{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:43:46Z","timestamp":1773773026339,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.metabol.2010.08.007","type":"journal-article","created":{"date-parts":[[2010,10,14]],"date-time":"2010-10-14T05:46:15Z","timestamp":1287035175000},"page":"874-880","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood"],"prefix":"10.1016","volume":"60","author":[{"given":"David","family":"Dimock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Cushing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia B.","family":"Purdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Worrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey B.","family":"Kopp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohan","family":"Hazra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Hadigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2010.08.007_bb0005","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1056\/NEJMra041811","article-title":"Cardiovascular risk and body fat abnormalities in HIV-infected adults","volume":"352","author":"Grinspoon","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0010","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1681\/ASN.2005040340","article-title":"Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease","volume":"16","author":"Schwartz","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.metabol.2010.08.007_bb0015","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.amjmed.2007.01.025","article-title":"HIV-associated nephropathy in the era of antiretroviral therapy","volume":"120","author":"Wyatt","year":"2007","journal-title":"Am J Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0020","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/jac\/dkm475","article-title":"Metabolic consequences and therapeutic options in highly active antiretroviral therapy in human immunodeficiency virus\u20131 infection","volume":"61","author":"Samaras","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.metabol.2010.08.007_bb0025","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.2337\/dc07-2013","article-title":"Incidence and risk factors for new-onset diabetes in HIV-infected patients: the data collection on adverse events of anti-HIV drugs (D:A:D) study","volume":"31","author":"De Wit","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2010.08.007_bb0030","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/archinte.165.10.1179","article-title":"Antiretroviral therapy and the prevalence and incidence of diabetes mellitus in the multicenter AIDS cohort study","volume":"165","author":"Brown","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0035","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMoa062744","article-title":"Class of antiretroviral drugs and the risk of myocardial infarction","volume":"356","author":"Friis-Moller","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0040","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1097\/QAD.0b013e32832d3b85","article-title":"Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study","volume":"23","author":"Grunfeld","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.08.007_bb0045","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/QAD.0b013e3282f70694","article-title":"Insulin resistance predicts endothelial dysfunction and cardiovascular risk in HIV-infected persons on long-term highly active antiretroviral therapy","volume":"22","author":"Mondy","year":"2008","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.08.007_bb0050","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jpeds.2008.04.016","article-title":"Risk factors for cardiovascular disease in children infected with human immunodeficiency virus-1","volume":"153","author":"Miller","year":"2008","journal-title":"J Pediatr"},{"key":"10.1016\/j.metabol.2010.08.007_bb0055","doi-asserted-by":"crossref","first-page":"e129","DOI":"10.1542\/peds.2007-2467","article-title":"Lipid and glucose alterations in HIV-infected children beginning or changing antiretroviral therapy","volume":"122","author":"Chantry","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.metabol.2010.08.007_bb0060","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00042560-200105010-00005","article-title":"Lipodystrophy in HIV-infected children is associated with high viral load and low CD4+ -lymphocyte count and CD4+ -lymphocyte percentage at baseline and use of protease inhibitors and stavudine","volume":"27","author":"Arpadi","year":"2001","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.metabol.2010.08.007_bb0065","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1542\/peds.114.2.e235","article-title":"Natural history of lipid abnormalities and fat redistribution among human immunodeficiency virus-infected children receiving long-term, protease inhibitor\u2013containing, highly active antiretroviral therapy regimens","volume":"114","author":"Taylor","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.metabol.2010.08.007_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/01.qai.0000218344.88304.db","article-title":"Dyslipidemia among perinatally HIV-infected children enrolled in the PACTS-HOPE cohort, 1999-2004: a longitudinal analysis","volume":"41","author":"Carter","year":"2006","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.metabol.2010.08.007_bb0075","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1203\/01.pdr.0000228335.64894.26","article-title":"Serum adiponectin and leptin concentrations in HIV-infected children with fat redistribution syndrome","volume":"60","author":"Verkauskiene","year":"2006","journal-title":"Pediatr Res"},{"key":"10.1016\/j.metabol.2010.08.007_bb0080","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1097\/QAD.0b013e328133f29c","article-title":"Increased carotid intima media thickness and cardiac biomarkers in HIV infected children","volume":"21","author":"McComsey","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.08.007_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2010.04.008","article-title":"Heightened inflammation is linked to carotid intima-media thickness and endothelial activation in HIV-infected children","author":"Ross","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2010.08.007_bb0090","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2010.08.007_bb0095","doi-asserted-by":"crossref","first-page":"137","DOI":"10.7326\/0003-4819-139-2-200307150-00013","article-title":"National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"139","author":"Levey","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0100","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1681\/ASN.V1341034","article-title":"Use of the albumin\/creatinine ratio to detect microalbuminuria: implications of sex and