{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T19:26:16Z","timestamp":1776713176404,"version":"3.51.2"},"reference-count":25,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.metabol.2004.06.019","type":"journal-article","created":{"date-parts":[[2004,11,27]],"date-time":"2004-11-27T13:12:10Z","timestamp":1101561130000},"page":"1538-1543","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effects of peroxisome proliferator-activated receptor-\u03b32 Pro12Ala polymorphism on body fat distribution in female Korean subjects"],"prefix":"10.1016","volume":"53","author":[{"given":"Kil Soo","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Mi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Uoo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoosik","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2004.06.019_BIB1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2337\/diabetes.47.4.507","article-title":"PPAR\u03b3","volume":"47","author":"Spiegelman","year":"1998","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2004.06.019_BIB2","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1006\/bbrc.1996.1044","article-title":"Moleular cloning, expression and characterization of human peroxisome proliferators activated receptors \u03b31 and \u03b32","volume":"224","author":"Elbrecht","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2004.06.019_BIB3","doi-asserted-by":"crossref","first-page":"20230","DOI":"10.1074\/jbc.272.32.20230","article-title":"Ligand-independent activation domain in the N-terminus of peroxisome proliferators activated receptor \u03b3","volume":"272","author":"Werman","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2004.06.019_BIB4","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/47254","article-title":"Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension","volume":"402","author":"Barroso","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2004.06.019_BIB5","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1056\/NEJM199810013391403","article-title":"Obesity associated with a mutation in a genetic regulator of adipocyte differentiation","volume":"339","author":"Ristow","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2004.06.019_BIB6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/bbrc.1997.7798","article-title":"Molecular scanning of the human peroxisome proliferators activated receptor \u03b3 (hPPAR\u03b3) gene in diabetic Caucasians","volume":"241","author":"Yen","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2004.06.019_BIB7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/79216","article-title":"The Common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes","volume":"26","author":"Altshuler","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2004.06.019_BIB8","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/jmg.40.10.773","article-title":"Effect of the peroxisome proliferators activated receptor-\u03b3 gene Pro12Ala variant on body mass index","volume":"40","author":"Masud","year":"2003","journal-title":"J Med Genet"},{"key":"10.1016\/j.metabol.2004.06.019_BIB9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1034\/j.1399-0004.2003.00026.x","article-title":"The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome","volume":"63","author":"Robitaille","year":"2003","journal-title":"Clin Genet"},{"key":"10.1016\/j.metabol.2004.06.019_BIB10","first-page":"234","article-title":"Association of Pro12Ala variant in peroxisome proliferator-activated receptor-gamma2 gene with type 2 diabetes mellitus","volume":"19","author":"Fu","year":"2002","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"10.1016\/j.metabol.2004.06.019_BIB11","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1053\/meta.2000.9517","article-title":"Peroxisome proliferator-activated receptor gamma 2 Pro12Ala gene variant is strongly associated with larger body mass in the Taiwanese","volume":"49","author":"Lei","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2004.06.019_BIB12","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2337\/diabetes.50.4.891","article-title":"The Pro12Ala substitution in PPARgamma is associated with resistance to development of diabetes in the general population","volume":"50","author":"Mori","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2004.06.019_BIB13","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.2337\/diabetes.47.11.1806","article-title":"Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations","volume":"47","author":"Beamer","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2004.06.019_BIB14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1385\/ENDO:14:3:369","article-title":"Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort","volume":"14","author":"Schaffler","year":"2001","journal-title":"Endocrine"},{"key":"10.1016\/j.metabol.2004.06.019_BIB15","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1210\/jc.2002-020603","article-title":"Effect of the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor (PPAR) gamma2 gene on the expression of PPARgamma target genes in adipose tissue of massively obese subjects","volume":"88","author":"Kolehmainen","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2004.06.019_BIB16","series-title":"Exercise Testing and Prescription","author":"Nieman","year":"1999"},{"key":"10.1016\/j.metabol.2004.06.019_BIB17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/bbrc.1998.9421","article-title":"Effect of the Pro12Ala variant of the human peroxisome proliferators-activated receptor gamma2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men","volume":"251","author":"Mori","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2004.06.019_BIB18","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1172\/JCI119424","article-title":"Peroxisome proliferator-activated receptor gene expression in human tissues","volume":"99","author":"Vidal-Puig","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2004.06.019_BIB19","doi-asserted-by":"crossref","first-page":"686","DOI":"10.2337\/diabetes.50.3.686","article-title":"Evidence for gene-nutrient interaction at the PPARgamma locus","volume":"50","author":"Luan","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2004.06.019_BIB20","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2337\/diab.47.1.98","article-title":"Depot-specific differences in adipose tissue gene expression in lean and obese subjects","volume":"47","author":"Lefebvre","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2004.06.019_BIB21","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2337\/diacare.14.12.1132","article-title":"Metabolic implication of body fat distribution","volume":"14","author":"Bjorntorp","year":"1991","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2004.06.019_BIB22","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.2337\/diacare.23.8.1067","article-title":"Efficacy of troglitazone on body fat distribution in type 2 diabetes","volume":"23","author":"Akazawa","year":"2000","journal-title":"Diabetes Care"},{"issue":"suppl 5","key":"10.1016\/j.metabol.2004.06.019_BIB23","first-page":"645S","article-title":"Visceral fat accumulation and cardiovascular disease","volume":"3","author":"Matsuzawa","year":"1995","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2004.06.019_BIB24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/3099","article-title":"A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity","volume":"20","author":"Deeb","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2004.06.019_BIB25","doi-asserted-by":"crossref","first-page":"34167","DOI":"10.1074\/jbc.M104421200","article-title":"Distinct transcriptional profiles of adipogenesis in vivo and in vitro","volume":"36","author":"Soukas","year":"2001","journal-title":"J Biol Chem"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049504002744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049504002744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T02:46:09Z","timestamp":1758422769000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049504002744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0026049504002744"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2004.06.019","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of peroxisome proliferator-activated receptor-\u03b32 Pro12Ala polymorphism on body fat distribution in female Korean subjects","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2004.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}