{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T01:07:35Z","timestamp":1773277655589,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,11,1]],"date-time":"2005-11-01T00:00:00Z","timestamp":1130803200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2005,11]]},"DOI":"10.1016\/j.metabol.2005.05.020","type":"journal-article","created":{"date-parts":[[2005,10,27]],"date-time":"2005-10-27T07:20:54Z","timestamp":1130397654000},"page":"1524-1528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population"],"prefix":"10.1016","volume":"54","author":[{"given":"Shih-Yi","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pi-Haw","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-An","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne Huey-Herng","family":"Sheu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2005.05.020_bib1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2337\/diab.37.12.1595","article-title":"Role of insulin resistance in human disease","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2005.05.020_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1001\/archinte.163.4.427","article-title":"The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutritional Examination Survey, 1988-1994","volume":"163","author":"Park","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2005.05.020_bib3","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1001\/jama.288.21.2709","article-title":"The metabolic syndrome and total and total and cardiovascular disease mortality in middle-aged men","volume":"288","author":"Lakka","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2005.05.020_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0889-8529(01)00023-8","article-title":"Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion","volume":"31","author":"Douyon","year":"2002","journal-title":"Endocrinol Metab Clin North Am"},{"key":"10.1016\/j.metabol.2005.05.020_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-2999(02)01420-6","article-title":"Thyroid hormones in the pathogenesis and treatment of obesity","volume":"440","author":"Krotkiewski","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.metabol.2005.05.020_bib6","first-page":"1118","article-title":"Resting energy expenditure is sensitive to small dose change in patients with chronic thyroid hormone replacement","volume":"82","author":"al-Adsani","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1046\/j.1365-2265.2003.01836.x","article-title":"The effect of body weight and weight loss on thyroid volume and function in obese women","volume":"59","author":"Sari","year":"2003","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.metabol.2005.05.020_bib8","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1046\/j.1365-2265.2003.01762.x","article-title":"Serum concentrations of remnant-like particles in hypothyroid patients before and after thyroxine replacement","volume":"58","author":"Ito","year":"2003","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.metabol.2005.05.020_bib9","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1210\/endo.138.3.4981","article-title":"Effects of thyroid hormone on GLUT4 glucose transporter gene expression and NIDDM in rats","volume":"138","author":"Torrance","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2005.05.020_bib10","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1210\/jcem.87.5.8464","article-title":"The role of thyroid hormone in blood pressure homeostasis: evidence from short-term hypothyroidism in humans","volume":"87","author":"Fommei","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib11","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","author":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2005.05.020_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1093\/ajcn\/79.1.31","article-title":"Body mass index and obesity-related metabolic disorders between Taiwanese and US whites and blacks: implication of definitions of overweight and obesity for Asians","volume":"79","author":"Pan","year":"2004","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 8","key":"10.1016\/j.metabol.2005.05.020_bib13","first-page":"S732","article-title":"Criteria and classification of obesity in Japan and Asia-Oceania","volume":"11","author":"Kanazawa","year":"2002","journal-title":"Asia Pac J Clin Nutr"},{"key":"10.1016\/j.metabol.2005.05.020_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/japplphysiol.00499.2002","article-title":"Effect of hyperthyroidism on spontaneous physical activity, and energy expenditure in rats","volume":"94","author":"Levine","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.metabol.2005.05.020_bib15","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/sj.ijo.0802308","article-title":"Relative influence of diet and physical activity on cardiovascular risk factors in urban Chinese adults","volume":"27","author":"Yao","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.metabol.2005.05.020_bib16","doi-asserted-by":"crossref","first-page":"840","DOI":"10.7326\/0003-4819-112-11-840","article-title":"Screening for thyroid disease","volume":"112","author":"Helfand","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2005.05.020_bib17","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.2337\/diabetes.52.11.2740","article-title":"Identification of subjects with insulin resistance and \u03b2-cell dysfunction using alternative definitions of the metabolic syndrome","volume":"52","author":"Hanley","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2005.05.020_bib18","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1210\/jc.2003-030173","article-title":"The Gly16\u2192Arg16 and Gln27\u2192 Glu27 