","article-title":"GABAA receptors containing the \u03b15 subunit mediate the trace effect in aversive and appetitive conditioning and extinction of conditioned fear","volume":"20","author":"Yee","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.mehy.2021.110655_b0195","doi-asserted-by":"crossref","first-page":"7077","DOI":"10.1523\/JNEUROSCI.14-11-07077.1994","article-title":"Assembly of GABA(A) receptor subunits: Role of the \u03b4 subunit","volume":"14","author":"Saxena","year":"1994","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.mehy.2021.110655_b0200","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrn1625","article-title":"Variations on an inhibitory theme: Phasic and tonic activation of GABA A receptors","volume":"6","author":"Farrant","year":"2005","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"10.1016\/j.mehy.2021.110655_b0205","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.brainresrev.2005.11.001","article-title":"Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems","volume":"51","author":"Birzniece","year":"2006","journal-title":"Brain Res Rev"},{"issue":"4","key":"10.1016\/j.mehy.2021.110655_b0210","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0028-3908(02)00172-7","article-title":"The influence of subunit composition on the interaction of neurosteroids with GABAA receptors","volume":"43","author":"Belelli","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mehy.2021.110655_b0215","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0026-895X(25)08530-X","article-title":"Novel properties of homomeric \u03b21 \u03b3-aminobutyric acid type A receptors: Actions of the anesthetics propofol and pentobarbital","volume":"47","author":"Sanna","year":"1995","journal-title":"Mol Pharmacol"},{"issue":"1-2","key":"10.1016\/j.mehy.2021.110655_b0220","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0006-8993(98)01316-X","article-title":"Subunit dependent modulation of GABA(A) receptor function by neuroactive steroids","volume":"819","author":"Maitra","year":"1999","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.mehy.2021.110655_b0225","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1124\/mol.56.1.110","article-title":"Preferential coassembly of \u03b14 and \u03b4 subunits of the \u03b3-aminobutyric acid(A) receptor in rat thalamus","volume":"56","author":"Sur","year":"1999","journal-title":"Mol Pharmacol"},{"issue":"6619","key":"10.1016\/j.mehy.2021.110655_b0230","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/385820a0","article-title":"Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit","volume":"385","author":"Davies","year":"1997","journal-title":"Nature"},{"issue":"1-3","key":"10.1016\/j.mehy.2021.110655_b0235","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0165-0173(01)00124-2","article-title":"Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids","volume":"37","author":"Lambert","year":"2001","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.mehy.2021.110655_b0240","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1399-04.2004","article-title":"Slow actions of neuroactive steroids at GABAA receptors","author":"Shu","year":"2004","journal-title":"J Neurosci"},{"key":"10.1016\/j.mehy.2021.110655_b0245","doi-asserted-by":"crossref","unstructured":"Stell BM, Mody I. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. J Neurosci 2002;22:815\u2013850. 10.1523\/jneurosci.22-10-j0003.2002.","DOI":"10.1523\/JNEUROSCI.22-10-j0003.2002"},{"issue":"5","key":"10.1016\/j.mehy.2021.110655_b0250","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1523\/JNEUROSCI.22-05-01541.2002","article-title":"Enhanced neurosteroid potentiation of ternary GABAA receptors containing the \u03b4 subunit","volume":"22","author":"Wohlfarth","year":"2002","journal-title":"J Neurosci"},{"issue":"9","key":"10.1016\/j.mehy.2021.110655_b0255","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.1007\/s13197-015-1731-5","article-title":"Bioactive peptides of animal origin: a review","volume":"52","author":"Bhat","year":"2015","journal-title":"J Food Sci Technol"},{"issue":"5","key":"10.1016\/j.mehy.2021.110655_b0260","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.sjbs.2015.06.005","article-title":"Milk derived bioactive peptides and their impact on human health \u2013 a review","volume":"23","author":"Mohanty","year":"2016","journal-title":"Saudi J Biol Sci"},{"issue":"1","key":"10.1016\/j.mehy.2021.110655_b0265","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1039\/C0FO00016G","article-title":"Bioactive peptides derived from milk proteins and their health beneficial potentials: An