{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:54:27Z","timestamp":1758970467117,"version":"3.44.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.metabol.2006.03.005","type":"journal-article","created":{"date-parts":[[2006,6,19]],"date-time":"2006-06-19T09:44:00Z","timestamp":1150710240000},"page":"972-979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Effects of raloxifene on lipid and lipoprotein levels in postmenopausal osteoporotic women with and without hypertriglyceridemia"],"prefix":"10.1016","volume":"55","author":[{"given":"Thomas","family":"Dayspring","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongming","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Keech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"author":"American Heart Association","key":"10.1016\/j.metabol.2006.03.005_bib1"},{"key":"10.1016\/j.metabol.2006.03.005_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00043798-199604000-00014","article-title":"Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies","volume":"3","author":"Hokanson","year":"1996","journal-title":"J Cardiovasc Risk"},{"key":"10.1016\/j.metabol.2006.03.005_bib3","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1001\/archinte.161.7.949","article-title":"Applicability of cholesterol-lowering primary prevention trials to a general population: the Framingham Heart Study","volume":"161","author":"Lloyd-Jones","year":"2001","journal-title":"Arch Intern Med"},{"issue":"Suppl M","key":"10.1016\/j.metabol.2006.03.005_bib4","first-page":"M8","article-title":"The emergence of triglycerides as a significant independent risk factor in coronary artery disease","volume":"19","author":"Assmann","year":"1998","journal-title":"Eur Heart J"},{"key":"10.1016\/j.metabol.2006.03.005_bib5","doi-asserted-by":"crossref","first-page":"7B","DOI":"10.1016\/S0002-9149(98)00031-9","article-title":"Hypertriglyceridemia as a cardiovascular risk factor","volume":"81","author":"Austin","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.metabol.2006.03.005_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1161\/01.ATV.11.1.2","article-title":"Plasma triglyceride and coronary heart disease","volume":"11","author":"Austin","year":"1991","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.metabol.2006.03.005_bib7","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of The Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2006.03.005_bib8","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1056\/NEJM199506013322207","article-title":"Management of primary hyperlipidemia","volume":"332","author":"Havel","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2006.03.005_bib9","doi-asserted-by":"crossref","first-page":"13B","DOI":"10.1016\/S0002-9149(98)00032-0","article-title":"Atherogenicity of triglyceride-rich lipoproteins","volume":"81","author":"Krauss","year":"1998","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.metabol.2006.03.005_bib10","first-page":"27","article-title":"Coronary heart disease in women: triglycerides and lipoprotein biology","volume":"5","author":"Dayspring","year":"2002","journal-title":"J Gend Specif Med"},{"key":"10.1016\/j.metabol.2006.03.005_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1001\/jama.280.7.605","article-title":"Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen\/progestin Replacement Study (HERS) Research Group","volume":"280","author":"Hulley","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2006.03.005_bib12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0015-0282(01)01829-5","article-title":"Effects of lower doses of conjugated equine estrogens and medroxyprogesterone acetate on plasma lipids and lipoproteins, coagulation factors, and carbohydrate metabolism","volume":"76","author":"Lobo","year":"2001","journal-title":"Fertil Steril"},{"key":"10.1016\/j.metabol.2006.03.005_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/01.ATV.0000046033.32478.6D","article-title":"Hormone replacement therapy and risk of cardiovascular disease: implications of the results of the Women's Health Initiative","volume":"23","author":"Kuller","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"year":"2001","series-title":"Evista package insert","key":"10.1016\/j.metabol.2006.03.005_bib14"},{"key":"10.1016\/j.metabol.2006.03.005_bib15","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/S0149-2918(01)80127-2","article-title":"Effect of raloxifene on serum triglycerides in postmenopausal women: influence of predisposing factors for hypertriglyceridemia","volume":"23","author":"Mosca","year":"2001","journal-title":"Clin Ther"},{"key":"10.1016\/j.metabol.2006.03.005_bib16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/jama.287.7.847","article-title":"Raloxifene and cardiovascular events in osteoporotic postmenopausal women: four-year results from the MORE (Multiple Outcomes of Raloxifene Evaluation) randomized trial","volume":"287","author":"Barrett-Connor","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2006.03.005_bib17","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/S0002-9149(01)01497-7","article-title":"Using both \u201crelative risk reduction\u201d and \u201cnumber needed to treat\u201d in evaluating primary and secondary clinical trials of lipid reduction","volume":"87","author":"Moriarty","year":"2001","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.metabol.2006.03.005_bib18","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1001\/jama.279.18.1445","article-title":"Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women","volume":"279","author":"Walsh","year":"1998","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2006.03.005_bib19","first-page":"214","article-title":"The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: a randomized, controlled trial","volume":"85","author":"Walsh","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2006.03.005_bib20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1016\/j.metabol.2006.03.005_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(99)00083-9","article-title":"Cell and molecular biology of the assembly and secretion of apolipoprotein B\u2013containing lipoproteins by the