polymorphisms of \u03b22-adrenergic receptors are associated with metabolic syndrome in men","volume":"88","author":"Dallongeville","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib19","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1152\/ajpendo.00231.2003","article-title":"Uncoupling protein-2 polymorphisms in type 2 diabetes, obesity, and insulin secretion","volume":"286","author":"Wang","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib20","first-page":"3989","article-title":"Studies of the Pro12Ala polymorphism of the PPAR-\u03b3 gene in the Danish MONICA cohort: homozygosity of the Ala confers a decreased risk of the insulin resistance syndrome","volume":"87","author":"Frederiksen","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib21","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/embo-reports\/kve107","article-title":"Thyroid hormone regulates obesity gene tub","volume":"2","author":"Koritschoner","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.metabol.2005.05.020_bib22","doi-asserted-by":"crossref","first-page":"880","DOI":"10.2337\/diabetes.51.3.880","article-title":"Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor","volume":"51","author":"Mentuccia","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2005.05.020_bib23","doi-asserted-by":"crossref","first-page":"38913","DOI":"10.1074\/jbc.M306120200","article-title":"A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice","volume":"278","author":"Liu","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2005.05.020_bib24","doi-asserted-by":"crossref","first-page":"E745","DOI":"10.1152\/ajpendo.2001.280.5.E745","article-title":"Adipose tissue tumor necrosis and interleukin-6 expression in human obesity and insulin resistance","volume":"280","author":"Kern","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib25","first-page":"971","article-title":"Soluble cytokine receptors and the low 3,5,3\u2032-triiodothyronine syndrome in patients with nonthyroid disease","volume":"80","author":"Boelen","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib26","doi-asserted-by":"crossref","first-page":"788","DOI":"10.2337\/diacare.27.3.788","article-title":"Predictors of the incident metabolic syndrome in adults: the Insulin Resistance Atherosclerosis Study","volume":"27","author":"Palaniappan","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2005.05.020_bib27","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1210\/jc.2003-032143","article-title":"Thyroid function and blood pressure homeostasis in euthyroid subjects","volume":"89","author":"Gumieniak","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2005.05.020_bib28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1677\/erc.0.0110345","article-title":"Chronic thyrotropin-suppressive therapy with levothyroxine and short-term overt hypothyroidism after thyroxine withdrawal are associated undesirable cardiovascular effects in patients with differentiated thyroid carcinoma","volume":"11","author":"Botella-Carretero","year":"2004","journal-title":"Endocr Relat Cancer"},{"key":"10.1016\/j.metabol.2005.05.020_bib29","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/archinte.160.13.1993","article-title":"Excess triiodothyronine as a risk factor of coronary events","volume":"160","author":"Peters","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2005.05.020_bib30","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/sj.ijo.0800493","article-title":"Small doses of triiodothyronine can change some risk factors associated with abdominal obesity","volume":"21","author":"Krotkiewski","year":"1997","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.metabol.2005.05.020_bib31","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1001\/jama.291.2.228","article-title":"Subclinical thyroid disease: scientific review and guidelines for diagnosis and management","volume":"291","author":"Surks","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2005.05.020_bib32","first-page":"847","article-title":"The molecular basis of thyroid hormone action","volume":"331","author":"Brent","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2005.05.020_bib33","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2337\/diacare.23.2.260a","article-title":"Contribution of abnormalities of thyroid hormones to type 2 diabetes","volume":"23","author":"Kim","year":"2000","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2005.05.020_bib34","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0306-9877(02)00211-6","article-title":"A hypothesis of synergism: the interrelationship of T3 and insulin to disturbances in metabolic homeostasis","volume":"59","author":"Kim","year":"2002","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.metabol.2005.05.020_bib35","first-page":"1206","article-title":"The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects","volume":"86","author":"Bakker","year":"2001","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049505002283?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049505002283?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:07:00Z","timestamp":1758424020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049505002283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,11]]}},"alternative-id":["S0026049505002283"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2005.05.020","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2005,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lower serum free thyroxine levels are associated with metabolic syndrome in a Chinese population","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2005.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}