{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:21:30Z","timestamp":1791811290905,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","metabolismjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Metabolism"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.metabol.2014.04.004","type":"journal-article","created":{"date-parts":[[2014,4,12]],"date-time":"2014-04-12T18:00:38Z","timestamp":1397325638000},"page":"922-929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Impaired incretin secretion and pancreatic dysfunction with older age and diabetes"],"prefix":"10.1016","volume":"63","author":[{"given":"Bruno","family":"Geloneze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria da Saude","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Junqueira","family":"Vasques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Satake","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Pareja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Antonio","family":"Tambascia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"374","key":"10.1016\/j.metabol.2014.04.004_bb0005","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/S0140-6736(09)61460-4","article-title":"Ageing populations: the challenges ahead","volume":"3","author":"Christensen","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.metabol.2014.04.004_bb0010","doi-asserted-by":"crossref","first-page":"e4144","DOI":"10.1371\/journal.pone.0004144","article-title":"Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis","volume":"4","author":"Lu","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.metabol.2014.04.004_bb0015","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2014.04.004_bb0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/dmrr.1078","article-title":"Does abnormal insulin action or insulin secretion explain the increase in prevalence of impaired glucose metabolism with age in populations of different ethnicities?","volume":"26","author":"Ning","year":"2010","journal-title":"Diabetes Metab Res Rev"},{"key":"10.1016\/j.metabol.2014.04.004_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/S1262-3636(05)73649-1","article-title":"Diabetes mellitus in the elderly: insulin resistance and\/or impaired insulin secretion?","author":"Scheen","year":"2005","journal-title":"Diabetes Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0030","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1210\/jcem-41-3-498","article-title":"Acute-phase insulin secretion and glucose tolerance in young and aged normal men and diabetic patients","volume":"41","author":"Palmer","year":"1975","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0035","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1152\/ajpendo.00366.2002","article-title":"Aging and insulin secretion","volume":"284","author":"Chang","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0040","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1210\/jcem.84.3.5542","article-title":"Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance","volume":"84","author":"Iozzo","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0045","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0026-0495(98)90328-6","article-title":"Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans","volume":"47","author":"Stumvoll","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.metabol.2014.04.004_bb0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/ageing\/12.1.54","article-title":"The effect of age and sex on the response of enteropancreatic polypeptides to oral glucose","volume":"12","author":"McConnell","year":"1983","journal-title":"Age Ageing"},{"key":"10.1016\/j.metabol.2014.04.004_bb0055","doi-asserted-by":"crossref","first-page":"950","DOI":"10.2337\/diab.33.10.950","article-title":"The enteric enhancement of glucose-stimulated insulin release. The role of GIP in aging, obesity, and non-insulin-dependent diabetes mellitus","volume":"33","author":"Elahi","year":"1984","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0060","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/ajcn\/69.5.999","article-title":"Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility","volume":"69","author":"MacIntosh","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.metabol.2014.04.004_bb0065","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s001250051070","article-title":"The ageing entero-insular axis","volume":"41","author":"Ranganath","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2014.04.004_bb0070","doi-asserted-by":"crossref","first-page":"M575","DOI":"10.1093\/gerona\/56.9.M575","article-title":"Effect of aging and diabetes on the enteroinsular axis","volume":"56","author":"Korosi","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.metabol.2014.04.004_bb0075","first-page":"2925","article-title":"The effect of age and glycemic level on the response of the beta-cell to glucose-dependent insulinotropic polypeptide and peripheral tissue sensitivity to endogenously released insulin","volume":"83","author":"Meneilly","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0080","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0167-0115(94)90136-8","article-title":"The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects","volume":"51","author":"Elahi","year":"1994","journal-title":"Regul Pept"},{"issue":"Suppl. 1","key":"10.1016\/j.metabol.2014.04.004_bb0085","first-page":"S11","article-title":"Standards of medical care in diabetes--2012","volume":"35","author":"American Diabetes Association","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2014.04.004_bb0090","author":"The Oxford Centre for Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0095","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2337\/diacare.24.3.539","article-title":"A model-based method for assessing insulin sensitivity from the oral glucose tolerance test","volume":"24","author":"Mari","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2014.04.004_bb0100","doi-asserted-by":"crossref","first-page":"E1159","DOI":"10.1152\/ajpendo.00093.2002","article-title":"Meal and oral glucose tests for assessment of \u03b2-cell function: modeling analysis in normal subjects","volume":"283","author":"Mari","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0105","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1172\/JCI111542","article-title":"Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus","volume":"74","author":"Ward","year":"1984","journal-title":"J Clin Invest"},{"key":"10.1016\/j.metabol.2014.04.004_bb0110","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2337\/diab.42.11.1663","article-title":"Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function","volume":"42","author":"Kahn","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0115","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.2337\/dc10-2377","article-title":"Glycemic control, complications, and death in older diabetic patients: the diabetes and aging