{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:55:11Z","timestamp":1793310911880,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1016\/j.metabol.2013.06.012","type":"journal-article","created":{"date-parts":[[2013,8,5]],"date-time":"2013-08-05T18:30:51Z","timestamp":1375727451000},"page":"1651-1661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice"],"prefix":"10.1016","volume":"62","author":[{"given":"Virginia L.","family":"Malloy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen E.","family":"Perrone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight A.L.","family":"Mattocks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gene P.","family":"Ables","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Caliendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Orentreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Orentreich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.metabol.2013.06.012_bb0005","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.2337\/dc10-0856","article-title":"Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes","volume":"33","author":"Lazo","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2013.06.012_bb0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1126\/science.1204265","article-title":"Human fatty liver disease: old questions and new insights","volume":"332","author":"Cohen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.metabol.2013.06.012_bb0015","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1542\/peds.2006-1212","article-title":"Prevalence of fatty liver in children and adolescents","volume":"118","author":"Schwimmer","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.metabol.2013.06.012_bb0020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1055\/s-2001-12932","article-title":"Animal models of steatosis","volume":"21","author":"Koteish","year":"2001","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.metabol.2013.06.012_bb0025","doi-asserted-by":"crossref","first-page":"13087","DOI":"10.1074\/jbc.M800533200","article-title":"Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis","volume":"283","author":"Reid","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2013.06.012_bb0030","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1074\/jbc.M109.081877","article-title":"Growth retardation, impaired triacylglycerol catabolism, hepatic steatosis, and lethal skin barrier defect in mice lacking comparative gene identification-58 (CGI-58)","volume":"285","author":"Radner","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2013.06.012_bb0035","doi-asserted-by":"crossref","first-page":"916","DOI":"10.2337\/db09-1403","article-title":"C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis","volume":"59","author":"Obstfeld","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2013.06.012_bb0040","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/MOL.0b013e3282ff5e55","article-title":"Hepatic triglyceride synthesis and nonalcoholic fatty liver disease","volume":"19","author":"Choi","year":"2008","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0045","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1474-9726.2005.00152.x","article-title":"Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance","volume":"4","author":"Miller","year":"2005","journal-title":"Aging Cell"},{"key":"10.1016\/j.metabol.2013.06.012_bb0050","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1474-9726.2006.00220.x","article-title":"Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction","volume":"5","author":"Malloy","year":"2006","journal-title":"Aging Cell"},{"key":"10.1016\/j.metabol.2013.06.012_bb0055","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jn\/123.2.269","article-title":"Low methionine ingestion by rats extends life span","volume":"123","author":"Orentreich","year":"1993","journal-title":"J Nutr"},{"key":"10.1016\/j.metabol.2013.06.012_bb0060","doi-asserted-by":"crossref","first-page":"R728","DOI":"10.1152\/ajpregu.00837.2009","article-title":"Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states","volume":"299","author":"Hasek","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0065","doi-asserted-by":"crossref","first-page":"R740","DOI":"10.1152\/ajpregu.00838.2009","article-title":"Role of beta-adrenergic receptors in the hyperphagic and hypermetabolic responses to dietary methionine restriction","volume":"299","author":"Plaisance","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0070","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.metabol.2009.10.023","article-title":"Methionine restriction effects on mitochondrial biogenesis and aerobic capacity in white adipose tissue, liver, and skeletal muscle of F344 rats","volume":"59","author":"Perrone","year":"2010","journal-title":"Metab Clin Exp"},{"key":"10.1016\/j.metabol.2013.06.012_bb0075","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1194\/jlr.M010215","article-title":"Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase","volume":"52","author":"Elshorbagy","year":"2011","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2013.06.012_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0959-9673.2006.00465.x","article-title":"Mouse models in non-alcoholic fatty liver disease and steatohepatitis research","volume":"87","author":"Anstee","year":"2006","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0085","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1440-1746.2008.05543.x","article-title":"Animal models of NASH: getting both pathology and metabolic context right","volume":"23","author":"Larter","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0090","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2013.06.012_bb0095","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/jhep.2003.50048","article-title":"Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease","volume":"37","author":"Li","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0100","doi-asserted-by":"crossref","first-page":"E986","DOI":"10.1152\/ajpendo.00399.2006","article-title":"Peroxisomal\u2013mitochondrial oxidation in a rodent model of obesity-associated insulin resistance","volume":"293","author":"Noland","year":"2007","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2013.06.012_bb0105","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2013.06.012_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhep.2010.10.024","article-title":"Distinct regulation of adiponutrin\/PNPLA3 gene expression by the transcription factors ChREBP and SREBP1c in mouse and human hepatocytes","volume":"55","author":"Dubuquoy","year":"2011","journal-title":"J Hepatol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0115","doi-asserted-by":"crossref","first-page":"e51357","DOI":"10.1371\/journal.pone.0051357","article-title":"Methionine-restricted C57BL\/6J mice are resistant to diet-induced obesity and insulin resistance but have low bone density","volume":"7","author":"Ables","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2013.06.012_bb0120","doi-asserted-by":"crossref","first-page":"28721","DOI":"10.1074\/jbc.M601576200","article-title":"ChREBP*Mlx is the principal mediator of glucose-induced gene expression in the liver","volume":"281","author":"Ma","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2013.06.012_bb0125","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2013.06.012_bb0130","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/hep.20283","article-title":"Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway","volume":"40","author":"Feldstein","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0135","doi-asserted-by":"crossref","first-page":"E350","DOI":"10.1152\/ajpendo.00307.2010","article-title":"Regulation of adiponectin production by insulin: interactions with tumor necrosis factor- and interleukin-6","volume":"300","author":"Hajri","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2013.06.012_bb0140","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.2337\/diabetes.50.9.2094","article-title":"PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein","volume":"50","author":"Maeda","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2013.06.012_bb0145","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1111\/j.1572-0241.2007.01774.x","article-title":"Increased