{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T09:59:09Z","timestamp":1758448749929,"version":"3.44.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1016\/j.metabol.2011.03.018","type":"journal-article","created":{"date-parts":[[2011,6,19]],"date-time":"2011-06-19T04:37:02Z","timestamp":1308458222000},"page":"1521-1529","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired adrenergic- and corticotropic-axis outflow during exercise in chronic obstructive pulmonary disease"],"prefix":"10.1016","volume":"60","author":[{"given":"Ali","family":"Iranmanesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dudley F.","family":"Rochester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes D.","family":"Veldhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2011.03.018_bb0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1152\/jappl.1989.66.1.161","article-title":"Hypothalamic-pituitary-adrenal responses to short-duration high-intensity cycle exercise","volume":"66","author":"Kraemer","year":"1989","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004210050661","article-title":"Hormonal responses to high- and moderate-intensity strength exercise","volume":"82","author":"Raastad","year":"2000","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0015","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3109\/00365518009101864","article-title":"Increased plasma noradrenaline concentration in patients with chronic obstructive lung disease: relation to haemodynamics and blood gases","volume":"40","author":"Henriksen","year":"1980","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1016\/j.metabol.2011.03.018_bb0020","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.nut.2010.07.009","article-title":"Nutritional status in chronic obstructive pulmonary disease: role of hypoxia","volume":"27","author":"Raguso","year":"2011","journal-title":"Nutrition"},{"key":"10.1016\/j.metabol.2011.03.018_bb0025","first-page":"396","article-title":"Renin-angiotensin II-aldosterone and ACTH-cortisol control during acute hypoxemia and exercise in patients with chronic obstructive pulmonary disease","volume":"133","author":"Raff","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.metabol.2011.03.018_bb0030","doi-asserted-by":"crossref","first-page":"127S","DOI":"10.1378\/chest.121.5_suppl.127S","article-title":"Systemic effects in COPD","volume":"121","author":"Wouters","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.metabol.2011.03.018_bb0035","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/EJE-08-0544","article-title":"Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans","volume":"159","author":"Zarkovic","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF03179825","article-title":"Influence of fitness on the integrated neuroendocrine response to aerobic exercise until exhaustion","volume":"57","author":"de Diego Acosta","year":"2001","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.metabol.2011.03.018_bb0045","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1164\/ajrccm\/146.4.935","article-title":"Exercise capacity and ventilatory, circulatory, and symptom limitation in patients with chronic airflow limitation","volume":"146","author":"Killian","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.metabol.2011.03.018_bb0050","first-page":"R197","article-title":"Hormonal response to exercise in humans: influence of hypoxia and physical training","volume":"254","author":"Kjaer","year":"1988","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0055","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1178","article-title":"Plasma levels of atrial natriuretic factor, renin activity, and aldosterone in patients with chronic obstructive pulmonary disease. Response to O2 removal and to hyperoxia","volume":"141","author":"Adnot","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.metabol.2011.03.018_bb0060","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1210\/en.2006-0198","article-title":"Angiotensin II inhibition reduces stress sensitivity of hypothalamo-pituitary-adrenal axis in spontaneously hypertensive rats","volume":"147","author":"Raasch","year":"2006","journal-title":"Endocrinol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0065","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1378\/chest.107.6.1590","article-title":"Reproducibility of Borg scale measurements of dyspnea during exercise in patients with COPD","volume":"107","author":"Mador","year":"1995","journal-title":"Chest"},{"key":"10.1016\/j.metabol.2011.03.018_bb0070","first-page":"E6","article-title":"Amplitude modulation of a burst-like mode of cortisol secretion subserves the circadian glucocorticoid rhythm in man","volume":"257","author":"Veldhuis","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0075","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1210\/jcem-71-2-452","article-title":"Amplitude, but not frequency, modulation of ACTH secretory bursts gives rise to the nyctohemeral rhythm of the corticotropic axis in man","volume":"71","author":"Veldhuis","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0080","first-page":"R664","article-title":"Physiological control of pituitary hormone secretory-burst mass, frequency and waveform: a statistical formulation and analysis","volume":"285","author":"Keenan","year":"2003","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0085","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/er.2008-0005","article-title":"Motivations and methods for analyzing pulsatile hormone secretion","volume":"29","author":"Veldhuis","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.metabol.2011.03.018_bb0090","doi-asserted-by":"crossref","first-page":"E538","DOI":"10.1152\/ajpendo.00071.2009","article-title":"Sensitivity and specificity of pulse detection using a new deconvolution method","volume":"297","author":"Liu","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0095","first-page":"R721","article-title":"Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans","volume":"280","author":"Veldhuis","year":"2001","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0100","first-page":"R440","article-title":"Analysis of bidirectional pattern synchrony of concentration-secretion pairs: implementation in the human testicular and adrenal axes","volume":"288","author":"Liu","year":"2005","journal-title":"Am J Physiol"},{"year":"1996","series-title":"Biostatistical analysis","author":"Zar","key":"10.1016\/j.metabol.2011.03.018_bb0105"},{"key":"10.1016\/j.metabol.2011.03.018_bb0110","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2307\/2531110","article-title":"The appropriateness of analysis of variance and multiple-comparison procedures","volume":"39","author":"O'Brien","year":"1983","journal-title":"Biometrics"},{"key":"10.1016\/j.metabol.2011.03.018_bb0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1164\/ajrccm.155.1.9001298","article-title":"Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms","volume":"155","author":"O'Donnell","year":"1997","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.metabol.2011.03.018_bb0120","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1183\/09031936.93.04080917","article-title":"Effort