{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:15:48Z","timestamp":1786994148567,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1016\/j.metabol.2010.07.009","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T06:03:38Z","timestamp":1284703418000},"page":"S32-S36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"S1","title":["Gout: epitome of painful arthritis"],"prefix":"10.1016","volume":"59","author":[{"given":"Theodore B.","family":"VanItallie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2010.07.009_bb0005","series-title":"The burden of musculoskeletal conditions at the start of the new millennium","year":"2003"},{"key":"10.1016\/j.metabol.2010.07.009_bb0010","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/art.21562","article-title":"Projections of US prevalence of arthritis and associated activity limitations","volume":"54","author":"Hootman","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.metabol.2010.07.009_bb0015","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/art.10913","article-title":"The costs of arthritis","volume":"49","author":"Dunlop","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.metabol.2010.07.009_bb0020","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.pain.2004.04.017","article-title":"The prevalence of pain and pain interference in a general population of older adults: cross-sectional findings from the North Staffordshire Osteoarthritis Project (NorStOP)","volume":"110","author":"Thomas","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.metabol.2010.07.009_bb0025","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/rheumatology\/kem013","article-title":"Osteoarthritis as a public health problem: the impact of developing knee pain on physical function in adults living in the community: (KNEST 3)","volume":"46","author":"Jinks","year":"2007","journal-title":"Rheumatology"},{"key":"10.1016\/j.metabol.2010.07.009_bb0030","unstructured":"http:\/\/www.cdc.gov\/arthritis\/resources\/spotlights\/dsArthritis.htm."},{"issue":"Suppl 5","key":"10.1016\/j.metabol.2010.07.009_bb0035","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.3949\/ccjm.75.Suppl_5.S9","article-title":"Epidemiology of gout","volume":"75","author":"Weaver","year":"2008","journal-title":"CCJM"},{"key":"10.1016\/j.metabol.2010.07.009_bb0040","author":"Saag"},{"key":"10.1016\/j.metabol.2010.07.009_bb0045","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/BOR.0b013e328335ef38","article-title":"A prescription for lifestyle change in patients with hyperuricemia and gout","volume":"22","author":"Choi","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0050","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ng.106","article-title":"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout","volume":"40","author":"Vitart","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.metabol.2010.07.009_bb0055","doi-asserted-by":"crossref","first-page":"R177","DOI":"10.1093\/hmg\/ddp369","article-title":"Recent insights into the pathogenesis of hyperuricemia and gout","volume":"18","author":"Riches","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.metabol.2010.07.009_bb0060","doi-asserted-by":"crossref","first-page":"E831","DOI":"10.1152\/ajpendo.00296.2009","article-title":"Facilitative glucose transporter 9, a unique hexose and urate transporter","volume":"297","author":"Doblado","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.07.009_bb0065","doi-asserted-by":"crossref","first-page":"15501","DOI":"10.1073\/pnas.0904411106","article-title":"Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy","volume":"106","author":"Preitner","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2010.07.009_bb0070","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1073\/pnas.0901249106","article-title":"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout","volume":"106","author":"Woodward","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2010.07.009_bb0075","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0002-9343(87)90441-4","article-title":"Asymptomatic hyperuricemia. Risks and consequences in the Normative Aging Study","volume":"82","author":"Campion","year":"1987","journal-title":"Am J Med"},{"key":"10.1016\/j.metabol.2010.07.009_bb0080","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0749-0690(18)30103-4","article-title":"Crystal-associated arthritis","volume":"14","author":"Agudelo","year":"1998","journal-title":"Clin Geriatr Med"},{"key":"10.1016\/j.metabol.2010.07.009_bb0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/art.1780150209","article-title":"The influence of temperature on the solubility of monosodium urate","volume":"15","author":"Loeb","year":"1972","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.metabol.2010.07.009_bb0090","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/icb.2009.93","article-title":"Intracellular innate immunity in gout arthritis: role of NALP3 inflammasome","volume":"88","author":"Liu-Bryan","year":"2010","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Ann Rev Immunol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/BOR.0b013e328014529a","article-title":"Recent advances in crystal-induced acute