{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:15:12Z","timestamp":1790892912743,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.metabol.2006.06.007","type":"journal-article","created":{"date-parts":[[2006,9,20]],"date-time":"2006-09-20T07:42:19Z","timestamp":1158738139000},"page":"1365-1374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob\/ob mouse"],"prefix":"10.1016","volume":"55","author":[{"given":"Vikkie A.","family":"Mustad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"DeMichele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Sheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Mika","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Lubbers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Berthiaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Polakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad","family":"Zinker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2006.06.007_bib1","first-page":"165","article-title":"Fat versus carbohydrate in insulin resistance, obesity, diabetes and cardiovascular disease","volume":"6","author":"Hung","year":"2003","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.metabol.2006.06.007_bib2","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1056\/NEJM198809293191304","article-title":"Comparison of a high carbohydrate diet with a high-monounsaturated-fat diet in patients with non\u2013insulin-dependent diabetes mellitus","volume":"319","author":"Garg","year":"1988","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2006.06.007_bib3","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1001\/jama.1994.03510420053034","article-title":"Effects of varying carbohydrate content of diet in patients with non\u2013insulin-dependent diabetes mellitus","volume":"271","author":"Garg","year":"1994","journal-title":"J Am Med Assoc"},{"key":"10.1016\/j.metabol.2006.06.007_bib4","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/0026-0495(92)90111-M","article-title":"A high monounsaturated fat low carbohydrate diet improves peripheral insulin sensitivity in non-insulin dependent diabetic patients","volume":"41","author":"Parillo","year":"1992","journal-title":"Metabolism"},{"issue":"3 Suppl","key":"10.1016\/j.metabol.2006.06.007_bib5","doi-asserted-by":"crossref","first-page":"577S","DOI":"10.1093\/ajcn\/67.3.577S","article-title":"High-monounsaturated-fat diets for patients with diabetes mellitus: a meta-analysis","volume":"67","author":"Garg","year":"1998","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 1","key":"10.1016\/j.metabol.2006.06.007_bib6","first-page":"S36","article-title":"Nutrition principles and recommendations in diabetes","volume":"27","author":"Franz","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2006.06.007_bib7","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1161\/01.CIR.0000013952.86046.DD","article-title":"Prevention Conference VI: diabetes and cardiovascular disease","volume":"105","author":"Grundy","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2006.06.007_bib8","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1161\/01.CIR.0000038493.65177.94","article-title":"Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease","volume":"106","author":"Kris-Etherton","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2006.06.007_bib9","series-title":"The Cochrane library, issue 4","article-title":"Fish oil in people with type 2 diabetes mellitus (Cochrane review)","author":"Farmer","year":"2001"},{"key":"10.1016\/j.metabol.2006.06.007_bib10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jada.2004.11.029","article-title":"n-3 long-chain polyunsaturated fatty acids in type 2 diabetes; a review","volume":"105","author":"Nettleton","year":"2005","journal-title":"J Am Diet Assoc"},{"key":"10.1016\/j.metabol.2006.06.007_bib11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2337\/diaspect.16.1.56","article-title":"So many nutrition recommendations\u2014contradictory or compatible?","volume":"16","author":"Franz","year":"2003","journal-title":"Diabetes Spectr"},{"key":"10.1016\/j.metabol.2006.06.007_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2337\/diab.40.2.280","article-title":"Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid","volume":"40","author":"Storlien","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2006.06.007_bib13","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/jn\/126.6.1549","article-title":"Dietary fish oil enhances insulin sensitivity in miniature pigs","volume":"126","author":"Behme","year":"1996","journal-title":"J Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1017\/S0007114500001409","article-title":"Dietary n-3 fatty acids affect mRNA level of brown adipose tissue uncoupling protein 1, and white adipose tissue leptin and glucose transporter 4 in the rat","volume":"84","author":"Takahashi","year":"2000","journal-title":"Br J Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib15","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1007\/BF02637087","article-title":"Skeletal muscle membrane lipids and insulin resistance","volume":"31","author":"Storlien","year":"1996","journal-title":"Lipids"},{"key":"10.1016\/j.metabol.2006.06.007_bib16","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1017\/S0007114500000969","article-title":"Polyunsaturated fatty acid regulation of gene transcription; a mechanism to improve energy balance and insulin resistance","volume":"83","author":"Clarke","year":"2000","journal-title":"Br J Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib17","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1079\/BJN2001496","article-title":"Effect of eicosapentaenoic acid ethyl ester v. oleic acid\u2013rich safflower oil on insulin resistance in type 2 diabetic model rats with hypertriacylglycerolaemia","volume":"87","author":"Minami","year":"2002","journal-title":"Br J Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib18","doi-asserted-by":"crossref","first-page":"E664","DOI":"10.1152\/ajpendo.00320.2001","article-title":"N-3 polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle","volume":"282","author":"Taouis","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2006.06.007_bib19","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/jn\/131.4.1129","article-title":"Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome","volume":"131","author":"Clarke","year":"2001","journal-title":"J Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib20","first-page":"R840","article-title":"Menhaden oil prevents but does not reverse sucrose-induced insulin resistance in rats","volume":"274","author":"Podolin","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2006.06.007_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/j.1462-8902.2004.00356.x","article-title":"Effect of dietary fatty acids on insulin sensitivity and secretion","volume":"6","author":"Manco","year":"2004","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.metabol.2006.06.007_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/ajcn\/76.2.331","article-title":"Association of the fatty acid profile of serum lipids with glucose and insulin metabolism during 2 fat-modified diets in subjects with impaired glucose tolerance","volume":"76","author":"Louheranta","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib23","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1248\/jhs.46.489","article-title":"Effect of alpha-linolenic acid on blood glucose, insulin and GLUT4 protein content of type 2 diabetic mice","volume":"46","author":"Kato","year":"2000","journal-title":"J Health Sci"},{"key":"10.1016\/j.metabol.2006.06.007_bib24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/bbrc.1999.0733","article-title":"Increased uncoupling protein2 mRNA in white adipose tissue, and decreasing leptin, visceral fat, blood glucose and cholesterol in KK-AY mice fed with eicosapentaenoic and docosahexaenoic acids in addition to ALA acid","volume":"259","author":"Hun","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2006.06.007_bib25","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2337\/diacare.19.5.463","article-title":"A comparison of the effects of n-3 fatty acids from linseed oil and fish oil in well-controlled type II diabetes","volume":"19","author":"McManus","year":"1996","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2006.06.007_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s001250050641","article-title":"Effect of w3 fatty acid on plasma lipids, cholesterol and lipoprotein fatty acid content in NIDDM patients","volume":"40","author":"Goh","year":"1997","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2006.06.007_bib27","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1161\/01.ATV.17.6.1163","article-title":"Arterial compliance in obese subjects is improved with dietary plant n-3 fatty acid from flaxseed oil despite increased LDL oxidizability","volume":"18","author":"Nestel","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2006.06.007_bib28","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.2337\/diabetes.51.6.1825","article-title":"The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats","volume":"51","author":"Dobbins","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2006.06.007_bib29","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1152\/jappl.2000.89.6.2382","article-title":"Reduction of obesity, as induced by leptin, reverses endothelial dysfunction in obese (Lepob) mice","volume":"89","author":"Winters","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.metabol.2006.06.007_bib30","first-page":"507","article-title":"Direct vascular anti-atherogenic effects of oleic acid: a clue to the cardioprotective effects of the Mediterranean diet","volume":"44","author":"Massaro","year":"1999","journal-title":"Cardiologia"},{"key":"10.1016\/j.metabol.2006.06.007_bib31","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1079\/BJN2001397","article-title":"Effects of dietary oleic-rich oils (virgin olive and high oleic-acid sunflower) on vascular reactivity in Wistar-Kyoto and spontaneously hypertensive rats","volume":"86","author":"Herrera","year":"2001","journal-title":"Br J Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0021-9150(02)00033-3","article-title":"Protective effect of dietary monounsaturated fat on arteriosclerosis: beyond cholesterol","volume":"163","author":"Perez-Jimenez","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2006.06.007_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0008-6363(01)00406-0","article-title":"Long-chain n-3 polyunsaturated fatty acids and blood vessel function","volume":"52","author":"Abeywardena","year":"2001","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.metabol.2006.06.007_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/sj.ejcn.1601766","article-title":"Long-chain polyunsaturated fatty acids interact with nitric oxide superoxide anion, and transforming growth factor\u2013beta to prevent human essential hypertension","volume":"58","author":"Das","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.metabol.2006.06.007_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00125-004-1600-7","article-title":"Acute effects of monounsaturated fatty acids with and without omega-3 fatty acids on vascular reactivity in individuals with type 2 diabetes","volume":"48","author":"West","year":"2005","journal-title":"Diabetologia"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049506002125?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049506002125?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:17:13Z","timestamp":1758424633000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049506002125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0026049506002125"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2006.06.007","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effects of n-3 polyunsaturated fatty acids on metabolic control and vascular reactivity in the type 2 diabetic ob\/ob mouse","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2006.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}