study","volume":"34","author":"Huang","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2014.04.004_bb0120","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2337\/diabetes.52.6.1475","article-title":"The natural history of progression from normal glucose tolerance to type 2 diabetes in the Baltimore Longitudinal Study of Aging","volume":"52","author":"Meigs","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0125","first-page":"2275","article-title":"Reduced pancreatic B cell compensation to the insulin resistance of aging: impact on proinsulin and insulin levels","volume":"85","author":"R\u00f8der","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1532-5415.1998.tb01019.x","article-title":"Assessment of insulin sensitivity in older adults using the hyperglycemic clamp technique","volume":"46","author":"Meneilly","year":"1998","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.metabol.2014.04.004_bb0135","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1152\/jappl.1999.87.6.2375","article-title":"Peak muscle perfusion and oxygen uptake in humans: importance of precise estimates of muscle mass","volume":"87","author":"Radegran","year":"1999","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.metabol.2014.04.004_bb0140","doi-asserted-by":"crossref","first-page":"947","DOI":"10.2337\/diab.45.7.947","article-title":"Insulin action and age. European Group for the Study of Insulin Resistance (EGIR)","volume":"45","author":"Ferrannini","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0145","first-page":"1125","article-title":"Role of body fat distribution in the decline in insulin sensitivity and glucose tolerance with age","volume":"75","author":"Coon","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0150","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/nm0909-996","article-title":"Connecting obesity, aging and diabetes","volume":"15","author":"Ahima","year":"2009","journal-title":"Nat Med"},{"key":"10.1016\/j.metabol.2014.04.004_bb0155","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00125-002-1009-0","article-title":"The relative contributions of insulin resistance and beta-cell dysfunction to the physiopathology of type 2 diabetes","volume":"46","author":"Kahn","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.metabol.2014.04.004_bb0160","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.2337\/diabetes.51.7.2170","article-title":"Beta-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S","volume":"51","author":"Jensen","year":"2002","journal-title":"Diabetes"},{"issue":"Suppl. 1","key":"10.1016\/j.metabol.2014.04.004_bb0165","doi-asserted-by":"crossref","first-page":"S234","DOI":"10.2337\/diabetes.51.2007.S234","article-title":"Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans","volume":"51","author":"Fritsche","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0170","doi-asserted-by":"crossref","first-page":"E1038","DOI":"10.1152\/ajpendo.00665.2010","article-title":"The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes","volume":"300","author":"Lund","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.metabol.2014.04.004_bb0175","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/db10-1332","article-title":"GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes. Mentis N","volume":"60","author":"Vardarli","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0180","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.2337\/diabetes.50.5.1004","article-title":"Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats","volume":"50","author":"Lynn","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.metabol.2014.04.004_bb0185","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrendo.2013.256","article-title":"Metformin \u2014 mode of action and clinical implications for diabetes and cancer","volume":"10","author":"Pernicova","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.metabol.2014.04.004_bb0190","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1056\/NEJM199508313330903","article-title":"Metabolic effects of metformin in non-insulin-dependet diabetes mellitus","volume":"333","author":"Stumvoll","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.metabol.2014.04.004_bb0195","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1111\/j.1464-5491.2012.03675.x","article-title":"Effects of chronic treatment with metformin on dipeptidyl peptidase-4 activity, glucagon-like peptide 1 and ghrelin in obese patients with type 2 diabetes mellitus","volume":"29","author":"Thondam","year":"2012","journal-title":"Diabet Med"},{"key":"10.1016\/j.metabol.2014.04.004_bb0200","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.2337\/dc12-2072","article-title":"Mehcanisms of glucose lowering of dipeptidyl peptidase-4 inhibitor sitagliptin when used alone or with metformin in type 2 diabetes","volume":"36","author":"Solis-Herrera","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.metabol.2014.04.004_bb0205","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1464-5491.2005.01461.x","article-title":"Inhibition of dipeptidyl peptidase IV activity by oral metformin in type 2 diabetes","volume":"22","author":"Lindsay","year":"2005","journal-title":"Diabet Med"},{"key":"10.1016\/j.metabol.2014.04.004_bb0210","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/j.1464-5491.2009.02748.x","article-title":"Investigation of the effect of oral metformin in dipeptidylpeptidase-4 (DPP-4) activity in type 2 diabetes","volume":"26","author":"Cuthbertson","year":"2009","journal-title":"Diabet Med"},{"key":"10.1016\/j.metabol.2014.04.004_bb0215","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1532-5415.2007.01156.x","article-title":"Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept","volume":"55","author":"Inouye","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.metabol.2014.04.004_bb0220","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0140-6736(09)61457-4","article-title":"10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study","volume":"374","author":"Diabetes Prevention Program Research Group","year":"2009","journal-title":"Lancet"}],"container-title":["Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049514001127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026049514001127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T04:03:56Z","timestamp":1758427436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026049514001127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":44,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0026049514001127"],"URL":"https:\/\/doi.org\/10.1016\/j.metabol.2014.04.004","relation":{},"ISSN":["0026-0495"],"issn-type":[{"value":"0026-0495","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impaired incretin secretion and pancreatic dysfunction with older age and diabetes","name":"articletitle","label":"Article Title"},{"value":"Metabolism","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.metabol.2014.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}