update","volume":"2","author":"Nagpal","year":"2011","journal-title":"Food Funct"},{"issue":"4","key":"10.1016\/j.mehy.2021.110655_b0270","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s00394-008-0710-2","article-title":"Bioactive peptides and proteins from foods: Indication for health effects","volume":"47","author":"M\u00f6ller","year":"2008","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.mehy.2021.110655_b0275","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2174\/1381612033454892","article-title":"Food-derived Bioactive Peptides - Opportunities for Designing Future Foods","volume":"9","author":"Korhonen","year":"2005","journal-title":"Curr Pharm Des"},{"issue":"10","key":"10.1016\/j.mehy.2021.110655_b0280","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1096\/fj.00-0685fje","article-title":"Characterization of \u03b1-casozepine, a tryptic peptide from bovine \u03b1 s1 -casein with benzodiazepine-like activity","volume":"15","author":"Miclo","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.mehy.2021.110655_b0285","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbr.2016.07.013","article-title":"A tryptic hydrolysate from bovine milk \u03b1s1-casein enhances pentobarbital-induced sleep in mice via the GABAA receptor","volume":"313","author":"dela Pe\u00f1a","year":"2016","journal-title":"Behav Brain Res"},{"issue":"6","key":"10.1016\/j.mehy.2021.110655_b0290","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.peptides.2005.10.001","article-title":"A tryptic hydrolysate from bovine milk \u03b1S1-casein improves sleep in rats subjected to chronic mild stress","volume":"27","author":"Guesdon","year":"2006","journal-title":"Peptides"},{"issue":"8","key":"10.1016\/j.mehy.2021.110655_b0295","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.jevs.2014.06.003","article-title":"Modestly improved compliance and apparent comfort of horses with aversions to mildly aversive routine health care procedures following short-term alpha-casozepine supplementation","volume":"34","author":"McDonnell","year":"2014","journal-title":"J Equine Vet Sci"},{"key":"10.1016\/j.mehy.2021.110655_b0300","doi-asserted-by":"crossref","unstructured":"Cakir-Kiefer C, Le Roux Y, Balandras F, Trabalon M, Dary A, Laurent F, et al. In vitro digestibility of \u03b1-casozepine, a benzodiazepine-like peptide from bovine casein, and biological activity of its main proteolytic fragment. J Agric Food Chem 2011;59:4464\u201372. 10.1021\/jf104089c.","DOI":"10.1021\/jf104089c"},{"issue":"7","key":"10.1016\/j.mehy.2021.110655_b0305","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1096\/fj.12-225474","article-title":"Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine \u03b1S-casein","volume":"27","author":"Mizushige","year":"2013","journal-title":"FASEB J"},{"issue":"2","key":"10.1016\/j.mehy.2021.110655_b0310","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s00394-004-0534-7","article-title":"Effects of a tryptic hydrolysate from bovine milk \u03b1S1- casein on hemodynamic responses in healthy human volunteers facing successive mental and physical stress situations","volume":"44","author":"Messaoudi","year":"2005","journal-title":"Eur J Nutr"},{"key":"10.1016\/j.mehy.2021.110655_b0315","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jff.2017.09.014","article-title":"Mapping in mice the brain regions involved in the anxiolytic-like properties of \u03b1-casozepine, a tryptic peptide derived from bovine \u03b1s1-casein","volume":"38","author":"Benoit","year":"2017","journal-title":"J Funct Foods"},{"key":"10.1016\/j.mehy.2021.110655_b0320","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1432-1033.1997.00872.x","article-title":"Two-dimensional 1H-NMR and CD structural analysis in a micellar medium of a bovine \u03b1(s1)-casein fragment having benzodiazepine-like properties","volume":"248","author":"Lecouvey","year":"1997","journal-title":"Eur J Biochem"},{"issue":"4","key":"10.1016\/j.mehy.2021.110655_b0325","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/sj.ejcn.1602553","article-title":"Efficacy of \u03b1s1-casein hydrolysate on stress-related symptoms in women","volume":"61","author":"Kim","year":"2007","journal-title":"Eur J Clin Nutr"},{"issue":"6","key":"10.1016\/j.mehy.2021.110655_b0330","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jveb.2010.04.004","article-title":"Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs","volume":"5","author":"Palestrini","year":"2010","journal-title":"J Vet Behav Clin Appl