{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:10:46Z","timestamp":1790982646522,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.metabol.2012.09.015","type":"journal-article","created":{"date-parts":[[2012,12,4]],"date-time":"2012-12-04T11:30:29Z","timestamp":1354620629000},"page":"661-668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function"],"prefix":"10.1016","volume":"62","author":[{"given":"K.A. Elisa","family":"Kallio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kati","family":"Hyv\u00e4rinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petri T.","family":"Kovanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Jauhiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirkko J.","family":"Pussinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2012.09.015_bb0005","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.1994.tb00020.x","article-title":"Microbial etiological agents of destructive periodontal diseases","volume":"5","author":"Haffajee","year":"1994","journal-title":"Periodontol 2000"},{"key":"10.1016\/j.metabol.2012.09.015_bb0010","series-title":"Health 2000 survey. Publications of the National Public Health Institute B25\/2008","first-page":"49","article-title":"Periodontal status. In: Oral health in the Finnish adult population","author":"Knuuttila","year":"2008"},{"key":"10.1016\/j.metabol.2012.09.015_bb0015","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1128\/JCM.02560-06","article-title":"Population-based study of salivary carriage of periodontal pathogens in adults","volume":"45","author":"Kononen","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0020","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1161\/CIRCULATIONAHA.107.758524","article-title":"Bacteremia associated with toothbrushing and dental extraction","volume":"117","author":"Lockhart","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2012.09.015_bb0025","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1161\/01.ATV.0000145979.82184.9f","article-title":"Severe periodontitis enhances macrophage activation via increased serum lipopolysaccharide","volume":"24","author":"Pussinen","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0030","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.ATV.0000155018.67835.1a","article-title":"Human atherosclerotic plaque contains viable invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis","volume":"25","author":"Kozarov","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0035","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1128\/JCM.39.3.1114-1117.2001","article-title":"Detection of Treponema denticola in atherosclerotic lesions","volume":"39","author":"Okuda","year":"2001","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0040","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/01.ATV.0000147534.69062.dc","article-title":"Potential role of endotoxin as a proinflammatory mediator of atherosclerosis","volume":"24","author":"Stoll","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/09680519050110020501","article-title":"Apolipoproteins modulate the inflammatory response to lipopolysaccharide","volume":"11","author":"Berbee","year":"2005","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0050","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1128\/IAI.69.5.2821-2828.2001","article-title":"Distribution and kinetics of lipoprotein-bound endotoxin","volume":"69","author":"Levels","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.metabol.2012.09.015_bb0055","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1177\/1753425908095130","article-title":"Lipopolysaccharide associates with pro-atherogenic lipoproteins in periodontitis patients","volume":"14","author":"Kallio","year":"2008","journal-title":"Innate Immun"},{"key":"10.1016\/j.metabol.2012.09.015_bb0060","doi-asserted-by":"crossref","first-page":"12040","DOI":"10.1073\/pnas.90.24.12040","article-title":"In vivo protection against endotoxin by plasma high density lipoprotein","volume":"90","author":"Levine","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2012.09.015_bb0065","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/01.CCM.0000063260.07222.76","article-title":"Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure","volume":"31","author":"Levels","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.metabol.2012.09.015_bb0070","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0021-9150(93)90224-I","article-title":"Lipopolysaccharide stimulation of RAW 264.7 macrophages induces lipid accumulation and foam cell formation","volume":"98","author":"Funk","year":"1993","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2012.09.015_bb0075","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/09680519060120010601","article-title":"Pro-atherogenic properties of lipopolysaccharide from the periodontal pathogen Actinobacillus actinomycetemcomitans","volume":"12","author":"Lakio","year":"2006","journal-title":"J Endotoxin Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1161\/CIRCRESAHA.110.218420","article-title":"Low doses of lipopolysaccharide and minimally oxidized low-density lipoprotein cooperatively activate macrophages via nuclear factor kappa B and activator protein-1: possible mechanism for acceleration of atherosclerosis by subclinical endotoxemia","volume":"107","author":"Wiesner","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0085","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00041433-200410000-00013","article-title":"Periodontal infections and atherosclerosis: mere associations?","volume":"15","author":"Pussinen","year":"2004","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0090","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2217\/clp.10.27","article-title":"Lipoproteins and lipoprotein metabolism in periodontal disease","volume":"5","author":"Griffiths","year":"2010","journal-title":"Clin Lipidol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1194\/jlr.M300250-JLR200","article-title":"Periodontitis