{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:22:04Z","timestamp":1790871724207,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.metabol.2008.07.005","type":"journal-article","created":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T07:42:55Z","timestamp":1221637375000},"page":"S40-S43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"S2","title":["Autism, a brain developmental disorder: some new pathopysiologic and genetics findings"],"prefix":"10.1016","volume":"57","author":[{"given":"Jorge Alberto","family":"Costa e Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2008.07.005_bib1","volume":"vol. 23","year":"2001"},{"key":"10.1016\/j.metabol.2008.07.005_bib2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annu Rev Neuroscience"},{"key":"10.1016\/j.metabol.2008.07.005_bib3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.conb.2007.01.009","article-title":"Autism spectrum disorders: developmental disconnection syndromes","volume":"17","author":"Geschwind","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.metabol.2008.07.005_bib4","series-title":"American Psychiatric Association. Diagnostic and statistical manual of mental disorders\u20144th ed","year":"1994"},{"key":"10.1016\/j.metabol.2008.07.005_bib5","series-title":"World Health Organiztion. The ICD-10 classification of mental and behavioural disorders clinical descriptions and diagnostic guidelines","year":"1992"},{"key":"10.1016\/j.metabol.2008.07.005_bib6","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1098\/rstb.2002.1208","article-title":"The role of the fusiform face area in social cognition: implications for the pathobiology of autism","volume":"358","author":"Schultz","year":"2003","journal-title":"Philos Trans R Soc Ser B"},{"key":"10.1016\/j.metabol.2008.07.005_bib7","first-page":"217","article-title":"Autistic disturbances of affective contact","volume":"2","author":"Kanner","year":"1943","journal-title":"Nerv Child"},{"key":"10.1016\/j.metabol.2008.07.005_bib8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF01540677","article-title":"Minor physical anomalies in normal, neurotic, learning disabled, and severely disturbed children","volume":"5","author":"Steg","year":"1975","journal-title":"J Autism Child Schizophr"},{"key":"10.1016\/j.metabol.2008.07.005_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/BF01537727","article-title":"Incidence of minor physical anomaly in autism","volume":"7","author":"Walker","year":"1977","journal-title":"J Autism Child Schizophr"},{"key":"10.1016\/j.metabol.2008.07.005_bib10","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/0140-6736(93)91065-T","article-title":"Autism and megalencephaly","volume":"341","author":"Bailey","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2008.07.005_bib11","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1176\/ajp.154.7.926","article-title":"Neuroanatomical correlates of happiness, sadness, and disgust","volume":"154","author":"Lane","year":"1997","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.metabol.2008.07.005_bib12","first-page":"350","article-title":"Reduced medial prefrontal dopaminergic activity in autistic children","author":"Ernst","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2008.07.005_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bandc.2006.02.009","article-title":"Autism and the amygdale: an endocrine hypothesis","volume":"65","author":"Schulkin","year":"2007","journal-title":"Brain Cogn"},{"key":"10.1016\/j.metabol.2008.07.005_bib14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0028-3932(94)90025-6","article-title":"Medial temporal lobe structures and autism: a review of clinical and experimental findings","volume":"32","author":"Bachevalier","year":"1994","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.metabol.2008.07.005_bib15","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/cercor\/7.8.740","article-title":"Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporolimbic lesions: a proton magnetic resonance spectroscopic imaging study","volume":"7","author":"Bertolino","year":"1997","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.metabol.2008.07.005_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/30245","article-title":"Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine","volume":"393","author":"Saunders","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2008.07.005_bib17","first-page":"434","article-title":"The neurobiology of Autism","author":"Prado","year":"2007","journal-title":"J Compil Int Soc Neuropathol Brain Pathol"},{"key":"10.1016\/j.metabol.2008.07.005_bib18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yebeh.2007.03.010","article-title":"Autism: the first firm finding = underconnectivity?","volume":"11","author":"Hughes","year":"2007","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.metabol.2008.07.005_bib19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1017\/S0033291700028099","article-title":"Autism as a strongly genetic disorder: evidence from a British twin study","volume":"25","author":"Bailey","year":"1995","journal-title":"Psychol Med"},{"key":"10.1016\/j.metabol.2008.07.005_bib20","first-page":"932","article-title":"Complex segregation analysis of autism","volume":"49","author":"Jorde","year":"1991","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000452","article-title":"Autism: The quest for the genes","volume":"9","author":"Sykes","year":"2007","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.metabol.2008.07.005_bib22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.spen.2008.01.005","article-title":"Genetic evaluation of autism","volume":"15","author":"Mendelsohn","year":"2008","journal-title":"Semin Pediatr Neurol"},{"key":"10.1016\/j.metabol.2008.07.005_bib23","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1126\/science.1138659","article-title":"Strong association of the novo copy number mutation with autism","volume":"316","author":"Sebat","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.metabol.2008.07.005_bib24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/jmg.2006.043166","article-title":"Array-based comparative genomic hybridization identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders","volume":"43","author":"Jacquemont","year":"2006","journal-title":"J Med Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/sj.mp.4001953","article-title":"Association of Per1 and Npas2 with autistic disorder: support for the clock genes\/social timing hypothesis","author":"Nicholas","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.metabol.2008.07.005_bib26","article-title":"Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression","author":"Lintas","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.metabol.2008.07.005_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.2008.057505","article-title":"Disruption of contactin 4 in 3 subjects with autism spectrum disorder","author":"Roohi","year":"2008","journal-title":"J Med Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajhg.2007.09.005","article-title":"Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene","volume":"82","author":"Alarc\u00f3n","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2008.01.012","article-title":"Immune transcriptome alterations in the temporal cortex of subjects with autism","author":"Garbett","year":"2008","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.metabol.2008.07.005_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.b.30739","article-title":"An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene","author":"Ramoz","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.b.30738","article-title":"Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene","author":"Davis","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/ejhg.2008.7","article-title":"Two patients with balanced translocations and autistic disorder: CSMD3 as a candidate gene for autism found in their common 8q23 breakpoint area","author":"Floris","year":"2008","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2007.11.015","article-title":"Genes controlling affiliative behavior as candidate genes for autism","author":"Yrigollen","year":"2008","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.metabol.2008.07.005_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/ajmg.b.30655","article-title":"A. DRD1 haplotype is associated with risk for autism spectrum disorders in male-only affected sib-pair families","author":"Hettinger","year":"2008","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib35","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ajhg.2007.09.011","article-title":"Disruption of neurexin 1 associated with autism spectrum disorder","volume":"82","author":"Kim","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/sj.mp.4002120","article-title":"SLC2A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects","volume":"13","author":"Lepagnol-Bestel","year":"2008","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.metabol.2008.07.005_bib37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/ajmg.a.32142","article-title":"A novel mutation in JARID1C\/SMCX in a patient with autism spectrum disorder (ASD)","author":"Adegbola","year":"2008","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.metabol.2008.07.005_bib38","doi-asserted-by":"crossref","DOI":"10.1007\/s00439-008-0484-x","article-title":"Pax6 3\u2032 deletion results in aniridia, autism and mental retardation","author":"Davis","year":"2008","journal-title":"Hum Genet"},{"key":"10.1016\/j.metabol.2008.07.005_bib39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nrg2346","article-title":"Advances in autism genetics: on the threshold of a new neurobiology","volume":"9","author":"Abrahams","year":"2008","journal-title":"Nat Rev Genet"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002604950800245X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002604950800245X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:28:48Z","timestamp":1758425328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002604950800245X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":39,"alternative-id":["S002604950800245X"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2008.07.005","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autism, a brain developmental disorder: some new pathopysiologic and genetics findings","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2008.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2008 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}