{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T01:27:36Z","timestamp":1779931656924,"version":"3.53.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.metabol.2012.08.015","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T04:36:50Z","timestamp":1348547810000},"page":"S15-S19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"S1","title":["The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy"],"prefix":"10.1016","volume":"62","author":[{"given":"JoAnn E.","family":"Manson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2012.08.015_bb0005","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/gme.0b013e3181d0f6b9","article-title":"Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society","volume":"17","author":"North American Menopause Society","year":"2010","journal-title":"Menopause"},{"key":"10.1016\/j.metabol.2012.08.015_bb0010","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1210\/jc.2009-2509","article-title":"Postmenopausal hormone therapy: an Endocrine Society scientific statement","volume":"95","author":"Santen","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2012.08.015_bb0015","unstructured":"Manson JE, Bassuk SS. The menopause transition and postmenopausal hormone therapy. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jamison JL, Loscalzo J, eds. Harrison's principles of internal medicine: McGraw-Hill, 2011."},{"key":"10.1016\/j.metabol.2012.08.015_bb0020","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1080\/13697130903195606","article-title":"Aging, menopause, cardiovascular disease and HRT. International Menopause Society Consensus Statement","volume":"12","year":"2009","journal-title":"Climacteric"},{"key":"10.1016\/j.metabol.2012.08.015_bb0025","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1001\/jama.297.13.1465","article-title":"Effects of postmenopausal hormone therapy on cardiovascular disease by age and years since menopause","volume":"297","author":"Rossouw","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0030","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/aje\/kwm213","article-title":"Invited commentary. Hormone therapy and risk of coronary heart disease: why renew the focus on the early years of menopause?","volume":"166","author":"Manson","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.metabol.2012.08.015_bb0035","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.amjcard.2008.01.043","article-title":"Usefulness of baseline lipids and C-reactive protein in women receiving menopausal hormone therapy as predictors of treatment-related coronary events","volume":"101","author":"Bray","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.metabol.2012.08.015_bb0040","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1126\/science.1112062","article-title":"Molecular and cellular basis of cardiovascular gender differences","volume":"308","author":"Mendelsohn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.metabol.2012.08.015_bb0045","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1056\/NEJMsb022365","article-title":"Understanding the divergent data on postmenopausal hormone therapy","volume":"348","author":"Grodstein","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0197-2456(97)00078-0","article-title":"Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group","volume":"19","year":"1998","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.metabol.2012.08.015_bb0055","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial","volume":"288","author":"Writing Group for the Women's Health Initiative Investigators","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0060","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1001\/jama.291.14.1701","article-title":"Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial","volume":"291","author":"Women's Health Initiative Steering Committee","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0065","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1056\/NEJMoa030808","article-title":"Estrogen plus progestin and the risk of coronary heart disease","volume":"349","author":"Manson","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0070","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/archinte.166.3.357","article-title":"Conjugated equine estrogens and the risk of coronary heart disease: the Women's Health Initiative","volume":"166","author":"Hsia","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0075","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1001\/jama.292.13.1573","article-title":"Estrogen plus progestin and risk of venous thrombosis","volume":"292","author":"Cushman","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0080","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/CIRCULATIONAHA.106.642280","article-title":"Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study","volume":"115","author":"Canonico","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2012.08.015_bb0085","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1001\/jama.2011.382","article-title":"Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial","volume":"305","author":"LaCroix","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0090","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1001\/jama.289.20.2673","article-title":"Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial","volume":"289","author":"Wassertheil-Smoller","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0095","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/archinte.166.7.772","article-title":"Venous thrombosis and conjugated equine estrogen in women without a uterus","volume":"166","author":"Curb","year":"2006","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0100","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1001\/archinte.168.20.2245","article-title":"Inflammatory, lipid, thrombotic, and genetic markers of coronary heart disease risk in the Women's Health Initiative trials of hormone therapy","volume":"168","author":"Rossouw","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.atherosclerosis.2010.03.012","article-title":"ABO blood group alleles: a risk factor for coronary artery disease","volume":"211","author":"Carpeggiani","year":"2010","journal-title":"An angiographic study. Atherosclerosis"},{"key":"10.1016\/j.metabol.2012.08.015_bb0110","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1161\/ATVBAHA.110.215087","article-title":"Estrogen receptor polymorphisms and the vascular effects of hormone therapy","volume":"31","author":"Rossouw","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2012.08.015_bb0115","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/01.AOG.0000158120.47542.18","article-title":"Menopausal symptoms and treatment-related effects of estrogen and progestin in the Women's Health Initiative","volume":"105","author":"Barnabei","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.metabol.2012.08.015_bb0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1001\/jama.294.2.183","article-title":"Symptom experience after discontinuing use of estrogen plus progestin","volume":"294","author":"Ockene","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.metabol.2012.08.015_bb0125","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1056\/NEJMoa030311","article-title":"Effects of estrogen plus progestin on health-related quality of life","volume":"348","author":"Hays","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0130","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1001\/archinte.165.17.1976","article-title":"Effects of conjugated equine estrogen on health-related quality of life in postmenopausal women with hysterectomy: results from the Women's Health Initiative Randomized Clinical Trial","volume":"165","author":"Brunner","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.metabol.2012.08.015_bb0135","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/gme.0b013e3181d76953","article-title":"Menopausal symptom experience before and after stopping estrogen therapy in the Women's Health Initiative randomized, placebo-controlled trial","volume":"17","author":"Brunner","year":"2010","journal-title":"Menopause"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049512003198?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049512003198?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:57:57Z","timestamp":1758427077000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049512003198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":27,"alternative-id":["S0026049512003198"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2012.08.015","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of personalized medicine in identifying appropriate candidates for menopausal estrogen therapy","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2012.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}