{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T09:59:11Z","timestamp":1758448751748,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.metabol.2010.07.023","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T04:52:21Z","timestamp":1284612741000},"page":"754-760","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope study"],"prefix":"10.1016","volume":"60","author":[{"given":"Rajagopal V.","family":"Sekhar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeet G.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjian","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok","family":"Balasubramanyam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaleel","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farook","family":"Jahoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fehmida","family":"Visnegarwala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2010.07.023_bb0005","doi-asserted-by":"crossref","first-page":"F51","DOI":"10.1097\/00002030-199807000-00003","article-title":"A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors","volume":"12","author":"Carr","year":"1998","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.07.023_bb0010","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1097\/00002030-200305230-00010","article-title":"Cardiovascular disease risk factors in HIV patients\u2014association with antiretroviral therapy. Results from the DAD study","volume":"17","author":"Friis-Moller","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.07.023_bb0015","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1097\/00002030-200409030-00010","article-title":"Cardio- and cerebrovascular events in HIV-infected persons","volume":"18","author":"d'Arminio","year":"2004","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.07.023_bb0020","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1097\/00002030-200311210-00010","article-title":"Increased risk of myocardial infarction with duration of protease inhibitor therapy in HIV-infected men","volume":"17","author":"Mary-Krause","year":"2003","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.07.023_bb0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ahj.2003.07.007","article-title":"Acute myocardial infarction in patients infected with human immunodeficiency virus","volume":"147","author":"Varriale","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.metabol.2010.07.023_bb0030","doi-asserted-by":"crossref","first-page":"E332","DOI":"10.1152\/ajpendo.00058.2002","article-title":"Metabolic basis of HIV-lipodystrophy syndrome","volume":"E283","author":"Sekhar","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.07.023_bb0035","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/ajcn\/81.6.1405","article-title":"Severely dysregulated disposal of postprandial triacylglycerols exacerbates hypertriacylglycerolemia in HIV lipodystrophy syndrome","volume":"81","author":"Sekhar","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2010.07.023_bb0040","doi-asserted-by":"crossref","first-page":"E490","DOI":"10.1152\/ajpendo.00118.2003","article-title":"Alterations in lipid kinetics in men with HIV-dyslipidemia","volume":"285","author":"Reeds","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.07.023_bb0045","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1053\/meta.2002.34704","article-title":"Increased rates of lipolysis among human immunodeficiency virus\u2013infected men receiving highly active antiretroviral therapy","volume":"51","author":"Hadigan","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2010.07.023_bb0050","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","article-title":"An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)","volume":"270","author":"Lehmann","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2010.07.023_bb0055","doi-asserted-by":"crossref","first-page":"81","DOI":"10.5551\/jat1994.3.81","article-title":"Regulation of triglyceride metabolism by PPARs: fibrates and thiazolidinediones have distinct effects","volume":"3","author":"Auwerx","year":"1996","journal-title":"J Atheroscler Thromb"},{"key":"10.1016\/j.metabol.2010.07.023_bb0060","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.2337\/db06-0551","article-title":"Mechanisms of the depot specificity of peroxisome proliferator-activated receptor gamma action on adipose tissue metabolism","volume":"55","author":"Laplante","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2010.07.023_bb0065","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/135965350300800303","article-title":"Rosiglitazone in the treatment of HAART-associated lipodystrophy\u2014a randomized double-blind placebo-controlled study","volume":"8","author":"Sutinen","year":"2003","journal-title":"Antivir Ther"},{"key":"10.1016\/j.metabol.2010.07.023_bb0070","doi-asserted-by":"crossref","first-page":"786","DOI":"10.7326\/0003-4819-140-10-200405180-00008","article-title":"Metabolic effects of rosiglitazone in HIV lipodystrophy: a randomized, controlled trial","volume":"140","author":"Hadigan","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2010.07.023_bb0075","first-page":"99","article-title":"Effect of metformin and rosiglitazone on lipid metabolism in HIV infected patients receiving protease inhibitor containing HAART","volume":"14","author":"Tomazic","year":"2005","journal-title":"Acta Dermatovenerol Alp Panonica Adriat"},{"key":"10.1016\/j.metabol.2010.07.023_bb0080","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00126334-200210010-00006","article-title":"Improved insulin sensitivity and body fat distribution in HIV-infected patients treated with rosiglitazone: a pilot study","volume":"31","author":"Gelato","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.metabol.2010.07.023_bb0085","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1086\/427697","article-title":"Improvement in highly active antiretroviral therapy-induced metabolic syndrome by treatment with pioglitazone but not with fenofibrate: a 2 \u00d7 2 factorial, randomized, double-blinded, placebo-controlled trial","volume":"40","author":"Gavrila","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.metabol.2010.07.023_bb0090","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0140-6736(04)15489-5","article-title":"No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, placebo-controlled