{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T15:38:19Z","timestamp":1762875499866,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.metabol.2012.12.006","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T15:30:32Z","timestamp":1358350232000},"page":"786-792","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Nondiabetic patients with either subclinical Cushing's or nonfunctional adrenal incidentalomas have lower insulin sensitivity than healthy controls: Clinical implications"],"prefix":"10.1016","volume":"62","author":[{"given":"Miomira","family":"Ivovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ljiljana V.","family":"Marina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana","family":"Vujovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milina","family":"Tan\u010di\u0107-Gaji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milo\u0161","family":"Stojanovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevena V.","family":"Radonji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milan","family":"Gaji\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Soldatovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Mici\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.metabol.2012.12.006_bb0005","doi-asserted-by":"crossref","first-page":"12","DOI":"10.14310\/horm.2002.1178","article-title":"Adrenal incidentaloma (adrenaloma)","volume":"2","author":"Linos","year":"2003","journal-title":"Hormones (Athens)"},{"issue":"3","key":"10.1016\/j.metabol.2012.12.006_bb0010","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1677\/erc.1.00951","article-title":"Adrenal incidentalomas \u2014 a continuing management dilemma","volume":"12","author":"Nawar","year":"2005","journal-title":"Endocr Relat Cancer"},{"issue":"7\u20138","key":"10.1016\/j.metabol.2012.12.006_bb0015","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2298\/SARH0608315I","article-title":"Insulin sensitivity in patients with adrenal incidentaloma","volume":"134","author":"Ivovi\u0107","year":"2006","journal-title":"Srp Arh Celok Lek"},{"issue":"11","key":"10.1016\/j.metabol.2012.12.006_bb0020","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1210\/jc.2002-021436","article-title":"Adrenal incidentaloma\u2014a modern disease with old complications","volume":"87","author":"Angeli","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.metabol.2012.12.006_bb0025","first-page":"1440","article-title":"Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features","volume":"85","author":"Rossi","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.metabol.2012.12.006_bb0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ecl.2005.01.008","article-title":"Subclinical Cushing's syndrome in adrenal incidentalomas","volume":"34","author":"Terzolo","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"10.1016\/j.metabol.2012.12.006_bb0035","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/01.CIR.0000111245.75752.C6","article-title":"Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute\/American Heart Association Conference on Scientific Issues Related to Definition","volume":"109","author":"Grundy","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.metabol.2012.12.006_bb0040","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1210\/rp.59.1.207","article-title":"Obesity, insulin resistance, and cardiovascular disease","volume":"59","author":"Reaven","year":"2004","journal-title":"Recent Prog Horm Res"},{"issue":"3","key":"10.1016\/j.metabol.2012.12.006_bb0045","doi-asserted-by":"crossref","first-page":"E214","DOI":"10.1152\/ajpendo.1979.237.3.E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2012.12.006_bb0050","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2012.12.006_bb0055","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.cll.2006.06.007","article-title":"Measures of insulin sensitivity","volume":"26","author":"Bloomgarden","year":"2006","journal-title":"Clin Lab Med"},{"issue":"7","key":"10.1016\/j.metabol.2012.12.006_bb0060","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple accurate method for assessing insulin sensitivity in humans","volume":"85","author":"Katz","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"10.1016\/j.metabol.2012.12.006_bb0065","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.2337\/diabetes.54.7.1914","article-title":"Assessing the predictive accuracy of QUICKI as a surrogate index for insulin sensitivity using a calibration model","volume":"54","author":"Chen","year":"2005","journal-title":"Diabetes"},{"issue":"8","key":"10.1016\/j.metabol.2012.12.006_bb0070","first-page":"2694","article-title":"A fasting glucose to insulin ratio is a useful measure of insulin sensitivity in women with polycystic ovary syndrome","volume":"83","author":"Legro","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2012.12.006_bb0075","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ajog.2005.06.073","article-title":"Insulin resistance in postmenopausal women with metabolic syndrome and the measurements of adiponectin, leptin, resistin, and ghrelin","volume":"194","author":"Chu","year":"2006","journal-title":"Am J Obstet Gynecol"},{"issue":"7","key":"10.1016\/j.metabol.2012.12.006_bb0080","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin sensitivity","volume":"95","author":"Guerrero-Romero","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.metabol.2012.12.006_bb0085","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"first-page":"800","year":"2011","series-title":"The Merck manual of diagnosis and therapy","key":"10.1016\/j.metabol.2012.12.006_bb0090"},{"issue":"6","key":"10.1016\/j.metabol.2012.12.006_bb0095","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1161\/01.HYP.0000038478.59760.41","article-title":"Drug effects on aldosterone\/plasma renin activity ratio in primary aldosteronism","volume":"40","author":"Mulatero","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.metabol.2012.12.006_bb0100","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2337\/dc09-S013","article-title":"Standards of medical care in diabetes\u20142009","volume":"32","author":"Association A D","year":"2009","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.metabol.2012.12.006_bb0105","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1530\/EJE-10-0602","article-title":"Accuracy of several parameters of hypothalamic-pituitary-adrenal axis activity in predicting before surgery the metabolic effects of the removal of an adrenal incidentaloma","volume":"163","author":"Eller-Vainicher","year":"2010","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2012.12.006_bb0110","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.beem.2009.04.001","article-title":"Management of adrenal incidentaloma","volume":"23","author":"Terzolo","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.metabol.2012.12.006_bb0115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1442-2042.2000.00154.x","article-title":"Preclinical Cushing's syndrome: