{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:52:59Z","timestamp":1787662379969,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1016\/j.metabol.2010.02.018","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T04:38:49Z","timestamp":1270096729000},"page":"1597-1602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reference range thyroid-stimulating hormone is associated with physical activity energy expenditure in overweight and obese postmenopausal women: a Montreal-Ottawa New Emerging Team Study"],"prefix":"10.1016","volume":"59","author":[{"given":"Genevi\u00e8ve","family":"Rondeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Rutamucero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Messier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lacramioara","family":"Burlacu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Prud'homme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Mircescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9mi","family":"Rabasa-Lhoret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2010.02.018_bib1","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1210\/jc.2003-030398","article-title":"Hypothyroidism and atherosclerosis","volume":"88","author":"Cappola","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0002-9343(92)90782-7","article-title":"Spectrum of subclinical and overt hypothyroidism: effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues","volume":"92","author":"Staub","year":"1992","journal-title":"Am J Med"},{"key":"10.1016\/j.metabol.2010.02.018_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.7326\/0003-4819-68-2-338","article-title":"Myxedema and coronary artery disease\u2014a comparative autopsy study","volume":"68","author":"Steinberg","year":"1968","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2010.02.018_bib4","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1210\/edrv-6-3-432","article-title":"Hypothyroidism and atherosclerotic heart disease: pathogenesis, medical management, and the role of coronary artery bypass surgery","volume":"6","author":"Becker","year":"1985","journal-title":"Endocr Rev"},{"key":"10.1016\/j.metabol.2010.02.018_bib5","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1530\/eje.0.1340168","article-title":"Body composition and energy expenditure in thyroidectomized patients during short-term hypothyroidism and thyrotropin-suppressive thyroxine therapy","volume":"134","author":"Wolf","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2010.02.018_bib6","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1210\/er.2006-0043","article-title":"The clinical significance of subclinical thyroid dysfunction","volume":"29","author":"Biondi","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.metabol.2010.02.018_bib7","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2265.1995.tb01894.x","article-title":"The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey","volume":"43","author":"Vanderpump","year":"1995","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.metabol.2010.02.018_bib8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/eje.1.02333","article-title":"The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study.","volume":"156","author":"Asvold","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2010.02.018_bib9","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1210\/jc.2006-2208","article-title":"Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study","volume":"92","author":"Asvold","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib10","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/sj.jhh.1002091","article-title":"Blood pressure in relation to serum thyrotropin: the Tromso study","volume":"20","author":"Iqbal","year":"2006","journal-title":"J Hum Hypertens"},{"key":"10.1016\/j.metabol.2010.02.018_bib11","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1365-2265.2006.02619.x","article-title":"Subclinical thyroid dysfunction and blood pressure: a community-based study","volume":"65","author":"Walsh","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.metabol.2010.02.018_bib12","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2265.2005.02247.x","article-title":"Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women","volume":"62","author":"Iacobellis","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.metabol.2010.02.018_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/sj.ijo.0803112","article-title":"Serum TSH is positively associated with BMI","volume":"30","author":"Nyrnes","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.metabol.2010.02.018_bib14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2265.2007.02874.x","article-title":"Free triiodothyronine and thyroid stimulating hormone are directly associated with waist circumference, independently of insulin resistance, metabolic parameters and blood pressure in overweight and obese women","volume":"67","author":"De Pergola","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.metabol.2010.02.018_bib15","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1210\/jc.2004-2225","article-title":"Small differences in thyroid function may be important for body mass index and the occurrence of obesity in the population","volume":"90","author":"Knudsen","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1365-2265.2006.02433.x","article-title":"Lack of association between serum TSH or free T4 and body mass index in euthyroid subjects","volume":"64","author":"Manji","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.metabol.2010.02.018_bib17","first-page":"1206","article-title":"The relationship between thyrotropin and low density lipoprotein cholesterol is modified by insulin sensitivity in healthy euthyroid subjects","volume":"86","author":"Bakker","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1001\/archinte.168.8.855","article-title":"Thyrotropin levels and risk of fatal coronary heart disease: the HUNT study","volume":"168","author":"Asvold","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2010.02.018_bib19","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1001\/archinte.165.21.2467","article-title":"Subclinical thyroid dysfunction as a risk factor for cardiovascular