and dyspnoea during work of varying intensity and duration","volume":"4","author":"Kearon","year":"1991","journal-title":"Eur Respir J"},{"key":"10.1016\/j.metabol.2011.03.018_bb0125","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1113\/jphysiol.1977.sp012054","article-title":"Production of corticotrophin releasing hormone by the isolated hypothalamus of the rat","volume":"272","author":"Buckingham","year":"1977","journal-title":"J Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0130","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1055\/s-2007-979147","article-title":"Epinephrine or norepinephrine fail to influence pituitary-adrenal secretion in man","volume":"28","author":"Oberbeck","year":"1996","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.metabol.2011.03.018_bb0135","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1210\/endo-128-1-65","article-title":"The effect of acute exercise on the secretion of corticotropin-releasing factor, arginine vasopressin, and adrenocorticotropin as measured in pituitary venous blood from the horse","volume":"128","author":"Alexander","year":"1991","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2011.03.018_bb0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1365-2265.1991.tb01735.x","article-title":"Corticotrophin-releasing hormone (CRH1-41) stimulates the secretion of adrenocorticotrophin, vasopressin and oxytocin but not adrenocorticotrophin precursors: evidence from petrosal sinus sampling in man","volume":"34","author":"Nussey","year":"1991","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0145","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1210\/jc.2007-0523","article-title":"Putative somatostatin suppression potentiates adrenocorticotropin secretion driven by ghrelin and human corticotropin-releasing hormone","volume":"92","author":"Iranmanesh","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0150","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1053\/meta.2002.35194","article-title":"Circulating brain natriuretic peptide values in healthy men before and after exercise","volume":"51","author":"Huang","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2011.03.018_bb0155","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/0024-3205(92)90543-X","article-title":"Atrial natriuretic factor inhibits the CRH-stimulated secretion of ACTH and cortisol in man","volume":"50","author":"Kellner","year":"1992","journal-title":"Life Sci"},{"key":"10.1016\/j.metabol.2011.03.018_bb0160","first-page":"E243","article-title":"Effect of hypoxia on atrial natriuretic factor and aldosterone regulation in humans","volume":"258","author":"Lawrence","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0165","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1210\/jcem-73-2-302","article-title":"Corticotropin-releasing hormone is not the sole factor mediating exercise-induced adrenocorticotropin release in humans","volume":"73","author":"Smoak","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0170","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.1210\/jcem.86.11.8046","article-title":"Corticotropin secretory dynamics in humans under low glucocorticoid feedback","volume":"86","author":"Veldhuis","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0175","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1080\/03610929208830963","article-title":"Approximate entropy: statistical properties and applications","volume":"21","author":"Pincus","year":"1992","journal-title":"Commun Statist-Theory Meth"},{"key":"10.1016\/j.metabol.2011.03.018_bb0180","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1210\/jc.2009-1378","article-title":"Insulin-like growth factor\u2013I and cancer mortality in older men","volume":"95","author":"Major","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0185","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF02388620","article-title":"The influence of fitness on neuroendocrine responses to exhaustive treadmill exercise","volume":"59","author":"Oleshansky","year":"1990","journal-title":"Eur J Appl Physiol Occup Physiol"},{"key":"10.1016\/j.metabol.2011.03.018_bb0190","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJM198705213162105","article-title":"Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. Physiologic adaptations to physical training","volume":"316","author":"Luger","year":"1987","journal-title":"N Engl J Med."},{"key":"10.1016\/j.metabol.2011.03.018_bb0195","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/BF03345606","article-title":"Exercise and circulating cortisol levels: the intensity threshold effect","volume":"31","author":"Hill","year":"2008","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.metabol.2011.03.018_bb0200","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1210\/jcem-73-6-1224","article-title":"Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome","volume":"73","author":"Demitrack","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0205","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1210\/jc.2004-0086","article-title":"Elevated resting and exercise-induced cortisol levels after mineralocorticoid receptor blockade with canrenoate in healthy humans","volume":"89","author":"Wellhoener","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2011.03.018_bb0210","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0952-8180(90)90027-Z","article-title":"Effects of diltiazem on renin-aldosterone and ACTH-adrenocortical function during upper abdominal surgery","volume":"2","author":"Kono","year":"1990","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.metabol.2011.03.018_bb0215","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/BF00180552","article-title":"Pituitary and adrenal hormone responses to pharmacological, physical, and psychological stimulation in habitual smokers and nonsmokers","volume":"72","author":"Kirschbaum","year":"1994","journal-title":"Clin Investig"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049511000837?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049511000837?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:54:56Z","timestamp":1758426896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049511000837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0026049511000837"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2011.03.018","relation":{},"ISSN":["0026-0495"],"issn-type":[{"type":"print","value":"0026-0495"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired adrenergic- and corticotropic-axis outflow during exercise in chronic obstructive pulmonary disease","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2011.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}