decreases the antiatherogenic potency of high density lipoprotein","volume":"45","author":"Pussinen","year":"2004","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0100","first-page":"1","article-title":"Metabolites 3: lipids, amino acids and related compounds","volume":"Vol 3","author":"Bergmeyer","year":"1985"},{"key":"10.1016\/j.metabol.2012.09.015_bb0105","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"10.1016\/j.metabol.2012.09.015_bb0110","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000205234","article-title":"Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens","volume":"17","author":"Clauss","year":"1957","journal-title":"Acta Haematol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0115","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1194\/jlr.M300059-JLR200","article-title":"PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma","volume":"44","author":"Siggins","year":"2003","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2012.09.015_bb0125","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1194\/jlr.M600051-JLR200","article-title":"Absence of endogenous phospholipid transfer protein impairs ABCA1-dependent efflux of cholesterol from macrophage foam cells","volume":"47","author":"Lee-Rueckert","year":"2006","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0130","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.metabol.2012.09.015_bb0135","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1161\/ATVBAHA.106.138743","article-title":"Endotoxemia, immune response to periodontal pathogens, and systemic inflammation associate with incident cardiovascular disease events","volume":"27","author":"Pussinen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0140","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0735-1097(99)00448-9","article-title":"Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study","volume":"34","author":"Wiedermann","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0145","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1600-051X.2011.01710.x","article-title":"Endotoxemia and the host systemic response during experimental gingivitis","volume":"38","author":"Wahaidi","year":"2011","journal-title":"J Clin Periodontol"},{"key":"10.1016\/j.metabol.2012.09.015_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2011.02.043","article-title":"Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease","volume":"216","author":"Erridge","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2012.09.015_bb0155","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1161\/01.CIR.64.6.1174","article-title":"Intermediate-density lipoprotein and cholesterol-rich very low density lipoprotein in angiographically determined coronary artery disease","volume":"64","author":"Tatami","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.metabol.2012.09.015_bb0160","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1161\/01.ATV.14.11.1767","article-title":"Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque","volume":"14","author":"Rapp","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"10.1016\/j.metabol.2012.09.015_bb0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.numecd.2009.03.003","article-title":"Periodontitis is associated with altered plasma fatty acids and cardiovascular risk markers","volume":"20","author":"Ramirez-Tortosa","year":"2010","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.metabol.2012.09.015_bb0170","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1172\/JCI110590","article-title":"Hypertriglyceridemic very low density lipoproteins induce triglyceride synthesis and accumulation in mouse peritoneal macrophages","volume":"70","author":"Gianturco","year":"1982","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2012.09.015_bb0175","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.bi.52.070183.001255","article-title":"Lipoprotein metabolism in the macrophage: implications for cholesterol deposition in atherosclerosis","volume":"52","author":"Brown","year":"1983","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.metabol.2012.09.015_bb0180","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.atherosclerosis.2004.12.002","article-title":"Very low density lipoprotein potentiates tumor necrosis factor-alpha expression in macrophages","volume":"179","author":"Stollenwerk","year":"2005","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2012.09.015_bb0185","unstructured":"Newnhall HH: Endothelial lipases and lipid transfers in the regulation of the particle size distribution of high density lipoproteins. PhD thesis. Department of Medicine, Monash University, Clayton, Victoria; 1990."},{"key":"10.1016\/j.metabol.2012.09.015_bb0190","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.atherosclerosis.2009.03.035","article-title":"Periodontal treatment influences risk markers for atherosclerosis in patients with severe periodontitis","volume":"206","author":"Buhlin","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.metabol.2012.09.015_bb0195","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa063186","article-title":"Treatment of periodontitis and endothelial function","volume":"356","author":"Tonetti","year":"2007","journal-title":"N Engl J Med"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049512004234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049512004234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T03:58:38Z","timestamp":1758427118000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049512004234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0026049512004234"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2012.09.015","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Very low density lipoproteins derived from periodontitis patients facilitate macrophage activation via lipopolysaccharide function","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2012.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}