{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:20:22Z","timestamp":1782969622711,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.metabol.2009.08.023","type":"journal-article","created":{"date-parts":[[2009,11,16]],"date-time":"2009-11-16T04:22:04Z","timestamp":1258345324000},"page":"575-580","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome"],"prefix":"10.1016","volume":"59","author":[{"given":"Elisabeth","family":"Wehr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascha","family":"Schweighofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albrecht","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Pieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Obermayer-Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2009.08.023_bib1","first-page":"2434","article-title":"A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain","volume":"85","author":"Asunci\u00f3n","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2009.08.023_bib2","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jcem.84.11.6148","article-title":"A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile","volume":"84","author":"Diamanti-Kandarakis","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2009.08.023_bib3","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"10.1016\/j.metabol.2009.08.023_bib4","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2009.08.023_bib5","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.ijo.0801994","article-title":"Obesity and the polycystic ovary syndrome","volume":"26","author":"Gambineri","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"10.1016\/j.metabol.2009.08.023_bib6","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s00508-009-1162-2","article-title":"Subcutaneous adipose tissue topography and metabolic disturbances in polycystic ovary syndrome","volume":"121","author":"Wehr","year":"2009","journal-title":"Wien Klin Wochenschr"},{"key":"10.1016\/j.metabol.2009.08.023_bib7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199509283331307","article-title":"Polycystic ovary syndrome","volume":"333","author":"Franks","year":"1995","journal-title":"N Engl J Med"},{"issue":"Spec No 2","key":"10.1016\/j.metabol.2009.08.023_bib8","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1093\/hmg\/ddl215","article-title":"Genetics of obesity and the prediction of risk for health","volume":"15","author":"Walley","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.metabol.2009.08.023_bib9","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"Wellcome Trust Case Control Consortium","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.metabol.2009.08.023_bib10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.metabol.2009.08.023_bib11","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1371\/journal.pgen.0030115","article-title":"Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits","volume":"3","author":"Scuteri","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1016\/j.metabol.2009.08.023_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/nrg2178","article-title":"Genome-wide association studies provide new insights into type 2 diabetes aetiology","volume":"8","author":"Frayling","year":"2007","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.metabol.2009.08.023_bib13","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1210\/jc.2008-1336","article-title":"Common type 2 diabetes risk gene variants associate with gestational diabetes","volume":"94","author":"Lauenborg","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2009.08.023_bib14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1467-789X.2008.00481.x","article-title":"FTO: the first gene contributing to common forms of human obesity","volume":"9","author":"Loos","year":"2008","journal-title":"Obes Rev"},{"key":"10.1016\/j.metabol.2009.08.023_bib15","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.1151710","article-title":"The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase","volume":"318","author":"Gerken","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.metabol.2009.08.023_bib16","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1210\/en.2007-1457","article-title":"The obesity gene, FTO, is of ancient origin, up-regulated during food deprivation and expressed in neurons of feeding-related nuclei of the brain","volume":"149","author":"Fredriksson","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2009.08.023_bib17","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/ng2048","article-title":"Variation in FTO contributes to childhood obesity and severe adult obesity","volume":"39","author":"Dina","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2009.08.023_bib18","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbrc.2008.06.039","article-title":"FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome","volume":"373","author":"Attaoua","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2009.08.023_bib19","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00125-008-1028-6","article-title":"Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome","volume":"51","author":"Barber","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2009.08.023_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","year":"2004","journal-title":"Hum Reprod"},{"key":"10.1016\/j.metabol.2009.08.023_bib21","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: implications, etiology, and management","volume":"140","author":"Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.metabol.2009.08.023_bib22","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/01.OGX.0000109523.25076.E2","article-title":"Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls","volume":"59","author":"Legro","year":"2004","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.metabol.2009.08.023_bib23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/(SICI)1520-6300(200003\/04)12:2<231::AID-AJHB9>3.0.CO;2-X","article-title":"Measurement of subcutaneous adipose tissue topography (SAT-Top) by means of a new optical device, LIPOMETER, and the evaluation of standard factor coefficients in healthy subjects","volume":"12","author":"M\u00f6ller","year":"2000","journal-title":"Am J Hum Biol"},{"key":"10.1016\/j.metabol.2009.08.023_bib24","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1056\/NEJMoa0803839","article-title":"An obesity-associated FTO gene variant and increased energy intake in children","volume":"359","author":"Cecil","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2009.08.023_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00439-003-0935-3","article-title":"Complex haplotypes of IRS2 gene are associated with severe obesity and reveal heterogeneity in the effect of Gly1057Asp mutation","volume":"113","author":"Lautier","year":"2003","journal-title":"Hum Genet"},{"key":"10.1016\/j.metabol.2009.08.023_bib26","doi-asserted-by":"crossref","first-page":"505","DOI":"10.2337\/db08-0906","article-title":"Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data","volume":"58","author":"Timpson","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2009.08.023_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2337\/db07-0910","article-title":"Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation","volume":"57","author":"Andreasen","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2009.08.023_bib28","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ymgme.2007.10.011","article-title":"Variants in the FTO gene are associated with common obesity in the Belgian population","volume":"93","author":"Peeters","year":"2008","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.metabol.2009.08.023_bib29","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1177\/153537020322800610","article-title":"Subcutaneous adipose tissue pattern in lean and obese women with polycystic ovary syndrome","volume":"228","author":"Tafeit","year":"2003","journal-title":"Exp Biol Med (Maywood)"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049509003679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049509003679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:46:35Z","timestamp":1758426395000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049509003679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0026049509003679"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2009.08.023","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2009.08.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}