{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:25:08Z","timestamp":1791599108240,"version":"4.3.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1016\/j.metabol.2013.05.022","type":"journal-article","created":{"date-parts":[[2013,7,5]],"date-time":"2013-07-05T00:37:39Z","timestamp":1372984659000},"page":"1470-1476","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test- and glucose clamp-based disposition indexes"],"prefix":"10.1016","volume":"62","author":[{"given":"Yoko","family":"Okuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Komada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushi","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Seino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2013.05.022_bb0005","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.1104345","article-title":"Type 2 diabetes\u2015a matter of beta-cell life and death?","volume":"307","author":"Rhodes","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.metabol.2013.05.022_bb0010","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1136\/bmj.288.6435.1956","article-title":"The difficult choice of treatment for poorly controlled maturity onset diabetes: tablets or insulin?","volume":"288","author":"Peacock","year":"1985","journal-title":"Br Med J"},{"key":"10.1016\/j.metabol.2013.05.022_bb0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.diabet.2010.03.007","article-title":"Decreasing postprandial C-peptide levels over time are not associated with long-term use of sulphonylurea: an observational study","volume":"36","author":"Nyb\u00e4ck-Nakell","year":"2010","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.metabol.2013.05.022_bb0020","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1507\/endocrj.K09E-279","article-title":"Body mass index, fasting plasma glucose levels, and C-peptide levels as predictors of the future insulin use in Japanese type 2 diabetic patients","volume":"57","author":"Goto","year":"2010","journal-title":"Endocr J"},{"key":"10.1016\/j.metabol.2013.05.022_bb0025","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1507\/endocrj.K10E-399","article-title":"Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes","volume":"58","author":"Saisho","year":"2011","journal-title":"Endocr J"},{"key":"10.1016\/j.metabol.2013.05.022_bb0030","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.2040-1124.2010.00096.x","article-title":"Utility of indices using C-peptide levels for indication of insulin therapy to achieve good glycemic control in Japanese patients with type 2 diabetes","volume":"2","author":"Funakoshi","year":"2011","journal-title":"J. Diabetes Invest"},{"key":"10.1016\/j.metabol.2013.05.022_bb0035","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/db08-1611","article-title":"Functional assessment of pancreatic beta-cell area in humans","volume":"58","author":"Meier","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2013.05.022_bb0040","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1007\/s00125-012-2466-8","article-title":"Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans","volume":"55","author":"Meier","year":"2012","journal-title":"Diabetologia"},{"issue":"Suppl 3","key":"10.1016\/j.metabol.2013.05.022_bb0045","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2362.32.s3.5.x","article-title":"The evolution of \u03b2-cell dysfunction and insulin resistance in type 2 diabetes","volume":"32","author":"Bergman","year":"2002","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.metabol.2013.05.022_bb0050","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/oby.2008.307","article-title":"Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test","volume":"16","author":"Retnakaran","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.metabol.2013.05.022_bb0055","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2337\/dc08-1478","article-title":"Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels","volume":"32","author":"Utzschneider","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.05.022_bb0060","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.2040-1124.2010.00099.x","article-title":"Age-dependent decline in \u03b2-cell function assessed by an oral glucose tolerance test-based disposition index","volume":"2","author":"Komada","year":"2011","journal-title":"J. Diabetes Invest."},{"key":"10.1016\/j.metabol.2013.05.022_bb0065","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.2337\/dc10-0004","article-title":"From pre-diabetes to type 2 diabetes in obese youth: pathophysiological characteristics along the spectrum of glucose dysregulation","volume":"33","author":"Bacha","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.05.022_bb0070","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2337\/dc11-0423","article-title":"Declining \u03b2-cell function relative to insulin sensitivity with escalating OGTT 2-h glucose concentrations in the nondiabetic through the diabetic range in overweight youth","volume":"34","author":"Burns","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.05.022_bb0075","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.2337\/dc12-0747","article-title":"HbA1c diagnostic categories and \u03b2-cell function relative to insulin sensitivity in overweight\/obese adolescents","volume":"35","author":"Sjaarda","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.05.022_bb0080","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.metabol.2005.01.020","article-title":"Inverse correlation between serum adiponectin concentration and hepatic lipid content in Japanese with type 2 diabetes","volume":"54","author":"Maeda","year":"2005","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2013.05.022_bb0085","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.2337\/diacare.22.9.1462","article-title":"Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp","volume":"22","author":"Matsuda","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.05.022_bb0090","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.2040-1124.2012.00207.x","volume":"3","author":"Kashiwagi","year":"2012","journal-title":"J Diabetes Invest"},{"key":"10.1016\/j.metabol.2013.05.022_bb0095","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"DeFronzo","year":"1979","journal-title":"Am J Physiol"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049513001753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049513001753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:03:03Z","timestamp":1758427383000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049513001753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0026049513001753"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2013.05.022","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postprandial serum C-peptide to plasma glucose concentration ratio correlates with oral glucose tolerance test- and glucose clamp-based disposition indexes","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2013.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}