{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:15:46Z","timestamp":1786994146738,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.metabol.2003.11.022","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T12:09:07Z","timestamp":1079784547000},"page":"430-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"title":["Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines"],"prefix":"10.1016","volume":"53","author":[{"given":"G","family":"Valsamakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G","family":"McTernan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Chetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Al Daghri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Hanif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.H","family":"Barnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2003.11.022_BIB1","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2337\/diabetes.49.6.883","article-title":"The perils of portliness","volume":"49","author":"Montague","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2003.11.022_BIB2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1464-5491.2002.00764.x","article-title":"Predictors of insulin sensitivity in type 2 diabetes","volume":"19","author":"Bonora","year":"2002","journal-title":"Diabetic Med"},{"key":"10.1016\/j.metabol.2003.11.022_BIB3","doi-asserted-by":"crossref","first-page":"655","DOI":"10.7326\/0003-4819-119-7_Part_2-199310011-00006","article-title":"Medical hazards of obesity","volume":"119","author":"Pi-Sunyer","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2003.11.022_BIB4","first-page":"384","article-title":"The relation of markers of inflammation to the development of glucose disorders in the elderly","volume":"50","author":"Brazilay","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2003.11.022_BIB5","first-page":"397","article-title":"Beneficial health effects of modest weight loss","volume":"16","author":"Goldstein","year":"1992","journal-title":"Int J Obes"},{"key":"10.1016\/j.metabol.2003.11.022_BIB6","series-title":"Clinical Guideline on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults","year":"1998"},{"key":"10.1016\/j.metabol.2003.11.022_BIB7","series-title":"Obesity Pathophysiology, Psychology and Treatment","first-page":"167","article-title":"Long term health effects associated with significant weight loss","author":"Kanders","year":"1994"},{"key":"10.1016\/j.metabol.2003.11.022_BIB8","first-page":"241","article-title":"Lipase inhibition","volume":"17","author":"Drent","year":"1993","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.metabol.2003.11.022_BIB9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/jama.281.3.235","article-title":"Weight control and risk reduction in obese subjects treated for 2 years with orlistat","volume":"281","author":"Davidson","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2003.11.022_BIB10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0140-6736(97)11509-4","article-title":"Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients","volume":"352","author":"Sjostrom","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2003.11.022_BIB11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/j.1550-8528.1999.tb00701.x","article-title":"Sibutramine produces dose-related weight loss","volume":"7","author":"Bray","year":"1999","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2003.11.022_BIB12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2169\/internalmedicine.38.202","article-title":"Role of adipocytokines on the pathogenesis of atherosclerosis in visceral obesity","volume":"38","author":"Funahashi","year":"1999","journal-title":"Int Med"},{"key":"10.1016\/j.metabol.2003.11.022_BIB13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","article-title":"Adipose expression of tumor necrosis factor-alpha","volume":"259","author":"Hotamisligil","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.metabol.2003.11.022_BIB14","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/43448","article-title":"Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy","volume":"401","author":"Shimomura","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2003.11.022_BIB15","first-page":"1","article-title":"Regulation of circulating leptin levels in humans","volume":"7","author":"Ahren","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2003.11.022_BIB16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/oby.2000.5","article-title":"Leptin responses to weight loss in postmenopausal women","volume":"8","author":"Van Rossum","year":"2000","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2003.11.022_BIB17","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1161\/01.CIR.103.8.1057","article-title":"Adipocyte derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages","volume":"103","author":"Ouchi","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2003.11.022_BIB18","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2337\/diabetes.52.7.1655","article-title":"Induction of adiponectin, a fat derived antidiabetic and antiatherogenic factor, by nuclear receptors","volume":"52","author":"Iwaki","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2003.11.022_BIB19","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","article-title":"Paradoxical decrease of an adipocyte-specific protein, adiponectin in obesity","volume":"257","author":"Arita","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2003.11.022_BIB20","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.1999.tb07793.x","article-title":"Molecular mechanism of metabolic syndrome X","volume":"892","author":"Matsuzawa","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.metabol.2003.11.022_BIB21","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1161\/01.CIR.100.25.2473","article-title":"Novel modulator for endothelial adhesion molecules","volume":"100","author":"Ouchi","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2003.11.022_BIB22","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","article-title":"Plasma concentrations of a novel adipose specific protein, adiponectin, in type 2 diabetic patients","volume":"20","author":"Hotta","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2003.11.022_BIB23","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1210\/jcem.86.8.7741","article-title":"Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin","volume":"86","author":"Yang","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2003.11.022_BIB24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormine resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2003.11.022_BIB25","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0140-6736(02)07281-1","article-title":"Resistin, central obesity, and type 2 diabetes","volume":"359","author":"McTernan","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2003.11.022_BIB26","doi-asserted-by":"crossref","first-page":"11252","DOI":"10.1074\/jbc.C100028200","article-title":"A cysteine rich adipose tissue-specific secretory factor inhibits adipocyte differentiation","volume":"276","author":"Kim","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2003.11.022_BIB27","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge","volume":"13","author":"Friedwald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1016\/j.metabol.2003.11.022_BIB28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2003.11.022_BIB29","series-title":"SPSS for Windows","year":"1999"},{"issue":"suppl","key":"10.1016\/j.metabol.2003.11.022_BIB30","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1038\/sj.ijo.0802215","article-title":"Updated review on the benefits of weight loss","volume":"26","author":"Vidal","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"issue":"suppl","key":"10.1016\/j.metabol.2003.11.022_BIB31","first-page":"116S","article-title":"Management of obesity as a chronic disease","volume":"10","author":"Fujioka","year":"2002","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2003.11.022_BIB32","first-page":"A308","article-title":"Sibutramine enhances weight loss and improves glycaemic control and plasma lipid profile in obese patients with type 2 diabetes mellitus","volume":"48","author":"Heath","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2003.11.022_BIB33","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1291\/hypres.25.881","article-title":"Relationship between changes in serum leptin levels and blood pressure after weight loss","volume":"25","author":"Itoh","year":"2002","journal-title":"Hypertens Res"},{"key":"10.1016\/j.metabol.2003.11.022_BIB34","first-page":"4197","article-title":"A low serum leptin level at baseline and a large early decline in leptin predict a large 1-year weight reduction in energy-restricted obese humans","volume":"84","author":"Torgerson","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2003.11.022_BIB35","first-page":"391","article-title":"Changes in insulin responses and binding in adipocytes from monkeys with obesity progressing to diabetes","volume":"12","author":"Hansen","year":"1988","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.metabol.2003.11.022_BIB36","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1463-1326.2003.00254.x","article-title":"Fasting serum adiponectin is lower in Indo-Asians and is related to HDL cholesterol","volume":"5","author":"Valsamakis","year":"2003","journal-title":"Diabetes Obesity Metab"},{"key":"10.1016\/j.metabol.2003.11.022_BIB37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2337\/diabetes.52.2.239","article-title":"Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism","volume":"52","author":"Tschritter","year":"2003","journal-title":"Diabetes"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049503005535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049503005535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T02:02:01Z","timestamp":1758420121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049503005535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0026049503005535"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2003.11.022","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modest weight loss and reduction in waist circumference after medical treatment are associated with favorable changes in serum adipocytokines","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2003.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}