{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:52:01Z","timestamp":1787961121070,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine (NCCAM)","doi-asserted-by":"crossref","award":["P50AT002776-01"],"award-info":[{"award-number":["P50AT002776-01"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements (ODS)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.metabol.2013.03.004","type":"journal-article","created":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T22:20:23Z","timestamp":1369088423000},"page":"1239-1249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"title":["Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway"],"prefix":"10.1016","volume":"62","author":[{"given":"Zhong Q.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian H.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell C.","family":"Tipton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Raskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ribnicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Cefalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2013.03.004_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408363.2011.596521","article-title":"Non-alcoholic fatty liver disease","volume":"48","author":"Smith","year":"2011","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"6037","key":"10.1016\/j.metabol.2013.03.004_bb0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.metabol.2013.03.004_bb0015","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000104140","article-title":"Artemisia herba-alba Asso (Asteraceae) has equivalent effects to green and black tea decoctions on antioxidant processes and some metabolic parameters in rats","volume":"51","author":"Abid","year":"2007","journal-title":"Ann Nutr Metab"},{"key":"10.1016\/j.metabol.2013.03.004_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2012.10.022","article-title":"Evaluation of anti-nociceptive, anti-inflammatory and antipyretic activities of Artemisia scoparia hydromethanolic extract","volume":"145","author":"Habib","year":"2013","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0025","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1089\/jmf.2009.0039","article-title":"Antilipogenic and hypolipidemic effects of ethanol extracts from two variants of Artemisia princeps Pampanini in obese diabetic mice","volume":"12","author":"Jung","year":"2009","journal-title":"J Med Food"},{"key":"10.1016\/j.metabol.2013.03.004_bb0030","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.fct.2010.05.005","article-title":"Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats","volume":"48","author":"Sefi","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0035","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.jep.2010.11.019","article-title":"Treatment of high fat diet induced type 2 diabetes in C57BL\/6J mice by two medicinal plants used in traditional treatment of diabetes in the east of Algeria","volume":"133","author":"Hamza","year":"2011","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1039\/C0FO00129E","article-title":"Anti-obesity and anti- diabetic effects of ethanol extract of Artemisia princeps in C57BL\/6 mice fed a high-fat diet","volume":"2","author":"Yamamoto","year":"2011","journal-title":"Food Funct"},{"key":"10.1016\/j.metabol.2013.03.004_bb0045","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.metabol.2008.04.003","article-title":"Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture","volume":"57","author":"Wang","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2013.03.004_bb0050","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jnutbio.2009.11.015","article-title":"An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice","volume":"22","author":"Wang","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.metabol.2013.03.004_bb0055","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2337\/db11-0396","article-title":"Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells","volume":"61","author":"Obanda","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2013.03.004_bb0060","first-page":"119","article-title":"The essential oil of Artemisia scoparia from Tajikistan is dominated by phenyldiacetylenes","volume":"6","author":"Sharopov","year":"2011","journal-title":"Nat Prod Commun"},{"key":"10.1016\/j.metabol.2013.03.004_bb0065","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0306-3623(95)02112-4","article-title":"Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential","volume":"27","author":"Hoult","year":"1996","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0070","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.fct.2010.01.017","article-title":"In vitro screening of essential oil from young and mature leaves of Artemisia scoparia compared to its major constituents for free radical scavenging activity","volume":"48","author":"Singh","year":"2010","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0075","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/cvr\/28.11.1679","article-title":"Morphological evidence for the antiatherogenic effect of scoparone in hyperlipidaemic diabetic rabbits","volume":"28","author":"Chen","year":"1994","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.metabol.2013.03.004_bb0080","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1080\/14786410902726126","article-title":"Antidiabetic effects of Scoparic acid D isolated from Scoparia dulcis in rats with streptozotocin-induced diabetes","volume":"23","author":"Latha","year":"2009","journal-title":"Nat Prod Res"},{"key":"10.1016\/j.metabol.2013.03.004_bb0085","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/eje.0.1480293","article-title":"The role of the novel adipocyte-derived hormone adiponectin in human disease","volume":"148","author":"Diez","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0090","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1073\/pnas.98.4.2005","article-title":"Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice","volume":"98","author":"Fruebis","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2013.03.004_bb0095","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr Rev"},{"key":"10.1016\/j.metabol.2013.03.004_bb0100","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/90984","article-title":"The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity","volume":"7","author":"Yamauchi","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2013.03.004_bb0105","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/90992","article-title":"The