liver","volume":"1440","author":"Davis","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.metabol.2006.03.005_bib22","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1016\/S0140-6736(01)07098-2","article-title":"High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study","volume":"358","author":"Walldius","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2006.03.005_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.CIR.101.5.477","article-title":"Relation between baseline and on-treatment lipid parameters and first acute major coronary events in the Air Force\/Texas Coronary Atherosclerosis Prevention Study (AFCAPS\/TexCAPS)","volume":"101","author":"Gotto","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2006.03.005_bib24","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1161\/01.CIR.97.15.1453","article-title":"Lipoprotein changes and reduction in the incidence of major coronary heart disease events in the Scandinavian Simvastatin Survival Study (4S)","volume":"97","author":"Pedersen","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2006.03.005_bib25","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/jama.1996.03540110029028","article-title":"Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women","volume":"276","author":"Gardner","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2006.03.005_bib26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jacc.2004.07.001","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines","volume":"44","author":"Grundy","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2006.03.005_bib27","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1001\/archinte.161.11.1413","article-title":"Non\u2013high-density lipoprotein cholesterol level as a predictor of cardiovascular disease mortality","volume":"161","author":"Cui","year":"2001","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2006.03.005_bib28","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1161\/01.CIR.0000038419.53000.D6","article-title":"Low-density lipoprotein, non\u2013high-density lipoprotein, and apolipoprotein B as targets of lipid-lowering therapy","volume":"106","author":"Grundy","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2006.03.005_bib29","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1056\/NEJM199908123410707","article-title":"Drug treatment of lipid disorders","volume":"341","author":"Knopp","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2006.03.005_bib30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.metabol.2005.02.010","article-title":"Effects of raloxifene and low-dose simvastatin coadministration on plasma lipids in postmenopausal women with primary hypercholesterolemia","volume":"54","author":"Insull","year":"2005","journal-title":"Metabolism"},{"year":"1999","series-title":"Contemporary diagnosis and management of lipid disorders","author":"Gotto","key":"10.1016\/j.metabol.2006.03.005_bib31"},{"key":"10.1016\/j.metabol.2006.03.005_bib32","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.2337\/diacare.28.7.1555","article-title":"Effect of raloxifene on serum triglycerides in women with a history of hypertriglyceridemia while on oral estrogen therapy","volume":"28","author":"Carr","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2006.03.005_bib33","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1161\/01.ATV.0000183727.90611.4f","article-title":"Value of high density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial","volume":"25","author":"Asztalos","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"Suppl","key":"10.1016\/j.metabol.2006.03.005_bib34","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1016\/0021-9150(94)05379-W","article-title":"Effects of estrogens on lipoprotein metabolism and cardiovascular disease in women","volume":"110","author":"Knopp","year":"1994","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2006.03.005_bib35","first-page":"367","article-title":"Effect of estrogen and simvastatin on low-density lipoprotein subclasses in hypercholesterolemic postmenopausal women","volume":"92","author":"Wakatsuki","year":"1998","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.metabol.2006.03.005_bib36","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0735-1097(00)01153-0","article-title":"Estrogen-induced small low density lipoprotein particles may be atherogenic in postmenopausal women","volume":"37","author":"Wakatsuki","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2006.03.005_bib37","first-page":"II-67","article-title":"Raloxifene reduces macrophage accumulation and matrix metalloproteinase expression in carotid lesions of ovariectomized, cholesterol-fed rabbits","volume":"104","author":"Baetta","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2006.03.005_bib38","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1210\/jcem.85.8.6853","article-title":"Raloxifene acutely stimulates nitric oxide release from human endothelial cells via an activation of endothelial nitric oxide synthase","volume":"85","author":"Simoncini","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2006.03.005_bib39","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1210\/jc.2002-021557","article-title":"Endothelial function and menopause: effects of raloxifene administration","volume":"88","author":"Colacurci","year":"2003","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002604950600103X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002604950600103X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:11:14Z","timestamp":1758424274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002604950600103X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":39,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S002604950600103X"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2006.03.005","relation":{},"ISSN":["0026-0495"],"issn-type":[{"type":"print","value":"0026-0495"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of raloxifene on lipid and lipoprotein levels in postmenopausal osteoporotic women with and without hypertriglyceridemia","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2006.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}