Res"},{"issue":"2","key":"10.1016\/j.mehy.2021.110655_b0335","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pharmthera.2012.08.006","article-title":"\u03b12-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders","volume":"136","author":"Engin","year":"2012","journal-title":"Pharmacol Ther"},{"issue":"4","key":"10.1016\/j.mehy.2021.110655_b0340","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S0306-4522(00)00442-5","article-title":"GABA(A) receptors: Immunocytochemical distribution of 13 subunits in the adult rat brain","volume":"101","author":"Pirker","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2021.110655_b0345","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0031-6997(24)01424-8","article-title":"Enigma of the peripheral benzodiazepine receptor","volume":"51","author":"Gavish","year":"1999","journal-title":"Pharmacol Rev"},{"issue":"3","key":"10.1016\/j.mehy.2021.110655_b0350","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuroscience.2005.05.063","article-title":"Peripheral-type benzodiazepine receptor in neurosteroid biosynthesis, neuropathology and neurological disorders","volume":"138","author":"Papadopoulos","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2021.110655_b0355","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0026-895X(25)15026-8","article-title":"Characterization of peripheral-type benzodiazepine binding sites in brain using [3H]Ro 5\u20134864","volume":"22","author":"Marangos","year":"1982","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.mehy.2021.110655_b0360","first-page":"3625","article-title":"Progesterone-metabolite prevents protein kinase c-dependent modulation of \u03b3-aminobutyric acid type A receptors in oxytocin neurons","volume":"97","author":"Brussaard","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"10.1016\/j.mehy.2021.110655_b0365","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1172\/JCI200215903","article-title":"Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase C\u03b5","volume":"110","author":"Hodge","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.mehy.2021.110655_b0370","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.yfrne.2014.06.001","article-title":"GABAA receptor-acting neurosteroids: A role in the development and regulation of the stress response","volume":"36","author":"Gunn","year":"2015","journal-title":"Front Neuroendocrinol"},{"issue":"3","key":"10.1016\/j.mehy.2021.110655_b0375","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/(SICI)1096-9861(20000410)419:3<344::AID-CNE6>3.0.CO;2-Z","article-title":"GABA(A) receptor subunit expression within hypophysiotropic CRH neurons: A dual hybridization histochemical study","volume":"419","author":"Cullinan","year":"2000","journal-title":"J Comp Neurol"},{"issue":"1","key":"10.1016\/j.mehy.2021.110655_b0380","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/cne.903590111","article-title":"GABAA-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits","volume":"359","author":"Fritschy","year":"1995","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.mehy.2021.110655_b0385","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroscience.2013.01.008","article-title":"Patterns of mRNA and protein expression for 12 GABAA receptor subunits in the mouse brain","volume":"236","author":"H\u00f6rtnagl","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.mehy.2021.110655_b0390","first-page":"395","article-title":"Neurosteroid coadministration prevents development of tolerance and augments recovery from benzodiazepine withdrawal anxiety and hyperactivity in mice","volume":"19","author":"Reddy","year":"1997","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"10.1016\/j.mehy.2021.110655_b0395","first-page":"100203","article-title":"Pleiotropic actions of allopregnanolone underlie therapeutic benefits in stress-related disease. Neurobiol","volume":"12","author":"Boero","year":"2020","journal-title":"Stress"}],"container-title":["Medical Hypotheses"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987721001742?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0306987721001742?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:25:04Z","timestamp":1759692304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0306987721001742"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":79,"alternative-id":["S0306987721001742"],"URL":"https:\/\/doi.org\/10.1016\/j.mehy.2021.110655","relation":{},"ISSN":["0306-9877"],"issn-type":[{"value":"0306-9877","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine","name":"articletitle","label":"Article Title"},{"value":"Medical Hypotheses","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mehy.2021.110655","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"110655"}}