adipocyte-secreted protein Acrp30 enhances hepatic insulin action","volume":"7","author":"Berg","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2013.03.004_bb0110","doi-asserted-by":"crossref","first-page":"6018","DOI":"10.1210\/en.2008-0816","article-title":"Fibroblast growth factor 21 corrects obesity in mice","volume":"149","author":"Coskun","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2013.03.004_bb0115","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/978-1-4614-0887-1_14","article-title":"FGF21 as a therapeutic reagent","volume":"728","author":"Zhao","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0120","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.metabol.2013.03.004_bb0125","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1507\/endocrj.EJ12-0228","article-title":"Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver","volume":"59","author":"Takamura","year":"2012","journal-title":"Endocr J"},{"key":"10.1016\/j.metabol.2013.03.004_bb0130","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/MEG.0b013e32834f15dd","article-title":"The association between adipocytokines and biomarkers for nonalcoholic fatty liver disease-induced liver injury: a study in the general population","volume":"24","author":"Zelber-Sagi","year":"2012","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0135","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0002-9440(10)62476-5","article-title":"The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology","volume":"166","author":"Ding","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0140","doi-asserted-by":"crossref","first-page":"665","DOI":"10.5114\/aoms.2011.24137","article-title":"Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population","volume":"7","author":"Yang","year":"2011","journal-title":"Arch Med Sci"},{"key":"10.1016\/j.metabol.2013.03.004_bb0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1055\/s-0028-1087207","article-title":"The effect of chronic hyperinsulinemia on plasma adiponectin levels in Sprague\u2013Dawley rats","volume":"41","author":"Kamari","year":"2009","journal-title":"Horm Metab Res"},{"key":"10.1016\/j.metabol.2013.03.004_bb0150","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.2337\/diacare.27.7.1721","article-title":"Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus","volume":"27","author":"Winzer","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.03.004_bb0155","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1016\/j.biochi.2012.01.021","article-title":"Adiponectin and leptin in human severe insulin resistance \u2014 diagnostic utility and biological insights","volume":"94","author":"Groeneveld","year":"2012","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.metabol.2013.03.004_bb0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1467-789X.2005.00159.x","article-title":"Adiponectin: action, regulation and association to insulin sensitivity","volume":"6","author":"Lihn","year":"2005","journal-title":"Obes Rev"},{"key":"10.1016\/j.metabol.2013.03.004_bb0165","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2337\/diabetes.52.4.935","article-title":"Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance","volume":"52","author":"Brozinick","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2013.03.004_bb0170","first-page":"69","article-title":"Biochemistry, molecular biology, and pharmacology of fatty acid synthase, an emerging therapeutic target and diagnosis\/prognosis marker","volume":"1","author":"Liu","year":"2010","journal-title":"Int J Biochem Mol Biol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0092-8674(05)80095-9","article-title":"SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene","volume":"75","author":"Yokoyama","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.metabol.2013.03.004_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(98)00016-3","article-title":"Metabolism and drug interactions of 3-hydroxy-3- methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?","volume":"80","author":"Christians","year":"1998","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.metabol.2013.03.004_bb0185","doi-asserted-by":"crossref","first-page":"10207","DOI":"10.1073\/pnas.1733877100","article-title":"Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat\/high-carbohydrate diets","volume":"100","author":"Abu-Elheiga","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.metabol.2013.03.004_bb0190","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1074\/jbc.271.2.611","article-title":"Mammalian AMP-activated protein kinase subfamily","volume":"271","author":"Stapleton","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2013.03.004_bb0195","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1476-5381.2011.01560.x","article-title":"Adiponectin receptor signalling in the brain","volume":"165","author":"Thundyil","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.metabol.2013.03.004_bb0200","doi-asserted-by":"crossref","first-page":"254S","DOI":"10.3945\/ajcn.2009.28449B","article-title":"Fibroblast growth factor 21: from pharmacology to physiology","volume":"91","author":"Kliewer","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2013.03.004_bb0205","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1210\/jc.2012-1221","article-title":"Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis","volume":"97","author":"Reinehr","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2013.03.004_bb0210","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.diabres.2011.02.034","article-title":"Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently","volume":"93","author":"Li","year":"2011","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.metabol.2013.03.004_bb0215","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diabres.2010.03.019","article-title":"Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes","volume":"89","author":"Eto","year":"2010","journal-title":"Diabetes Res Clin Pract"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002604951300084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002604951300084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:02:05Z","timestamp":1758427325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002604951300084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S002604951300084X"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2013.03.004","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2013.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}