disease","volume":"165","author":"Walsh","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2010.02.018_bib20","first-page":"38","article-title":"Mortality in older adults in relation to daily activity energy expenditure","volume":"40","author":"Singer","year":"2008","journal-title":"J Insur Med"},{"key":"10.1016\/j.metabol.2010.02.018_bib21","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1001\/jama.296.2.171","article-title":"Daily activity energy expenditure and mortality among older adults","volume":"296","author":"Manini","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2010.02.018_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-201X.2005.01463.x","article-title":"Thyroid hormones as molecular determinants of thermogenesis","volume":"184","author":"Silvestri","year":"2005","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.metabol.2010.02.018_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/oby.2001.21","article-title":"Subclinical hypothyroidism in obese patients: relation to resting energy expenditure, serum leptin, body composition, and lipid profile","volume":"9","author":"Tagliaferri","year":"2001","journal-title":"Obes Res"},{"key":"10.1016\/j.metabol.2010.02.018_bib24","first-page":"1118","article-title":"Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement","volume":"82","author":"al-Adsani","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib25","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1210\/jc.2004-2344","article-title":"Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine","volume":"90","author":"Caraccio","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib26","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1210\/jc.2003-031669","article-title":"Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study","volume":"89","author":"Monzani","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib27","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1249\/MSS.0b013e318187c010","article-title":"Improvements in insulin sensitivity are blunted by subclinical hypothyroidism","volume":"41","author":"Amati","year":"2009","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.metabol.2010.02.018_bib28","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2008-2706","article-title":"Resistance training does not contribute to improve the metabolic profile after a 6-month weight loss program in overweight and obese postmenopausal women","author":"Brochu","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.02.018_bib29","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2010.02.018_bib30","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1152\/jappl.1982.53.4.955","article-title":"Measurement of energy expenditure in humans by doubly labeled water method","volume":"53","author":"Schoeller","year":"1982","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.metabol.2010.02.018_bib31","first-page":"540","article-title":"Physical activity, cardiorespiratory fitness, and adiposity: contributions to disease risk","volume":"9","author":"LaMonte","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.metabol.2010.02.018_bib32","article-title":"Initial thyroid status and cardio-vascular risk factors: the EPIC-Norfolk prospective population study","author":"Boekholdt","year":"2009","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.metabol.2010.02.018_bib33","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0140-6736(08)61076-4","article-title":"Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study","volume":"372","author":"McQueen","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2010.02.018_bib34","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(09)60447-5","article-title":"Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial","volume":"373","author":"Ridker","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2010.02.018_bib35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1507\/endocrj.52.89","article-title":"Subclinical hypothyroidism may be associated with elevated high-sensitive c-reactive protein (low grade inflammation) and fasting hyperinsulinemia","volume":"52","author":"Tuzcu","year":"2005","journal-title":"Endocr J"},{"key":"10.1016\/j.metabol.2010.02.018_bib36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0021-9150(02)00372-6","article-title":"Elevated C-reactive protein and homocysteine values: cardiovascular risk factors in hypothyroidism? A cross-sectional and a double-blind, placebo-controlled trial.","volume":"166","author":"Christ-Crain","year":"2003","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2010.02.018_bib37","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise capacity and mortality among men referred for exercise testing","volume":"346","author":"Myers","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2010.02.018_bib38","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1161\/01.CIR.0000091080.57509.E9","article-title":"Exercise capacity and the risk of death in women: the St James Women Take Heart Project","volume":"108","author":"Gulati","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2010.02.018_bib39","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1001\/jama.1995.03520380029031","article-title":"Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men.","volume":"273","author":"Blair","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2010.02.018_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/thy.2006.16.73","article-title":"Thyroid function in humans with morbid obesity","volume":"16","author":"Michalaki","year":"2006","journal-title":"Thyroid"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510000727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510000727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:51:14Z","timestamp":1758426674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049510000727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["S0026049510000727"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2010.02.018","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reference range thyroid-stimulating hormone is associated with physical activity energy expenditure in overweight and obese postmenopausal women: a Montreal-Ottawa New Emerging Team Study","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2010.02.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}