report of seven cases and a review of the literature","volume":"7","author":"Morioka","year":"2000","journal-title":"Int J Urol"},{"issue":"4","key":"10.1016\/j.metabol.2012.12.006_bb0120","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1530\/eje.0.1440401","article-title":"Biochemical screening for subclinical cortisol-secreting adenomas amongst adrenal incidentalomas","volume":"144","author":"Valli","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2012.12.006_bb0125","doi-asserted-by":"crossref","first-page":"133s","DOI":"10.1016\/S0753-3322(00)80030-X","article-title":"Current management of incidentally discovered adrenal masses, with a review of Japanese literature","volume":"54","author":"Murai","year":"2000","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.metabol.2012.12.006_bb0130","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.fertnstert.2004.01.041","article-title":"Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome","volume":"82","author":"Carmina","year":"2004","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.metabol.2012.12.006_bb0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2337\/diacare.18.2.245","article-title":"The use of areas under curves in diabetes research","volume":"18","author":"Allison","year":"1995","journal-title":"Diabetes Care"},{"issue":"2","key":"10.1016\/j.metabol.2012.12.006_bb0140","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2337\/diacare.17.2.152","article-title":"A mathematical model for the determination of total area under glucose tolerance and other metabolic curves","volume":"17","author":"Tai","year":"1994","journal-title":"Diabetes Care"},{"issue":"4","key":"10.1016\/j.metabol.2012.12.006_bb0145","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1530\/EJE-09-0473","article-title":"Definition of an optimal strategy to evaluate and follow-up adrenal incidentalomas: time for further research","volume":"161","author":"Terzolo","year":"2009","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"10.1016\/j.metabol.2012.12.006_bb0150","doi-asserted-by":"crossref","first-page":"5698","DOI":"10.1210\/jc.2005-0799","article-title":"The metabolic syndrome, insulin resistance, and cardiovascular risk in diabetic and nondiabetic patients","volume":"90","author":"Saely","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"19","key":"10.1016\/j.metabol.2012.12.006_bb0155","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","volume":"285","year":"2001","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.metabol.2012.12.006_bb0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1046\/j.1365-2265.1998.00437.x","article-title":"Study of glucose tolerance in consecutive patients harbouring incidental adrenal tumours","volume":"49","author":"Fern\u00e1ndez-Real","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"11","key":"10.1016\/j.metabol.2012.12.006_bb0165","first-page":"5301","article-title":"Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome","volume":"86","author":"Garrapa","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.metabol.2012.12.006_bb0170","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s00268-009-0178-0","article-title":"Cardiovascular risk in patients with nonfunctional adrenal incidentaloma: myth or reality?","volume":"33","author":"Erbil","year":"2009","journal-title":"World J Surg"},{"issue":"10","key":"10.1016\/j.metabol.2012.12.006_bb0175","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.metabol.2010.01.007","article-title":"Insulin resistance and metabolic syndrome in patients with nonfunctioning adrenal incidentalomas: a cause\u2013effect relationship?","volume":"59","author":"Peppa","year":"2010","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.metabol.2012.12.006_bb0180","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1210\/jcem-73-4-691","article-title":"Insulin resistance in obese and nonobese man","volume":"73","author":"Caro","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.metabol.2012.12.006_bb0185","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1172\/JCI119628","article-title":"Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR)","volume":"100","author":"Ferrannini","year":"1997","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.metabol.2012.12.006_bb0190","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1210\/jc.2001-011766","article-title":"Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk","volume":"87","author":"Tauchmanova","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.metabol.2012.12.006_bb0195","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1210\/jcem.87.3.8277","article-title":"Adrenal incidentaloma: a new cause of the metabolic syndrome?","volume":"87","author":"Terzolo","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.metabol.2012.12.006_bb0200","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s11102-005-4024-6","article-title":"Subclinical Cushing's syndrome","volume":"7","author":"Terzolo","year":"2004","journal-title":"Pituitary"},{"issue":"5","key":"10.1016\/j.metabol.2012.12.006_bb0205","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1210\/jc.2010-2722","article-title":"Diagnosis and treatment of subclinical hypercortisolism","volume":"96","author":"Chiodini","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.metabol.2012.12.006_bb0210","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1210\/jc.2009-2387","article-title":"Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism","volume":"95","author":"Chiodini","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1016\/j.metabol.2012.12.006_bb0215","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1365-2362.2010.02330.x","article-title":"Role of glucocorticoid receptor polymorphism in adrenal incidentalomas","volume":"40","author":"Morelli","year":"2010","journal-title":"Eur J Clin Invest"},{"issue":"00283835","key":"10.1016\/j.metabol.2012.12.006_bb0220","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000314319","article-title":"Pathophysiology of diabetes mellitus in Cushing's syndrome","volume":"92","author":"Pivonello","year":"2010","journal-title":"Neuroendocrinology"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049512004593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049512004593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:00:27Z","timestamp":1758427227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049512004593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0026049512004593"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2012.12.006","relation":{},"ISSN":["0026-0495"],"issn-type":[{"type":"print","value":"0026-0495"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nondiabetic patients with either subclinical Cushing's or nonfunctional adrenal incidentalomas have lower insulin sensitivity than healthy controls: Clinical implications","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2012.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}