hepatic and circulating interleukin-6 levels in human nonalcoholic steatohepatitis","volume":"103","author":"Wieckowska","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","article-title":"Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity","volume":"257","author":"Arita","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.metabol.2013.06.012_bb0155","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1172\/JCI31021","article-title":"Obesity-associated improvements in metabolic profile through expansion of adipose tissue","volume":"117","author":"Kim","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2013.06.012_bb0160","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/endo.137.1.8536636","article-title":"Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat","volume":"137","author":"Braissant","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0165","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1172\/JCI1235","article-title":"Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats","volume":"101","author":"Okuno","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2013.06.012_bb0170","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI34275","article-title":"Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice","volume":"118","author":"Postic","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2013.06.012_bb0175","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI200317797","article-title":"The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice","volume":"112","author":"Xu","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2013.06.012_bb0180","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1210\/jc.2007-0890","article-title":"Total and high molecular weight but not trimeric or hexameric forms of adiponectin correlate with markers of the metabolic syndrome and liver injury in Thai subjects","volume":"92","author":"Liu","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2013.06.012_bb0185","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/296537","article-title":"Altered hepatic lipid metabolism contributes to nonalcoholic fatty liver disease in leptin-deficient Ob\/Ob mice","author":"Perfield","year":"2013","journal-title":"J Obes"},{"key":"10.1016\/j.metabol.2013.06.012_bb0190","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.132384699","article-title":"Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity","volume":"99","author":"Ntambi","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.metabol.2013.06.012_bb0195","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1194\/jlr.R800018-JLR200","article-title":"Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis","volume":"49","author":"Yen","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.metabol.2013.06.012_bb0200","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1126\/science.1056843","article-title":"Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2","volume":"291","author":"Abu-Elheiga","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.metabol.2013.06.012_bb0205","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1074\/jbc.273.10.5678","article-title":"Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor alpha (PPARalpha)","volume":"273","author":"Aoyama","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.metabol.2013.06.012_bb0210","doi-asserted-by":"crossref","first-page":"E836","DOI":"10.1210\/jc.2010-2493","article-title":"Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome","volume":"96","author":"Plaisance","year":"2011","journal-title":"J Clin Endocrinol Metabol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0215","doi-asserted-by":"crossref","first-page":"G1281","DOI":"10.1152\/ajpgi.00074.2008","article-title":"Gene expression in human NAFLD","volume":"294","author":"Greco","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.metabol.2013.06.012_bb0220","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1042\/BJ20101861","article-title":"FAT\/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation","volume":"437","author":"Smith","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.metabol.2013.06.012_bb0225","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1053\/jhep.2002.32527","article-title":"Apolipoprotein synthesis in nonalcoholic steatohepatitis","volume":"35","author":"Charlton","year":"2002","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0230","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1172\/JCI6576","article-title":"Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice","volume":"103","author":"Raabe","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2013.06.012_bb0235","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.2337\/db07-0156","article-title":"Genes involved in fatty acid partitioning and binding, lipolysis, monocyte\/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects","volume":"56","author":"Westerbacka","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2013.06.012_bb0240","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.hepres.2005.09.022","article-title":"Lessons from animal models of NASH","volume":"33","author":"Diehl","year":"2005","journal-title":"Hepatol Res"},{"key":"10.1016\/j.metabol.2013.06.012_bb0245","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.21687","article-title":"Effects of rosiglitazone on the liver histology and mitochondrial function in ob\/ob mice","volume":"46","author":"Garc\u00eda-Ruiz","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0250","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/gt.2010.41","article-title":"PPARgamma is essential for protection against nonalcoholic steatohepatitis","volume":"17","author":"Wu","year":"2010","journal-title":"Gene Ther"},{"key":"10.1016\/j.metabol.2013.06.012_bb0255","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0260","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10522-008-9130-1","article-title":"Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver","volume":"9","author":"Caro","year":"2008","journal-title":"Biogerontology"},{"key":"10.1016\/j.metabol.2013.06.012_bb0265","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jnutbio.2010.03.009","article-title":"Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob\/ob mice","volume":"22","author":"Park","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.metabol.2013.06.012_bb0270","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1124\/dmd.110.035006","article-title":"Diversity in antioxidant response enzymes in progressive stages of human nonalcoholic fatty liver disease","volume":"38","author":"Hardwick","year":"2010","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.metabol.2013.06.012_bb0275","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1096\/fasebj.8.15.8001743","article-title":"Methionine restriction increases blood glutathione and longevity in F344 rats","volume":"8","author":"Richie","year":"1994","journal-title":"FASEB J"},{"key":"10.1016\/j.metabol.2013.06.012_bb0280","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1038\/labinvest.2010.112","article-title":"Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice","volume":"90","author":"Haque","year":"2010","journal-title":"Lab Invest"},{"key":"10.1016\/j.metabol.2013.06.012_bb0285","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.taap.2011.09.017","article-title":"Lipid metabolism and body composition in Gclm(\u2212\/\u2212) mice","volume":"257","author":"Kendig","year":"2011","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049513001935?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049513001935?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:01:32Z","timestamp":1758427292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049513001935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0026049513001935"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2013.06.012","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2013,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2013.06.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}