{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:37:26Z","timestamp":1793234246363,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007312","name":"Cleveland Clinic Foundation","doi-asserted-by":"crossref","award":["DK079937"],"award-info":[{"award-number":["DK079937"]}],"id":[{"id":"10.13039\/100007312","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.metabol.2010.03.006","type":"journal-article","created":{"date-parts":[[2010,4,28]],"date-time":"2010-04-28T09:12:05Z","timestamp":1272445925000},"page":"404-413","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":532,"title":["Plasma metabolomic profile in nonalcoholic fatty liver disease"],"prefix":"10.1016","volume":"60","author":[{"given":"Satish C.","family":"Kalhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Edmison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Dasarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur J.","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Milburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2010.03.006_bb0005","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1042\/CS20070402","article-title":"Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations","volume":"115","author":"Preiss","year":"2008","journal-title":"Clin Sci"},{"key":"10.1016\/j.metabol.2010.03.006_bb0010","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2010.03.006_bb0015","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/CS20080253","article-title":"Metabolic disturbances in non-alcoholic fatty liver disease","volume":"116","author":"Byrne","year":"2009","journal-title":"Clin Sci"},{"key":"10.1016\/j.metabol.2010.03.006_bb0020","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1172\/JCI200422422","article-title":"Molecular mediators of hepatic steatosis and liver injury","volume":"114","author":"Browning","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2010.03.006_bb0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/ajcn\/82.3.497","article-title":"Metabolomics in human nutrition: opportunities and challenges","volume":"682","author":"Gibney","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2010.03.006_bb0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/bib\/bbm030","article-title":"Current progress in computational metabolomics","volume":"8","author":"Wishart","year":"2007","journal-title":"Brief Bioinform"},{"key":"10.1016\/j.metabol.2010.03.006_bb0035","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1002\/pmic.200600106","article-title":"Metabolomics: current technologies and future trends","volume":"6","author":"Hollywood","year":"2006","journal-title":"Proteomics"},{"key":"10.1016\/j.metabol.2010.03.006_bb0040","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/ac901536h","article-title":"Integrated, nontargeted ultrahigh performance liquid chromatography\/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems","volume":"81","author":"Evans","year":"2009","journal-title":"Anal Chem"},{"key":"10.1016\/j.metabol.2010.03.006_bb0045","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2010.03.006_bb0050","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1570-0232(02)00401-4","article-title":"Plasma total homocysteine quantification: an improvement of the classical high-performance liquid chromatographic method with fluorescence detection of the thiol-SBD derivatives","volume":"779","author":"Garcia","year":"2002","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.metabol.2010.03.006_bb0055","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2010.03.006_bb0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1136\/jcp.31.1.58","article-title":"Serum bile acids in patient with hyperlipidaemia","volume":"31","author":"Pennington","year":"1978","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.metabol.2010.03.006_bb0065","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/gut.19.6.492","article-title":"Serum bile acids in hepatobiliary disease","volume":"19","author":"Bouchier","year":"1978","journal-title":"Gut"},{"key":"10.1016\/j.metabol.2010.03.006_bb0070","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0025-7125(16)31692-3","article-title":"Clearance tests of liver function","volume":"63","author":"Brody","year":"1979","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.metabol.2010.03.006_bb0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1751-2980.2009.00369.x","article-title":"Bile acids and insulin resistance: implications for treating nonalcoholic fatty liver disease","volume":"10","author":"Wei","year":"2009","journal-title":"J Dig Dis"},{"key":"10.1016\/j.metabol.2010.03.006_bb0080","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0005-2760(78)90064-4","article-title":"Bile acid pool changes and regulation of cholate synthesis in experimental diabetes","volume":"529","author":"Nerfi","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.metabol.2010.03.006_bb0085","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1254\/jjp.29.553","article-title":"Altered bile acid metabolism in alloxan diabetic rats","volume":"29","author":"Uchida","year":"1978","journal-title":"Jpn J Pharmacol"},{"key":"10.1016\/j.metabol.2010.03.006_bb0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/oxfordjournals.jbchem.a022584","article-title":"Insulin is a dominant suppressor of sterol 12\u03b1-hydroxylase P450 (CYP8B) expression in rat liver: possible role of insulin in circadian rhythm of CYP8B","volume":"127","author":"Ishida","year":"2000","journal-title":"J Biochem"},{"key":"10.1016\/j.metabol.2010.03.006_bb0095","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nm1785","article-title":"Hepatic