{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T12:29:47Z","timestamp":1773491387638,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.metabol.2009.05.028","type":"journal-article","created":{"date-parts":[[2009,7,16]],"date-time":"2009-07-16T04:09:05Z","timestamp":1247717345000},"page":"1731-1736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The association between normal alanine aminotransferase levels and the metabolic syndrome: 2005 Korean National Health and Nutrition Examination Survey"],"prefix":"10.1016","volume":"58","author":[{"given":"Sang-Yeon","family":"Suh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Eun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yup","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nak-Jin","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2009.05.028_bib1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1056\/NEJM200004273421707","article-title":"Evaluation of abnormal liver-enzyme results in asymptomatic patients","volume":"342","author":"Pratt","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2009.05.028_bib2","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.2337\/diabetes.51.6.1889","article-title":"High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes","volume":"51","author":"Vozarova","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2009.05.028_bib3","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.2337\/diabetes.54.11.3140","article-title":"Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study","volume":"54","author":"Hanley","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2009.05.028_bib4","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/j.1464-5491.2007.02100.x","article-title":"Alanine aminotransferase and the 6-year risk of the metabolic syndrome in Caucasian men and women: the Hoorn Study","volume":"24","author":"Schindhelm","year":"2007","journal-title":"Diabet Med"},{"key":"10.1016\/j.metabol.2009.05.028_bib5","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3349\/ymj.2006.47.4.542","article-title":"Normal serum aminotransferase levels and the metabolic syndrome: Korean National Health and Nutrition Examination Surveys","volume":"47","author":"Kim","year":"2006","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.metabol.2009.05.028_bib6","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1016\/j.metabol.2005.05.018","article-title":"Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women","volume":"54","author":"Choi","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2009.05.028_bib7","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/bmj.38050.593634.63","article-title":"Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study","volume":"328","author":"Kim","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.metabol.2009.05.028_bib8","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/sj.ijo.0802698","article-title":"Metabolic syndrome and ALT: a community study in adult Koreans","volume":"28","author":"Jeong","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.metabol.2009.05.028_bib9","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: an American Heart Association\/National Heart, Lung, and Blood Institute Scientific Statement","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2009.05.028_bib10","series-title":"The Asia-Pacific perspective: redefining obesity and its treatment","author":"Steering Committee of the Western Pacific Region of the Study of Obesity at IOTF","year":"2000"},{"key":"10.1016\/j.metabol.2009.05.028_bib11","first-page":"1961","article-title":"Nonalcoholic fatty liver disease","volume":"73","author":"Bayard","year":"2006","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.metabol.2009.05.028_bib12","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1002\/hep.20466","article-title":"Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity","volume":"40","author":"Browning","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2009.05.028_bib13","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2337\/diabetes.54.3.603","article-title":"Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes","volume":"54","author":"Petersen","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2009.05.028_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/01.ATV.0000148324.63685.6a","article-title":"Association between elevated liver enzymes and C-reactive protein: possible hepatic contribution to systemic inflammation in the metabolic syndrome","volume":"25","author":"Kerner","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2009.05.028_bib15","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/oby.2005.147","article-title":"Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults","volume":"13","author":"Shen","year":"2005","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2009.05.028_bib16","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.2337\/dc07-0086","article-title":"Alanine aminotransferase and directly measured insulin sensitivity in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study","volume":"30","author":"Hanley","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2009.05.028_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-137-1-200207020-00006","article-title":"Updated definitions of healthy ranges for serum alanine aminotransferase levels","volume":"137","author":"Prati","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2009.05.028_bib18","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/jc.2006-1010","article-title":"Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin, and visceral fat","volume":"91","author":"Burgert","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2009.05.028_bib19","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1373\/clinchem.2006.081257","article-title":"Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease","volume":"53","author":"Chang","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.metabol.2009.05.028_bib20","first-page":"69","article-title":"Subcapsular steatonecrosis in response to peritoneal insulin delivery: a clue to the pathogenesis of steatonecrosis in obesity","volume":"2","author":"Wanless","year":"1989","journal-title":"Mod Pathol"},{"key":"10.1016\/j.metabol.2009.05.028_bib21","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","article-title":"Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities","volume":"120","author":"Sanyal","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.metabol.2009.05.028_bib22","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3346\/jkms.2005.20.6.985","article-title":"The prevalence of hepatitis C virus infection in Korea: pooled analysis","volume":"20","author":"Shin","year":"2005","journal-title":"J Korean Med Sci"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049509002431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049509002431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:46:09Z","timestamp":1758426369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049509002431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S0026049509002431"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2009.05.028","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The association between normal alanine aminotransferase levels and the metabolic syndrome: 2005 Korean National Health and Nutrition Examination Survey","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2009.05.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}