trial","volume":"363","author":"Carr","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2010.07.023_bb0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s15010-006-5022-y","article-title":"Evaluation of safety and efficacy of rosiglitazone in the treatment of HIV-associated lipodystrophy syndrome","volume":"34","author":"Feldt","year":"2006","journal-title":"Infection"},{"key":"10.1016\/j.metabol.2010.07.023_bb0100","doi-asserted-by":"crossref","first-page":"337","DOI":"10.7326\/0003-4819-143-5-200509060-00009","article-title":"Comparison of rosiglitazone and metformin for treating HIV lipodystrophy: a randomized trial","volume":"143","author":"van Wijk","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2010.07.023_bb0105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1097\/00002030-200001070-00005","article-title":"Fat distribution evaluated by computed tomography and metabolic abnormalities in patients undergoing antiretroviral therapy: preliminary results of the LIPOCO study","volume":"14","author":"Saint-Marc","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.07.023_bb0110","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00126334-200308150-00004","article-title":"An objective lipodystrophy severity grading scale derived from the lipodystrophy case definition score","volume":"33","author":"Carr","year":"2003","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.metabol.2010.07.023_bb0115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2010.07.023_bb0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0003-2697(92)90595-X","article-title":"A mass spectrometric method for measuring glycerol levels and enrichments in plasma using 13C and 2H stable isotopic tracers","volume":"205","author":"Gilker","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1016\/j.metabol.2010.07.023_bb0125","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1021\/ac00009a017","article-title":"Isotopic determination of organic keto acid pentafluorobenzyl esters in biological fluids by negative chemical ionization gas chromatography\/mass spectrometry","volume":"63","author":"Hachey","year":"1991","journal-title":"Anal Chem"},{"issue":"4 Pt 1","key":"10.1016\/j.metabol.2010.07.023_bb0130","first-page":"E649","article-title":"A new correction factor for use in tracer estimations of plasma fatty acid oxidation","volume":"269","author":"Sidossis","year":"1995","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2010.07.023_bb0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1463-1326.2008.00916.x","article-title":"Regulation of adipose triglyceride lipase by rosiglitazone","volume":"11","author":"Liu","year":"2009","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.metabol.2010.07.023_bb0140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/MCB.15.1.351","article-title":"PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene","volume":"15","author":"Tontonoz","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.metabol.2010.07.023_bb0145","doi-asserted-by":"crossref","first-page":"R1116","DOI":"10.1152\/ajpregu.00339.2004","article-title":"Actions of PPARgamma agonism on adipose tissue remodeling, insulin sensitivity, and lipemia in absence of glucocorticoids","volume":"287","author":"Berthiaume","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.metabol.2010.07.023_bb0150","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1210\/rp.59.1.359","article-title":"Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue","volume":"59","author":"Seckl","year":"2004","journal-title":"Recent Prog Horm Res"},{"key":"10.1016\/j.metabol.2010.07.023_bb0155","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1210\/endo.142.4.8114","article-title":"Minireview: 11beta-hydroxysteroid dehydrogenase type 1\u2014a tissue-specific amplifier of glucocorticoid action","volume":"142","author":"Seckl","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2010.07.023_bb0160","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1194\/jlr.M800165-JLR200","article-title":"A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetes","volume":"49","author":"Beysen","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2010.07.023_bb0165","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/S0140-6736(06)69420-8","article-title":"Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial","volume":"368","author":"Gerstein","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2010.07.023_bb0170","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1074\/jbc.M512943200","article-title":"Rosiglitazone controls fatty acid cycling in human adipose tissue by means of glyceroneogenesis and glycerol phosphorylation","volume":"281","author":"Leroyer","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2010.07.023_bb0175","doi-asserted-by":"crossref","first-page":"E941","DOI":"10.1152\/ajpendo.00490.2003","article-title":"Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy","volume":"286","author":"Sutinen","year":"2004","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.07.023_bb0180","doi-asserted-by":"crossref","unstructured":"Tungsiripat M, Bejjani DE, Rizk N, O'Riordan MA, Ross AC, Hileman C, et al. Rosiglitazone improves lipoatrophy in patients receiving thymidine-sparing regimens. AIDS 24:1291-8.","DOI":"10.1097\/QAD.0b013e328339e274"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510002519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510002519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:53:22Z","timestamp":1758426802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049510002519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0026049510002519"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2010.07.023","relation":{},"ISSN":["0026-0495"],"issn-type":[{"type":"print","value":"0026-0495"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of rosiglitazone on abnormal lipid kinetics in HIV-associated dyslipidemic lipodystrophy: a stable isotope study","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2010.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}