inflammation","volume":"19","author":"Akahoshi","year":"2007","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0105","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1002\/art.20317","article-title":"Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal\u2013induced inflammation","volume":"50","author":"Yagnik","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.metabol.2010.07.009_bb0110","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/ar2930","article-title":"High-density lipoproteins down-regulate CCL2 production in human fibroblast-like synoviocytes stimulated by urate crystals","volume":"12","author":"Scanut","year":"2010","journal-title":"Athritis Res Ther"},{"key":"10.1016\/j.metabol.2010.07.009_bb0115","series-title":"The works of Thomas Sydenham","article-title":"\u201cOn gout\u201d vol. II, 123-162","author":"Sydenham","year":"1848"},{"key":"10.1016\/j.metabol.2010.07.009_bb0120","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3899\/jrheum.080938","article-title":"Serum urate during acute gout","volume":"36","author":"Schlesinger","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0125","doi-asserted-by":"crossref","first-page":"452","DOI":"10.7326\/0003-4819-54-3-452","article-title":"Identification of urate crystals in gouty synovial fluid","volume":"54","author":"McCarty","year":"1961","journal-title":"Ann Int Med"},{"key":"10.1016\/j.metabol.2010.07.009_bb0130","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0140-6736(09)61595-6","article-title":"Bacterial septic arthritis in adults","volume":"375","author":"Mathews","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2010.07.009_bb0135","first-page":"902","article-title":"Rare coexistence of gouty and septic arthritis: a report of 14 cases","volume":"27","author":"Weng","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0140","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.2214\/AJR.09.2428","article-title":"Dual-energy CT as a potential new diagnostic tool in the management of gout in the acute setting","volume":"194","author":"Nicolaou","year":"2010","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0145","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-0028-1109820","article-title":"Dual energy CT\u2014a new perspective in the diagnosis of gout","volume":"182","author":"Artmann","year":"2010","journal-title":"Rofo"},{"key":"10.1016\/j.metabol.2010.07.009_bb0150","first-page":"25","article-title":"Crystal arthritis. Gout and pseudogout in the geriatric patient","volume":"59","author":"Cassetta","year":"2004","journal-title":"Geriatrics"},{"key":"10.1016\/j.metabol.2010.07.009_bb0155","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3899\/jrheum.080374","article-title":"Gout in the axial skeleton","volume":"36","author":"Konatalapalli","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0160","first-page":"143","article-title":"Thoracic spinal gout mimicking metastasis","volume":"15","author":"Chan","year":"2009","journal-title":"Hong Kong Med J"},{"key":"10.1016\/j.metabol.2010.07.009_bb0165","first-page":"1949","article-title":"Tophaceous gout of the lumbar spine mimicking an epidural abscess: MR features","volume":"17","author":"Bonaldi","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0170","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0248-8663(99)83053-7","article-title":"Spinal cord compression due to tophaceous vertebral gout: a case report and literature review","volume":"20","author":"Marsaudon","year":"1999","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.metabol.2010.07.009_bb0175","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.healun.2009.05.039","article-title":"Pancreatic gout masquerading as pancreatic cancer in a heart transplant candidate","volume":"28","author":"Gupta","year":"2009","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.metabol.2010.07.009_bb0180","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s002560050299","article-title":"Gouty tophus simulating soft tissue tumor in a heart transplant recipient","volume":"26","author":"Chaoul","year":"1997","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.metabol.2010.07.009_bb0185","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1136\/ard.2009.109355","article-title":"Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis","volume":"68","author":"Torres","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.metabol.2010.07.009_bb0190","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1172\/JCI28075","article-title":"MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals","volume":"116","author":"Chen","year":"2006","journal-title":"J Clin Invest"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510002295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510002295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:49:57Z","timestamp":1758426597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049510002295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":38,"alternative-id":["S0026049510002295"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2010.07.009","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gout: epitome of painful arthritis","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2010.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}