race","volume":"13","author":"Mattix","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.metabol.2010.08.007_bb0105","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF03179918","article-title":"Insulin resistance and impaired glucose tolerance in obese children and adolescents","volume":"59","author":"Tresaco","year":"2003","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.metabol.2010.08.007_bb0110","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/BF03167055","article-title":"Homeostatic model assessment (HOMA) index cut-off values to identify the metabolic syndrome in children","volume":"61","author":"Tresaco","year":"2005","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.metabol.2010.08.007_bb0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.numecd.2005.12.007","article-title":"Insulin resistance and impaired glucose tolerance in obese children and adolescents from Southern Italy","volume":"16","author":"Valerio","year":"2006","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.metabol.2010.08.007_bb0120","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/QAD.0b013e3283269dfb","article-title":"Morphologic and metabolic abnormalities in vertically HIV-infected children and youth","volume":"23","author":"Aldrovandi","year":"2009","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.08.007_bb0125","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.qai.0000178930.93033.f2","article-title":"Longitudinal evaluation and risk factors of lipodystrophy and associated metabolic changes in HIV-infected children","volume":"40","author":"Beregszaszi","year":"2005","journal-title":"J Acquir Immune Defic Syndr"},{"key":"10.1016\/j.metabol.2010.08.007_bb0130","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1097\/00002030-200009290-00008","article-title":"Clinical and metabolic presentation of the lipodystrophic syndrome in HIV-infected children","volume":"14","author":"Jaquet","year":"2000","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.08.007_bb0135","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1530\/EJE-07-0414","article-title":"Evaluation of insulin resistance in a cohort of HIV-infected youth","volume":"157","author":"Rosso","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2010.08.007_bb0140","series-title":"Growth and body composition in children beginning or changing antiretroviral therapy. PACTG1010. XVI International AIDS Conference; 2006 August 13-18","year":"2006"},{"key":"10.1016\/j.metabol.2010.08.007_bb0145","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1586\/14779072.1.1.143","article-title":"Hyperlipidemia in children with HIV infection: an emerging problem","volume":"1","author":"Kamin","year":"2003","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1016\/j.metabol.2010.08.007_bb0150","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1001\/archinte.160.13.2050","article-title":"Effects of protease inhibitors on hyperglycemia, hyperlipidemia, and lipodystrophy: a 5-year cohort study","volume":"160","author":"Tsiodras","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0155","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.atherosclerosis.2005.09.015","article-title":"The association of microalbuminuria with clinical cardiovascular disease and subclinical atherosclerosis in the elderly: the cardiovascular health study","volume":"187","author":"Cao","year":"2006","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2010.08.007_bb0160","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1001\/archinte.167.22.2490","article-title":"Association of kidney function and albuminuria with cardiovascular mortality in older vs younger individuals: The HUNT II Study","volume":"167","author":"Hallan","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0165","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/QAD.0b013e3280d3587f","article-title":"Microalbuminuria in HIV infection","volume":"21","author":"Szczech","year":"2007","journal-title":"AIDS"},{"key":"10.1016\/j.metabol.2010.08.007_bb0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1542\/peds.2007-3594","article-title":"Being overweight modifies the association between cardiovascular risk factors and microalbuminuria in adolescents","volume":"121","author":"Nguyen","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.metabol.2010.08.007_bb0175","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/sj.ijo.0803136","article-title":"Microalbuminuria in pediatric obesity: prevalence and relation to other cardiovascular risk factors","volume":"30","author":"Burgert","year":"2006","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.metabol.2010.08.007_bb0180","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1210\/jc.2009-0340","article-title":"Whither recombinant human leptin treatment for HIV-associated lipoatrophy and the metabolic syndrome?","volume":"94","author":"Mantzoros","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.08.007_bb0185","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1210\/jc.2008-1588","article-title":"The effects of recombinant human leptin on visceral fat, dyslipidemia, and insulin resistance in patients with human immunodeficiency virus\u2013associated lipoatrophy and hypoleptinemia","volume":"94","author":"Mulligan","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2010.08.007_bb0190","article-title":"Adipokine profiles and lipodystrophy in HIV-infected children during the first 4 years on highly active antiretroviral therapy","author":"Resino","year":"2010","journal-title":"HIV Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0195","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1468-1293.2007.00490.x","article-title":"Serum leptin concentrations and fat redistribution in HIV-1-infected children on highly active antiretroviral therapy","volume":"8","author":"Dzwonek","year":"2007","journal-title":"HIV Med"},{"key":"10.1016\/j.metabol.2010.08.007_bb0200","first-page":"209","article-title":"Overweight HIV patients with abdominal fat distribution treated with protease inhibitors are at high risk for abnormalities in glucose metabolism\u2014a reason for glycemic control","volume":"13","author":"Blass","year":"2008","journal-title":"Eur J Med Res"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510002957?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049510002957?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:54:18Z","timestamp":1758426858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049510002957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0026049510002957"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2010.08.007","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal assessment of metabolic abnormalities in adolescents and young adults with HIV-infection acquired perinatally or in early childhood","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2010.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}