insulin resistance directly promotes formation of cholesterol gallstones","volume":"14","author":"Biddinger","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2010.03.006_bb0100","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1002\/hep.22618","article-title":"Insulin and cholesterol gallstones: new insights for a complex pathogenic relationship","volume":"48","author":"Aanlungo","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2010.03.006_bb0105","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1038\/sj.emboj.7601049","article-title":"Endocrine functions of bile acids","volume":"25","author":"Houten","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.metabol.2010.03.006_bb0110","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.3748\/wjg.14.5620","article-title":"Endocrine and paracrine role of bile acids","volume":"14","author":"Keitel","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.metabol.2010.03.006_bb0115","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.2337\/dc09-S355","article-title":"Bile acids and metabolic regulation. Mechanisms and clinical response to bile acid sequestration","volume":"32","author":"Staels","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2010.03.006_bb0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1440-1746.1992.tb00926.x","article-title":"Significance of plasma glutathione determination in patients with alcoholic and non-alcoholic liver disease","volume":"7","author":"Shigesawa","year":"1992","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.metabol.2010.03.006_bb0125","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0024-3205(88)90544-9","article-title":"Hepatic glutathione content in patients with alcoholic and non alcoholic liver diseases","volume":"43","author":"Altomar","year":"1988","journal-title":"Life Sci"},{"key":"10.1016\/j.metabol.2010.03.006_bb0130","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/13813450701661198","article-title":"The central role of glutathione in the pathophysiology of human disease","volume":"113","author":"Franco","year":"2007","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.metabol.2010.03.006_bb0135","doi-asserted-by":"crossref","first-page":"G567","DOI":"10.1152\/ajpgi.00042.2009","article-title":"Glycine and urea kinetics in non-alcoholic steatohepatitis in human: effect of intralipid infusion","volume":"297","author":"Dasarathy","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.metabol.2010.03.006_bb0140","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s00125-005-1682-x","article-title":"Insulin resistance in non-diabetic patient with non-alcoholic fatty liver disease: sites and mechanisms","volume":"48","author":"Bugianesi","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2010.03.006_bb0145","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1053\/gast.2001.23256","article-title":"Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities","volume":"120","author":"Sanyal","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.metabol.2010.03.006_bb0150","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2337\/diabetes.54.1.190","article-title":"Evidence for accelerated rates of glutathione utilization and glutathione depletion in adolescents with poorly controlled type 1 diabetes","volume":"54","author":"Darmaun","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2010.03.006_bb0155","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/hep.21763","article-title":"A lipidomic analysis of nonalcoholic fatty liver disease","volume":"46","author":"Puri","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2010.03.006_bb0160","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cmet.2009.02.002","article-title":"A branched-chain amino acid\u2013related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance","volume":"9","author":"Newgard","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.metabol.2010.03.006_bb0165","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00125-005-0066-6","article-title":"Elevations of plasma methylarginines in obesity and ageing are related to insulin sensitivity and rates of protein turnover","volume":"49","author":"Marliss","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2010.03.006_bb0170","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2337\/db07-0887","article-title":"Insulin resistance of protein metabolism in type 2 diabetes","volume":"57","author":"Pereira","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2010.03.006_bb0175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2337\/dc07-1268","article-title":"Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes","volume":"31","author":"Gougeon","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2010.03.006_bb0180","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1210\/jc.2009-1235","article-title":"Fatty acids, insulin resistance and protein metabolism","volume":"94","author":"Kalhan","year":"2009","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510000867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510000867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:51:37Z","timestamp":1758426697000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049510000867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0026049510000867"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2010.03.006","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasma metabolomic profile in nonalcoholic fatty liver disease","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2010.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}